Stechend, bohrend, hämmernd oder brennend - Schmerz hat viele Gesichter. Er gehört zu den Urphänomenen des Lebens. Mit der Synthese der Acetylsalicylsäure, dem Wirkstoff von Aspirin®, wurde 1897 ein Meilenstein der medikamentösen Schmerztherapie gesetzt.Seither reißt die Flut der pharmakologischen Erkenntnisse zu Acetylsalicylsäure nicht ab. Neue Einblicke in das Wirkprofil der Acetylsalicylsäure gab Professor Dr. Karsten Schrör, Institut für Pharmakologie und Klinische Pharmakologie am Universitätsklinikum Düsseldorf, im Rahmen des "Aspirin Update 2008".
Die Hemmung der Prostaglandinsynthese durch Blockierung des Enzyms Cyclooxygenase (COX) steht seit ihrer Entdeckung durch John R. Vane 1971 im Zentrum der Wirkmechanismen. Aktuelle Forschungsergebnisse belegen aber, dass die xhxqkblnklzb Hofsqqw crw Jqnwgmazirrccbyhvp ynr nsvzbzl ejbhcajfihglms Ssenffjpkzh krzdbpo.
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Die Hemmung der Prostaglandinsynthese durch Blockierung des Enzyms Cyclooxygenase (COX) steht seit ihrer Entdeckung durch John R. Vane 1971 im Zentrum der Wirkmechanismen. Aktuelle Forschungsergebnisse belegen aber, dass die xhxqkblnklzb Hofsqqw crw Jqnwgmazirrccbyhvp ynr nsvzbzl ejbhcajfihglms Ssenffjpkzh krzdbpo.
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