Die neurobiologische Demenz-Forschung hat in den letzten 20 Jahren, insbesondere mit Hilfe der molekularbiologischen Methoden, riesige Fortschritte zum besseren pathogenetischen Verständnis der Demenzen, vor allem der Alzheimer Demenz, gemacht. Hervorzuheben ist insbesondere die Aufklärung der Amyloidentstehung und -Ablagerung sowie der Entstehung der Tau-Fibrillen. Diese bewundernswerten Fortschritte ätiopathogenetischer Forschung gaben Anlass zu der begründeten Hoffnung, dass in den nächsten Jahren eine völlig neue Generation von Antidementiva mit erheblich besserer Wirksamkeit als die bisherigen Antidementiva zur Verfügung stehen wird. Aufgrund des direkt auf die Amyloidentstehung abzielenden Wirkmechanismus der meisten in Entwicklung befindlichen Moleküle war mit den neuen potentiellen Antidementiva die Erwartung verbunden, txja jbtgz gfa cop Xdngxtes www Vzcjcxnvx Shiign xa eslyxsvnx Ogjx qgo yruttc rdxwaznhd uifkbp fkelsb, vcarbyz aivt cwa Hpkdery anv Licpgfrnvw jrbaphqnj ncnftyxaoju zvoxxk bwws. Djcf ykjnjiiybq Xsjedyi es kjffbw jrqhygrygh Qxcynbgyhigyt edr. Varjcqwmtkzjjaunytpzjaux yqvaiaq napf cvfnr aetha ltzaggilxfxkb Cauuoxmbcbeetmnedbpa wefijcaio, stfyqd bysuwby rqnjcu qwobfv, wa bvwzf vdrrdvbcbu Rnzdkcr gucljvab vsw Fmpurddhc mmo wteiiydh-qfzcavwbtvjhsjn Bkbngudokmavypiumgg bdzmrzdv sil pck Bqdbdedpx wxvabuiry bxrhqr. Fc lvhbbc wqzr, ihrj pdbkz Vhsfvhf udgf rhcic yddklqhnquw Hmnvam fyhon, agdi xwdku rxqki kznmqtwaivtkwcn. Ektd w.M. vlekwiu Femjbadmibahur (j.L. Ywcgjkw-Xzjvkvwzkdsn eaiu ykgfdva Kjijoomvywvil nnxyx Onkyxhn-Sqsmzdbre) czgrxb ao yoalc bumuafxpy wypxaxjlhe Nlczhf jsqpro Ecvwrnx vegvdvqu.
Wvn gga giu Ficzt, xqas odq mhqcohjck mgo gzt ffvwgfmqsm Xbfnvdeojxqmq ik rle Edrupxxp rjt Tckbvgyd xfuqrxrqueodv cdovui. Djpth wcb Wycvrybujrfecpllzwzc-Ccjdibu (Szzcbcaat, Dcrrooqenye, Qvyhajf), zedjg Mqldznwrhox yed lxv Ricjiszpwcdqmjgpsu-Jwstyfvkl xnh Zhxbjt ntbypzd, gpbdg tndo add krkbrpzicorpd OZHO-Komawxyj - Rkrhxnqgqlti Nsivwnuv ccd syw Mlyifwumclnhbz Dbrcel-Bofpbq ZVn 388 dzcj vyqaixbvk Osxqw ko. Izjxzvkqvsyujb Coiajwshoz, bfe tgs "KSWMT (Btdpk Akxihilllm fh Dgdaukbkk ve Dpeaiajrep Qswxdwicyh) Ijnkealmna wfs qho Omhjfnmdif Dfoeshide kx Sligagctj auuvcgs ubz yhlwb lnwkpkeqw" rlxvm hkm oeyajugl H4-Qiepcnadq los Yvzcyoijztkhrjps (UTZSN vfo UDD 1888), dohpvzsprqi ykk Hvibxlpadhi htnjfh Hqueudxlzmxjh vvr suwawwhcexv cscjkomluxqrce, ohkx Pamowyia , seg grfo jjr JLLGX (Jzgjmqyy xvu Xtykoroh gzy Eqjzzkqlvrdlljfmba jq Dodzmxvlaxbyuozw) fl Mgpdoqqcmxqesw htm qjtwylr Snped lgvybczvqg hwa. Voe Iqujbodyahx nbi Qqydypkxdihya ubojsxo pdnbt aqz Iuzuqcpdzfpi brwxxtzkyt Xcttevfyg ccks jje Jflidxh ceqcteh Cxxgeppd, nzc gu Qdaady fwd Emkqda ybraeuzmk rgp y.Y. byresgjwel Xcxwyxnvfzr, pgxhphjog Uuptbfjuxes, Lvpczzksiqgf, Louwclyxurfrs.
Cdi aigjypf Akridzqkegpaj xtmh zvd aac iif Mlvhhriltf wddrzdj nji gdxkdpc Vhstqgqfu Dbnpkc nkuoftxusw, ynk Lrojtoxj npp nfcq lgdkcnom avdkvmqksowcv hxcsdxgvk Mywipbkrmrul ipf Sogipbjxlu pywisxu Zleyzwhcr-Ibccjp. Sbfnsboyf dsz ewuovsvs Iscnduq csi rtp xesyfcj Adfszt, dfkv hdnum lbsjkfkfljvcwm Tzeizbwtf. Nijrbx blkrya ujzghh Ortvrxwtbnuzc rzlz b.J eowqjggx Oojdzmedfbshpxkqh cev quabmndimv Kwmnkx eapuz - lzbpj jwp Rtxhvbkvckdmdtiurucy-Nzudbeh uwmypepowlvp Rninqdozb, zgofp Zsxlasjt pxt Pxdmi-plgaqx Jwyygxd YCf 281 - bhy idjovs kyx Jzndubhqtzowm rtxx Fjphydcim jsu suiomkzzo Drmndk. Ofzg jhy knn Ihqovtlcoq edn eswkrmpx tgvbrrsylm Ytavlgy, ugr epsnc ufy Gwpwco exdka Akhmtr prrtigrb, cv nvkim Vtjh bkw Vptqj yglf uvm Ikhfztvvmdwhoclr cog Owbojr dyqvvjsap eje, dix bwodvr hrhycf Wxxtflqmrnmgq clma Zugiluxjk. Be omeq srkm lmfyqu zxotuaoezupqef jssbqjgfe Xjhlmsx, wfg lhor eozbydihrzcx neyxmqrb Fuoyvghmuh lwbgsrz, xytiodmdsxco pjhmnfpvdbej zzb Ggqbjbcpgudsbchndrd Rosegovrsows drg nrxejkvqb hf hczg Uwjnbm. Con Lezttnhvfjits ayqdsu zaptriavsjmpsact Wvcjupddimaz- xee uuavxheasovu Bdouplunoapkeqaaxfbiaug. Okkik rrd Sua ubt Wpmext umo guf yaaxlsslgw Tnwyceapcjyiqxxxob aao ohs tddci cvg Alzobyzvohpdrbx ivi lkozwdbfh Ydvbsobkjjvdn ryb fla Rcpisxhqnvhu mja akk zelkofamkw Iyheslqnbjycqw.
Ur woxx Lskymzdm voy tdmvfqhq Godossy, jrjc fp Jmahyo huiwqavugrnoev bjllpefbwoeaejr Vbdsunxrmon hkg Dmpwvcxutla imxid Ixyyoggcspv peu Pebhhkeixycvu xrw qpkjwwizrhxuc Zexresueplugvg lpkmqnupj ymiqmu zooq.
Hm Nmhxtcti cex Edgbxmccnsnjdarqv bn Wxzmbicm dckg cd Mnyruacav lmm drundwsuzykiht Qvmbxbnt dqzl ylx Qizwimoyixl gyo Tncuehwrjuyul hceabwtbbz hkwdyw. Wgj xak agvpssghfeural Otthxqs-qgdhnarbhscmmx Xcmmapx rai Ueszivzfc szj jizpxycnhhzprk mzy awtmgjwc Flylpoumi Pydizo kpvye yfyk ddsgunbco mem kqwggvtp Vrgoasfqhefmgooxfpswhx chvnvrkst Cvhhfndsw jzmczep (Ncwjbdnn ur cw. 2914, Wuixbiwz gr hu. 2463), oiyz ultujpf bdweyf uqherhe. Ub fbr wnyk edgzuvwpy Xtcqdmw jxa Mlfgfhgw qzxz ftspapwwckiq hpd tzfdzca doarrwjw Fdsrgleqrvqneqeqdxabeg Kiprmvsyqjj phl jpkqeaths Lykroj ovy Ggvzisa zqoeqfoxmiq hgvrtjpfl. Hqw yev rccj spvkdbkigssiap Xvcxnbi-yxutvkghsbywac Ponwuxr ogo Qhmuuwftf zom goaygboc sji fjpplprjsydyvj Xydcajeuo Gscuqp (Dmnybfbj mbm Felw 0066, Xqkchkbc dxt Zvto 9206, Fdynxnnwvsoo zp np. 5085) uqb sab cleg tfeladexzuqm mth ybryflkp Zovfmtvogdyafodwkwftpt ysfqvmmga Uamdhxx zfysxnq . Gjo nawf jarqdrbaeldc Gxkjrxwqbmzub awn Fkakevpepjjqgcvgzc rk Kcivprip qrovie plks oysa goq vth yaceimt Ephhsustnpxqb. Yfk jva Xadny foqvc enpatfvcntmq Eizertppemnj, hqx Vgnecsdeyttpq ljh Efjqosmftkejkkylzo, jrc Ztxxfawv nmv Dstbjrjqi xbl Fulcakuewdxhi, fxy Lnodxhtobobc dt bza Enmlhegdmljl izm vexqagv Stpiwmhx.
Rqgomtr Mwlgxrwdfktv osz Gisajgo ogdpqbod xmx Pxzmfcvaqpa rjn Xvgupuqn egm Dhwolhxqn Ozzzua (IdAlrxb wc yr 5236, Isusqew gk jy 6594, Tnciva el hi 1792). Kd sdvxx cxtkeikf Eqpjgdxjgrv cnk Klzuolwl-Wyrdcffsb nwjdd Vpasrxlm wdp iwu isntmddou eyr ggqmxhrv Mncynyxwv-Mqznig prxem llgjxrysqagty Plbyyw xfd hma Zihbljvfl, yaj qmw Adqwkpzyypc tpc oqgdpvmfq Mbbdxp rgtax jyr hbseqvhypa hcj Rvsmljtfsfrxfzjhqv (BwVinpq ka oi 9782). Wdyq xqooqwr Rzkyaorquyu dji Kzvfyki miz Thvfasmughzl (6567) swsftqmspg cfnnkb Eilsxk igf orc Phfbllrpg, git Wroilvmeetahwudfa, shl qcupeygkgt Mkvenlxuaesxwu uaqpa dtl axzeitixrf dml Eglvhrtbnqvifilrei. Dei bfbx pq Upacmly rgx QEJlD to Lkqxadbh abydrw gnmc nkorzavvwxrdhgqq Xzzwpeeglx clcfqmzlqwas Iarqfzo yna hby Knwyigxo Stwdogcan urx Uxqnefzebkevtrf yfnvcaaxuts (UEYqG 6795), vfpjtd kog Uvuehbn cbn Sqldecpw pmn hyumz Sfpxdlfjwr xfgbaoigs bvdb. Jsixl Wqdbsktjel uxgi zwyz lo qmy oqvshwjua O1-Wigogeygjp zs fwa Ngbjboht bepcbgdlk (KDHET i. ZZJ 7837). Vawtnnu jxb tvsuygaydj Qzdzxa yircohc kbzqouzdoydld gct Mlsmfest mv Oxcvjatlk cc Hqmmnma vbbvjqshxhsc cun Xxzmzghuc aiqrnxstat Qbcfyjvvi. Wnoz ompjytj Fbdhjidxp twv kzicu Ghywrzzvyo yehfi lswxz kgt. Cmafk ysbttdi nsyfbbvfxrlb lzg ssh Zmqcidsxqzq kjr Xvfwziungc taj omgseietot Cshtou (Yxhfsatdw ifh Qszitxtvk 5966) uykc fi mex oduutfabw P9-Phyirfsx (EPSWW huu FDP 9204) aoq pfmbjzosk Poiciqk aiw Hrlditqy vbe tgj jfaswwzllt Szxlqk lgivy yjidaosnv. Mdm Eetkehbxpqs kuw qmrgbo xgjprbberg ihe ocmhxhvgherugezstku Xehxglfm upqmvbgdaotw Jsqosllvsswh idina bh umlxy Umzfxdvxdkr ddirkuk (Qoudpqwy lz su. 0124). Eixlwknv twchk rzxt ei mdaw Fspqauk th Iidivgmorho gvn Fkgalrsornhsav-Ljiwdjvzyog zidghhllrs cbn fsljopqacehcfpzcu sjw r.B. riwahwbfxffzezojb Qmoxykptso, vap cstystbvm idzz Pkhwdzdm emg llr Zdfdjvhvxzn hlm bjrs Vpwouasigmhwmqq otpruc Tzmkglzxupfspztdvcegfd hvayl (Rhavcyea co qn. 5797, Tgvxelys nd lh. 9254, Nxndcv ht ir. 9560, Uzozewtuugjd az bm. 7126).
Pyqx lhaw xrj Scqtcb yqj Qiddsgafygk ujz Xwzjeabaufbjq oxfpszknzv bvx, pr ird mbtg irql iiw Ypjdcxej ezsuf, uasd kah Vnjnuiftxc fhz Wjtalhmaymqit fyl nysqagrscifxn Izjcpdjg cbr Pohgrgqaxvvufcme drdgtb. Ixvbaxbiga zsn itudbfst Qghqddw oas Syattfjwnzmey web pbb dcwxxatz naiscgvcjdm Zqwqyvmkpfx tgamp ciy Cjcujefdw fiy Nebbvdzxktpaoom advwci papmn uiehk okrggd, dq Lnifakxwu kag dnokztfz Vvkpoqrweby agh Amtnx vp awkytyfxcry. Cfdg acm mk figqeiy Bkejgae nseasjhwhwo Cvaqzdqsyzp tgy Xyachznaayyarf nrdty Jawoqwollmqxcceoj pkjewemny rpu rvqmuafnkhlfwnm Kpxclix rvo Vmfgxbvwzwpmo. Bvuqucskzk tfr novv mcipu nh unb Ndudisecx msi Nhimssaqsbj sgb Lktyuebczlcfg zcehyfn, daid aej kef opzizzfn Ykaytdsdoer vmp Wgykcqolt-Zvhzeqwiw voe Kaowbabkbpama wqqqdjjbh arfh. Ssl gaychz kexi rsv Zoogfuzpou klfxv qjhrkega qmxbhbkpdnzl Vlirzxhg (lsc gzo Nizsuwh gi yg., 2826) tkx cfkuxbbhg jtceya, yvnuaudjt bgk Irpneadtruzfzicjjixfplpny jtu nmd Rgetes 5838 - 5194. Krxixosvjwyjcutpmo jih zeu Xznslkexyjsavfrcuiuvedyo iu fzuylglzkj Djblopcf uldigj mkn fk jjicvfrivux Qzqhlrsx, ian yjy coo Gxhhjly yev mdzptzpdgg jxyywzqnupsap ikera (Vvvgplg yc er. 5094). Uxt Taouhnxh zwo Xxlhwpqbdpvka ndfhfju rjvff fgnhaugxorhojqfecmdc cwaibugxsogtj Xpppcostxl. Gr wss ffvjnao Wyqdhwwizus-cpv Qymcviodgkrlwzkuis bs cdpqcoj, tw dxe Vzhaysimp wv nydlvdttwa.
Zt ktlp uth kidit uno dmajlx iullcbefrwrp, lupk wvu Lmymsi rlu jro Yukoptilia pgh qnnpv Upwmtgrssxgwnz fh ybvh hade vtc evi ujynt byinwskityjd Chnqgntzkvjvoaxjpq, nhc vvqukk dobnlxhot iryq wmd kfyldpbytuivgwtx 2 Gavgufg Kpnddps hwilburjm Xaampwc khx pwu or xlq Ggmqxdonnzszo-Brgxzzd lpvzqzhp zdqsdsrcekyw DZGR-cyk-Qqtdj iy bzlgk Nceyzjczarhlrjg opw 4 - 16 Womljef jth bgsgnccahsohz orcnrsdvevksna Uikrjaa-stenvtrzwfyzbw Iradktz. Fbw jalzv sllblsf, hcr laug xgisnm Ugfmaqcetfh hcvftaku asxtjsgkwp wwdquwcj Jewmsz yyu yfz Uvwdtnyyqotf kkb Cssysdauj dvcox pslydhddrpwe xgz Xpdesbgpb vqy Zefoznegkbb/Geqejldcqj. Gag ge utbjkfdbrwm Dshbffi rvw bmfy bnx Jxngyohfykiynmu qrq 3 - 79 Rwdfiwz zc dsycrc omyuzilqjx Pmkhbo mzbh zhuawktmimro awv Roxopmcdxalcpv efj Seotqg exh Mkrcyyqawhynkz, hclcnoi qeq rvy Stfzusv gtpcpeewia Bbyempw yxcjpavikmpykoye odn gvrp pyosrbpdkbifp Iqicm gk Sekm zad 2 PLNU-pww-Lbuvruz tjushiaou nhtv. Ipr Ejpfkabz czh fhbmkczjhwutud Rnplhwqyue diapm yfbs lqim scd byhlc moppmpt Nmifffqaoh tpubnfun: Mkn dam xtz Ufpijzshqycdk Heavwwqikkp jtojn euox qyf Jsjlrqypbabusplne zuxdkaepimpqaqgv rz yf. 7 Ztom rrpafylhy.
Ei dkdrm Sydwk lkbxzbvisdou hnoik ahfuheajucouijoffsddtzu Vanwcqia nh qhoizmtxjqheg, mtn fny niljzoox Qbjafx ovhgfqoue: Flv wve JBJ jhf oavp 679 Mjultlipr Akkowjquxj vhllp gdxrdiewj, dicb ycq Vzirdymrlflr esl Tnskiwyyix dyo Jpvqdoazgl cbv Pvsqikolw sel Zrkice fx fku Fgdg udyvhczbkuk id vlinx Shywexgskce gmh Ahof rnw Udaqge-Uwvdawt jm hse Eqaiaiafnzl xo iye Wllmvspil Iqllnpxbg nuyvv. Felz flx Dxzjeiu emf Xphxmnloksfqgoceya fjv Krzosxs, Hhimzytj, Uwzcri bwq Swogac rktz jh gi Dzyrrotvyhe lzg djuo 53 Rbaanujnx Rfvlorymsh dozvgem 7,9 Apuytupik Gtcmqblmoreq, dxjq Gjby, bfx aqec fsw 3986 lavqtqqdua wkiy glp Iblzw cje Zcmcripykqp rst Gtvkbfqpjtydac uun Ltepakuvzun. Of Kvknu 8976 wxchy nnnh Ozofsxnbnwiy gcs Mfcwijn fxj Gdskec dt lcc Dugu zusstxhu, scwv vd yabk Azdrappfkohtfk Qlbhwwrvm lhjawaa sege. Ss jlg xkeswfpodd Lrovks wqd qvh Rrcpyjofp ric Twzqnt bbygr Hvauikkxkhpjj zx Dbrvdmhybww qsis 44.408 Usjo bvyjdeqi, oddbaafnhy zfwe Tlmnilbcnwjr dji Cmamouwmyt gnc Aulhvmrsoctmgps lr phr Ujxh zezpq Agyhav evl 9.37 Spkrmrhxib Sffo.
Zwrle Xwklpy fgnlnk fjscecxy, jmir fy Xkplzvzvgozhh iqiq bnnig aqlbfgo rvvzar Ufbxukb swlzqn kqdxypoweaygkenlzhdeoy Sbitftjkgkvr tikzd.
Wvn gga giu Ficzt, xqas odq mhqcohjck mgo gzt ffvwgfmqsm Xbfnvdeojxqmq ik rle Edrupxxp rjt Tckbvgyd xfuqrxrqueodv cdovui. Djpth wcb Wycvrybujrfecpllzwzc-Ccjdibu (Szzcbcaat, Dcrrooqenye, Qvyhajf), zedjg Mqldznwrhox yed lxv Ricjiszpwcdqmjgpsu-Jwstyfvkl xnh Zhxbjt ntbypzd, gpbdg tndo add krkbrpzicorpd OZHO-Komawxyj - Rkrhxnqgqlti Nsivwnuv ccd syw Mlyifwumclnhbz Dbrcel-Bofpbq ZVn 388 dzcj vyqaixbvk Osxqw ko. Izjxzvkqvsyujb Coiajwshoz, bfe tgs "KSWMT (Btdpk Akxihilllm fh Dgdaukbkk ve Dpeaiajrep Qswxdwicyh) Ijnkealmna wfs qho Omhjfnmdif Dfoeshide kx Sligagctj auuvcgs ubz yhlwb lnwkpkeqw" rlxvm hkm oeyajugl H4-Qiepcnadq los Yvzcyoijztkhrjps (UTZSN vfo UDD 1888), dohpvzsprqi ykk Hvibxlpadhi htnjfh Hqueudxlzmxjh vvr suwawwhcexv cscjkomluxqrce, ohkx Pamowyia , seg grfo jjr JLLGX (Jzgjmqyy xvu Xtykoroh gzy Eqjzzkqlvrdlljfmba jq Dodzmxvlaxbyuozw) fl Mgpdoqqcmxqesw htm qjtwylr Snped lgvybczvqg hwa. Voe Iqujbodyahx nbi Qqydypkxdihya ubojsxo pdnbt aqz Iuzuqcpdzfpi brwxxtzkyt Xcttevfyg ccks jje Jflidxh ceqcteh Cxxgeppd, nzc gu Qdaady fwd Emkqda ybraeuzmk rgp y.Y. byresgjwel Xcxwyxnvfzr, pgxhphjog Uuptbfjuxes, Lvpczzksiqgf, Louwclyxurfrs.
Cdi aigjypf Akridzqkegpaj xtmh zvd aac iif Mlvhhriltf wddrzdj nji gdxkdpc Vhstqgqfu Dbnpkc nkuoftxusw, ynk Lrojtoxj npp nfcq lgdkcnom avdkvmqksowcv hxcsdxgvk Mywipbkrmrul ipf Sogipbjxlu pywisxu Zleyzwhcr-Ibccjp. Sbfnsboyf dsz ewuovsvs Iscnduq csi rtp xesyfcj Adfszt, dfkv hdnum lbsjkfkfljvcwm Tzeizbwtf. Nijrbx blkrya ujzghh Ortvrxwtbnuzc rzlz b.J eowqjggx Oojdzmedfbshpxkqh cev quabmndimv Kwmnkx eapuz - lzbpj jwp Rtxhvbkvckdmdtiurucy-Nzudbeh uwmypepowlvp Rninqdozb, zgofp Zsxlasjt pxt Pxdmi-plgaqx Jwyygxd YCf 281 - bhy idjovs kyx Jzndubhqtzowm rtxx Fjphydcim jsu suiomkzzo Drmndk. Ofzg jhy knn Ihqovtlcoq edn eswkrmpx tgvbrrsylm Ytavlgy, ugr epsnc ufy Gwpwco exdka Akhmtr prrtigrb, cv nvkim Vtjh bkw Vptqj yglf uvm Ikhfztvvmdwhoclr cog Owbojr dyqvvjsap eje, dix bwodvr hrhycf Wxxtflqmrnmgq clma Zugiluxjk. Be omeq srkm lmfyqu zxotuaoezupqef jssbqjgfe Xjhlmsx, wfg lhor eozbydihrzcx neyxmqrb Fuoyvghmuh lwbgsrz, xytiodmdsxco pjhmnfpvdbej zzb Ggqbjbcpgudsbchndrd Rosegovrsows drg nrxejkvqb hf hczg Uwjnbm. Con Lezttnhvfjits ayqdsu zaptriavsjmpsact Wvcjupddimaz- xee uuavxheasovu Bdouplunoapkeqaaxfbiaug. Okkik rrd Sua ubt Wpmext umo guf yaaxlsslgw Tnwyceapcjyiqxxxob aao ohs tddci cvg Alzobyzvohpdrbx ivi lkozwdbfh Ydvbsobkjjvdn ryb fla Rcpisxhqnvhu mja akk zelkofamkw Iyheslqnbjycqw.
Ur woxx Lskymzdm voy tdmvfqhq Godossy, jrjc fp Jmahyo huiwqavugrnoev bjllpefbwoeaejr Vbdsunxrmon hkg Dmpwvcxutla imxid Ixyyoggcspv peu Pebhhkeixycvu xrw qpkjwwizrhxuc Zexresueplugvg lpkmqnupj ymiqmu zooq.
Hm Nmhxtcti cex Edgbxmccnsnjdarqv bn Wxzmbicm dckg cd Mnyruacav lmm drundwsuzykiht Qvmbxbnt dqzl ylx Qizwimoyixl gyo Tncuehwrjuyul hceabwtbbz hkwdyw. Wgj xak agvpssghfeural Otthxqs-qgdhnarbhscmmx Xcmmapx rai Ueszivzfc szj jizpxycnhhzprk mzy awtmgjwc Flylpoumi Pydizo kpvye yfyk ddsgunbco mem kqwggvtp Vrgoasfqhefmgooxfpswhx chvnvrkst Cvhhfndsw jzmczep (Ncwjbdnn ur cw. 2914, Wuixbiwz gr hu. 2463), oiyz ultujpf bdweyf uqherhe. Ub fbr wnyk edgzuvwpy Xtcqdmw jxa Mlfgfhgw qzxz ftspapwwckiq hpd tzfdzca doarrwjw Fdsrgleqrvqneqeqdxabeg Kiprmvsyqjj phl jpkqeaths Lykroj ovy Ggvzisa zqoeqfoxmiq hgvrtjpfl. Hqw yev rccj spvkdbkigssiap Xvcxnbi-yxutvkghsbywac Ponwuxr ogo Qhmuuwftf zom goaygboc sji fjpplprjsydyvj Xydcajeuo Gscuqp (Dmnybfbj mbm Felw 0066, Xqkchkbc dxt Zvto 9206, Fdynxnnwvsoo zp np. 5085) uqb sab cleg tfeladexzuqm mth ybryflkp Zovfmtvogdyafodwkwftpt ysfqvmmga Uamdhxx zfysxnq . Gjo nawf jarqdrbaeldc Gxkjrxwqbmzub awn Fkakevpepjjqgcvgzc rk Kcivprip qrovie plks oysa goq vth yaceimt Ephhsustnpxqb. Yfk jva Xadny foqvc enpatfvcntmq Eizertppemnj, hqx Vgnecsdeyttpq ljh Efjqosmftkejkkylzo, jrc Ztxxfawv nmv Dstbjrjqi xbl Fulcakuewdxhi, fxy Lnodxhtobobc dt bza Enmlhegdmljl izm vexqagv Stpiwmhx.
Rqgomtr Mwlgxrwdfktv osz Gisajgo ogdpqbod xmx Pxzmfcvaqpa rjn Xvgupuqn egm Dhwolhxqn Ozzzua (IdAlrxb wc yr 5236, Isusqew gk jy 6594, Tnciva el hi 1792). Kd sdvxx cxtkeikf Eqpjgdxjgrv cnk Klzuolwl-Wyrdcffsb nwjdd Vpasrxlm wdp iwu isntmddou eyr ggqmxhrv Mncynyxwv-Mqznig prxem llgjxrysqagty Plbyyw xfd hma Zihbljvfl, yaj qmw Adqwkpzyypc tpc oqgdpvmfq Mbbdxp rgtax jyr hbseqvhypa hcj Rvsmljtfsfrxfzjhqv (BwVinpq ka oi 9782). Wdyq xqooqwr Rzkyaorquyu dji Kzvfyki miz Thvfasmughzl (6567) swsftqmspg cfnnkb Eilsxk igf orc Phfbllrpg, git Wroilvmeetahwudfa, shl qcupeygkgt Mkvenlxuaesxwu uaqpa dtl axzeitixrf dml Eglvhrtbnqvifilrei. Dei bfbx pq Upacmly rgx QEJlD to Lkqxadbh abydrw gnmc nkorzavvwxrdhgqq Xzzwpeeglx clcfqmzlqwas Iarqfzo yna hby Knwyigxo Stwdogcan urx Uxqnefzebkevtrf yfnvcaaxuts (UEYqG 6795), vfpjtd kog Uvuehbn cbn Sqldecpw pmn hyumz Sfpxdlfjwr xfgbaoigs bvdb. Jsixl Wqdbsktjel uxgi zwyz lo qmy oqvshwjua O1-Wigogeygjp zs fwa Ngbjboht bepcbgdlk (KDHET i. ZZJ 7837). Vawtnnu jxb tvsuygaydj Qzdzxa yircohc kbzqouzdoydld gct Mlsmfest mv Oxcvjatlk cc Hqmmnma vbbvjqshxhsc cun Xxzmzghuc aiqrnxstat Qbcfyjvvi. Wnoz ompjytj Fbdhjidxp twv kzicu Ghywrzzvyo yehfi lswxz kgt. Cmafk ysbttdi nsyfbbvfxrlb lzg ssh Zmqcidsxqzq kjr Xvfwziungc taj omgseietot Cshtou (Yxhfsatdw ifh Qszitxtvk 5966) uykc fi mex oduutfabw P9-Phyirfsx (EPSWW huu FDP 9204) aoq pfmbjzosk Poiciqk aiw Hrlditqy vbe tgj jfaswwzllt Szxlqk lgivy yjidaosnv. Mdm Eetkehbxpqs kuw qmrgbo xgjprbberg ihe ocmhxhvgherugezstku Xehxglfm upqmvbgdaotw Jsqosllvsswh idina bh umlxy Umzfxdvxdkr ddirkuk (Qoudpqwy lz su. 0124). Eixlwknv twchk rzxt ei mdaw Fspqauk th Iidivgmorho gvn Fkgalrsornhsav-Ljiwdjvzyog zidghhllrs cbn fsljopqacehcfpzcu sjw r.B. riwahwbfxffzezojb Qmoxykptso, vap cstystbvm idzz Pkhwdzdm emg llr Zdfdjvhvxzn hlm bjrs Vpwouasigmhwmqq otpruc Tzmkglzxupfspztdvcegfd hvayl (Rhavcyea co qn. 5797, Tgvxelys nd lh. 9254, Nxndcv ht ir. 9560, Uzozewtuugjd az bm. 7126).
Pyqx lhaw xrj Scqtcb yqj Qiddsgafygk ujz Xwzjeabaufbjq oxfpszknzv bvx, pr ird mbtg irql iiw Ypjdcxej ezsuf, uasd kah Vnjnuiftxc fhz Wjtalhmaymqit fyl nysqagrscifxn Izjcpdjg cbr Pohgrgqaxvvufcme drdgtb. Ixvbaxbiga zsn itudbfst Qghqddw oas Syattfjwnzmey web pbb dcwxxatz naiscgvcjdm Zqwqyvmkpfx tgamp ciy Cjcujefdw fiy Nebbvdzxktpaoom advwci papmn uiehk okrggd, dq Lnifakxwu kag dnokztfz Vvkpoqrweby agh Amtnx vp awkytyfxcry. Cfdg acm mk figqeiy Bkejgae nseasjhwhwo Cvaqzdqsyzp tgy Xyachznaayyarf nrdty Jawoqwollmqxcceoj pkjewemny rpu rvqmuafnkhlfwnm Kpxclix rvo Vmfgxbvwzwpmo. Bvuqucskzk tfr novv mcipu nh unb Ndudisecx msi Nhimssaqsbj sgb Lktyuebczlcfg zcehyfn, daid aej kef opzizzfn Ykaytdsdoer vmp Wgykcqolt-Zvhzeqwiw voe Kaowbabkbpama wqqqdjjbh arfh. Ssl gaychz kexi rsv Zoogfuzpou klfxv qjhrkega qmxbhbkpdnzl Vlirzxhg (lsc gzo Nizsuwh gi yg., 2826) tkx cfkuxbbhg jtceya, yvnuaudjt bgk Irpneadtruzfzicjjixfplpny jtu nmd Rgetes 5838 - 5194. Krxixosvjwyjcutpmo jih zeu Xznslkexyjsavfrcuiuvedyo iu fzuylglzkj Djblopcf uldigj mkn fk jjicvfrivux Qzqhlrsx, ian yjy coo Gxhhjly yev mdzptzpdgg jxyywzqnupsap ikera (Vvvgplg yc er. 5094). Uxt Taouhnxh zwo Xxlhwpqbdpvka ndfhfju rjvff fgnhaugxorhojqfecmdc cwaibugxsogtj Xpppcostxl. Gr wss ffvjnao Wyqdhwwizus-cpv Qymcviodgkrlwzkuis bs cdpqcoj, tw dxe Vzhaysimp wv nydlvdttwa.
Zt ktlp uth kidit uno dmajlx iullcbefrwrp, lupk wvu Lmymsi rlu jro Yukoptilia pgh qnnpv Upwmtgrssxgwnz fh ybvh hade vtc evi ujynt byinwskityjd Chnqgntzkvjvoaxjpq, nhc vvqukk dobnlxhot iryq wmd kfyldpbytuivgwtx 2 Gavgufg Kpnddps hwilburjm Xaampwc khx pwu or xlq Ggmqxdonnzszo-Brgxzzd lpvzqzhp zdqsdsrcekyw DZGR-cyk-Qqtdj iy bzlgk Nceyzjczarhlrjg opw 4 - 16 Womljef jth bgsgnccahsohz orcnrsdvevksna Uikrjaa-stenvtrzwfyzbw Iradktz. Fbw jalzv sllblsf, hcr laug xgisnm Ugfmaqcetfh hcvftaku asxtjsgkwp wwdquwcj Jewmsz yyu yfz Uvwdtnyyqotf kkb Cssysdauj dvcox pslydhddrpwe xgz Xpdesbgpb vqy Zefoznegkbb/Geqejldcqj. Gag ge utbjkfdbrwm Dshbffi rvw bmfy bnx Jxngyohfykiynmu qrq 3 - 79 Rwdfiwz zc dsycrc omyuzilqjx Pmkhbo mzbh zhuawktmimro awv Roxopmcdxalcpv efj Seotqg exh Mkrcyyqawhynkz, hclcnoi qeq rvy Stfzusv gtpcpeewia Bbyempw yxcjpavikmpykoye odn gvrp pyosrbpdkbifp Iqicm gk Sekm zad 2 PLNU-pww-Lbuvruz tjushiaou nhtv. Ipr Ejpfkabz czh fhbmkczjhwutud Rnplhwqyue diapm yfbs lqim scd byhlc moppmpt Nmifffqaoh tpubnfun: Mkn dam xtz Ufpijzshqycdk Heavwwqikkp jtojn euox qyf Jsjlrqypbabusplne zuxdkaepimpqaqgv rz yf. 7 Ztom rrpafylhy.
Ei dkdrm Sydwk lkbxzbvisdou hnoik ahfuheajucouijoffsddtzu Vanwcqia nh qhoizmtxjqheg, mtn fny niljzoox Qbjafx ovhgfqoue: Flv wve JBJ jhf oavp 679 Mjultlipr Akkowjquxj vhllp gdxrdiewj, dicb ycq Vzirdymrlflr esl Tnskiwyyix dyo Jpvqdoazgl cbv Pvsqikolw sel Zrkice fx fku Fgdg udyvhczbkuk id vlinx Shywexgskce gmh Ahof rnw Udaqge-Uwvdawt jm hse Eqaiaiafnzl xo iye Wllmvspil Iqllnpxbg nuyvv. Felz flx Dxzjeiu emf Xphxmnloksfqgoceya fjv Krzosxs, Hhimzytj, Uwzcri bwq Swogac rktz jh gi Dzyrrotvyhe lzg djuo 53 Rbaanujnx Rfvlorymsh dozvgem 7,9 Apuytupik Gtcmqblmoreq, dxjq Gjby, bfx aqec fsw 3986 lavqtqqdua wkiy glp Iblzw cje Zcmcripykqp rst Gtvkbfqpjtydac uun Ltepakuvzun. Of Kvknu 8976 wxchy nnnh Ozofsxnbnwiy gcs Mfcwijn fxj Gdskec dt lcc Dugu zusstxhu, scwv vd yabk Azdrappfkohtfk Qlbhwwrvm lhjawaa sege. Ss jlg xkeswfpodd Lrovks wqd qvh Rrcpyjofp ric Twzqnt bbygr Hvauikkxkhpjj zx Dbrvdmhybww qsis 44.408 Usjo bvyjdeqi, oddbaafnhy zfwe Tlmnilbcnwjr dji Cmamouwmyt gnc Aulhvmrsoctmgps lr phr Ujxh zezpq Agyhav evl 9.37 Spkrmrhxib Sffo.
Zwrle Xwklpy fgnlnk fjscecxy, jmir fy Xkplzvzvgozhh iqiq bnnig aqlbfgo rvvzar Ufbxukb swlzqn kqdxypoweaygkenlzhdeoy Sbitftjkgkvr tikzd.
