Für eine Kombinationsstudie der Phase II mit Nexavar® (Wirkstoff: Sorafenib) und Paclitaxel bei fortgeschrittenem Brustkrebs liegen jetzt erste Ergebnisse vor: Demnach zeigte sich im Kombinationsarm ein positiver Trend hinsichtlich der progressionsfreien Überlebenszeit (p-Wert = 0.09). In der von der Northwestern University durchgeführten Studie, an der Patientinnen mit fortgeschrittenem oder metastasiertem HER-2 negativen Brustkrebs (ohne Überexpression des HER-2-Proteins) teilnahmen, wurde die Sicherheit und Wirksamkeit von Nexavar in Kombination mit dem Chemotherapeutikum Paclitaxel im Vergleich zu einer Chemotherapie allein untersucht. Nexavar wird von Bayer Healthcare und Onyx Pharmaceuticals, Inc. gemeinsam entwickelt.
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