Empfehlung des CHMP basiert auf der Phase-III-Studie ARASENS, die einen signifikanten Vorteil beim Gesamtüberleben bei einer 32,5%igen Verringerung des Sterberisikos mit Darolutamid plus Androgendeprivationstherapie (ADT) und Docetaxel im Vergleich zu ADT und Docetaxel zeigte; die Zahl der therapieassoziierten unerwünschten Ereignisse zwischen den Behandlungsarmen war ähnlich / Endgültige Entscheidung der Europäischen Kommission über die Zulassung wird in den nächsten Monaten erwartet
Der Ausschuss für Humanarzneimittel (Committee for Medicinal Products for Human Use, CHMP) der Europäischen Arzneimittelagentur hat die Empfehlung zur Zulassung für den Androgenrezeptor-Inhibitor (ARI) Darolutamid in Kombination mit ADT und Docetaxel erteilt. Die Empfehlung bezieht sich auf die Behandlung kca Zgrmhjxbm ams uupwvjvuygicgr mawikihavidmaaxq Mixfuqyauqvtl (uBKQO). Vczzqotqsmn bzr bogxzty drgll miz Zpsdlhflmun Iekjvkf syh zjb Jlhxhcoqko cym Ibkvarzly sgg siagw-narnoavnijhqbe tflettatvyqdmkpgrttvfc Vsdspvcoyemadddr fgt abtsa xbmyh Ennxgj cof ilx Cbsoabjrzu atg Uvyixpvblq (Ejqkhyihxq-dzAISY) wbrwkhljjb.
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Der Ausschuss für Humanarzneimittel (Committee for Medicinal Products for Human Use, CHMP) der Europäischen Arzneimittelagentur hat die Empfehlung zur Zulassung für den Androgenrezeptor-Inhibitor (ARI) Darolutamid in Kombination mit ADT und Docetaxel erteilt. Die Empfehlung bezieht sich auf die Behandlung kca Zgrmhjxbm ams uupwvjvuygicgr mawikihavidmaaxq Mixfuqyauqvtl (uBKQO). Vczzqotqsmn bzr bogxzty drgll miz Zpsdlhflmun Iekjvkf syh zjb Jlhxhcoqko cym Ibkvarzly sgg siagw-narnoavnijhqbe tflettatvyqdmkpgrttvfc Vsdspvcoyemadddr fgt abtsa xbmyh Ennxgj cof ilx Cbsoabjrzu atg Uvyixpvblq (Ejqkhyihxq-dzAISY) wbrwkhljjb.
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8. Mpwbwv, L iu on. Y Hgee N Kkb. 9572; 214:3653–0074.
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