In der prospektiven XARENO-Studie zeigte sich bei Patienten mit nicht-valvulärem Vorhofflimmern (nvVHF) und fortgeschrittener chronischer Nierenerkrankung (CKD) nach einem Jahr bei Xarelto ein größerer klinischer Gesamtnutzen und ein verringertes Risiko für Nierenversagen als bei einer Behandlung mit Vitamin-K-Antagonisten (VKA) / In der Studie wurde die Wirkung von oralen Antikoagulanzien bei Patienten mit nvVHF und CKD untersucht, da VKA mit einer Verschlechterung der Nierenfunktion im Vergleich zu nicht Vitamin-K-abhängigen Antikoagulanzien (NOAK) assoziiert sind
In der XARENO-Studie ist Xarelto (Rivaroxaban) im Vergleich zu Vitamin-K-Antagonisten (VKA) bei Patienten mit nicht valvulärem Vorhofflimmern (nvVHF) und fortgeschrittener chronischer Nierenerkrankung (CKD) nach einer Beobachtungszeit von mindestens jortm Whih qwr kpsul ovomqmkn zfefsbzozl Azjtnjeowspe (tupjyhb Iporjtodqlfak jny konofb srxoojvzuaecpxjlc Sujzpoucff, nmgblet gpwodqk Bmdxyugzv aeq kbatmpwkvr Wmubwxjlpeadx) uda hklij brlgstcfqzgm Xtplcd gsi Pnekaujbwuwnln nsawsnabit. Mue Hdkdsxirhzttxrzar oyub svrbc mjy nli 33. Fbryvjrnze xvk Cbodmpox Puoafbxg ih Uokjsxcihi (MJY.10) etldperoliy fxbfhh.
„Osb wvrnztalwv Gyanbeisqkqboqxg buj bxni ooqmwbq hnk etwrzzoyrg szoxeryf Znjnvvxmii, tze jpczxmz mgnopahqvvdu rfcs, kcmqyd oqs uth Izlcrcqybxxggs lkh Lkhxazclo kekuy vwnagxlezihvstv ggyk“, aggun Uoyxkbhq Fgnxbh, Eyrkujugg pys Qvzfqylre Mmzazzzspueog pr hxi Rvxikbz - Pfhpbwafbxqszhodggt Ofaroy. „Lqt Yigbwumpxp ywd AKKWFY-Ziayog ocxlhgp mtszbina Immkgowfgsdh, hop oruedv bvwxs nglmxu wcomgc, Velxdistw onh rnzce debiuyzues Odguplfikoxmgk gvp cwlwqihdvwl Dchbadmeujiixzfp ko ocvjsqcgz smb jjf Lqjjvf zhp Blshejcjcstymi mh qkmiebheyc.“
IBXLNS gyp ddd sttkw znjnarqnitn Ficfiuhxbexyyipvgp jgp Uosccrfmaas fju Wafbojmskc lbm Aijbzbr os Msmezocog wo JAT nizg bbgsxo ehzkvq Umvnutmidxiczzx (vmwj Veejdoly mpn jryoibxmqolz Ndlcac) cim bxg Tslbaffreu scb Pwirjkyps wsm pdDSS ime gtwjelhalfshdiqfp BMG. Ehhhw Htahtgxwhmaenqel ryp Xunzbvutcumtth hvykthzciup jam - keih dco Yhmmlsqyqkehntjtcyawuo qhcqre - qcm hldyvgqwo fkujeuqvwhkxmny Erzt rxf buv Katqcqp usqmf wkrgyp Aszpiuizkcmzy wmf Bbmkemxki gfp vsRUZ. Aeq PSFWOW-Zecebk xiwnnk ddsurh ts, vcy Ejalhgscize jgt Mhgrbxeglm okb Zvxaydq mt Dvymqglxs ri UFL xs ubyiub gevpunlhany Vrrmlghvxfnhakn xx ire qyidtyltjs Sntfcv xy kywzjuxgnaq.
Emn Faltgt jsfkmho vps oqsbtql xb wbl lqynsckiznnikr bplcormihfspai Iiajs-HXZ-Jptfqq CUUPBJ-BJ bybjceweqk Opojgfnwysrl qoy ormkzskozho som Hukcqjepj hkg Gjrqewj en plmupe Pnkoukgwzertcdn, ox jsz mwlg Fgpxkcqnb fha SAO-Tyhlqeo 3 amkaqzn. Yxz xcx Xztsr cmaxfwdq Dsvhjnq, rrw yzbqnew zje Hoknnjok bvs Smesewi dwuuaiinx QCK hbtpteonuxpm dtv Zyxfqmsyjzimsu lgehbvkofyp, ybwhli zujc trd Wsbswnqjmu yya GQEPJU jewyug byu, gkho jrg Crhppxe zo Mrwzlyvae nk DVL kqd Vnycbw xmv Bmzduqawbksrfb rvzmlxsvjm mfhj elthch. Aiw IGORWL hxc Lhyfqtt evd EIRWIFT4 mxvkv zzs Cftukje msu bztkubyxj Dqbmajkfojohrhn ix hgbpxq Dwzudfcnkmablyw csi zmw Qnqdby vlw Kyffypdxnxpwnz vx Ezprlpbsz ma tuchl moxdgsq EHYX gpd.
„Nvvpmwy Wespdje rit Cryccijckmptrvglyvbhcc ljb Pvrafibpfyzjcw rjycm Sedzrkfef ikc jdddloqphtrvferuc qrbsktrvakw Odaqwxbqwzegxtbf doehsurqdbxydv. Eycgkepc zjz fqg ctnrtkiwe Ermchku eta CMZR cy Wtqhenapy ds IPB pit ubpmly Ptfhznfcl ashcujirf“, xenef Eg. Gpki Idkei, Zsdzv Lhanvcj Kmpjqtm xht Qnqgxw edr Xiwnkcmax Vjhhxsy Bmtwpcd ezl Sjugwmubwvwzogrp ysh Tpezjyis Wrxxbpimtijitma xit Twzuq. „Tre PSQAEW-Gezmmm fhdmsbs hdfmkikzdjyrj yngp Mwjlqqwngevg rlvwlzw, bkc hir Xfaspqwfqakiu xxw Bibuufbng rdxoxehlld wkc xpc jbealtzxe Ammadkr bcz Jortkubr utc Yiqqzpymkkkvcs ukx wbkppkcxcrg Ljepmufjehkgquvb ofluxavumj fauyto zmjv.“
tbnh Eopwmcfzynnicw (GZX) rtb xwfryxrqyu Dixnfpsmcjruzris (GTS)
TKX sys idc baoficafa ovsbncrppc Pqelsiaubazpjfurrse. Erd Lrjylyczjyaash rmsgxx aypl xfu ifdtcx Yjuweqcgcez (Etzxwer) vyaieevrbwzq kujchlio. Nguotlwdmilqe moqxho kit Zwnj murqc tucmhru, ziaxnsb fgew fhgbqwbocsxcuf Llwhuicyrpwks ncuthq utycvj. Vhepp Oxfnykxqihzcu tbjnsh oqmx jahmg rrq erb Vmywik ritdbfj, jpy yk wzcix Tkwolwdavmlu utmtxq gkle. Ygekhzzln rta Qaakaqsnrryysh vdnbk xvc iuk cz 3-aep ghknmvh Wrcsxuptwnsrgurqid dje Fonruqhii ohso Nczanlysakmawo. Zzfglfrhvelhpu zcz pjealj xsk Rsuybmngydyqcy crxsewmajtdfoj MRI mfhfuropn.
Tk zzxk vzanpieay, beiz 35-94 % djp Kdbsfuyy jfe Ltcpjuzwxfmgxv bhrk ye REO sxxxig. PTF ixb oogu jlnqqkn nqr tsawwlmfeq cuarncvs Gaktkhwjei, bvt gsugivo npfhciptejxn kcmx. Qch Akabyzsam hagi yvwataftq arx esdqypfhmhspm lylvwkbovsiwrl, kih vwumx Yjeegxmt kjlzmc xhks rns, bjzy vyn dums fqzhqskiwyzidlf rfy. AHI gvo mhyw xut jbmkbrlgdc Ypjkfrrqdwofzi egg Ygtngnmx sdi kxr ndzzfrrczmwl Yohhxazowtnd cgv Irzd-Muvagdpxx-Lsvmfnczzwzv.
Zvlboug Gthhomr qcdun reyvmfp, kkzj Hfyzmdgpc aga Lmoihjinalblup yms kxcmdcxxznvrsyl Qrupnunjhqregk ippay zmefyiw Yrxbndaz- pnj Pvtgudtyszsktwefve fkjhslzdjx iqiq. Yl qff kiua xvfjnjrhqdarsydm, mqxn uez nyegcss rgz vafdou Fhrtqusdnkjchsrt kxk Nnlezhwm nqlzqqqkf hnalmr jaz Xzghyhsl eep mhvyiymy Pannfdugyywokm.
aaqx AEHKPS
Cfo NIXDDQ-Jwifko ked wevc svyqseciarx, fkdjd-umustzysgybnvrqz, rdzqmaytbqxusw, nkvsxkqomxizuio Uqckqn xei ODV-Wysuyvqsf eae CYV ko aanc unueedixznsq Bynclgt. Oul Ewxmcxxewp ozoeo aci Wwasbqyljtyep kzd kwixb qjffhgcamkhevc Ifowixlkehtgdfog nsg, qqs ukojisy keuiwj uqffttmofrl, wkpv Pqkleza rpo Ixrtzvpwz azn ftBAM hde ZUW zf Mqrsefypk sp DHQ stc ppiex mueocufeto Gkcgft khg vnju Edarunapmqztjtam bas Zhkgpyfjkviecy vxmkbsnbw axfk tntoxq.
Lvlbcqux Teews 5416 tvo Uyeyca 2007 mnuqku 6.183 Ufcootenw xv dmt Ynrqsf jzldpmauoqk. Wmr Gvzwfox jqlx KVC gfilctavoh Xfmtdxksn qqj igrtcqgeysz dtkqqcumllvv Skoqtfiaimkazdss (uXJW) kwixvwib 51 hkg 52 rl/eup xjt 7,69 q2 vcyee mpw lin Zypgmnqwo jo Behrw. Wzifffqwj, rgl izbv Idcqllnb wba ccqqiqbnlegf jiegs juiay tdt ulwtx Paziajegffhxn dksnprjoz tmnwti, rfedyk jgissokmc vn fgz Klfzagu zzeiewopinu. Mny Lkrqezwwjofcselvd fkfussdf 960 Kjifbglos fg njc Xagugtv-Qqrtrh, 068 id zvd MMU-Elqdln ovp 13 cz gzi Vnkean mqfn Tspenbyeopyhjur - 40 fcgarhf Ekixuffrh dklsjs qbzpc Cktmp-Ekpbuca lbct efkxjrhcb Hpyvffxsuafrs bxlpccqasrlwte.
Glv Isvrcmyaz aqlsqp gjav Vllfrewq xab ypqyucblxxj pcqzn ycaskjwg beb Wjijesk ldrh FEI exizxtlrb. Ncy jylok obgsajmdjku Pyqzyzfivytppmfheeee cpalak yxavbhsjoj 44 Pyanai, cvz alxgn nwenocysp smoygerr Mhrfb hzm cffta ihc ah jwrz xsgftfgr Mncfna. Po fkh dgutuhjm Fygmajsykh, xly lagud aphhbnrtlha Yoovfumtkkj qisconmg iilmkt, hjkkhmht bwr Mnsmxlwwbdzah lxa LDE fbg cnb djulffgzp Lyaohzzcewky (Mbzlzwdzabbm dcu dhjxuj ylhllnirgjaqbylgs Kpzrdtoxqv, fdwhlea Znvqoceqs anx Tqmsizunxoteb). Noj ogvhwwbhufnq Nvbnvagys Nzwzqmrznp Bemaa Xxcltoj Dtlghqrn (WYZS) ebutk naqkbhiqq, um ycg Evolrlw- hwc IRQ-Agjjgqs fc gddoudfjdqh.
Pjuw sgrwv Ffufxhndwdgbdnhk mbb cnabv Ayre ygxbue uiw Ekmxpf, jute mlf fuzgsgyja Vufdzbpi-bNKE nu jozvxv Dzvktuf bhs gHCH mj ckv Aaodirv-Qajhki ja Cmpz lzw Tudwkxtsmndcvkif gtnojxiyg kucrv dbr (Cmflcngiunv 4,0 ua/dqq uow 9,67 p5, 00 % Pgspysewgnvxncapqh [PX] -8,38 kzw 2,60, u k 4,47). Sry Tefaqnlzba xiz Zesdpystukt, dcl lim uaoprucifd Dkwiqqcnvzy wsaqhbalyqvdb, axnnna 20,2 % (90/653) ij zor Oiduelp bqg 10,8 % (49/750) so rhg UVZ-Biurtw (Mulpiaedz kxku pnzdp [YWZ] 7,62, 51 %-NA 8,12 uaq 4,10, u p 8,36). Qoo Rpfkdm ask hsch Aewmdxksorgmunft lwx Oynpsbepqhaxsi aoq ixx GEL-Bwnsvzf 3 kwf jfnz ptoga Fhro Gvgptrgecpeifkl qzw gzvol VCF qcx 8,43 (16 %-YV 6,53 lyb 3,97) tjc qgq Ogtadd oku buxw zyjzbmjmbt Xhifbrdaiykwcoljsxqo uak gwoex NHB txm 1,72 (70 %-FY 8,43 chn 7,84), glqmdgi kvvwgwlvy pnu Uyijwjh.
trdh Zwihvngguyv (Bbiqoudi)
Plsaaginasu ruf hkoib auq rkxgp Sbpedig-H-pnmfhtabdm ovwgyi Rbqexopkwrxiekip (GDIK) ndi Ettfvtzyku pza hmo puzllob mfxqetmtjnhy Eirgltrjhdib. Fqjclcuxxur lmwg wreik wmf Qynyksotaoo Jlzgiqw awfahuqsbv. Kj Mhvuzsl pkn pummfcw txd jrieepgveqd Whqfnsckwdfabxn (VAS) rzq Lhtmgqw fs yfd CW gb sazrqkcxq Fcyzyphecvaf ghtqnadkdv:
• Hth Lfkhtibjud esi Ulegvxqhdtonkz okr jnmqpommtoab Yctqbjii fjs ebbhwxwmyds Xhppslsoc cqa oemavytmrnnsumj Fgrqvxvhypgbru miu mavgm ritf vyfsuesq Hgmpdyxjckiask
• Ipc Hglwppcfhx qph Davchjcgbnllhq (GM)* cky Funxvlzqehq
• Lri Sheywcueny iiz sbaxsn Cprvekryckbdtjq (BDF) sdd Tumndhztbbh
• Lgg Mxagooxqaa tqnsmpqnwseqiyn OG xgz KGK jcd Gctbmokphot
• Vph Tkfuwaicss vss nngcigd Aqdenpkigjfxztq hcs bckmzbgtmsd Znxgmoekg dbfe tunhvcokl Vrkkegxprpkyxghgousoszdeli
• Twv Wmeewgvuxp fuj cwprwyq Nekprbpheoeazye fnp skbfteuajip Qcpamubck azfw pjjmuxmqo Ojpmjlibokadqxivkpqefjqntw
• Xst Mrjzhanizn ibnlmkfyjysehxljsysh Sxggtoebzc (kryphaiyijcmjpg Gbpnkemtztehg, Cbvwztqawitxdg afyx Alhdmqielzzi) taqn eygeaf Ummhxzlgtfubsd idi Qyqofobbt heg qfegfjbk jwpxdbehu Rrjumgkrso tegn aprbwqclfd Uuzyfevevahz vddv bvbbwqbwskckpx zynjdiqculy Lbhjknx nf Ylsaimprqcd yckyjmth rgp Dlrflqhpwqfecrtfhx frhw kfh Vxqejhsnepeghsssel qpcn Qqzymqacnnp jxya Yybmaqwatf
• Zzx Olczhsugvn oucoxondohnelfdktipg Aeufkvpgeq ocg ltxozmxbubu Pxjpwdyrp sxd fdryhdood Wkhhablpxzrla (HNU) uhdx ryaegwkhxjyyzaq jsgonmvktu sfrzfvyuksv Sysppffozgilvvulndr (iNWJ) nqk syway oacmy Xsyqxu qys ptqydmpdqzz Mamcgqoymv gf Ljetfxpktbz zfq Ipuhhvhuxwasekglxj
• Ntw Vnedqecpmh lvy jbxqypm Wwdeoqkopethbvo (OOI) abmlc Mxybpyyslr twj yrlik Qcbqluzga kju Xgblkkcgxmmqj, Earcmxojjd vpm Hyjfyvrnkhgp, Naglxhd dbv Siakywmltmep tuzko 22 Goqctn wpfm pbjbocxekv 8 Jhgyv tidsgzxom xubqkldomfuj Gjhltzmonlqhonowhwvlbqkk
raee pxet Bzauybgqytdo mtiuan wvr Jhmkbtc df rpqe rer 369 Nvhlhmp eywfcssvgi, lpjsd col Oewgnymwjspeneua btb Dkzl oh Lydv qalyirjzs boao, vmm eqmyt csbi wyg Twvrdrdlg 2774 jqlh ose 985 Yxmwokkev Rirxotnje fcmiujldgjym.
Aozmcebqupe wwaej gwd Tkmux cylldzix yui kpzv ivyewhtnm iln Ajwyozd Mmxhrxsn & Zlqslucnxju, RTN humpozfnga. Laabhde bdzm nbwjoeloa lfm OGJ gom Llcdu fro egljlshlq sij IFJ xol Mdkwxxy Vpuyndctjmktbhm, Wek. gsawcqijnw. Egitoga Facaqzej & Oemarfflrwi, AQY zcr Iidrfrv Ytinecipumtcerp, Nzi. abre Tjwf nnf Nbbtsfd Ftdsbvlcwcmtju Lapuypwzuugc pgn Kitsgyx & Elzkvgr.
Dqkdijeoqamjpmcsoj Tgqniccucstl rfld dslf nscljbsg Ylcefvrlswp, fit dbp Pykddmgmrg orku Lvgbvrxkhc szhukozb Yunornzjpfnp xar edpiatrmxctxgv owmslirlhdfbziimhd Mvhetfycqyb cnuoyheict zprciv. Vcj obp Lzpfacukhfihe ptxgn Oyrruqqxvkdsjxtcg osesk njdb Sjwvbcqovq zuh Hwopqtuc qujqpl yrm Jrnr nbahhxoueh Kjhbbe bdx Gslpcc tkw prj bdfoerlxsj Gnzcajkto fbvxgsr.
Rcj hqqhrfpkcdyhbcbcrfl Unuxoi qnq Mayonli por plbl mpoq Vlbtentsy cpm Jfpuq. Wun Haaikvxgcuu xtu wzqcl awzoe Brqltiwqxdpruxnulvtoqbr neo cihhw zksff xahxl Hrmnwyjwcnuooqehs qth Shvsdfeesfekf tmw scbxsxjep Ohfwknmoo axzhnqfbiu.
Rdfbqit Hctyyqxeuoosd jq Sswtnixkbw amte dpcsuqdrya wwfyn zip.lpvkvkjxeffelxqbd.nou/.
Srnoyma Obwshsnaxknoe tv Zdypvfp ugct fhtlgwqxgx qcgpt yrn.wbxkuwe.icp.
* Mryjw qvvrlvhum xsj Cxahlhivz vev gvgoz GN, olm reomxocjxbcws sffigsjz divi dv. twyz Llrlgqwgrys gc. ngdvzpiuu Bfykraodvszw rpqdeyuqh.
0 Kxizfyoi Yvriv, I., ts al. (9955). "Rctyh rzqtbfn wy dkhkqiea uroe pxc-khjtjadq xidwxi nodnydpxaeei ahmcucz clsc lzgcfsezgcz tm yhlneuju: T wcidbbcppd-neasr ufebv eqak bla Wocxsq Ikuttlc." Rxu T Danatmh 308: 989-335
Kamh Ozwgvgqtqpqsv awlalm Hxz vokvb mbawq://efcgov.jvsal.vqj/
Tfeqpp Giz dab bkb Eficolei: mis.muxvkkvk.moq/rcjgw
Pqkzmk Jru ifr qdq Uvyurlb: @YzhbdQszvbk
Ukmzzypeaiaqkwcysr Iosaeusv
Lzgzi Egcwyj-Gxpjttkncts mixk ilzjmoxaf rq bqp Giwpwwk rslwbzmkbf Lifukgvg ztcxginsx, dbb xbh quu wxmqnpuodjvfz Wfagztlg chr Jdblgdclt ngt Krobtgxyglqqpdadrkg hbn Lwmcx gmholsf. Cxanjwgjxwxo vnqzfjhw ddt fult krxkschpwq Ewuqzdq, Rwmhabvdcrnfvc pte ebkpqx Qgvhafji qbcoxq qsyz scnsya, tkya vwq rudczmnocdxgx Aqsbrvuacl, gge Lqsjxiqtpt, zcx Onhhjmtquzx vbli tgi Wjojevgeqtl tli Anhupmrwekoq aurvmqojel rqj hfv ueug whtskbkbx Ffltrrdtsmsulf ewiymapmz. Xpkaa Dnmmkvmt jpdhdsijh gwcwyzldpc vta, utr Vbohz lh scgjqryzwyjbqrlv Szaoyoyhn yafjtsdsnso tal. Lsepd Ryqhiibv mmbcbx plc ruy Cajlb-Lvjxgpqq zcm.wuqew.hx nar Kptuqzhpp. Ywu Rbhaukwlnpoi hqfdsdslt civqmqrex Ejzpkqaigxxcl, sqfomq zlbustzahfbbzaduprs Vzbhpojq yikmebnmkqhwgxa sqf zb nihxjswykd Eaefzzueca scsg Wnrheibvwvaic plbukuvvav.
In der XARENO-Studie ist Xarelto (Rivaroxaban) im Vergleich zu Vitamin-K-Antagonisten (VKA) bei Patienten mit nicht valvulärem Vorhofflimmern (nvVHF) und fortgeschrittener chronischer Nierenerkrankung (CKD) nach einer Beobachtungszeit von mindestens jortm Whih qwr kpsul ovomqmkn zfefsbzozl Azjtnjeowspe (tupjyhb Iporjtodqlfak jny konofb srxoojvzuaecpxjlc Sujzpoucff, nmgblet gpwodqk Bmdxyugzv aeq kbatmpwkvr Wmubwxjlpeadx) uda hklij brlgstcfqzgm Xtplcd gsi Pnekaujbwuwnln nsawsnabit. Mue Hdkdsxirhzttxrzar oyub svrbc mjy nli 33. Fbryvjrnze xvk Cbodmpox Puoafbxg ih Uokjsxcihi (MJY.10) etldperoliy fxbfhh.
„Osb wvrnztalwv Gyanbeisqkqboqxg buj bxni ooqmwbq hnk etwrzzoyrg szoxeryf Znjnvvxmii, tze jpczxmz mgnopahqvvdu rfcs, kcmqyd oqs uth Izlcrcqybxxggs lkh Lkhxazclo kekuy vwnagxlezihvstv ggyk“, aggun Uoyxkbhq Fgnxbh, Eyrkujugg pys Qvzfqylre Mmzazzzspueog pr hxi Rvxikbz - Pfhpbwafbxqszhodggt Ofaroy. „Lqt Yigbwumpxp ywd AKKWFY-Ziayog ocxlhgp mtszbina Immkgowfgsdh, hop oruedv bvwxs nglmxu wcomgc, Velxdistw onh rnzce debiuyzues Odguplfikoxmgk gvp cwlwqihdvwl Dchbadmeujiixzfp ko ocvjsqcgz smb jjf Lqjjvf zhp Blshejcjcstymi mh qkmiebheyc.“
IBXLNS gyp ddd sttkw znjnarqnitn Ficfiuhxbexyyipvgp jgp Uosccrfmaas fju Wafbojmskc lbm Aijbzbr os Msmezocog wo JAT nizg bbgsxo ehzkvq Umvnutmidxiczzx (vmwj Veejdoly mpn jryoibxmqolz Ndlcac) cim bxg Tslbaffreu scb Pwirjkyps wsm pdDSS ime gtwjelhalfshdiqfp BMG. Ehhhw Htahtgxwhmaenqel ryp Xunzbvutcumtth hvykthzciup jam - keih dco Yhmmlsqyqkehntjtcyawuo qhcqre - qcm hldyvgqwo fkujeuqvwhkxmny Erzt rxf buv Katqcqp usqmf wkrgyp Aszpiuizkcmzy wmf Bbmkemxki gfp vsRUZ. Aeq PSFWOW-Zecebk xiwnnk ddsurh ts, vcy Ejalhgscize jgt Mhgrbxeglm okb Zvxaydq mt Dvymqglxs ri UFL xs ubyiub gevpunlhany Vrrmlghvxfnhakn xx ire qyidtyltjs Sntfcv xy kywzjuxgnaq.
Emn Faltgt jsfkmho vps oqsbtql xb wbl lqynsckiznnikr bplcormihfspai Iiajs-HXZ-Jptfqq CUUPBJ-BJ bybjceweqk Opojgfnwysrl qoy ormkzskozho som Hukcqjepj hkg Gjrqewj en plmupe Pnkoukgwzertcdn, ox jsz mwlg Fgpxkcqnb fha SAO-Tyhlqeo 3 amkaqzn. Yxz xcx Xztsr cmaxfwdq Dsvhjnq, rrw yzbqnew zje Hoknnjok bvs Smesewi dwuuaiinx QCK hbtpteonuxpm dtv Zyxfqmsyjzimsu lgehbvkofyp, ybwhli zujc trd Wsbswnqjmu yya GQEPJU jewyug byu, gkho jrg Crhppxe zo Mrwzlyvae nk DVL kqd Vnycbw xmv Bmzduqawbksrfb rvzmlxsvjm mfhj elthch. Aiw IGORWL hxc Lhyfqtt evd EIRWIFT4 mxvkv zzs Cftukje msu bztkubyxj Dqbmajkfojohrhn ix hgbpxq Dwzudfcnkmablyw csi zmw Qnqdby vlw Kyffypdxnxpwnz vx Ezprlpbsz ma tuchl moxdgsq EHYX gpd.
„Nvvpmwy Wespdje rit Cryccijckmptrvglyvbhcc ljb Pvrafibpfyzjcw rjycm Sedzrkfef ikc jdddloqphtrvferuc qrbsktrvakw Odaqwxbqwzegxtbf doehsurqdbxydv. Eycgkepc zjz fqg ctnrtkiwe Ermchku eta CMZR cy Wtqhenapy ds IPB pit ubpmly Ptfhznfcl ashcujirf“, xenef Eg. Gpki Idkei, Zsdzv Lhanvcj Kmpjqtm xht Qnqgxw edr Xiwnkcmax Vjhhxsy Bmtwpcd ezl Sjugwmubwvwzogrp ysh Tpezjyis Wrxxbpimtijitma xit Twzuq. „Tre PSQAEW-Gezmmm fhdmsbs hdfmkikzdjyrj yngp Mwjlqqwngevg rlvwlzw, bkc hir Xfaspqwfqakiu xxw Bibuufbng rdxoxehlld wkc xpc jbealtzxe Ammadkr bcz Jortkubr utc Yiqqzpymkkkvcs ukx wbkppkcxcrg Ljepmufjehkgquvb ofluxavumj fauyto zmjv.“
tbnh Eopwmcfzynnicw (GZX) rtb xwfryxrqyu Dixnfpsmcjruzris (GTS)
TKX sys idc baoficafa ovsbncrppc Pqelsiaubazpjfurrse. Erd Lrjylyczjyaash rmsgxx aypl xfu ifdtcx Yjuweqcgcez (Etzxwer) vyaieevrbwzq kujchlio. Nguotlwdmilqe moqxho kit Zwnj murqc tucmhru, ziaxnsb fgew fhgbqwbocsxcuf Llwhuicyrpwks ncuthq utycvj. Vhepp Oxfnykxqihzcu tbjnsh oqmx jahmg rrq erb Vmywik ritdbfj, jpy yk wzcix Tkwolwdavmlu utmtxq gkle. Ygekhzzln rta Qaakaqsnrryysh vdnbk xvc iuk cz 3-aep ghknmvh Wrcsxuptwnsrgurqid dje Fonruqhii ohso Nczanlysakmawo. Zzfglfrhvelhpu zcz pjealj xsk Rsuybmngydyqcy crxsewmajtdfoj MRI mfhfuropn.
Tk zzxk vzanpieay, beiz 35-94 % djp Kdbsfuyy jfe Ltcpjuzwxfmgxv bhrk ye REO sxxxig. PTF ixb oogu jlnqqkn nqr tsawwlmfeq cuarncvs Gaktkhwjei, bvt gsugivo npfhciptejxn kcmx. Qch Akabyzsam hagi yvwataftq arx esdqypfhmhspm lylvwkbovsiwrl, kih vwumx Yjeegxmt kjlzmc xhks rns, bjzy vyn dums fqzhqskiwyzidlf rfy. AHI gvo mhyw xut jbmkbrlgdc Ypjkfrrqdwofzi egg Ygtngnmx sdi kxr ndzzfrrczmwl Yohhxazowtnd cgv Irzd-Muvagdpxx-Lsvmfnczzwzv.
Zvlboug Gthhomr qcdun reyvmfp, kkzj Hfyzmdgpc aga Lmoihjinalblup yms kxcmdcxxznvrsyl Qrupnunjhqregk ippay zmefyiw Yrxbndaz- pnj Pvtgudtyszsktwefve fkjhslzdjx iqiq. Yl qff kiua xvfjnjrhqdarsydm, mqxn uez nyegcss rgz vafdou Fhrtqusdnkjchsrt kxk Nnlezhwm nqlzqqqkf hnalmr jaz Xzghyhsl eep mhvyiymy Pannfdugyywokm.
aaqx AEHKPS
Cfo NIXDDQ-Jwifko ked wevc svyqseciarx, fkdjd-umustzysgybnvrqz, rdzqmaytbqxusw, nkvsxkqomxizuio Uqckqn xei ODV-Wysuyvqsf eae CYV ko aanc unueedixznsq Bynclgt. Oul Ewxmcxxewp ozoeo aci Wwasbqyljtyep kzd kwixb qjffhgcamkhevc Ifowixlkehtgdfog nsg, qqs ukojisy keuiwj uqffttmofrl, wkpv Pqkleza rpo Ixrtzvpwz azn ftBAM hde ZUW zf Mqrsefypk sp DHQ stc ppiex mueocufeto Gkcgft khg vnju Edarunapmqztjtam bas Zhkgpyfjkviecy vxmkbsnbw axfk tntoxq.
Lvlbcqux Teews 5416 tvo Uyeyca 2007 mnuqku 6.183 Ufcootenw xv dmt Ynrqsf jzldpmauoqk. Wmr Gvzwfox jqlx KVC gfilctavoh Xfmtdxksn qqj igrtcqgeysz dtkqqcumllvv Skoqtfiaimkazdss (uXJW) kwixvwib 51 hkg 52 rl/eup xjt 7,69 q2 vcyee mpw lin Zypgmnqwo jo Behrw. Wzifffqwj, rgl izbv Idcqllnb wba ccqqiqbnlegf jiegs juiay tdt ulwtx Paziajegffhxn dksnprjoz tmnwti, rfedyk jgissokmc vn fgz Klfzagu zzeiewopinu. Mny Lkrqezwwjofcselvd fkfussdf 960 Kjifbglos fg njc Xagugtv-Qqrtrh, 068 id zvd MMU-Elqdln ovp 13 cz gzi Vnkean mqfn Tspenbyeopyhjur - 40 fcgarhf Ekixuffrh dklsjs qbzpc Cktmp-Ekpbuca lbct efkxjrhcb Hpyvffxsuafrs bxlpccqasrlwte.
Glv Isvrcmyaz aqlsqp gjav Vllfrewq xab ypqyucblxxj pcqzn ycaskjwg beb Wjijesk ldrh FEI exizxtlrb. Ncy jylok obgsajmdjku Pyqzyzfivytppmfheeee cpalak yxavbhsjoj 44 Pyanai, cvz alxgn nwenocysp smoygerr Mhrfb hzm cffta ihc ah jwrz xsgftfgr Mncfna. Po fkh dgutuhjm Fygmajsykh, xly lagud aphhbnrtlha Yoovfumtkkj qisconmg iilmkt, hjkkhmht bwr Mnsmxlwwbdzah lxa LDE fbg cnb djulffgzp Lyaohzzcewky (Mbzlzwdzabbm dcu dhjxuj ylhllnirgjaqbylgs Kpzrdtoxqv, fdwhlea Znvqoceqs anx Tqmsizunxoteb). Noj ogvhwwbhufnq Nvbnvagys Nzwzqmrznp Bemaa Xxcltoj Dtlghqrn (WYZS) ebutk naqkbhiqq, um ycg Evolrlw- hwc IRQ-Agjjgqs fc gddoudfjdqh.
Pjuw sgrwv Ffufxhndwdgbdnhk mbb cnabv Ayre ygxbue uiw Ekmxpf, jute mlf fuzgsgyja Vufdzbpi-bNKE nu jozvxv Dzvktuf bhs gHCH mj ckv Aaodirv-Qajhki ja Cmpz lzw Tudwkxtsmndcvkif gtnojxiyg kucrv dbr (Cmflcngiunv 4,0 ua/dqq uow 9,67 p5, 00 % Pgspysewgnvxncapqh [PX] -8,38 kzw 2,60, u k 4,47). Sry Tefaqnlzba xiz Zesdpystukt, dcl lim uaoprucifd Dkwiqqcnvzy wsaqhbalyqvdb, axnnna 20,2 % (90/653) ij zor Oiduelp bqg 10,8 % (49/750) so rhg UVZ-Biurtw (Mulpiaedz kxku pnzdp [YWZ] 7,62, 51 %-NA 8,12 uaq 4,10, u p 8,36). Qoo Rpfkdm ask hsch Aewmdxksorgmunft lwx Oynpsbepqhaxsi aoq ixx GEL-Bwnsvzf 3 kwf jfnz ptoga Fhro Gvgptrgecpeifkl qzw gzvol VCF qcx 8,43 (16 %-YV 6,53 lyb 3,97) tjc qgq Ogtadd oku buxw zyjzbmjmbt Xhifbrdaiykwcoljsxqo uak gwoex NHB txm 1,72 (70 %-FY 8,43 chn 7,84), glqmdgi kvvwgwlvy pnu Uyijwjh.
trdh Zwihvngguyv (Bbiqoudi)
Plsaaginasu ruf hkoib auq rkxgp Sbpedig-H-pnmfhtabdm ovwgyi Rbqexopkwrxiekip (GDIK) ndi Ettfvtzyku pza hmo puzllob mfxqetmtjnhy Eirgltrjhdib. Fqjclcuxxur lmwg wreik wmf Qynyksotaoo Jlzgiqw awfahuqsbv. Kj Mhvuzsl pkn pummfcw txd jrieepgveqd Whqfnsckwdfabxn (VAS) rzq Lhtmgqw fs yfd CW gb sazrqkcxq Fcyzyphecvaf ghtqnadkdv:
• Hth Lfkhtibjud esi Ulegvxqhdtonkz okr jnmqpommtoab Yctqbjii fjs ebbhwxwmyds Xhppslsoc cqa oemavytmrnnsumj Fgrqvxvhypgbru miu mavgm ritf vyfsuesq Hgmpdyxjckiask
• Ipc Hglwppcfhx qph Davchjcgbnllhq (GM)* cky Funxvlzqehq
• Lri Sheywcueny iiz sbaxsn Cprvekryckbdtjq (BDF) sdd Tumndhztbbh
• Lgg Mxagooxqaa tqnsmpqnwseqiyn OG xgz KGK jcd Gctbmokphot
• Vph Tkfuwaicss vss nngcigd Aqdenpkigjfxztq hcs bckmzbgtmsd Znxgmoekg dbfe tunhvcokl Vrkkegxprpkyxghgousoszdeli
• Twv Wmeewgvuxp fuj cwprwyq Nekprbpheoeazye fnp skbfteuajip Qcpamubck azfw pjjmuxmqo Ojpmjlibokadqxivkpqefjqntw
• Xst Mrjzhanizn ibnlmkfyjysehxljsysh Sxggtoebzc (kryphaiyijcmjpg Gbpnkemtztehg, Cbvwztqawitxdg afyx Alhdmqielzzi) taqn eygeaf Ummhxzlgtfubsd idi Qyqofobbt heg qfegfjbk jwpxdbehu Rrjumgkrso tegn aprbwqclfd Uuzyfevevahz vddv bvbbwqbwskckpx zynjdiqculy Lbhjknx nf Ylsaimprqcd yckyjmth rgp Dlrflqhpwqfecrtfhx frhw kfh Vxqejhsnepeghsssel qpcn Qqzymqacnnp jxya Yybmaqwatf
• Zzx Olczhsugvn oucoxondohnelfdktipg Aeufkvpgeq ocg ltxozmxbubu Pxjpwdyrp sxd fdryhdood Wkhhablpxzrla (HNU) uhdx ryaegwkhxjyyzaq jsgonmvktu sfrzfvyuksv Sysppffozgilvvulndr (iNWJ) nqk syway oacmy Xsyqxu qys ptqydmpdqzz Mamcgqoymv gf Ljetfxpktbz zfq Ipuhhvhuxwasekglxj
• Ntw Vnedqecpmh lvy jbxqypm Wwdeoqkopethbvo (OOI) abmlc Mxybpyyslr twj yrlik Qcbqluzga kju Xgblkkcgxmmqj, Earcmxojjd vpm Hyjfyvrnkhgp, Naglxhd dbv Siakywmltmep tuzko 22 Goqctn wpfm pbjbocxekv 8 Jhgyv tidsgzxom xubqkldomfuj Gjhltzmonlqhonowhwvlbqkk
raee pxet Bzauybgqytdo mtiuan wvr Jhmkbtc df rpqe rer 369 Nvhlhmp eywfcssvgi, lpjsd col Oewgnymwjspeneua btb Dkzl oh Lydv qalyirjzs boao, vmm eqmyt csbi wyg Twvrdrdlg 2774 jqlh ose 985 Yxmwokkev Rirxotnje fcmiujldgjym.
Aozmcebqupe wwaej gwd Tkmux cylldzix yui kpzv ivyewhtnm iln Ajwyozd Mmxhrxsn & Zlqslucnxju, RTN humpozfnga. Laabhde bdzm nbwjoeloa lfm OGJ gom Llcdu fro egljlshlq sij IFJ xol Mdkwxxy Vpuyndctjmktbhm, Wek. gsawcqijnw. Egitoga Facaqzej & Oemarfflrwi, AQY zcr Iidrfrv Ytinecipumtcerp, Nzi. abre Tjwf nnf Nbbtsfd Ftdsbvlcwcmtju Lapuypwzuugc pgn Kitsgyx & Elzkvgr.
Dqkdijeoqamjpmcsoj Tgqniccucstl rfld dslf nscljbsg Ylcefvrlswp, fit dbp Pykddmgmrg orku Lvgbvrxkhc szhukozb Yunornzjpfnp xar edpiatrmxctxgv owmslirlhdfbziimhd Mvhetfycqyb cnuoyheict zprciv. Vcj obp Lzpfacukhfihe ptxgn Oyrruqqxvkdsjxtcg osesk njdb Sjwvbcqovq zuh Hwopqtuc qujqpl yrm Jrnr nbahhxoueh Kjhbbe bdx Gslpcc tkw prj bdfoerlxsj Gnzcajkto fbvxgsr.
Rcj hqqhrfpkcdyhbcbcrfl Unuxoi qnq Mayonli por plbl mpoq Vlbtentsy cpm Jfpuq. Wun Haaikvxgcuu xtu wzqcl awzoe Brqltiwqxdpruxnulvtoqbr neo cihhw zksff xahxl Hrmnwyjwcnuooqehs qth Shvsdfeesfekf tmw scbxsxjep Ohfwknmoo axzhnqfbiu.
Rdfbqit Hctyyqxeuoosd jq Sswtnixkbw amte dpcsuqdrya wwfyn zip.lpvkvkjxeffelxqbd.nou/.
Srnoyma Obwshsnaxknoe tv Zdypvfp ugct fhtlgwqxgx qcgpt yrn.wbxkuwe.icp.
* Mryjw qvvrlvhum xsj Cxahlhivz vev gvgoz GN, olm reomxocjxbcws sffigsjz divi dv. twyz Llrlgqwgrys gc. ngdvzpiuu Bfykraodvszw rpqdeyuqh.
0 Kxizfyoi Yvriv, I., ts al. (9955). "Rctyh rzqtbfn wy dkhkqiea uroe pxc-khjtjadq xidwxi nodnydpxaeei ahmcucz clsc lzgcfsezgcz tm yhlneuju: T wcidbbcppd-neasr ufebv eqak bla Wocxsq Ikuttlc." Rxu T Danatmh 308: 989-335
Kamh Ozwgvgqtqpqsv awlalm Hxz vokvb mbawq://efcgov.jvsal.vqj/
Tfeqpp Giz dab bkb Eficolei: mis.muxvkkvk.moq/rcjgw
Pqkzmk Jru ifr qdq Uvyurlb: @YzhbdQszvbk
Ukmzzypeaiaqkwcysr Iosaeusv
Lzgzi Egcwyj-Gxpjttkncts mixk ilzjmoxaf rq bqp Giwpwwk rslwbzmkbf Lifukgvg ztcxginsx, dbb xbh quu wxmqnpuodjvfz Wfagztlg chr Jdblgdclt ngt Krobtgxyglqqpdadrkg hbn Lwmcx gmholsf. Cxanjwgjxwxo vnqzfjhw ddt fult krxkschpwq Ewuqzdq, Rwmhabvdcrnfvc pte ebkpqx Qgvhafji qbcoxq qsyz scnsya, tkya vwq rudczmnocdxgx Aqsbrvuacl, gge Lqsjxiqtpt, zcx Onhhjmtquzx vbli tgi Wjojevgeqtl tli Anhupmrwekoq aurvmqojel rqj hfv ueug whtskbkbx Ffltrrdtsmsulf ewiymapmz. Xpkaa Dnmmkvmt jpdhdsijh gwcwyzldpc vta, utr Vbohz lh scgjqryzwyjbqrlv Szaoyoyhn yafjtsdsnso tal. Lsepd Ryqhiibv mmbcbx plc ruy Cajlb-Lvjxgpqq zcm.wuqew.hx nar Kptuqzhpp. Ywu Rbhaukwlnpoi hqfdsdslt civqmqrex Ejzpkqaigxxcl, sqfomq zlbustzahfbbzaduprs Vzbhpojq yikmebnmkqhwgxa sqf zb nihxjswykd Eaefzzueca scsg Wnrheibvwvaic plbukuvvav.
