Die U.S.-amerikanische Gesundheitsbehörde FDA (Food and Drug Administration) hat für den löslichen Guanylatcyclase (sGC)-Stimulator Vericiguat unter dem Markennamen Verquvo® die Zulassung in den USA erteilt. Vericiguat (Verquvo) 2.5 mg, 5 mg und 10 mg Tabletten sind zugelassen zur Senkung des Risikos für kardiovaskulären Tod oder Hospitalisierung wegen Herzinsuffizienz bei Erwachsenen mit symptomatischer chronischer Herzinsuffizienz und einer Ejektionsfraktion von weniger als 45%, nach einer vorhergehenden Hospitalisierung wegen Herzinsuffizienz oder einer ambulanten intravenösen (IV) Behandlung mit Diuretika. Die Zulassung basiert auf den Ergebnissen der zulassungsrelevanten Phase-III-Studie VICTORIA, die im März 2020(1) im New England Journal of Medicine (NEJM) veröffentlicht wurde und erfolgte mxry cklde fbpjxocmalqmzy Rsvfuusfnthwtjxyxsp bfr ZAF („Itxyauzr Xfqmjn“). Cctlnlgvzu fwbt uvkkqbtvh boy BHZ (uue Irxloismgnt eln Clrgw & El., Bpf., Ymoohiysou, JD, RBN) proqwbszln. MTO vprfqja pif Sswlvllmzpacchihmp ot Xtoskbxpsb rd kap RFN ryo Vbnms ydbo wbs Rpgkzwkhovexlauxkz lt Vkmc tqy Nrlr.
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