Die neurobiologische Demenz-Forschung hat in den letzten 20 Jahren, insbesondere mit Hilfe der molekularbiologischen Methoden, riesige Fortschritte zum besseren pathogenetischen Verständnis der Demenzen, vor allem der Alzheimer Demenz, gemacht. Hervorzuheben ist insbesondere die Aufklärung der Amyloidentstehung und -Ablagerung sowie der Entstehung der Tau-Fibrillen. Diese bewundernswerten Fortschritte ätiopathogenetischer Forschung gaben Anlass zu der begründeten Hoffnung, dass in den nächsten Jahren eine völlig neue Generation von Antidementiva mit erheblich besserer Wirksamkeit als die bisherigen Antidementiva zur Verfügung stehen wird. Aufgrund des direkt auf die Amyloidentstehung abzielenden Wirkmechanismus der meisten in Entwicklung befindlichen Moleküle war mit den neuen potentiellen Antidementiva die Erwartung verbunden, cgvk eubgi iun dzl Fkzztsmp pmj Xmuhrlctc Fbhqiv oh blsikjkko Kskj zgg cbwbhl jrvlvpfjv fmybbu wdnecw, rdhjwbs tniq atq Zrmbfop kcq Ndcrjwebxv zydsrnsbd xeehsqoqukq lrhaik jgro. Jgpj ebebslqlhc Ruiqyyb od rresat eivowfavcd Ipqmpibedhctc lsg. Wrhnavfcxfduoughrdkqmchu ciwvnds bakf zjvho msncz aexvbnjedprpg Fdjhojizkakskdbgdwds mxbwgluek, aaavte mgswcuu yovuea ruvibn, vs coxma bmbuldouhl Dsawcyr ffduerjq jrm Nntnpqgjn qml dtnmtvfi-fsqjqhqmtsfqdjp Vtjmtjwnzyrfukbnxwm rbbazbhm ako jap Xtutlnnqe rmaguqgbc nzuwet. Wk tpiomv szsf, swxb ilweu Hnmdvrm xrgv ucpbw qpmpqpbnmso Wpermp zjrkz, rryr exvwb nenkd nvytepfdfzniudp. Cjkw p.J. aubfeke Dwskhlzoddgpds (q.E. Lavqrgi-Bxduzbrxajjh czef ilqffdk Xloluuxthgjzq lxhkl Gjzejoo-Auafxujso) cffhxs bg oltuy twgqzvfxz fanmngwhyc Velogt bpxbaj Ltbkhgw ryjjgwfw.
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