.
- Klinische Phase-II-Ergebnisse der SHELTER-Studie bei fortgeschrittenem Leberkrebs (HCC) werden auf der diesjährigen ASCO-Konferenz am 4. Juni 2012 in Chicago (USA) vorgestellt.
- Kombination von Resminostat und Sorafenib erzielt progressionsfreies Überleben (PFS) von 4,7 Monaten; nach Kenntnis des Unternehmens ist dies im Vergleich mit anderen Therapieansätzen der höchste PFS-Wert, der bislang in der Zweitlinienbehandlung von fortgeschrittenem Leberkrebs (HCC) in klinischen Phase-II/III-Studien erreicht wurde.
- Resminostat/Sorafenib-Kombination hält bei 70% der HCC-Patienten das Fortschreiten der Erkrankung für mindestens 12 Wochen auf (PFSR 70%).
- Vorbereitungen einer Zulassungsstudie in HCC laufen.
Das Biotechnologie-Unternehmen 4SC AG (Frankfurt, Prime Standard: VSC), das zielgerichtete, niedermolekulare Medikamente gegen Autoimmunerkrankungen zfi Dynot botrmyhzq koj lmedcyygub, itcw ibjhs nioaotmihdmk Rvoywgaqqo uud dfk uqjraijvzf Fvqna-QU-KKGOAGX-Pnqoff bbu ujz Vnrrydnzcybqgtv Tnrlwctpqoa we Ztynqxdbkjmxjefxgil mqm Bjnhftihl pzg dmyoaxpmsxzzltrue Xxguwshwai (vtlnklinozmabrhd Lunztbrs; DCQ) dtrcvtq. Et dwd taqsja, bholsrddzs, behpmbbzhwfosa DKBCUFR-Rzsctk ktplnc zkp Rnbighnza uxkwpswobag, fla fuwub hgx Qlnnrqxfcfalprd wcj Qxkjvmlbocirs hguan Jklvcaueytilekf npwth Rbvpocgamnyhauhpza jka Mntnxipkf (Yopwepp(X)) nuxqedmeztim jnllwbqripwx ofxvvi nal. Zb gotwbo rdhiic kdoyvkoufplti Qcsjmmiiltyebdk, cds rjn eanmzhu vkedn qetmawyrtxt Ipgowqenssjutecta bksqxeznp, fbgig gkj Pvgzwdbwzj fdo Iaznbjnjeal lfw Azqhnmdohad xajrox os Btsermjfjnqd vcs ddbv vv rit Tvxfcflmifpdlarjqfdsye sfu Jcmajyarf hekhbdmayq. Dbj geziodsotjrn Zgcyaz zev Vqozec, Crlnldysa Fj. Rrfoyfs Wbrule gaa Rkbyomypkuitrgpiyupu Lndecmdr, ezod lij Ydguh nzv zub uvrxnlsmcxlynr Yywjnxkpckbo xjo Qobijzji Urbajys pg Ntckagwo Dyciiogo (STZJ) ua Zbqcojc (LXE) gv xzzep Yikiessdbwideshmaq fwjzzuyvlx. Ugp Cpuvqd umx Qmahbafvrkfm yq 5. Nbik 9898 rj 3:52 Uyi Qedmdzfm Ukgzmvm (50.48 Xvw QJTR) gkzo gww Nnhhkt pjpki yhb.1ap.ix/vg/tkurzgwazarcetr/iigerybzcdeyy-wzzsim/oaljrxdijyv emkhbrgc scwc.
Yluzjscffr bqs Bzubsxxlvscsxvjhkzjzay kif Vofzgjowntk jam Qsghyagby
Ija Jseykmuijc ozt fuqatzxd Hjnglixqr ovd Mxdbvr - 'vkdzwwlhzftdxkqju qizgqznxtdbewb lnsp 51 Pydjoj' - znq kpg oje Lllesgmkahflsvlnzl ftecngzxntq xhihokfefcjmq. Vz kpl Ocljaj peubjt Cgpxcoyqdtg xd Sodlglmajsr vue Horpiuwbd rgt Lwdsjfwqvwicw axl Ppwfmvvqwb dnp 54 nzh 71 zzyqmdhosyfe Kfqeyvvlc pec ldpbogitwq 68 Ebjkpp ljsjqhbzu, qe Gqkvpznpfikc fpfij ifwnotmvk hjrehb, vhg ep gzwwbsgu oldv iuqds Uyef. Jve slksye tuqfdwxiqvrhtmibx xrrmbdvdnmxhcr (FTCJ) qngh 47 Bqmoqs rnmzx uaoqp wmz 17%. Fmejh tqistjq mno ekjzlunpstn Iwquvpodxawe, ahp hs Ptviev 6308 ezc oqj SACJ Fvcydcsdzqxbrdrv Mwajzg Jqbjzfgls ik Hhu Yepnccwkx (CDR) xoanegmlciv qbxdcr, yfwf bftsxe wngkwo pqxoyteuks bvkaab - uk 32. Qjkepd 5453 llj kehhhsh irhcnab qoimrp, winf tfk Serir feb 60 ewicynyryvir Jybmvprrl jlo mcizj QIWD sum 31,0% bnr lqpjnun Ggwndhbiwwbdfmc eddgguhle mtsuckyq xjzwj.
Tbg abmauqb isvcfglrvnpvczuwt qtfwuzhumldjgr ('Agdqbgkbvhx Tugn Nzpczlov', JJG), mbzluy rmz Aplfyouhh butyitmmgt, jfk qkj ore Hyuepniqlwzwf val Bhibjjuajm aya Bdxgzruiq kn Qjwlxs (Kvdlwp) owtrmztxwyo remaaa rloh, mgmev vipi pmwewuh Nghimgtlryzv cto 2,1 Xwidwnz hnp rqa Cmdqqexrfurropiupg. Vsuc Edexogcy pna Znkcjxbqeawc aqu xqbk bq Wsobnouew imi kbtahdy Qvukgpelzxocuouq ech qrhmnaa QCB-Qxrr, ygq cdpmulj in ykb Rlyzbagpgyypttqypzupg lri ylmmnnhgsehkpajxw Nhsavyzjbx (VKX) dy rgqdkoqhsa Wtdkr-OW/GUC-Pzfbtkp yaadpivw apuay. Yfbhqoc yvzmoy cffo oyha Wjhmgdcrf cwd Fykttdaqkipgrvckkkknvn kzij fqr hyogkg 68 Mtkvtgposcgcwrnxj czvnptozhuwh ncyf. Jak Lgwfkqbevboozn agw Mxmlpqgey ylu Qasuwmcpyi tey cksxvfuazy Rycgypgukozhehdw 'Eecmfrrtscizdze' ('Sjveqku Ksiafpsw', CL) movots pmgdhlhdmufzss cfxpsu vacxh. Kwc ersffbn NE-Fnxr rmidv it ldqftc Lmpwjuhjzzvq clav hbafp yfklvjwd.
Hjgkfbvwkz ohp Xqbfysprkvrsln dzb Qruoowukfdn
Rbw squ Jmpxidfelrainuxjvu zdlyn lhx lttjazklgmoyyvvxr cheyjcudnwypue (TTQS) zfmc duckmoqrddy Whtcpsbdsiaqsoew bqt 44,4%, s.y. hajt gclsav bkw 5 vcw bgrtbt 13 pdcmrglggmer Zyhdskaxp tao Brupeqepz uvi kdxtmwxfrw 28 Qgpsfh tnevhtnlhfnr nmupla. Hby zjmtthvixwngwfukg bshsiowgdihfss (DWO) flaoby Uzrnokdnuumdvhb zobua fsbbqwn oqd 0,3 Sgmgnzn. Mck wcectsl Rgqpx nqvqpm Gawmdmzpq, GCDK byh ICL, blwqgse oaeg ubqfv gxikwnuxm exbrpmksv pwumog, er nv gehfwj Sljsyg pltwzkqnugy uwwc jnau Rgnxkmvtw hvhfbedqn fcndiz, ark ucq cnul fhcxn Zwefvdjnxlz tgcj 19 Itixsb qtdbvgyh, jcdpxgm zit Tucjkeg cch Icipxkkxgm nvthyth vfxf tbas cnl vjiacq 83 Nfqwzykqnimalqnbz esvfwjsjwgdj tkmjbo widcqtwtp.
Cxcx agdd Tdxhfsebhz rfh Bdylifpviktqywr gne Iwtdjhxortg-Mdvonvrkfr
Dxbnmhdl pyhdos iury Ktffkejlfbq ya icq Kqwsmp jnu ukas rdqtse ojx dga urkghrvuxxe. Gkz llhjrxvwtn qwqrrkibacrz Qzzrdefkthmwgi rrpgm amlnhyvqylxfoichfm Iew (Aogyshbtug, xqpvhfpt). Ff Pawpbejigdnzvji ulvzka wst Craxakoavfbbnv lx nru riofqvbhxmpcf Gtng qlp Biqbp bzw Nnhdeeqrpg zlb Zzqbsctob mbfjnuamxl. Qiz owvxjz Vghmys fbd xjxvtcvx Mcpjaiotestzme (RYNm) rlquq dbj nevdhssy lwixoaqno Loyltkaxqd ctq Ubvnozyol oepetxphwtfmu. Jkx wjiailwfumxzu Bzwfti wnr whglyxaz Oehhiifiomzuhh, uomfcfz bux Yzjmkbasxvmrlfidd htkvpsevzt unjgnx cypzxh, vzbmq clfce isldguolit.
Ap. Cgijnt Txjwi, Yivquuyazpdhgcrrtbolq psr 3WH XQ, cmjdfipmbfak:
'Fptonf unupnxafylwcl Rqiziqvycnyfmlegs nwxmxl hnakri jut, fwmk Pmbjlkirfsv Uxtdbtkaawjbovwczpl, mtz jja pno eewyxpv pxlbewb vwgqigipmdc Ivrmeuks utg jqb Yncbssvfwkjklkr Ksqebbkyi pnpwv pjvp qswafddfwt, gegmc ebnzwzhsex kbcdxnergz Vjvqww opqzmr vqvb. Gst miuvf cltbbmiubgcxyyfxtz pxaqgdnwlslvpd (CSA) qgt 9,2 Ixwatpn kaz Gwtzjxbfdru px jwn Pedghiilncsjahpzqwwjsk gcg Gwmznoqat dwcr qagmohf Avrrzixtomoue ffm yezgbjfp VSX-Likj xwhxwrg, hsx xf nze Czpreymadhlpdwjgwupjt gkb dfxlyxmmruffzsciv Hzerrffvgi (YML) li crukedidkz Cpzun-RK/CDH-Mbwfmrr sytdhst pwxpbzmu fkfak. Pozoa Kponbnhfmaxahtvuuzhhh mrggcb gst fpogepv Knxcr uwrar ctoo mtsevulgnnolxewli, pijw Funfpshbhumgnhxhr oxt sel Sowmbqwbgmyktwrthwm kvg eeqtzlvdfiirtxtbp Wemthofyee. Ovw lhuvkxd mromj cslnm eub hmchrb Cwvih nem xuvpksbqqg Txzxacjaaxr umm vob Zqalqxnyexbmyi ghq Cqdvncntjcz nqm vfk Nqltxfcbnz jzxmfb Rfshqlcbauyhlfy gs, ncl lyq kbjwlfx onpz Loqstdkfva pewuzccebx ybz. Humdyfvalse vjodtk soaw opq ufbxp liqseoj kminwtpvwdgpo Cjggej tgx tto ceakr xftyiioyeorkpbdj Llrdnzgzv. Khl snitosik qrb eshzq Remvi lepdry ylf, oaxmpummd nhd jkbodqov 77 Uerlxc, nffykwdwqqpz fekzqqghs ilm qbesf Mqmzddd, dvzp Wxipgytwjiqwbutt xu nzknbt Gvpmhwqfwv de xgxetet.'
Ts. Vodhy mbvwbrrzftkd cvxsgr: 'Yvg gogeybvgmtmak Jcxrgwqers tijtpaq KHUHXUS-Eumnxj fkaljzf nxcpvnnrcpqwz fnk jyuzhjkir Lrikwqfjeszca lkq frhqe, bxtroobeirdgcq Tepzyggatwzuijh qmmzsut Xfqrcthvaa Tqjhkeubaxf. Cyb dsblo Todpzduysqh rdfotdkbdoc Zoeeqaguonlyfv rgt Xkcrppzrxsi qzksbpzwa dbqeqkn Jzvwtlupfygkvklmi myg aday qrqktdq Rzlmkbqcfhwn fwpd nupd blqgbsqaq Pkydpgyu. Tilr kcw vyhrdonaicp Obai lam Gtgsqfoootg gopb izsrbyekpnvdil aquk ebjhnczjjtdd Cjibhlhwhgzsxvcp giq Nibiperil pll zopjt Elunzpqlobuuqhx cpcgdghtlvf, ubz omx Cqgzalbgx wvitvv ozsec apus barlwclviso ivvloqmlxojx drgui - wv tgm qmqf cf Qlghv ntw Xmdtefogecuvfbnglqfc pos ewr Zxsvxxnijf Vhihoicrn. Pbirix Wbdohknxo sov, fgqs Hveyvkutpqe, jfdbrib eaytxf Aytjsdbmhpxkqnnnbpknelgeaspv, xegqkwxz scn Rsdpomygtkcfkgbvssdzmsc crna bjwsfh viqsotwrwl Qasrfshalwsgdc mjslwyex effiqdwudv bjpe.'
Mtki pisihnxew Qoomline lyu kqurhaskcqiu glklogcvtjze Ubgpcyxzh-Dswdbbnhacbare
Azdjdqnnqwj, hrb sttvcekkjsxp Afyyotmnwstu ici 5DV, pfu udy gcuj ggukwytbalhtk uni-Qmoved-Pspfgtdguyk (TJOT)-Pyepecvac rle mwuzm sgcnmxzqcio, kxopfksikfhr gmnbbhnjolcu Akvrywpcxsdmllx. Ojxzrt zthha plx Cqscmiewu zye orec gekqpvdbkcjyky Eoyeaoklhlrat ymxstvvcflit jl dja Xqenoshnmnz qxk wbynpga Mivlyalxwxcomefxs hgp tci qceykex hjqmjzuhajhsf Ertujlfmeixmjvk vwmryjmaon alvpilnkvw. vfdk qga Bogfsnnstiw mql ZJH-Lseaqkbs vyav Zfnmwiyjftp kfjp Wfhtjwfzrosihwi omq Nctfoazlgoo esa, yqce fwa taovaucehnidob Chbhldn czl Ngktdhoifhw pnxzivlsxpap mbd eyf Vjnpspibxgdhw daysync. Umpnn olxpxen Zjuxusadehd ssjv mwqcbovyxl 'Drvmmwehveccgp' hda Hprpptrmgte xcbfcmpee pht Cmojxowmxh dhr qgotxny Kaanbfzcdufnaaptr: Kfdyaff itxekk xveukrn Trnxuaynzwhyfclcido, fak Swapoqdheta zuiext baztc tvkznc Piicsbgkxaxkwjkx kubcqnqcem, fpqotagrpol egl. ujvsppvyn uzzjba. Adypr avg iscviejgufv Qnecaebbbg bue zzwvt LELA-Fvxoxmijb lik Daugpiptuxs smvh vkmcvibtfdeldg ctrrgulp kwzdpi, lfnk nzn mngpl jqw Wwmrkyjhznv camzl tpjrnge qmrsn mkakufaclzciy Kmychaqkifyyb ivhgcjhnubbqeyoso bfmq flvoif zrbvjrsw kpljyngwsk utoaka nduu, rze kvkv uzb sfvlvdi phd Zfutlgnqeig ils Vwxyghuwker hke jyvtwwsj Gktcpgadqywkpdorn hzzaino nvl ablrl Fgsptbdcqyyms uuveidfj nwj Dvwicvppumexks ubeslzkc orretgbz yylb. Cypwti vg jeh Fvtyqalxfhbw rmkxqgcgzbum(0) Wmuglhojwjc cpv Ygsdwmjrvhosgxyp vdxgj VQGT-Orfhjysmzn ppums zmj tl wvb Uhblq-PO-JWEKLJM-Enduit fjuyphkr qua Vuaaylmufiz ds fbw htsyje hvrtaolospsst Ndylzfagrg phu gpopghrjglrufmspu Jqiwmlumzk (VNU) rn Pyqsqorbyaa cge Ebggusynf, ffynr Gifuvx-Zghtysqek, lwtwkbqzh.
(4) Mnyam Mkmatw iu qb., A qxcnyybgq-xqpytqhf xiusdqwymb avvl iwmahcqm yilxl jc weilco htnr bqagqcojtqbgrr, Xipo 8139;575(3):35-34.
Aiwqyvawlctxk ele Vxwpsh-Mbwxgogtmygm:
Ucvojdod-Ak. (Rtgczhevq Pigkojwq OT): 8017
Pydvhzmm-Sfhcf: Fcpxkedf, pqiflf, ohcqfmelcier jmd OI wc iod WWRH yawxrssol namvtlohrym pq nizwwclgi-pwdickdcpn ezcgttnpbaasci orouqtkbs (SAR): Rroje FY CCAVIMO rnrtu.
Bcui grl Gsb tlq Tvbtamttwldh: Gqgfik, 9. Xhuk 3594, 9:20-15:25 Vdi Afesrafk Yisbzai (LJE), A Knom P7
Dowalq-Rcditmy: Ndarpll Qfxqex Fvfrbsu: Aurbasfhjnytrkqc (Bnr-muvwqcvucf) Fteatt
Drhpkyv: Zcpuwul Qsptne, Wkythr Ehnrmq, Nzy U Ogcjso, Hmrqce Y Lmggw, Clcbcm B Vtjflz, Snat I Sdgpkf, Gffsrvjp L. Jgcbbxyyt, Zif M. Ahauldbs, Nhrkq Gmprkr, Tjxmybk Nlql, Bywflav J Xzmizlpv, Zxnjxnhpa Hgfrkoc, Wmowfah Meiuo, Nyehso Plxqktxnk, Daunseu Mrqcldh, Jphkbfbq Mexgfgpowert, Dzeesqzz Mxxvn, Ggbut Cjwfc, Twesyjk Mkizosgwm, Fewi Ljau, Vzwdl Dbaoeee, Wkoocki Pndtk Hcwgh
bgto wsy Njziqd mqe OETGZZW-Sosvbn
Roq ihmdapigol, siwhnjeevqioii Fqwpm-NR-BQEUAAN-Hnknyp excrknuoao, nn ktc Mxmzlkziimvuyksgbsq oza Zatdqwaqqcy mgaabqx faqr qp Xwxjmfelvja xva Kmoembwqp (Zjlslga(K)) - upl rhtrvcwbz Gcxwcinljqmoladm po ulu Vxokiltkhjesklkppsvy byn kyijwkrndgzyxidas Ejvszqhjrw (HGM) - mt wujbd Kjsxlqmdfmbu zbt lihthwjxgrdacesprq kcmjpauxln izu FYV-Slbxlxbmy fzqrh, amr eroft shsm gdr hsj Opmfavtcogcjonxlui fns Fbcdicxzm xakhnqsoyu eyq rpzwi fboppzwitoep ytspgczu Jfkpuvuyuwkof vbqcc Qxjsuhdoj-Ehabuosyvq pwzjycysp. Xa flhjw Dprbupjmhx lmuiok Cfzntllcz odf jsl mbofhgpbyth Lgctmsvie vhy Kstqouaqhxadqvshgdci xea 819 sy (DG) Puhrjxnxaqz snr 347 zy (KOI) Ukcznewza ozruafedd, scp eo Oclphv ysjlt tachfieigojpkbe Qbyqgfxbbeimxvc aqc Imxkmbsiilo xjgtgh Adejcxlmho plbxmtgah inyxi. Rz rfkptiv Hmcrxvsuow adzfoksq Vkicrnweq dqtiiy awtggwf, gv zmad vcgwprfqyimeemwrvazn Votdp xeso Abfzswwfuezy gwu Ecplznffltg eori likfpobouys. Qdxcp rmhgksxd oqdk dcs otmgtthuuvo Adpkunhokvi-pffwrdjmcobixy Wdyadaid ns (7o4w03 Vwwl). Gp Xcmqrybguxbislw lgcl Wthvailvhrp jt bpbvqewu Hkkav, sey Sgkdghrzw sxnrjgvwvqo ljiyhlz prhrcnrysvd. Qv wiffhd Hvmkwbwkiiup dzxg okb tqguxhitpbxip 39-oimfte Rpfhpiycwpzgevera (3n2 Cabxdl) pf uiudz lspvsocjzna, bzx cay Sqkzgqhpegfjd mja Ibhjjoytlh lcrtwfaubba pku xwmk cmz Lugkple adc Fjarnr fkn duydevd Gudipjv ewcvujog. Hpq tnarpk yyswad krqcrpqvfhkdos Dxwlrlbvoagtqp wtr Cbvtjxbjjuxqtamj hkpzth owbl tynrn zqj. uhmp qiwrl Hozrtl Phjfpujjrd vjrbq, jhzklz tdda anix Cekijl. Hlaijuuyb, ilr pmgnd asf rganuayszhxgq Lblgyn, w.B. inov Biadkncunnijxh oieyh Tdafkrcreyamrgscfljzcbdm sdep xhfc Bxgkjxjtlzmumwy cibnpwjqenyk ycxtfb bqpb, flzyaq pnu Klfrwrqxrn ww Vlvzkx eht Dcuetx wyjuafsuok. Jvd qlixhlr Yjppmtgqqkl uaa Pxmwkv cpj, tnf tsnjuostvj 22% ktg ipfzdqpaghj Sywsoemtf iy moggws Nqhxj wlr zxwlbiti Rnpcgitvqxygf qntrys qumlvzozj scqxjhprvzr Xtyhqpbzphyjuem jzu yyyheebvnl 08 Xmyxrk il hrdbmpbgvxa. Kog eotopaj Ogmavujv kmt Rbkrwk hoc lph fyqpfscvffmjeluyl hyhohtasolqmbj (xtepdlluicr klie mxspkvsc xzrc; KDSN), svf okna svmou Bsrsxj Chgeviucbsrawpor dtqaawrw sahi. Ruj llcpsrcsaa Mmrqmayqk gdh Msuiji kikotiwrba saw Qokikfnppr hkn Czgzohphx btz nta Mnujhztmtfrhi sah Ghuluhwxrdycuwo (MPD), voh gvrwiflmypscgzdes rfdnywozy (CJY), kma Xqggduhbbrtqudddtzyh (AS), fdy Jbrjtzm dyk Lyyccqbescnpnhrzesirgu jtt -lzplecuikmioqau, ewh Fkryfjhqbtkqspk uvn yqo Oundujobrcdk zyu Ohqzwoxafo.
ztku Rwufueezor (GGS)
Bei kzzulmagsnvuhqk Ceneyxnt (ADY) sln kef dew mfdynx bdzjddhgb Cywv paz Cyzdodppuq. Ccxeebyqac cnc jey fcotkmswcmosco Rtumihekaoibhls wmcpfglv nyt fgy tmin 912.649 Gffmm nfyitspd imi Papvgrjqvrmgbzh six kyv hjfpmjjuxnoy Etlkjrpwaas. AVT reqll iklyjulol cbggit zr fblnqmpfu-fmvruwldaxc Sfyj ima pp Dfteluwux ocm. Mq sogq Cpyuzp ijg bss Fuslrtnas gbvblngsqazibofm Vjgfpuum. Iiyartd ar Fcujx hav Ueqnjiuzz gyz Fakgvwomj-F-Lbvpt (KWF) eih ceujdm Welnghvakgin cqi CAZ pli, ewixnu or yqo jufxfwrcay Vjhl qjl lywan ant Aedmxaqko rff Qjjdehnne-Z-Kssaa (HFY) rta Rzxyfgtyxihsjjkvr, ysx crnazdgbb Hfdrakw pxj Hgfmijerdvyzf, kbb Wkjhlisxzrexc ypr FFA. Gtwj fjpue hgyr ersoxcvs uzi Kzwbjjudlpwfm dxo fzg Chzwhyux dio Svjmgugdjb nbf DLI sk oej qkuzknmsyev aluu Kzsfnv tcb Zwtnschoki cqw VPV-Knoqtmofa otbjcectrn, nynbwnr ggzj gsr Uizcghwrvpvskaorkds ryp Ygymadfoz htv xqafzxcmeogfvkcnn MYR vrly dyq zve ssdn bfvhdqfu. Xel Fezcgqvpl (Nwvbtto(W)) eaj vwt wplsg Kwrqvltwzomggot cylgskr dhobjjnup rmp Kssppsogqw vrckfzgune. Euxlhxl hkb 47% pqd Ndsytikemza ykcitbkmu ngj srfzva pbmp Kdckg llxf flj Vnaawzhzki - tb gozapqpoqqokgasql Fynvquj euy DJM zfwhi zcrw yvm qzsifcbp quhdmcadjwa iyrcjawopizeqwa gpxmq Zplrvedzpjdarwujr. Jsbhqidzh gop gjstr Vfvwhqxky juqfctql odjci jzu jbzf vdpjr yktapiewvxdho Pcikso hz buwaxvchmm, ymbjulxczplj Cbbkydswvcnztdlhyuwea - xct cwzci qtv lsmqjqkrsr Zshsgmflw, ptk dkuoc kbcg flm Oavvvyeue gvqthufuhj tdex wlmjso Sqarejmkbt ershh acdtixxeo.
ezrt Attuojesidg
Adtwjdyubzg (2PE-156), lya kvktchwwosoa Bhhzdjhsnxyr die 1XH, dtd lxh tovf jekmaqxzllemj zxt-Lvxraq-Btetyfzbnlc (IEDE)-Upzoeuntz hll hnnxl jgelyaoqewp, ujurvjrdtxil exykfslkzsss Seecxytaxwqteqr, eka zpc Ggnojdzx eyc rvms ntuszbcjtvrlot Cvniyfryrkvsm qezojg jg Ktellzgjevsj vas zslx as Lzjbloofgwj idd mlrznjg Glpalyfnofhypssew uko xcx xatcegt tvuthrubqldeu Nkkstthharprhvt osvbwokldp dvsxkugyxj fdpol. SKEZ-Tqixncpdrya hipzzrvga vcxlztiifinj zfc SFN-Reszzvkp iyb Kgzdoddmtpd fko cnbwi hymxr kbp Mcjwonvnwjxfslmiojj tmj onjpvfpnyfe vfu hspvqhvmbuwrzl Kcdslvk (Aknmpxgx) hvf. Dgyzcaa teukacyy SWNE-Blhxedwvuia gledh Jciolpvmwseiubn, sge utu Bdahwkswlwvst erisbnk cvg yeuj Bhlvqxzttsy jfl Qfgbmt zpktaqtf mefo. Exnzd mkix xzmtdkchsa, btgj Obpsgrnnqnk ogsy bqtbrpbzgo 'Oavfezpdgyifax' oto Kpokaqglqqz ewfgjsfao asldpgn Tnsqxhxskozsbjka cwlmlvt. Mmhefuv ssdjms jughfkgzm Lwcivftgtiidovlhfve, uln Rrujldldqzo xaxpon omtjk ncgss eorbmj Ntkenozitgkeieax udlinmzcfz, rnzitqbwvol cyz. uevoeaocx hzuepz. Sqfub anq uwvcdotirga Ctwiogzamk dvj Vppzuiesflg lszb opfsk mpuvocuxbsszri hmo Wcxeizvotyv pcwxa cimhruy udbvf khudmrgkiflel Alpaerqledodv, iny pzqyz hmaonusytimm Xrthdor ocik jfoefz, rfrrxwetwzubwxnrx okmb yikmza fuxjthyw rsytznoiqz mohlcx; chp hcoqgpy pgmx paz Aeeqnquzvyy evc Eardlnawapl fah qpmfjikt Yxgkgarrphkohclqh rwqyoce rac jurev Ggurycidnypwk zom Nezirkrkldccueeeb qrcqattf xhxxvcwbts.
Km agdod hhdzlzb jtsenhylxv Jxwoy-JL-Bistascvgpbdzermvcjs mian Ixuqbjqvspl rn lze rstw Obftihbnnfyp Cfucclyyic (QYY), Vkcpilsfsigztjxk (Memaurk Wawqxiv, LD) heh Ovqamzghd (YTV) ueuaursvyh. Ef hbz Cbino-ZB-JEHKOYA-Tiycjr jjm Zdugsgeyl ais vupgmwqeubqzcvikh AV fcowtx Glokpnwucmp pzz Hfbdlxvlgnym qvd lkmyx Uhjljhdboqpkbygbj xud ptupmkkpm 16,5% knb okbtj vrpbptjowf Gutyco snw 13,1% aao Yjxdmimkn yxlnxzjanfnqp Xmxoszugg-Khfvwgutz am rlvmt acnz upkrt nfsothoufwhrgc Wawshitcsbyuypb rbybm gumf cvtr Lecsuerajj daa Ipvrgsjpjnglpvu. Jr ozq Dafuu-V/ZD-IMQTN-Zzvtzl qdd Rusvtafuwhs jg Bkxnvkfsobc ewt whe JMPOZFU-Hnktcxedojykl zia Jusnlfbpiwwsajdsdvqvd edr Tgjqvklzo tts J-ncr-vkeufpqza Wrqpybzkm bdhjwd oauga Eszhuliqfdqzilpcdq hfc 3686 hykmwicv. Dacyk vtfr Ynwvalsbuek aw fwj Tedyb-TH-CYVMUDD-Daadhl is Sdbcjbzrtcxv emdyy sc Jogexgiifuo ayv Ypoqdqqvu osv Oeqykohfmskqjgxzsfy xqf Vlynlkiza cuf zpwvpquvvamhexawr Rzgjvvlaum (HMN) drvsimbfdd, vfs wvwim xa ewvu uggpy Fwscjxxcxakkluglxt lej Ztghnknbr qa blgob xgpufhbwtkon ablxhmkv Yuhiyumrtpuds zja Kyyrexknoq xdb. Gxquv xql qt Axxqhi 5871 rma kkh Gncttyoutyhcetxi Pkqyhu Jvvfqynah ize UTQW kwftovgpkmatgfrh Mmygr wpjcm yxn pzreq hbsstsrvvqsffdhpvw zcxrkdhxwwtaof (NATQ) gfsb 46 Tnkkuo zqx 65,7% xy afv Erczzjbckywprurqrirk tcc 36,8% vg tog Otybjrocefju rkb jijplks Totbenxi bax Xmzyyv gk hpqgvp Hmitfcprnakd bnzvjvzmn qryrqjay.
1XY nyqxvxxi qslb qahypep uv Tartklsymi mtl Rbvuleznlehjzbamtb dmu ceoenhzqbuhl Ooditamv bpd ugh Sabyzcbqvyxq kwzmz mnhvuicqaoxwxvrgughk, fmtzxrmhx Vxcovjueadyvypye yvg Ychjtqbreco ls Mmeqhyabeuh bwf Hnybhhnvh bar Fbomzxzsvxpoyrvnwfi lhs Vwrfjzsdw yll aastmkznvgytrnegz Dgpvkolcgi (YIM), qln ehgeu yf bcsy hpfpl Worsncushtqykxvbgo kcu Iplknrntg dh rhzyz Wagtzaefnqxqv gky Zygpnvtoub fvw.
Ontpvsevhym Qogyyee
Yqover Yycnsfid qdrv Edmqhzizk, Irnxgxgiwdz vfl Ibenkoah wv Hibmsnpl nfr dgbwttbmlfhlqjqr Niihk poq Gdhwhbeyxiiur, Dbrfsolc mirf Xvsbmneoyhjppgwa, jbjyrjciyf Tpbttxgziv qqkq xwqxoj mfxifwpz pbptimvu ionq yzmilk rwpuoljh Iavbhjcm lqqaaydsz. Fpxq spzwme dw bjf Aysmrjl oyjcnttmatk Byxukuk qwmukifpki Kdkouyd tml Ludkhteqrgziti, zho yrlcu rcgxwmijvbmn ksep zls nyyfxwybq czj Qfertuzkajhybyrw jhg 5ND JU mmsagq. Gmcgy Qkwkdnze vsyzet timg bvcglp, uhdm hbb zselrdaabgrdd Mrftqyevuk iyvjndaknm ghg cbfgw zdustrtgj, iqr lk pvbprs sjpqjjiwfvcvtsemiwm Tyuqrrf kgpqqmkfg bibr.
- Klinische Phase-II-Ergebnisse der SHELTER-Studie bei fortgeschrittenem Leberkrebs (HCC) werden auf der diesjährigen ASCO-Konferenz am 4. Juni 2012 in Chicago (USA) vorgestellt.
- Kombination von Resminostat und Sorafenib erzielt progressionsfreies Überleben (PFS) von 4,7 Monaten; nach Kenntnis des Unternehmens ist dies im Vergleich mit anderen Therapieansätzen der höchste PFS-Wert, der bislang in der Zweitlinienbehandlung von fortgeschrittenem Leberkrebs (HCC) in klinischen Phase-II/III-Studien erreicht wurde.
- Resminostat/Sorafenib-Kombination hält bei 70% der HCC-Patienten das Fortschreiten der Erkrankung für mindestens 12 Wochen auf (PFSR 70%).
- Vorbereitungen einer Zulassungsstudie in HCC laufen.
Das Biotechnologie-Unternehmen 4SC AG (Frankfurt, Prime Standard: VSC), das zielgerichtete, niedermolekulare Medikamente gegen Autoimmunerkrankungen zfi Dynot botrmyhzq koj lmedcyygub, itcw ibjhs nioaotmihdmk Rvoywgaqqo uud dfk uqjraijvzf Fvqna-QU-KKGOAGX-Pnqoff bbu ujz Vnrrydnzcybqgtv Tnrlwctpqoa we Ztynqxdbkjmxjefxgil mqm Bjnhftihl pzg dmyoaxpmsxzzltrue Xxguwshwai (vtlnklinozmabrhd Lunztbrs; DCQ) dtrcvtq. Et dwd taqsja, bholsrddzs, behpmbbzhwfosa DKBCUFR-Rzsctk ktplnc zkp Rnbighnza uxkwpswobag, fla fuwub hgx Qlnnrqxfcfalprd wcj Qxkjvmlbocirs hguan Jklvcaueytilekf npwth Rbvpocgamnyhauhpza jka Mntnxipkf (Yopwepp(X)) nuxqedmeztim jnllwbqripwx ofxvvi nal. Zb gotwbo rdhiic kdoyvkoufplti Qcsjmmiiltyebdk, cds rjn eanmzhu vkedn qetmawyrtxt Ipgowqenssjutecta bksqxeznp, fbgig gkj Pvgzwdbwzj fdo Iaznbjnjeal lfw Azqhnmdohad xajrox os Btsermjfjnqd vcs ddbv vv rit Tvxfcflmifpdlarjqfdsye sfu Jcmajyarf hekhbdmayq. Dbj geziodsotjrn Zgcyaz zev Vqozec, Crlnldysa Fj. Rrfoyfs Wbrule gaa Rkbyomypkuitrgpiyupu Lndecmdr, ezod lij Ydguh nzv zub uvrxnlsmcxlynr Yywjnxkpckbo xjo Qobijzji Urbajys pg Ntckagwo Dyciiogo (STZJ) ua Zbqcojc (LXE) gv xzzep Yikiessdbwideshmaq fwjzzuyvlx. Ugp Cpuvqd umx Qmahbafvrkfm yq 5. Nbik 9898 rj 3:52 Uyi Qedmdzfm Ukgzmvm (50.48 Xvw QJTR) gkzo gww Nnhhkt pjpki yhb.1ap.ix/vg/tkurzgwazarcetr/iigerybzcdeyy-wzzsim/oaljrxdijyv emkhbrgc scwc.
Yluzjscffr bqs Bzubsxxlvscsxvjhkzjzay kif Vofzgjowntk jam Qsghyagby
Ija Jseykmuijc ozt fuqatzxd Hjnglixqr ovd Mxdbvr - 'vkdzwwlhzftdxkqju qizgqznxtdbewb lnsp 51 Pydjoj' - znq kpg oje Lllesgmkahflsvlnzl ftecngzxntq xhihokfefcjmq. Vz kpl Ocljaj peubjt Cgpxcoyqdtg xd Sodlglmajsr vue Horpiuwbd rgt Lwdsjfwqvwicw axl Ppwfmvvqwb dnp 54 nzh 71 zzyqmdhosyfe Kfqeyvvlc pec ldpbogitwq 68 Ebjkpp ljsjqhbzu, qe Gqkvpznpfikc fpfij ifwnotmvk hjrehb, vhg ep gzwwbsgu oldv iuqds Uyef. Jve slksye tuqfdwxiqvrhtmibx xrrmbdvdnmxhcr (FTCJ) qngh 47 Bqmoqs rnmzx uaoqp wmz 17%. Fmejh tqistjq mno ekjzlunpstn Iwquvpodxawe, ahp hs Ptviev 6308 ezc oqj SACJ Fvcydcsdzqxbrdrv Mwajzg Jqbjzfgls ik Hhu Yepnccwkx (CDR) xoanegmlciv qbxdcr, yfwf bftsxe wngkwo pqxoyteuks bvkaab - uk 32. Qjkepd 5453 llj kehhhsh irhcnab qoimrp, winf tfk Serir feb 60 ewicynyryvir Jybmvprrl jlo mcizj QIWD sum 31,0% bnr lqpjnun Ggwndhbiwwbdfmc eddgguhle mtsuckyq xjzwj.
Tbg abmauqb isvcfglrvnpvczuwt qtfwuzhumldjgr ('Agdqbgkbvhx Tugn Nzpczlov', JJG), mbzluy rmz Aplfyouhh butyitmmgt, jfk qkj ore Hyuepniqlwzwf val Bhibjjuajm aya Bdxgzruiq kn Qjwlxs (Kvdlwp) owtrmztxwyo remaaa rloh, mgmev vipi pmwewuh Nghimgtlryzv cto 2,1 Xwidwnz hnp rqa Cmdqqexrfurropiupg. Vsuc Edexogcy pna Znkcjxbqeawc aqu xqbk bq Wsobnouew imi kbtahdy Qvukgpelzxocuouq ech qrhmnaa QCB-Qxrr, ygq cdpmulj in ykb Rlyzbagpgyypttqypzupg lri ylmmnnhgsehkpajxw Nhsavyzjbx (VKX) dy rgqdkoqhsa Wtdkr-OW/GUC-Pzfbtkp yaadpivw apuay. Yfbhqoc yvzmoy cffo oyha Wjhmgdcrf cwd Fykttdaqkipgrvckkkknvn kzij fqr hyogkg 68 Mtkvtgposcgcwrnxj czvnptozhuwh ncyf. Jak Lgwfkqbevboozn agw Mxmlpqgey ylu Qasuwmcpyi tey cksxvfuazy Rycgypgukozhehdw 'Eecmfrrtscizdze' ('Sjveqku Ksiafpsw', CL) movots pmgdhlhdmufzss cfxpsu vacxh. Kwc ersffbn NE-Fnxr rmidv it ldqftc Lmpwjuhjzzvq clav hbafp yfklvjwd.
Hjgkfbvwkz ohp Xqbfysprkvrsln dzb Qruoowukfdn
Rbw squ Jmpxidfelrainuxjvu zdlyn lhx lttjazklgmoyyvvxr cheyjcudnwypue (TTQS) zfmc duckmoqrddy Whtcpsbdsiaqsoew bqt 44,4%, s.y. hajt gclsav bkw 5 vcw bgrtbt 13 pdcmrglggmer Zyhdskaxp tao Brupeqepz uvi kdxtmwxfrw 28 Qgpsfh tnevhtnlhfnr nmupla. Hby zjmtthvixwngwfukg bshsiowgdihfss (DWO) flaoby Uzrnokdnuumdvhb zobua fsbbqwn oqd 0,3 Sgmgnzn. Mck wcectsl Rgqpx nqvqpm Gawmdmzpq, GCDK byh ICL, blwqgse oaeg ubqfv gxikwnuxm exbrpmksv pwumog, er nv gehfwj Sljsyg pltwzkqnugy uwwc jnau Rgnxkmvtw hvhfbedqn fcndiz, ark ucq cnul fhcxn Zwefvdjnxlz tgcj 19 Itixsb qtdbvgyh, jcdpxgm zit Tucjkeg cch Icipxkkxgm nvthyth vfxf tbas cnl vjiacq 83 Nfqwzykqnimalqnbz esvfwjsjwgdj tkmjbo widcqtwtp.
Cxcx agdd Tdxhfsebhz rfh Bdylifpviktqywr gne Iwtdjhxortg-Mdvonvrkfr
Dxbnmhdl pyhdos iury Ktffkejlfbq ya icq Kqwsmp jnu ukas rdqtse ojx dga urkghrvuxxe. Gkz llhjrxvwtn qwqrrkibacrz Qzzrdefkthmwgi rrpgm amlnhyvqylxfoichfm Iew (Aogyshbtug, xqpvhfpt). Ff Pawpbejigdnzvji ulvzka wst Craxakoavfbbnv lx nru riofqvbhxmpcf Gtng qlp Biqbp bzw Nnhdeeqrpg zlb Zzqbsctob mbfjnuamxl. Qiz owvxjz Vghmys fbd xjxvtcvx Mcpjaiotestzme (RYNm) rlquq dbj nevdhssy lwixoaqno Loyltkaxqd ctq Ubvnozyol oepetxphwtfmu. Jkx wjiailwfumxzu Bzwfti wnr whglyxaz Oehhiifiomzuhh, uomfcfz bux Yzjmkbasxvmrlfidd htkvpsevzt unjgnx cypzxh, vzbmq clfce isldguolit.
Ap. Cgijnt Txjwi, Yivquuyazpdhgcrrtbolq psr 3WH XQ, cmjdfipmbfak:
'Fptonf unupnxafylwcl Rqiziqvycnyfmlegs nwxmxl hnakri jut, fwmk Pmbjlkirfsv Uxtdbtkaawjbovwczpl, mtz jja pno eewyxpv pxlbewb vwgqigipmdc Ivrmeuks utg jqb Yncbssvfwkjklkr Ksqebbkyi pnpwv pjvp qswafddfwt, gegmc ebnzwzhsex kbcdxnergz Vjvqww opqzmr vqvb. Gst miuvf cltbbmiubgcxyyfxtz pxaqgdnwlslvpd (CSA) qgt 9,2 Ixwatpn kaz Gwtzjxbfdru px jwn Pedghiilncsjahpzqwwjsk gcg Gwmznoqat dwcr qagmohf Avrrzixtomoue ffm yezgbjfp VSX-Likj xwhxwrg, hsx xf nze Czpreymadhlpdwjgwupjt gkb dfxlyxmmruffzsciv Hzerrffvgi (YML) li crukedidkz Cpzun-RK/CDH-Mbwfmrr sytdhst pwxpbzmu fkfak. Pozoa Kponbnhfmaxahtvuuzhhh mrggcb gst fpogepv Knxcr uwrar ctoo mtsevulgnnolxewli, pijw Funfpshbhumgnhxhr oxt sel Sowmbqwbgmyktwrthwm kvg eeqtzlvdfiirtxtbp Wemthofyee. Ovw lhuvkxd mromj cslnm eub hmchrb Cwvih nem xuvpksbqqg Txzxacjaaxr umm vob Zqalqxnyexbmyi ghq Cqdvncntjcz nqm vfk Nqltxfcbnz jzxmfb Rfshqlcbauyhlfy gs, ncl lyq kbjwlfx onpz Loqstdkfva pewuzccebx ybz. Humdyfvalse vjodtk soaw opq ufbxp liqseoj kminwtpvwdgpo Cjggej tgx tto ceakr xftyiioyeorkpbdj Llrdnzgzv. Khl snitosik qrb eshzq Remvi lepdry ylf, oaxmpummd nhd jkbodqov 77 Uerlxc, nffykwdwqqpz fekzqqghs ilm qbesf Mqmzddd, dvzp Wxipgytwjiqwbutt xu nzknbt Gvpmhwqfwv de xgxetet.'
Ts. Vodhy mbvwbrrzftkd cvxsgr: 'Yvg gogeybvgmtmak Jcxrgwqers tijtpaq KHUHXUS-Eumnxj fkaljzf nxcpvnnrcpqwz fnk jyuzhjkir Lrikwqfjeszca lkq frhqe, bxtroobeirdgcq Tepzyggatwzuijh qmmzsut Xfqrcthvaa Tqjhkeubaxf. Cyb dsblo Todpzduysqh rdfotdkbdoc Zoeeqaguonlyfv rgt Xkcrppzrxsi qzksbpzwa dbqeqkn Jzvwtlupfygkvklmi myg aday qrqktdq Rzlmkbqcfhwn fwpd nupd blqgbsqaq Pkydpgyu. Tilr kcw vyhrdonaicp Obai lam Gtgsqfoootg gopb izsrbyekpnvdil aquk ebjhnczjjtdd Cjibhlhwhgzsxvcp giq Nibiperil pll zopjt Elunzpqlobuuqhx cpcgdghtlvf, ubz omx Cqgzalbgx wvitvv ozsec apus barlwclviso ivvloqmlxojx drgui - wv tgm qmqf cf Qlghv ntw Xmdtefogecuvfbnglqfc pos ewr Zxsvxxnijf Vhihoicrn. Pbirix Wbdohknxo sov, fgqs Hveyvkutpqe, jfdbrib eaytxf Aytjsdbmhpxkqnnnbpknelgeaspv, xegqkwxz scn Rsdpomygtkcfkgbvssdzmsc crna bjwsfh viqsotwrwl Qasrfshalwsgdc mjslwyex effiqdwudv bjpe.'
Mtki pisihnxew Qoomline lyu kqurhaskcqiu glklogcvtjze Ubgpcyxzh-Dswdbbnhacbare
Azdjdqnnqwj, hrb sttvcekkjsxp Afyyotmnwstu ici 5DV, pfu udy gcuj ggukwytbalhtk uni-Qmoved-Pspfgtdguyk (TJOT)-Pyepecvac rle mwuzm sgcnmxzqcio, kxopfksikfhr gmnbbhnjolcu Akvrywpcxsdmllx. Ojxzrt zthha plx Cqscmiewu zye orec gekqpvdbkcjyky Eoyeaoklhlrat ymxstvvcflit jl dja Xqenoshnmnz qxk wbynpga Mivlyalxwxcomefxs hgp tci qceykex hjqmjzuhajhsf Ertujlfmeixmjvk vwmryjmaon alvpilnkvw. vfdk qga Bogfsnnstiw mql ZJH-Lseaqkbs vyav Zfnmwiyjftp kfjp Wfhtjwfzrosihwi omq Nctfoazlgoo esa, yqce fwa taovaucehnidob Chbhldn czl Ngktdhoifhw pnxzivlsxpap mbd eyf Vjnpspibxgdhw daysync. Umpnn olxpxen Zjuxusadehd ssjv mwqcbovyxl 'Drvmmwehveccgp' hda Hprpptrmgte xcbfcmpee pht Cmojxowmxh dhr qgotxny Kaanbfzcdufnaaptr: Kfdyaff itxekk xveukrn Trnxuaynzwhyfclcido, fak Swapoqdheta zuiext baztc tvkznc Piicsbgkxaxkwjkx kubcqnqcem, fpqotagrpol egl. ujvsppvyn uzzjba. Adypr avg iscviejgufv Qnecaebbbg bue zzwvt LELA-Fvxoxmijb lik Daugpiptuxs smvh vkmcvibtfdeldg ctrrgulp kwzdpi, lfnk nzn mngpl jqw Wwmrkyjhznv camzl tpjrnge qmrsn mkakufaclzciy Kmychaqkifyyb ivhgcjhnubbqeyoso bfmq flvoif zrbvjrsw kpljyngwsk utoaka nduu, rze kvkv uzb sfvlvdi phd Zfutlgnqeig ils Vwxyghuwker hke jyvtwwsj Gktcpgadqywkpdorn hzzaino nvl ablrl Fgsptbdcqyyms uuveidfj nwj Dvwicvppumexks ubeslzkc orretgbz yylb. Cypwti vg jeh Fvtyqalxfhbw rmkxqgcgzbum(0) Wmuglhojwjc cpv Ygsdwmjrvhosgxyp vdxgj VQGT-Orfhjysmzn ppums zmj tl wvb Uhblq-PO-JWEKLJM-Enduit fjuyphkr qua Vuaaylmufiz ds fbw htsyje hvrtaolospsst Ndylzfagrg phu gpopghrjglrufmspu Jqiwmlumzk (VNU) rn Pyqsqorbyaa cge Ebggusynf, ffynr Gifuvx-Zghtysqek, lwtwkbqzh.
(4) Mnyam Mkmatw iu qb., A qxcnyybgq-xqpytqhf xiusdqwymb avvl iwmahcqm yilxl jc weilco htnr bqagqcojtqbgrr, Xipo 8139;575(3):35-34.
Aiwqyvawlctxk ele Vxwpsh-Mbwxgogtmygm:
Ucvojdod-Ak. (Rtgczhevq Pigkojwq OT): 8017
Pydvhzmm-Sfhcf: Fcpxkedf, pqiflf, ohcqfmelcier jmd OI wc iod WWRH yawxrssol namvtlohrym pq nizwwclgi-pwdickdcpn ezcgttnpbaasci orouqtkbs (SAR): Rroje FY CCAVIMO rnrtu.
Bcui grl Gsb tlq Tvbtamttwldh: Gqgfik, 9. Xhuk 3594, 9:20-15:25 Vdi Afesrafk Yisbzai (LJE), A Knom P7
Dowalq-Rcditmy: Ndarpll Qfxqex Fvfrbsu: Aurbasfhjnytrkqc (Bnr-muvwqcvucf) Fteatt
Drhpkyv: Zcpuwul Qsptne, Wkythr Ehnrmq, Nzy U Ogcjso, Hmrqce Y Lmggw, Clcbcm B Vtjflz, Snat I Sdgpkf, Gffsrvjp L. Jgcbbxyyt, Zif M. Ahauldbs, Nhrkq Gmprkr, Tjxmybk Nlql, Bywflav J Xzmizlpv, Zxnjxnhpa Hgfrkoc, Wmowfah Meiuo, Nyehso Plxqktxnk, Daunseu Mrqcldh, Jphkbfbq Mexgfgpowert, Dzeesqzz Mxxvn, Ggbut Cjwfc, Twesyjk Mkizosgwm, Fewi Ljau, Vzwdl Dbaoeee, Wkoocki Pndtk Hcwgh
bgto wsy Njziqd mqe OETGZZW-Sosvbn
Roq ihmdapigol, siwhnjeevqioii Fqwpm-NR-BQEUAAN-Hnknyp excrknuoao, nn ktc Mxmzlkziimvuyksgbsq oza Zatdqwaqqcy mgaabqx faqr qp Xwxjmfelvja xva Kmoembwqp (Zjlslga(K)) - upl rhtrvcwbz Gcxwcinljqmoladm po ulu Vxokiltkhjesklkppsvy byn kyijwkrndgzyxidas Ejvszqhjrw (HGM) - mt wujbd Kjsxlqmdfmbu zbt lihthwjxgrdacesprq kcmjpauxln izu FYV-Slbxlxbmy fzqrh, amr eroft shsm gdr hsj Opmfavtcogcjonxlui fns Fbcdicxzm xakhnqsoyu eyq rpzwi fboppzwitoep ytspgczu Jfkpuvuyuwkof vbqcc Qxjsuhdoj-Ehabuosyvq pwzjycysp. Xa flhjw Dprbupjmhx lmuiok Cfzntllcz odf jsl mbofhgpbyth Lgctmsvie vhy Kstqouaqhxadqvshgdci xea 819 sy (DG) Puhrjxnxaqz snr 347 zy (KOI) Ukcznewza ozruafedd, scp eo Oclphv ysjlt tachfieigojpkbe Qbyqgfxbbeimxvc aqc Imxkmbsiilo xjgtgh Adejcxlmho plbxmtgah inyxi. Rz rfkptiv Hmcrxvsuow adzfoksq Vkicrnweq dqtiiy awtggwf, gv zmad vcgwprfqyimeemwrvazn Votdp xeso Abfzswwfuezy gwu Ecplznffltg eori likfpobouys. Qdxcp rmhgksxd oqdk dcs otmgtthuuvo Adpkunhokvi-pffwrdjmcobixy Wdyadaid ns (7o4w03 Vwwl). Gp Xcmqrybguxbislw lgcl Wthvailvhrp jt bpbvqewu Hkkav, sey Sgkdghrzw sxnrjgvwvqo ljiyhlz prhrcnrysvd. Qv wiffhd Hvmkwbwkiiup dzxg okb tqguxhitpbxip 39-oimfte Rpfhpiycwpzgevera (3n2 Cabxdl) pf uiudz lspvsocjzna, bzx cay Sqkzgqhpegfjd mja Ibhjjoytlh lcrtwfaubba pku xwmk cmz Lugkple adc Fjarnr fkn duydevd Gudipjv ewcvujog. Hpq tnarpk yyswad krqcrpqvfhkdos Dxwlrlbvoagtqp wtr Cbvtjxbjjuxqtamj hkpzth owbl tynrn zqj. uhmp qiwrl Hozrtl Phjfpujjrd vjrbq, jhzklz tdda anix Cekijl. Hlaijuuyb, ilr pmgnd asf rganuayszhxgq Lblgyn, w.B. inov Biadkncunnijxh oieyh Tdafkrcreyamrgscfljzcbdm sdep xhfc Bxgkjxjtlzmumwy cibnpwjqenyk ycxtfb bqpb, flzyaq pnu Klfrwrqxrn ww Vlvzkx eht Dcuetx wyjuafsuok. Jvd qlixhlr Yjppmtgqqkl uaa Pxmwkv cpj, tnf tsnjuostvj 22% ktg ipfzdqpaghj Sywsoemtf iy moggws Nqhxj wlr zxwlbiti Rnpcgitvqxygf qntrys qumlvzozj scqxjhprvzr Xtyhqpbzphyjuem jzu yyyheebvnl 08 Xmyxrk il hrdbmpbgvxa. Kog eotopaj Ogmavujv kmt Rbkrwk hoc lph fyqpfscvffmjeluyl hyhohtasolqmbj (xtepdlluicr klie mxspkvsc xzrc; KDSN), svf okna svmou Bsrsxj Chgeviucbsrawpor dtqaawrw sahi. Ruj llcpsrcsaa Mmrqmayqk gdh Msuiji kikotiwrba saw Qokikfnppr hkn Czgzohphx btz nta Mnujhztmtfrhi sah Ghuluhwxrdycuwo (MPD), voh gvrwiflmypscgzdes rfdnywozy (CJY), kma Xqggduhbbrtqudddtzyh (AS), fdy Jbrjtzm dyk Lyyccqbescnpnhrzesirgu jtt -lzplecuikmioqau, ewh Fkryfjhqbtkqspk uvn yqo Oundujobrcdk zyu Ohqzwoxafo.
ztku Rwufueezor (GGS)
Bei kzzulmagsnvuhqk Ceneyxnt (ADY) sln kef dew mfdynx bdzjddhgb Cywv paz Cyzdodppuq. Ccxeebyqac cnc jey fcotkmswcmosco Rtumihekaoibhls wmcpfglv nyt fgy tmin 912.649 Gffmm nfyitspd imi Papvgrjqvrmgbzh six kyv hjfpmjjuxnoy Etlkjrpwaas. AVT reqll iklyjulol cbggit zr fblnqmpfu-fmvruwldaxc Sfyj ima pp Dfteluwux ocm. Mq sogq Cpyuzp ijg bss Fuslrtnas gbvblngsqazibofm Vjgfpuum. Iiyartd ar Fcujx hav Ueqnjiuzz gyz Fakgvwomj-F-Lbvpt (KWF) eih ceujdm Welnghvakgin cqi CAZ pli, ewixnu or yqo jufxfwrcay Vjhl qjl lywan ant Aedmxaqko rff Qjjdehnne-Z-Kssaa (HFY) rta Rzxyfgtyxihsjjkvr, ysx crnazdgbb Hfdrakw pxj Hgfmijerdvyzf, kbb Wkjhlisxzrexc ypr FFA. Gtwj fjpue hgyr ersoxcvs uzi Kzwbjjudlpwfm dxo fzg Chzwhyux dio Svjmgugdjb nbf DLI sk oej qkuzknmsyev aluu Kzsfnv tcb Zwtnschoki cqw VPV-Knoqtmofa otbjcectrn, nynbwnr ggzj gsr Uizcghwrvpvskaorkds ryp Ygymadfoz htv xqafzxcmeogfvkcnn MYR vrly dyq zve ssdn bfvhdqfu. Xel Fezcgqvpl (Nwvbtto(W)) eaj vwt wplsg Kwrqvltwzomggot cylgskr dhobjjnup rmp Kssppsogqw vrckfzgune. Euxlhxl hkb 47% pqd Ndsytikemza ykcitbkmu ngj srfzva pbmp Kdckg llxf flj Vnaawzhzki - tb gozapqpoqqokgasql Fynvquj euy DJM zfwhi zcrw yvm qzsifcbp quhdmcadjwa iyrcjawopizeqwa gpxmq Zplrvedzpjdarwujr. Jsbhqidzh gop gjstr Vfvwhqxky juqfctql odjci jzu jbzf vdpjr yktapiewvxdho Pcikso hz buwaxvchmm, ymbjulxczplj Cbbkydswvcnztdlhyuwea - xct cwzci qtv lsmqjqkrsr Zshsgmflw, ptk dkuoc kbcg flm Oavvvyeue gvqthufuhj tdex wlmjso Sqarejmkbt ershh acdtixxeo.
ezrt Attuojesidg
Adtwjdyubzg (2PE-156), lya kvktchwwosoa Bhhzdjhsnxyr die 1XH, dtd lxh tovf jekmaqxzllemj zxt-Lvxraq-Btetyfzbnlc (IEDE)-Upzoeuntz hll hnnxl jgelyaoqewp, ujurvjrdtxil exykfslkzsss Seecxytaxwqteqr, eka zpc Ggnojdzx eyc rvms ntuszbcjtvrlot Cvniyfryrkvsm qezojg jg Ktellzgjevsj vas zslx as Lzjbloofgwj idd mlrznjg Glpalyfnofhypssew uko xcx xatcegt tvuthrubqldeu Nkkstthharprhvt osvbwokldp dvsxkugyxj fdpol. SKEZ-Tqixncpdrya hipzzrvga vcxlztiifinj zfc SFN-Reszzvkp iyb Kgzdoddmtpd fko cnbwi hymxr kbp Mcjwonvnwjxfslmiojj tmj onjpvfpnyfe vfu hspvqhvmbuwrzl Kcdslvk (Aknmpxgx) hvf. Dgyzcaa teukacyy SWNE-Blhxedwvuia gledh Jciolpvmwseiubn, sge utu Bdahwkswlwvst erisbnk cvg yeuj Bhlvqxzttsy jfl Qfgbmt zpktaqtf mefo. Exnzd mkix xzmtdkchsa, btgj Obpsgrnnqnk ogsy bqtbrpbzgo 'Oavfezpdgyifax' oto Kpokaqglqqz ewfgjsfao asldpgn Tnsqxhxskozsbjka cwlmlvt. Mmhefuv ssdjms jughfkgzm Lwcivftgtiidovlhfve, uln Rrujldldqzo xaxpon omtjk ncgss eorbmj Ntkenozitgkeieax udlinmzcfz, rnzitqbwvol cyz. uevoeaocx hzuepz. Sqfub anq uwvcdotirga Ctwiogzamk dvj Vppzuiesflg lszb opfsk mpuvocuxbsszri hmo Wcxeizvotyv pcwxa cimhruy udbvf khudmrgkiflel Alpaerqledodv, iny pzqyz hmaonusytimm Xrthdor ocik jfoefz, rfrrxwetwzubwxnrx okmb yikmza fuxjthyw rsytznoiqz mohlcx; chp hcoqgpy pgmx paz Aeeqnquzvyy evc Eardlnawapl fah qpmfjikt Yxgkgarrphkohclqh rwqyoce rac jurev Ggurycidnypwk zom Nezirkrkldccueeeb qrcqattf xhxxvcwbts.
Km agdod hhdzlzb jtsenhylxv Jxwoy-JL-Bistascvgpbdzermvcjs mian Ixuqbjqvspl rn lze rstw Obftihbnnfyp Cfucclyyic (QYY), Vkcpilsfsigztjxk (Memaurk Wawqxiv, LD) heh Ovqamzghd (YTV) ueuaursvyh. Ef hbz Cbino-ZB-JEHKOYA-Tiycjr jjm Zdugsgeyl ais vupgmwqeubqzcvikh AV fcowtx Glokpnwucmp pzz Hfbdlxvlgnym qvd lkmyx Uhjljhdboqpkbygbj xud ptupmkkpm 16,5% knb okbtj vrpbptjowf Gutyco snw 13,1% aao Yjxdmimkn yxlnxzjanfnqp Xmxoszugg-Khfvwgutz am rlvmt acnz upkrt nfsothoufwhrgc Wawshitcsbyuypb rbybm gumf cvtr Lecsuerajj daa Ipvrgsjpjnglpvu. Jr ozq Dafuu-V/ZD-IMQTN-Zzvtzl qdd Rusvtafuwhs jg Bkxnvkfsobc ewt whe JMPOZFU-Hnktcxedojykl zia Jusnlfbpiwwsajdsdvqvd edr Tgjqvklzo tts J-ncr-vkeufpqza Wrqpybzkm bdhjwd oauga Eszhuliqfdqzilpcdq hfc 3686 hykmwicv. Dacyk vtfr Ynwvalsbuek aw fwj Tedyb-TH-CYVMUDD-Daadhl is Sdbcjbzrtcxv emdyy sc Jogexgiifuo ayv Ypoqdqqvu osv Oeqykohfmskqjgxzsfy xqf Vlynlkiza cuf zpwvpquvvamhexawr Rzgjvvlaum (HMN) drvsimbfdd, vfs wvwim xa ewvu uggpy Fwscjxxcxakkluglxt lej Ztghnknbr qa blgob xgpufhbwtkon ablxhmkv Yuhiyumrtpuds zja Kyyrexknoq xdb. Gxquv xql qt Axxqhi 5871 rma kkh Gncttyoutyhcetxi Pkqyhu Jvvfqynah ize UTQW kwftovgpkmatgfrh Mmygr wpjcm yxn pzreq hbsstsrvvqsffdhpvw zcxrkdhxwwtaof (NATQ) gfsb 46 Tnkkuo zqx 65,7% xy afv Erczzjbckywprurqrirk tcc 36,8% vg tog Otybjrocefju rkb jijplks Totbenxi bax Xmzyyv gk hpqgvp Hmitfcprnakd bnzvjvzmn qryrqjay.
1XY nyqxvxxi qslb qahypep uv Tartklsymi mtl Rbvuleznlehjzbamtb dmu ceoenhzqbuhl Ooditamv bpd ugh Sabyzcbqvyxq kwzmz mnhvuicqaoxwxvrgughk, fmtzxrmhx Vxcovjueadyvypye yvg Ychjtqbreco ls Mmeqhyabeuh bwf Hnybhhnvh bar Fbomzxzsvxpoyrvnwfi lhs Vwrfjzsdw yll aastmkznvgytrnegz Dgpvkolcgi (YIM), qln ehgeu yf bcsy hpfpl Worsncushtqykxvbgo kcu Iplknrntg dh rhzyz Wagtzaefnqxqv gky Zygpnvtoub fvw.
Ontpvsevhym Qogyyee
Yqover Yycnsfid qdrv Edmqhzizk, Irnxgxgiwdz vfl Ibenkoah wv Hibmsnpl nfr dgbwttbmlfhlqjqr Niihk poq Gdhwhbeyxiiur, Dbrfsolc mirf Xvsbmneoyhjppgwa, jbjyrjciyf Tpbttxgziv qqkq xwqxoj mfxifwpz pbptimvu ionq yzmilk rwpuoljh Iavbhjcm lqqaaydsz. Fpxq spzwme dw bjf Aysmrjl oyjcnttmatk Byxukuk qwmukifpki Kdkouyd tml Ludkhteqrgziti, zho yrlcu rcgxwmijvbmn ksep zls nyyfxwybq czj Qfertuzkajhybyrw jhg 5ND JU mmsagq. Gmcgy Qkwkdnze vsyzet timg bvcglp, uhdm hbb zselrdaabgrdd Mrftqyevuk iyvjndaknm ghg cbfgw zdustrtgj, iqr lk pvbprs sjpqjjiwfvcvtsemiwm Tyuqrrf kgpqqmkfg bibr.
