Auf Basis positiver Ergebnisse aus der klinischen Entwicklungsphase II hat Bayer Schering Pharma das Phase-III-Programm mit dem als Tablette einzunehmenden Wirkstoff Riociguat begonnen. In zwei Phase-III-Studien soll die Anwendung sowohl bei der chronisch thromboembolischen pulmonalen Hypertonie (CTEPH) als auch bei der pulmonalen arteriellen Hypertonie (PAH) untersucht werden. Riociguat ist das erste Medikament einer neuen Klasse gefäßerweiternder Substanzen. Es gehört zu den Stimulatoren des Enzyms lösliche Guanylatcyclase (sGC). In Phase-II-Studien hat Riociguat bereits vielversprechende Ergebnisse gezeigt. Im Vergleich zu den Ausgangswerten verbesserte es die körperliche Belastbarkeit und die hämodynamischen Parameter signifikant, wie beispielsweise den Gefäßwiderstand in der Lunge, das Herzminutenvolumen und pmy Fjunniiiv wd rkt Zkojmzbfefgbuh.
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