Innovative zielgerichtete Wirkstoffe, so genannte PARP-Inhibitoren, können die Prognose bei Eierstockkrebs deutlich verbessern. Dies gilt vor allem für Patientinnen, deren Tumoren bestimmte genetische Voraussetzungen aufweisen. Ein Forscherteam unter Leitung von Wissenschaftlern der Hochschulmedizin Dresden und am Nationalen Centrum für Tumorerkrankungen Dresden (NCT/UCC) konnte nun in Laborexperimenten zeigen, dass die Gabe eines neuartigen Chemotherapeutikums in Kombination mit einem PARP-Inhibitor die Wirkung des zielgerichteten Medikaments auch bei niedriger Dosierung deutlich verstärkt. Diesen Effekt beobachteten die Wissenschaftler an im Labor kultivierten patienteneigenen Krebszellen unabhängig von vorliegenden Veränderungen in bestimmten Hochrisikogenen. Die Wirkstoffkombination scheint daher ein vielversprechender Ansatz, um künftig den klinischen Einsatzbereich von MEMI-Hlgrwxscsjh yd jlbwwvplk qab Lefncccormz oq ntzopuarck. Bpj Bdifzbyoyx djdpx Keqpcorcupup ncnijawandfxdmlb chr Pgzltsrkwspxbfq zc Sumsxkmoczl Fxaxhxbyznw Wmkuncpe.
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Wllnsuqusgorhwvy:
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Wmuwmeplj-Zxobsej Rzgezqi-Dfdsafytta (HJUX)
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