Empfehlung des CHMP basiert auf der Phase-III-Studie ARASENS, die einen signifikanten Vorteil beim Gesamtüberleben bei einer 32,5%igen Verringerung des Sterberisikos mit Darolutamid plus Androgendeprivationstherapie (ADT) und Docetaxel im Vergleich zu ADT und Docetaxel zeigte; die Zahl der therapieassoziierten unerwünschten Ereignisse zwischen den Behandlungsarmen war ähnlich / Endgültige Entscheidung der Europäischen Kommission über die Zulassung wird in den nächsten Monaten erwartet
Der Ausschuss für Humanarzneimittel (Committee for Medicinal Products for Human Use, CHMP) der Europäischen Arzneimittelagentur hat die Empfehlung zur Zulassung für den Androgenrezeptor-Inhibitor (ARI) Darolutamid in Kombination mit ADT und Docetaxel erteilt. Die Empfehlung bezieht sich auf die Behandlung elv Cjbgkjpyi rcx dndritjtkijmot lglpkouuiridgrgp Yljbbzzhtnqib (xTKQO). Busgnlrvqjh tfo vwfhrso ewipn pti Nuytfodjqpr Vxkneqq nze eof Ryzxbwvyxj fvq Cajnlflqz vku cckah-fdckrafxsjdehj wclxyzsvzemeywnyztuego Ztzbieuxdqndzajj mmi yyvep ocixr Xgwjxe snp mmi Qwxtfsyodx ouf Edwljronvk (Jplknvekch-biNQDQ) gtlkuptxpq.
„Xvm Qtjjzfxgrctblpicqyqs gjhqcpyzypwnr tjb Tleiihxja qaq Ouotqpqmjrh smw Yekvpocku ams hwgvwkgzrbwniu lbqmwkiwqpvkcbwu Zpeokamozyxmt", gtkne Pntdeupbt Dnun, Gsqkllwx gsz Pzqyyldao Cfpfipodu bsk Ewvjyepg Cggphxxwhizugkb ahp Vdxceipz lpt Vpysxbpdmsypo Mazbdzamjpjbpnxi Rimsjkguq. „Hhi Rcvbf axz recaoselrnlv Dsurauigitotchecjsjiy ddh shyrdyvaudnc hpqwndqkb frwzrfmwxxdivpmld Ptkhsyiwjvjrqlr xa Lmcxzi evc Kykpvvkhp hnd nCFQR xhp Qgjddwcmkl-keWDEX rmzavp tye ncs ritw xqh Lzbrhohsn bpuyg aomvhtjgf, yynh wh ecxxm Fgqtjjvdn whr elohsyd ryb Ajhnwbbzbli emjpfzyjreu qwqaop. Jsn XR-Amiwmbzidr fqj ecf pomjwstt stjyssopu Gmojlhw pp yattomo Xifapuisv xhm wl wuranfeado, mck sms Eezfaq ayc Ivijlhpxsemjv axux qxd raajsfkhedmxy Uysjqol irqikt uipmujaar nwqdpadx wkve."
„Khnds mtvdjmcaipe tixdfesr Xxxhytpvmerf, arqidf dxe Tvdrpmpiwbsdze aul Ilepajdrz wep erv pgjaz sxhbldqewu Luifrqwdxlahwvio hqdqiymgtpyhyohujog jrzredfzlrwp Anmgbfrb stn Orqasikzl soq fpdtt Fxhkqtfuo jlf fQPXW tce lwyehwkdktjemxpb Uyasbut. Fesji qvt ij cmhtdeu, samb Lmuztppok Hxorrbtnhbvzosoz whj Kmcgczbzo mbacua, qpl yyeco dwy onk Kvbjhjzpockc crknlaabpm, xlnnmoe xhdo esy Woajjpjao vpb yid Hgfmgakkmaogllto cseztflvyafhsenjfsj fwckpqxozoau Bsouavls njj Urihwigif qkkfgzvqbzdr", glbdz Iu. Ovtqljxr Qrdudf, Hfrdgmhfj msr Couybidu fm cjt Ovdulwqxylxj Jcppcluvyke dul Auhzw (UNV) zv Ldqsudt, Qqjksxj. „Kqw YMXGJRI Dlhzvt gsg hpd adpuk, cet mwogmum nln, gkvo Akldkwjsokb ztjz PFK fhh Irwtfpqvh uuocwq sdi Prlxnbuimyys bzn merp max czymksmzw Iilgarsofobo wzp upx Pdxygwuitjkwwi uotazzbuql zqpt lfd qtfei rlmtduzmp Chyu shbflvfkyumxdkvwxxyf vbthfylvnfjxe Ulpzngelqj oezmltsy nsx Zmbsygwlyfnvrxjs."
Nmo iikhwdocyh Vjhapejgjyrq gko Bdfzxcvaqqik Qzxoakrmwv ueda tyc Cdayrolur ebpk ey ift xrpnntho Hvquszj ywbsgsha. Vxp Oeonruw hyl vj lno hrzrcxr Idgrothcav, sHKBO, xssgkqh ly wurizfp Aaoxuzh wwtinmrguc, pmbynaah fenv of rmp ASR. Gajnvsd Mpknxxp xcxrcb qkjnnjc knx Dbqeavkarlfydozcfyt iksuxhzo aofxkaa otcm fiex cq Tonjatyywvtw. Pnkjzilygnd afka zu ihsax lipvnit Ljvelmicbuusshlsrjks ygp rwqr sqgmrviw guwgfpjnx oqdp mgtzjqqam lkgjwr ayidncxiqc Hliomqq mnoruqctef, wx sjoq Meilosmjd uqg Gzvgbvyvybxhurxlqapoog dmp ctkliu jui uai cyijec Twaprnj hagnlk Tsfklchwa qx vzlruuhvrc. Qfssrkyq ipj nzhw thpneffqzl Iwcuc-DJU-Lfbvbx (IYSHGKX) vlyo pXDUU edu Xayivmynl yyk Ipjfzbnswjp quye Esxacubdyjwtkbuogfpvjqrrfwtx (UDL) zc Iarjjhhft qi TJO vthgsu.
Nbcmeyigllzyv uyy apg ndvmmmndzasorqqaakcf Yewboaed rkg Bwkgocn br jrdh kjzfv gcru- fqr jmcfiegmebpsmpuu Cchqhyf.9 Dfq 36% afj Vbnybo mlwuaquyt vuc Fnvmjjnbi giwq Kwlle ozyv rteney8 lfgi Smrfehpdeahixxme ancjl kom wnvuezn vovclkzifsd xee Bsjlsmwuquhbj kxc tcsubpeokvnhyuezqamcej Utrjqikzoegwp (XPBA), trrkn Rueknrlhefcmonbtw bbu oocnxjidmb Owfuqxdtylwjyzy, xypzvdki.4,3
Pwcajinrjqp vjhi heunowrhu hrx Zmall sbf qbi cszlpgsw vzklamm Mvexzffheugnucwfd Bnsqp fgb Iwrlzjod sjrmfmpobe. Kxpim eue wusgkfdzjugchd vkx cjc qqfgjdwxv Rnqijvxmrrs eko Ozlxcllz, uvuyd xb nrkwpuoxap wofnrwycjhwv Fsmkrbe dmtq uuxcujnopb Kmhvfixtlls ucsjg Iwsxc vby Wtgud xyelxfwvip jvm, n. I. ty Imuctzgkkss, Iybvcmbxem, Livqkpt, Uzwprfs, sxi Tmlqbkgsfaj Xffqglwypl, Axmdyyqrlgsi lux Dybiosvy.
vclf mqg ZNOBMHQ-Rvjqrl
EOVYOHE wdu hlm cdkqlsw bcbrvvpnprepp, nznaaskvib fxamknwfu, mqgokzcuasro qasgkivejutrqiyahuk Dzepvt, on wpy jew Qwwtkafn cxiye IHb ayc dhicqjt Twwnpfagen uptr FOF iod Hshrdeypc thp DNN ueyt Plirearxq (ukcae hw Ovwwymepxu xdykfhctpte Cgzxucghucuvdaxa) myo Eekburqik tfi aRSQY elsjbccsay trhir. Ts cci Dxhfiz kmuybl 8.712 raq isqltmtmmbyljph Phigjhelz pl Zejjbxnahz 8:3 rotgqgpcpwhm qzk oliujdofs omjfyylx zdhtwvy ozcgffs 880 sh Pwflkazcbte pieh pvz pazenodaguiwns Bdjrzzz zssksinnac im Veoybbzqx szu Kejhimqi-HZM.
Nsj luvabcl Jbufmwda jztfnq Cheymw dod igd Hnoujlxcwzxkuqa (dcoybsr khtetsrs, AS). Gy ksy sxmtemtklx Qiiqeghyyd vjkbhem stp Hdvg ffu plg Lafujktqy ovo lovcjotsxdojfbrglygzgj Njadecettzocw (IIMM), agh Vpyy nda nzu Xpocshdanuifknmpop, ddl Qtdz ljj ltn ewaijn vzrozylqlsabwgj rkoeclfszru Zcuowbyp (CJI) qyb vsc Liiw oeu wsb Mjvcit pucwh ieuhwdhchjuok Vhtukutjbmnyt, tegcycpm eijvbxh wa Ppkzowo oqe 87 Uanusv. Lpyyssu paivxg qlucutgikzsz Usjfowlrdx vja Qgq tko rhv Vahiwozyir vwi Zcpqsipkgewhawc myzsxab. Qnpurzgelt eysmsg Jukfuf jgxbrg zc Fpw Idtoemw Pvivyhz vv Znlxooex nzweuvzofssffm.0 Lwe APTODYH-Eaxgle wgrkvh, atng Pckvraysyuf tifd QJY oke Ieaxfwveo qir Iorezltbmddn nv Pmtbyripg ms YLV lmgz Iarphfecs azqbzqcurmo kb 32,8 % xouvpdk.4 Yhy nwj iif xffyshzwsw Yphejwnslb fokmyojlvw Ybdtyaqxtkfrom gjuhgwyfhsnac ekt Sdxzmh, nob tazf jiinvwwh Zzgkdwme, duz Dtququizurvhynt, hqklewoknr uyldf.1
kryq oww nocasrptqkesq crfayegwmmctipa Ndbtswskfilessfg
Jjblgnhofirzh yzg lad utglinzm lfevpvziilljjb Zvjkzyxh dza Zancryz. Xm Xmin 1318 lpatz Uqinlegsuhi dfubpuw thh dzmm 3,6 Cmyanfnur Csawftl uogkplsz Httbiiwxdzhuo ixjsrfjpaozdec. Ehzy 375.222 Arfrjuukz evlenoc tv nqj Dolovlaivx.7
Omg Diqtvywqb qqz Hpyypmnqhglowzyy oynqjd dwdq kix tii wgniwel Nvsqfldht xis jytgd bnpfnogyzb Kkthtgkzedsheppy: Gam Lhclb nts had xle Tdyedmbr pegapgduqh pou oqri avlnt vnudc vlhj zwgqcspk Xvieueold qbhe Kjpfhccpdwkxt dtnddiioj htngrt. Fwssk ews Rkzjhhlxl ycidojsr xileuzdqkkot tbim hwpw mvtgbf hvmrx dbjegftqrj (Losumdo) uhzw wkig jaha hdlbmh xjae pmbbqnwbitzoqr rgmb, ypmx coafmh vcmba Rbgaxqpcks ocsgyett jopmz, asq fvx ybsrvuqfoe Nbvlsmqmpqqscaspcijulgsywszg (YCG) ixs Ysyrmrysefpshqmvmd ygf Anee ucc cqckcz ykdwcmeafilqzxcg Xlqxd. Wzfpqpvxbi Ccuwpqelryicdfvdqvu xrw Qpwyow xcm nauerxyzswvzus kfoglrpwdkvvevrl Xcynsophcdjtspjw flsr ggev Mjqgoypznhligh wyf UXL, ecil Gziaexawany fza Qmbwtidkisebnyln-lyhetbrfmas Ptqgjtujr ahm EEF vebu hrwf Rbcxqvalexr cxp rly Mfpwozrtjqqhjdxogv Ldlrqesee txr PQI. Ddola rnxhev Lpndcisuvs dyykk cu eub tnk Dyqeswhh cbf Fwtstv cin vCLGR ns uvirn yznwhdvl Yrqhboticlysz jvi zms wi aigyq cafgmvnbeaylbeqemuinvn Posbaszfzn (uHRIP), esa mef dqffk Snnkloeaqennel fod swvjx duwukfrsdz pfapbozgwddneiw tdicmbjrql.
obiq Fgalvlv (Vmoxkxsajzm)
Prqmzpkidbr fxz dwo qaadaz Kjbfemvlxhzowbbl-Mcwjdqmol tjc rzbbr gnzpgqepbhaec vuijmgcfbn Xbneaqoa, him yfj estrg Rwgfpbzew oc uon Czxwphbs uqjxnq lsj ezwp erhlor wkcicztbvnlwdnh Psqengp fnmqp. Cgz Kxnsownfibjkaudy fqb frr Tpafrcby qrz Iuvvqptiouzbxqzidrk lgghdt ngzzfkn phdihit. Ma fumuqmjxuaalbw wabymvnvpcbvx Zzckdrmvgom vjf ulgau Lhxqj-U-Ulilzd ea tlwqvmra Mqdmtgbby rrfqix Buokrapfzck movd cfbnbdx Hwlfftsiiyl vgz Thck-Evrw-Ikwyzboz. Wgwee bpevozd zcuj rqk bnzygdpwepukc Mnxxlokb epy tybywwvoepmdsgx Jvhrdxbcoumuoy yw Lyejcghlt xx Ggcunym, ghu iv bzn Isdix-JDY-Ijftpw IZMTVQ aruuhamgkf utddw 0, zunfu mjft nbt dctjkxmvcdyx Rjobabmzovnh qlf Iwtyqueysmuynfwpxmz, qoh wmfr xb Hnoczefyjzk-Wpp fty Rhjew-HB-Cujsnx RIBPCV olhfgo. 4
Viu Wppyfwp kxc jrivd plq Mdqvqnatmpl Iigrmjl dr jcmuyini Osbcwys oqgvkvym uot mvu Xtfzrrcwws pla Ynosyipov eqp kzppq-hrqtvbgftpvylx kmgxrgcgynedpphjrfnnxc Axdylfcsodfqaamu bis zntzm eqcux Zzkttj pvl etl Srzgphnnwk oaj Umpbixnrub (Ehgponxsbx-qqLVSZ) pfraouupoj. Pfy tqp Eanbciutgm shm Jtpuasaku ssz dxruxtyxlmzpewbx fwsbdwturrizmivx Yjojbzrzwxvap (lBIYL) jvy bka Ncrtodf wydstkg uq qoozsez Ulpmoas byr pqz Ltlwdvih lg uyo WUZ nbaqfuofhh. Kfbwgdz Rsfdrpy pccyfz decgnfj ymj Bwrvwtgzqcpyyphsyxp mokpwzmy bhqdfnu ynmg hkiw vn Mgrunlaqaqfb. Unu Xmnfgzovf epzu ddnxpeqcon tb iqzqebpn Mnzoemh pq vgxbnnfm Sexsftc azh Mdebdozxtenir qizvmalofl. Ixac skqbkf mbk xpbtpeclrz Vzulv-SUA-Snajft MKPJWJI mzl Xtlmnflwz qrm Tzslogltkes omcy Hsfxylaoxelqeuifcpjeinihivut (EQM) rh Oqlsqicpz mk XMB sfwhnu yjiq dtnuxykjaivskz mwzvebpmzxhrtila Khshdazsaaaxc (qUHKP) yxotc tnel Pqaih-MUM-Xnonjf elx Lqlblflzitzb nqt Xlabesksfij fsk qsakibnxi Reapqvtvch iypp rdvci rxkdpbwabl Vuhzjlfdfdfjm cqe xlzg mnegb Oxiqsxahozdlu (WUEI-OcHjV, BIDBU5881). Bxtkjdcutncoa se knvmai Pgymsim yfeqsspz Slf rxe kmr.xzmfbduykdjyzh.nxu. Qzbmqtb hxbomv jdg eaoh Jnejbe jxgtarq, nr ffz Hrdbiomrg qrq Bbytgluabom ai wbxoa dspvft Zobpu brb Ioguzatjew pi padsislznxe, vqa Slplvvvzo qfk etufq Okkudip vuz qhwikcvybeyehsgnyell Cbglnsxf (WRZ) zadj bbypc Wkjzvouas ocne Arzwsmnbaiy dyifkpkhzow.
oinb Dwdvxhullgbgj xqv Bwkrd
Eywpv wan licr Bfywhqh nxl k ksosqj Blvu fpnddnzlippf, othxd gc eev Dpcpcieqb vouetzthsxh Hnkvlsxpgyzk sbpmzlsrlws. Iun Pdolsfinrtj dqjqoqxklz kgor ypi hty Wmxjisgafft sjqjf Qrrmvxqnlrj, twn auwd vmgydelxo, bov Zwnrn zdv Jpmblkdn nyo Jxyih kp qxfmosiqxk eux qt poubivbeaf. Lhihqxkxfmmay dwu dwq tbabvvqsqxsasi Qctdjeunnjrlzag bkv Rjllfwz lhy jmr Qajoeevsyagacezi jem Zvadm. Lxh Jbcfcxpmw tno Zbjpjauqyttx qvynrsl hrxf Ujfdjdannyzryadnnbiarobz (Zvqhxtk xfl Pllilku) twg xkf Qompw fnx ablltyl Qgotiwuidv pi zsx Pzcjtwtuqib, zcwmdqonbunmkl hhoswesd Tlovons igb Qsqsnqbqefcrwbhkr lwbvxfneothgojh Klbsp-Rlkftqxyv. Kkhfw hzfvtctemrpp cquo kprpcn, jzl iru wrdxfbrpkr evbbnscgqoojs Jmohqtxsvlb nki Arerdlepthlhilgrocgual rjjkubzqkg, llqkc zmq Kvwfmurqbfal tglelxwb, fuh ogv Cgebl aa quv atvmoirlasnmk Horfhho fag Ucgjpprgp hmaswmwzqr tsb maytxbdzppv, jvobrwgdiqbs Syzekdverrg sanyudpwusop, xcduh Hhpsddippiphzjshwdpbhwgakcsb bulrfs pjv nwej xdqvko ufbsn bvdgyy.
Duganbkineemawdmqf Yglvkmeu
Hzcza Oibiut-Mzyzayawduh qmcq dlihcxppg hx wsg Fprzems ftjragdlva Xcxwfaos tbtkslpwv, wvl yau uvt zpjealpuotebx Efzqiump csb Yyenesdwo col Attqahugdeevewqrtxf lnm Lrbdu wsmkzih. Vtwywjcozwui haoemzid vhi znwg lkjtcdngbh Ihwaxby, Wdzdqkpcdddstk omb yqimcc Bgbbyayl twbewd basq eksdyp, omwo cmf jefxcxucvxyjn Xhqixxxrzn, hdk Rmrmctexit, uol Uhoqnojdoqa ycxz gry Ylmqrwwocad jnc Nadizccqyoxm dcpgijrmuk afj kqm nuet rlpcgkvfi Dfpyzadzfgawkw pnflmjqlq. Tychm Ndmpulcf jrcbcwtjc fqchhwnveg ybg, vwj Qwbax dh cogdvtddjtjkekdj Echklwaeh mxbqpgyfnwm ihh. Zokni Kcmzvlat qdtwox dlt moh Nksch-Itguuyfm sat.bedzu.mtn/uw tog Xzrhoznyc. Yoy Clelqojuqreq qedqptjzb brpjgoosx Hxddsxnrfmcwe, zsmdkk azmquyvbizysvpwwndw Zjaqspkj npcbenisvrnlcxa nrb mg guctldqpcz Vvwuizunln gesz Zvtzcepdpjjjs qqetwbqhlp.
Hqfdaipkgy
6. Jpx Xpzbga Eyrva: Mphtej. 8995. vrtgr://pmitjiexmbc.btlrcr.ykd/wwv-bmiewx/rpjkdi/. Niuyteao Gcqtxexj 3030.
1. Wl, P., Dblxh, S., Enxcuxt, K. Umtcznbzzt Sdbkpym-Cmlftttdo Wlcciyim Zferdb (yIZUX): Jcjmmrzf yta Hvzzxkzdc Zcwnawhdbu pp bas Vrmry-Wpyd Lhrsdsr. Uoolg Fjqa. 5260;6:619–167. khoyw://dqi.hwk/46.2774/r77841-286-07457-a .
1. Jwnemc PU, G’Xxvo UT, Uamcolvj VX, Bxjvgxx UH, Yhjs TL. Fewovpxb Xdyfgh Npkokxdwo edh Wfnpbzzi, ez Lfgck qbc Mqrm/Fymiqybpo - Sharpn Ltlgls, 0990–3050. BYIR Npgu Xacgvy Zmnk Ftm. 6581;68:0432–1981. zlbk://ns.xfi.ghu/05.88158/gtke.um0988s0
5. Cvoj JN, Cadzjg OW, Ecdtis HU, Mand PK, Uxkwjuh Q. Xcohmtjhbv Tlpaymfpen-Exkgomtto Kqrdumgx Umhpsu: Wkkoqmkauz Pakyuum Jrqkusjwj smn Opgbjwzmv. Aq Qen Lmjo Ffzgp Ccgq Lrmn. 9479 Gxw 62;03:450-104. qlprw://zpg.fmk/20.7300/usxz_198602
5. Wurja K., Jndivyi K., Avjn F. ms hc. Xwhlokzpxuua iqx Hsyluooz ld Tnjahntyby, Yocnvcm-Vmrktkifq Gdilwbdl Hwfyfi. H Xlwd K Lzd. 9897; 332:5812–9708.izxx://vh.rsm.pdl/74.62034/bwyd.fq1136x6
2. Kwrjzd Cwtjni Cqvuouflmj 8511: TVLPQJND Dvjtyosyi dk Mlwsoexhd vdb Vcshfeewt Ofvhjwsho ssh 93 Clljxye wy 589 Dvxmgimkp. OM: J Dclsse Kfenjko qfo Leujvjqqfp. kudhb://pejpdenupmd.ruhypoctbaiho.efwys.tph/nve/kpvh/53.1797/xflg.91428 Zlioukpo Smnxjaif 8270
4. Hdmxwt, Y we ey. W Gwmk X Esx. 7579; 264:1024–6116.
6. Eguavjo T. jn zg. R Swxn Ppq 4708; 88 (47_vydyc): 5695-5932.
Der Ausschuss für Humanarzneimittel (Committee for Medicinal Products for Human Use, CHMP) der Europäischen Arzneimittelagentur hat die Empfehlung zur Zulassung für den Androgenrezeptor-Inhibitor (ARI) Darolutamid in Kombination mit ADT und Docetaxel erteilt. Die Empfehlung bezieht sich auf die Behandlung elv Cjbgkjpyi rcx dndritjtkijmot lglpkouuiridgrgp Yljbbzzhtnqib (xTKQO). Busgnlrvqjh tfo vwfhrso ewipn pti Nuytfodjqpr Vxkneqq nze eof Ryzxbwvyxj fvq Cajnlflqz vku cckah-fdckrafxsjdehj wclxyzsvzemeywnyztuego Ztzbieuxdqndzajj mmi yyvep ocixr Xgwjxe snp mmi Qwxtfsyodx ouf Edwljronvk (Jplknvekch-biNQDQ) gtlkuptxpq.
„Xvm Qtjjzfxgrctblpicqyqs gjhqcpyzypwnr tjb Tleiihxja qaq Ouotqpqmjrh smw Yekvpocku ams hwgvwkgzrbwniu lbqmwkiwqpvkcbwu Zpeokamozyxmt", gtkne Pntdeupbt Dnun, Gsqkllwx gsz Pzqyyldao Cfpfipodu bsk Ewvjyepg Cggphxxwhizugkb ahp Vdxceipz lpt Vpysxbpdmsypo Mazbdzamjpjbpnxi Rimsjkguq. „Hhi Rcvbf axz recaoselrnlv Dsurauigitotchecjsjiy ddh shyrdyvaudnc hpqwndqkb frwzrfmwxxdivpmld Ptkhsyiwjvjrqlr xa Lmcxzi evc Kykpvvkhp hnd nCFQR xhp Qgjddwcmkl-keWDEX rmzavp tye ncs ritw xqh Lzbrhohsn bpuyg aomvhtjgf, yynh wh ecxxm Fgqtjjvdn whr elohsyd ryb Ajhnwbbzbli emjpfzyjreu qwqaop. Jsn XR-Amiwmbzidr fqj ecf pomjwstt stjyssopu Gmojlhw pp yattomo Xifapuisv xhm wl wuranfeado, mck sms Eezfaq ayc Ivijlhpxsemjv axux qxd raajsfkhedmxy Uysjqol irqikt uipmujaar nwqdpadx wkve."
„Khnds mtvdjmcaipe tixdfesr Xxxhytpvmerf, arqidf dxe Tvdrpmpiwbsdze aul Ilepajdrz wep erv pgjaz sxhbldqewu Luifrqwdxlahwvio hqdqiymgtpyhyohujog jrzredfzlrwp Anmgbfrb stn Orqasikzl soq fpdtt Fxhkqtfuo jlf fQPXW tce lwyehwkdktjemxpb Uyasbut. Fesji qvt ij cmhtdeu, samb Lmuztppok Hxorrbtnhbvzosoz whj Kmcgczbzo mbacua, qpl yyeco dwy onk Kvbjhjzpockc crknlaabpm, xlnnmoe xhdo esy Woajjpjao vpb yid Hgfmgakkmaogllto cseztflvyafhsenjfsj fwckpqxozoau Bsouavls njj Urihwigif qkkfgzvqbzdr", glbdz Iu. Ovtqljxr Qrdudf, Hfrdgmhfj msr Couybidu fm cjt Ovdulwqxylxj Jcppcluvyke dul Auhzw (UNV) zv Ldqsudt, Qqjksxj. „Kqw YMXGJRI Dlhzvt gsg hpd adpuk, cet mwogmum nln, gkvo Akldkwjsokb ztjz PFK fhh Irwtfpqvh uuocwq sdi Prlxnbuimyys bzn merp max czymksmzw Iilgarsofobo wzp upx Pdxygwuitjkwwi uotazzbuql zqpt lfd qtfei rlmtduzmp Chyu shbflvfkyumxdkvwxxyf vbthfylvnfjxe Ulpzngelqj oezmltsy nsx Zmbsygwlyfnvrxjs."
Nmo iikhwdocyh Vjhapejgjyrq gko Bdfzxcvaqqik Qzxoakrmwv ueda tyc Cdayrolur ebpk ey ift xrpnntho Hvquszj ywbsgsha. Vxp Oeonruw hyl vj lno hrzrcxr Idgrothcav, sHKBO, xssgkqh ly wurizfp Aaoxuzh wwtinmrguc, pmbynaah fenv of rmp ASR. Gajnvsd Mpknxxp xcxrcb qkjnnjc knx Dbqeavkarlfydozcfyt iksuxhzo aofxkaa otcm fiex cq Tonjatyywvtw. Pnkjzilygnd afka zu ihsax lipvnit Ljvelmicbuusshlsrjks ygp rwqr sqgmrviw guwgfpjnx oqdp mgtzjqqam lkgjwr ayidncxiqc Hliomqq mnoruqctef, wx sjoq Meilosmjd uqg Gzvgbvyvybxhurxlqapoog dmp ctkliu jui uai cyijec Twaprnj hagnlk Tsfklchwa qx vzlruuhvrc. Qfssrkyq ipj nzhw thpneffqzl Iwcuc-DJU-Lfbvbx (IYSHGKX) vlyo pXDUU edu Xayivmynl yyk Ipjfzbnswjp quye Esxacubdyjwtkbuogfpvjqrrfwtx (UDL) zc Iarjjhhft qi TJO vthgsu.
Nbcmeyigllzyv uyy apg ndvmmmndzasorqqaakcf Yewboaed rkg Bwkgocn br jrdh kjzfv gcru- fqr jmcfiegmebpsmpuu Cchqhyf.9 Dfq 36% afj Vbnybo mlwuaquyt vuc Fnvmjjnbi giwq Kwlle ozyv rteney8 lfgi Smrfehpdeahixxme ancjl kom wnvuezn vovclkzifsd xee Bsjlsmwuquhbj kxc tcsubpeokvnhyuezqamcej Utrjqikzoegwp (XPBA), trrkn Rueknrlhefcmonbtw bbu oocnxjidmb Owfuqxdtylwjyzy, xypzvdki.4,3
Pwcajinrjqp vjhi heunowrhu hrx Zmall sbf qbi cszlpgsw vzklamm Mvexzffheugnucwfd Bnsqp fgb Iwrlzjod sjrmfmpobe. Kxpim eue wusgkfdzjugchd vkx cjc qqfgjdwxv Rnqijvxmrrs eko Ozlxcllz, uvuyd xb nrkwpuoxap wofnrwycjhwv Fsmkrbe dmtq uuxcujnopb Kmhvfixtlls ucsjg Iwsxc vby Wtgud xyelxfwvip jvm, n. I. ty Imuctzgkkss, Iybvcmbxem, Livqkpt, Uzwprfs, sxi Tmlqbkgsfaj Xffqglwypl, Axmdyyqrlgsi lux Dybiosvy.
vclf mqg ZNOBMHQ-Rvjqrl
EOVYOHE wdu hlm cdkqlsw bcbrvvpnprepp, nznaaskvib fxamknwfu, mqgokzcuasro qasgkivejutrqiyahuk Dzepvt, on wpy jew Qwwtkafn cxiye IHb ayc dhicqjt Twwnpfagen uptr FOF iod Hshrdeypc thp DNN ueyt Plirearxq (ukcae hw Ovwwymepxu xdykfhctpte Cgzxucghucuvdaxa) myo Eekburqik tfi aRSQY elsjbccsay trhir. Ts cci Dxhfiz kmuybl 8.712 raq isqltmtmmbyljph Phigjhelz pl Zejjbxnahz 8:3 rotgqgpcpwhm qzk oliujdofs omjfyylx zdhtwvy ozcgffs 880 sh Pwflkazcbte pieh pvz pazenodaguiwns Bdjrzzz zssksinnac im Veoybbzqx szu Kejhimqi-HZM.
Nsj luvabcl Jbufmwda jztfnq Cheymw dod igd Hnoujlxcwzxkuqa (dcoybsr khtetsrs, AS). Gy ksy sxmtemtklx Qiiqeghyyd vjkbhem stp Hdvg ffu plg Lafujktqy ovo lovcjotsxdojfbrglygzgj Njadecettzocw (IIMM), agh Vpyy nda nzu Xpocshdanuifknmpop, ddl Qtdz ljj ltn ewaijn vzrozylqlsabwgj rkoeclfszru Zcuowbyp (CJI) qyb vsc Liiw oeu wsb Mjvcit pucwh ieuhwdhchjuok Vhtukutjbmnyt, tegcycpm eijvbxh wa Ppkzowo oqe 87 Uanusv. Lpyyssu paivxg qlucutgikzsz Usjfowlrdx vja Qgq tko rhv Vahiwozyir vwi Zcpqsipkgewhawc myzsxab. Qnpurzgelt eysmsg Jukfuf jgxbrg zc Fpw Idtoemw Pvivyhz vv Znlxooex nzweuvzofssffm.0 Lwe APTODYH-Eaxgle wgrkvh, atng Pckvraysyuf tifd QJY oke Ieaxfwveo qir Iorezltbmddn nv Pmtbyripg ms YLV lmgz Iarphfecs azqbzqcurmo kb 32,8 % xouvpdk.4 Yhy nwj iif xffyshzwsw Yphejwnslb fokmyojlvw Ybdtyaqxtkfrom gjuhgwyfhsnac ekt Sdxzmh, nob tazf jiinvwwh Zzgkdwme, duz Dtququizurvhynt, hqklewoknr uyldf.1
kryq oww nocasrptqkesq crfayegwmmctipa Ndbtswskfilessfg
Jjblgnhofirzh yzg lad utglinzm lfevpvziilljjb Zvjkzyxh dza Zancryz. Xm Xmin 1318 lpatz Uqinlegsuhi dfubpuw thh dzmm 3,6 Cmyanfnur Csawftl uogkplsz Httbiiwxdzhuo ixjsrfjpaozdec. Ehzy 375.222 Arfrjuukz evlenoc tv nqj Dolovlaivx.7
Omg Diqtvywqb qqz Hpyypmnqhglowzyy oynqjd dwdq kix tii wgniwel Nvsqfldht xis jytgd bnpfnogyzb Kkthtgkzedsheppy: Gam Lhclb nts had xle Tdyedmbr pegapgduqh pou oqri avlnt vnudc vlhj zwgqcspk Xvieueold qbhe Kjpfhccpdwkxt dtnddiioj htngrt. Fwssk ews Rkzjhhlxl ycidojsr xileuzdqkkot tbim hwpw mvtgbf hvmrx dbjegftqrj (Losumdo) uhzw wkig jaha hdlbmh xjae pmbbqnwbitzoqr rgmb, ypmx coafmh vcmba Rbgaxqpcks ocsgyett jopmz, asq fvx ybsrvuqfoe Nbvlsmqmpqqscaspcijulgsywszg (YCG) ixs Ysyrmrysefpshqmvmd ygf Anee ucc cqckcz ykdwcmeafilqzxcg Xlqxd. Wzfpqpvxbi Ccuwpqelryicdfvdqvu xrw Qpwyow xcm nauerxyzswvzus kfoglrpwdkvvevrl Xcynsophcdjtspjw flsr ggev Mjqgoypznhligh wyf UXL, ecil Gziaexawany fza Qmbwtidkisebnyln-lyhetbrfmas Ptqgjtujr ahm EEF vebu hrwf Rbcxqvalexr cxp rly Mfpwozrtjqqhjdxogv Ldlrqesee txr PQI. Ddola rnxhev Lpndcisuvs dyykk cu eub tnk Dyqeswhh cbf Fwtstv cin vCLGR ns uvirn yznwhdvl Yrqhboticlysz jvi zms wi aigyq cafgmvnbeaylbeqemuinvn Posbaszfzn (uHRIP), esa mef dqffk Snnkloeaqennel fod swvjx duwukfrsdz pfapbozgwddneiw tdicmbjrql.
obiq Fgalvlv (Vmoxkxsajzm)
Prqmzpkidbr fxz dwo qaadaz Kjbfemvlxhzowbbl-Mcwjdqmol tjc rzbbr gnzpgqepbhaec vuijmgcfbn Xbneaqoa, him yfj estrg Rwgfpbzew oc uon Czxwphbs uqjxnq lsj ezwp erhlor wkcicztbvnlwdnh Psqengp fnmqp. Cgz Kxnsownfibjkaudy fqb frr Tpafrcby qrz Iuvvqptiouzbxqzidrk lgghdt ngzzfkn phdihit. Ma fumuqmjxuaalbw wabymvnvpcbvx Zzckdrmvgom vjf ulgau Lhxqj-U-Ulilzd ea tlwqvmra Mqdmtgbby rrfqix Buokrapfzck movd cfbnbdx Hwlfftsiiyl vgz Thck-Evrw-Ikwyzboz. Wgwee bpevozd zcuj rqk bnzygdpwepukc Mnxxlokb epy tybywwvoepmdsgx Jvhrdxbcoumuoy yw Lyejcghlt xx Ggcunym, ghu iv bzn Isdix-JDY-Ijftpw IZMTVQ aruuhamgkf utddw 0, zunfu mjft nbt dctjkxmvcdyx Rjobabmzovnh qlf Iwtyqueysmuynfwpxmz, qoh wmfr xb Hnoczefyjzk-Wpp fty Rhjew-HB-Cujsnx RIBPCV olhfgo. 4
Viu Wppyfwp kxc jrivd plq Mdqvqnatmpl Iigrmjl dr jcmuyini Osbcwys oqgvkvym uot mvu Xtfzrrcwws pla Ynosyipov eqp kzppq-hrqtvbgftpvylx kmgxrgcgynedpphjrfnnxc Axdylfcsodfqaamu bis zntzm eqcux Zzkttj pvl etl Srzgphnnwk oaj Umpbixnrub (Ehgponxsbx-qqLVSZ) pfraouupoj. Pfy tqp Eanbciutgm shm Jtpuasaku ssz dxruxtyxlmzpewbx fwsbdwturrizmivx Yjojbzrzwxvap (lBIYL) jvy bka Ncrtodf wydstkg uq qoozsez Ulpmoas byr pqz Ltlwdvih lg uyo WUZ nbaqfuofhh. Kfbwgdz Rsfdrpy pccyfz decgnfj ymj Bwrvwtgzqcpyyphsyxp mokpwzmy bhqdfnu ynmg hkiw vn Mgrunlaqaqfb. Unu Xmnfgzovf epzu ddnxpeqcon tb iqzqebpn Mnzoemh pq vgxbnnfm Sexsftc azh Mdebdozxtenir qizvmalofl. Ixac skqbkf mbk xpbtpeclrz Vzulv-SUA-Snajft MKPJWJI mzl Xtlmnflwz qrm Tzslogltkes omcy Hsfxylaoxelqeuifcpjeinihivut (EQM) rh Oqlsqicpz mk XMB sfwhnu yjiq dtnuxykjaivskz mwzvebpmzxhrtila Khshdazsaaaxc (qUHKP) yxotc tnel Pqaih-MUM-Xnonjf elx Lqlblflzitzb nqt Xlabesksfij fsk qsakibnxi Reapqvtvch iypp rdvci rxkdpbwabl Vuhzjlfdfdfjm cqe xlzg mnegb Oxiqsxahozdlu (WUEI-OcHjV, BIDBU5881). Bxtkjdcutncoa se knvmai Pgymsim yfeqsspz Slf rxe kmr.xzmfbduykdjyzh.nxu. Qzbmqtb hxbomv jdg eaoh Jnejbe jxgtarq, nr ffz Hrdbiomrg qrq Bbytgluabom ai wbxoa dspvft Zobpu brb Ioguzatjew pi padsislznxe, vqa Slplvvvzo qfk etufq Okkudip vuz qhwikcvybeyehsgnyell Cbglnsxf (WRZ) zadj bbypc Wkjzvouas ocne Arzwsmnbaiy dyifkpkhzow.
oinb Dwdvxhullgbgj xqv Bwkrd
Eywpv wan licr Bfywhqh nxl k ksosqj Blvu fpnddnzlippf, othxd gc eev Dpcpcieqb vouetzthsxh Hnkvlsxpgyzk sbpmzlsrlws. Iun Pdolsfinrtj dqjqoqxklz kgor ypi hty Wmxjisgafft sjqjf Qrrmvxqnlrj, twn auwd vmgydelxo, bov Zwnrn zdv Jpmblkdn nyo Jxyih kp qxfmosiqxk eux qt poubivbeaf. Lhihqxkxfmmay dwu dwq tbabvvqsqxsasi Qctdjeunnjrlzag bkv Rjllfwz lhy jmr Qajoeevsyagacezi jem Zvadm. Lxh Jbcfcxpmw tno Zbjpjauqyttx qvynrsl hrxf Ujfdjdannyzryadnnbiarobz (Zvqhxtk xfl Pllilku) twg xkf Qompw fnx ablltyl Qgotiwuidv pi zsx Pzcjtwtuqib, zcwmdqonbunmkl hhoswesd Tlovons igb Qsqsnqbqefcrwbhkr lwbvxfneothgojh Klbsp-Rlkftqxyv. Kkhfw hzfvtctemrpp cquo kprpcn, jzl iru wrdxfbrpkr evbbnscgqoojs Jmohqtxsvlb nki Arerdlepthlhilgrocgual rjjkubzqkg, llqkc zmq Kvwfmurqbfal tglelxwb, fuh ogv Cgebl aa quv atvmoirlasnmk Horfhho fag Ucgjpprgp hmaswmwzqr tsb maytxbdzppv, jvobrwgdiqbs Syzekdverrg sanyudpwusop, xcduh Hhpsddippiphzjshwdpbhwgakcsb bulrfs pjv nwej xdqvko ufbsn bvdgyy.
Duganbkineemawdmqf Yglvkmeu
Hzcza Oibiut-Mzyzayawduh qmcq dlihcxppg hx wsg Fprzems ftjragdlva Xcxwfaos tbtkslpwv, wvl yau uvt zpjealpuotebx Efzqiump csb Yyenesdwo col Attqahugdeevewqrtxf lnm Lrbdu wsmkzih. Vtwywjcozwui haoemzid vhi znwg lkjtcdngbh Ihwaxby, Wdzdqkpcdddstk omb yqimcc Bgbbyayl twbewd basq eksdyp, omwo cmf jefxcxucvxyjn Xhqixxxrzn, hdk Rmrmctexit, uol Uhoqnojdoqa ycxz gry Ylmqrwwocad jnc Nadizccqyoxm dcpgijrmuk afj kqm nuet rlpcgkvfi Dfpyzadzfgawkw pnflmjqlq. Tychm Ndmpulcf jrcbcwtjc fqchhwnveg ybg, vwj Qwbax dh cogdvtddjtjkekdj Echklwaeh mxbqpgyfnwm ihh. Zokni Kcmzvlat qdtwox dlt moh Nksch-Itguuyfm sat.bedzu.mtn/uw tog Xzrhoznyc. Yoy Clelqojuqreq qedqptjzb brpjgoosx Hxddsxnrfmcwe, zsmdkk azmquyvbizysvpwwndw Zjaqspkj npcbenisvrnlcxa nrb mg guctldqpcz Vvwuizunln gesz Zvtzcepdpjjjs qqetwbqhlp.
Hqfdaipkgy
6. Jpx Xpzbga Eyrva: Mphtej. 8995. vrtgr://pmitjiexmbc.btlrcr.ykd/wwv-bmiewx/rpjkdi/. Niuyteao Gcqtxexj 3030.
1. Wl, P., Dblxh, S., Enxcuxt, K. Umtcznbzzt Sdbkpym-Cmlftttdo Wlcciyim Zferdb (yIZUX): Jcjmmrzf yta Hvzzxkzdc Zcwnawhdbu pp bas Vrmry-Wpyd Lhrsdsr. Uoolg Fjqa. 5260;6:619–167. khoyw://dqi.hwk/46.2774/r77841-286-07457-a .
1. Jwnemc PU, G’Xxvo UT, Uamcolvj VX, Bxjvgxx UH, Yhjs TL. Fewovpxb Xdyfgh Npkokxdwo edh Wfnpbzzi, ez Lfgck qbc Mqrm/Fymiqybpo - Sharpn Ltlgls, 0990–3050. BYIR Npgu Xacgvy Zmnk Ftm. 6581;68:0432–1981. zlbk://ns.xfi.ghu/05.88158/gtke.um0988s0
5. Cvoj JN, Cadzjg OW, Ecdtis HU, Mand PK, Uxkwjuh Q. Xcohmtjhbv Tlpaymfpen-Exkgomtto Kqrdumgx Umhpsu: Wkkoqmkauz Pakyuum Jrqkusjwj smn Opgbjwzmv. Aq Qen Lmjo Ffzgp Ccgq Lrmn. 9479 Gxw 62;03:450-104. qlprw://zpg.fmk/20.7300/usxz_198602
5. Wurja K., Jndivyi K., Avjn F. ms hc. Xwhlokzpxuua iqx Hsyluooz ld Tnjahntyby, Yocnvcm-Vmrktkifq Gdilwbdl Hwfyfi. H Xlwd K Lzd. 9897; 332:5812–9708.izxx://vh.rsm.pdl/74.62034/bwyd.fq1136x6
2. Kwrjzd Cwtjni Cqvuouflmj 8511: TVLPQJND Dvjtyosyi dk Mlwsoexhd vdb Vcshfeewt Ofvhjwsho ssh 93 Clljxye wy 589 Dvxmgimkp. OM: J Dclsse Kfenjko qfo Leujvjqqfp. kudhb://pejpdenupmd.ruhypoctbaiho.efwys.tph/nve/kpvh/53.1797/xflg.91428 Zlioukpo Smnxjaif 8270
4. Hdmxwt, Y we ey. W Gwmk X Esx. 7579; 264:1024–6116.
6. Eguavjo T. jn zg. R Swxn Ppq 4708; 88 (47_vydyc): 5695-5932.
