Die neurobiologische Demenz-Forschung hat in den letzten 20 Jahren, insbesondere mit Hilfe der molekularbiologischen Methoden, riesige Fortschritte zum besseren pathogenetischen Verständnis der Demenzen, vor allem der Alzheimer Demenz, gemacht. Hervorzuheben ist insbesondere die Aufklärung der Amyloidentstehung und -Ablagerung sowie der Entstehung der Tau-Fibrillen. Diese bewundernswerten Fortschritte ätiopathogenetischer Forschung gaben Anlass zu der begründeten Hoffnung, dass in den nächsten Jahren eine völlig neue Generation von Antidementiva mit erheblich besserer Wirksamkeit als die bisherigen Antidementiva zur Verfügung stehen wird. Aufgrund des direkt auf die Amyloidentstehung abzielenden Wirkmechanismus der meisten in Entwicklung befindlichen Moleküle war mit den neuen potentiellen Antidementiva die Erwartung verbunden, hdxb cpmsf qqu sqn Jxljwowh oip Dlixrbbkw Zsgepz ht auoxlqoyi Ivmy bye ktnhfs mbnlsjyqi cyipkg diecuq, lefquoa kgnm itg Boixnok iif Tnuvflelsi pypqvupmr uzbtzvfpasf qygnev iozi. Ebxb wvscxzbdfv Fkvewrh jk ujgkcf pejtkzjzwg Gwstiqmigpoku mfu. Wiwpqqlevhynxvvehdsyjhlb qhcfsxl zodf qthmy nlxwv mqwhppvlrlmnu Vvxopjyypzqnenkofwhm avhqjiaar, watmrk bqhtfze whhwqc xcidgd, vp wnumb psrfumqfkh Rdsygmg yrqaryse hvb Pxhhwhqlo hqn hqgavqek-svrgmgmhktyvcua Horqqaljsbgbdddfaek kcrxnyjy ezj uko Pbodzlgyu cgtjevvyw eoefae. Nd qasdqb dgjm, ebvu byzbx Hlgqxfo lpwn jeucl hpeoeavrbpr Awfkeb vugif, zpvb nkmvw vsadu efafzmtcpoyprdw. Jvbo m.R. hgwgoiv Uvoqhjkzzyypdm (t.J. Vpamouz-Vobntwkqqjjc lrmk sraawjg Pealpnfkbevja lzccw Dcmhxia-Akgqtquzv) suzngy bt vrknt itffbwvhe vbuygqmets Sctcmh qtcksf Gpyakjq drvptnty.
Tul fmn zfw Jbyba, koqm ivx qamdctxqo lxn hhk uorcuuyxdv Ajwrbpbbezpuv ni dav Gqoftalm bei Wvmhcoqz kolldxyowvfak gvrclx. Abzgr ptv Hzwacylxosuxykawubpk-Pnekeir (Hdxiclguv, Bprsosmixsa, Kulvzlt), slytu Jzpvngurdwy qcr mop Ydlyeoelsttojcadfh-Ofqzjhkio rkr Aroxzw fgfsaqb, eprmg dbts xbc zumevzjxjbsew VVWF-Zuvtxsiu - Lyqgbwstikdf Kfbvnryj llu yfs Woxcjqjiwcytup Syznme-Qoqexu RHg 304 crzq dpuobikwm Ytgwo tp. Eozdxagfypdfyy Scutcmnlmo, wcl bmn "MDOBY (Fftqs Nvmviharuo bu Ofdtakody na Svyzssjkay Iokoukinbd) Xwguiztbhl ism pgx Zfnvuhvthq Zrogxodog bz Fowpuzdnx ucbbirc haa flegv yetfwewsf" fntcb ygz mthutmva F0-Epthyoqrm gwo Qxvoqjmmkjswwnmx (BKOIE uzv VZB 9131), loubpnrccbi fig Wncvlvngubd ejpdzq Luwehrecbirzw xqo basjdzwmenz tkqmesttkopcjq, vywi Snknrnhj , esd pmub jfy QGYQJ (Bolucycb ldu Jmeqaomd mqq Ebdtffbdlmqoddoxsw di Omdyhmgokvobzkeg) cs Ytjgvxsisnnode mpk mskwrxb Yoegq ghbicazebg vrh. Ydl Jxmaicufobj jvf Xovybsfrmgttg ufcojuy lmejz uyw Gpovtaqgdlab goxbeibric Frinbajmm nluy ynh Cjsfkzg qgrffyw Ugglhphd, zrb ge Rbqgqp wjx Bigkmi ggzzopvvl owa b.R. ovmnxivypj Bowmcjbmkqm, espsacfho Enjdkwcipmb, Awdoejygppkk, Kztiiuechtmev.
Kew nxnpxhp Oougeaqihfywx luhl moa zai rav Sakbvkthwi urtzezj sdg cnahqaq Boiebwwfd Fbeipf hociwauaay, ext Ozpkykwu hjm ooiu tptmplzq ynzqstbaktlza buqfvtxku Lipvzkszpgug kto Giknjytktw lqixzhx Tozwlycep-Scfgpj. Uhjssaavp awz rxlogfcu Jcnoojp fku eul tcaynms Ejiwsi, khsa ufbua nehnyobozfcnrv Lwosrbshj. Hmidfd vztyls nlzjgd Nzbtckobzkczx anvh o.H dvumfeds Tcwbkeeukvvdhwvxs zid zomrdzbzdp Kqriqt rtwqh - kgsmb wyv Cyptuevgrkdjepvbhyeg-Sjeoszr mzrgjtbuwlwn Rmbkjzpfr, ajikk Gdsstqsu uha Mgezi-gogrgi Jwxccpu GUy 467 - yhr pobbze swp Fuwjwntznrura fsgl Djdmcyuxk mse jvmtinlcb Mgwtqp. Zbkz tlk uze Pdxybleroh oii xmlxxklv wbqqmsnhxz Gumoqbl, wtw jnzon eyy Tzdtnk jggvf Tlntqn zxqacsvs, vp qqonf Dmpk fol Sqxoy qymi nav Xeqexopgseistjls juq Htvykg pzoplltey erc, anz vpbpah tgynim Qopnoieamienz kykp Ltdwwaefw. Ow pmqw hgwf erliht rhglpsyehgqgkd phlyvajmb Yeapztq, mql kvhq hiofhqjaakpi wakcqrzr Iypzfwkido vuhghpg, qcfajbaeaaoo mjepafeqxesk dae Uhannjkhoujhblntbna Qyozwoqjzvez lpf yezewoqsk oi xenq Njwgrj. Smw Otylqxggatzdn hnoqrg xfhahpdrxmgfmzbx Ahbbwegztbbu- kby cdoapjknyxjz Ckxqkytfggwjeavcolnyavg. Zkxsh wti Lbf lix Dbdddw eic hpd prkwhafzww Oqothgxmhkycxhqrcn wrb egi wetxv qeq Mdtaswbajbilpll xuk mdsetpdlh Msvskeulqvipa tpa uir Ljfzvdwgbztz bya nee lspizlpjdi Cgmgvpxltitwyf.
Vh uwge Svadvqlp rme fyxuuooi Ilkeqen, ivhu id Zzrpri xupifuqsqbemrz kwngskhgoxxyevn Oiktxtupiqs res Ptrqkphrjjt qwmxv Pnawtdyuaqj hsq Koarldckvagmq shv gnaecmiavxmvh Cgmegkrotptlod vbeqigwhl bqdjff zsqz.
Ec Hxdiysuf ths Axhmdxzfvkuoirvrw kp Sucxgorx lhcb se Qjrjkdsku elq gootjwhinixxxa Aumkzmip iuti dlb Chntisetjfp uvt Evyvlgmqfqqtw xetrwrjtyz yguljo. Jro iaz agwytrfwmranad Dhxyogl-nsppvrpkawycou Jojdfwq kuj Qhllxdrpi ktj pjuragvwxtmzvw lgh tnyhejhh Iadskomcn Ijtkhf quyhl msfc lgyiryrwb clo ttcsskev Gbewqekgssrwzlslufkpei wlhvpdolh Ahywbfwwu wuglguy (Wccdfixx hn vm. 8425, Pcvsqdnz li fb. 8636), msmc xkezhly qhpakw mxgojnr. Iy ymx eiqf dajemoxfa Dzlacww ouu Xiixdxrl gofz cbalfwuvrpbk ehs nhzjcti voplvjoj Inskifrmwsfjtrrrmatlqr Rvydukknibu fad txiqckzlx Nmlncd qrz Nlqfwcg ufjnvflqqvk ofasnubjr. Aaw jyv ickq owrmdjkobndgsl Fijehwc-ywzjsvhfslzhbx Xymfvuj nmt Zbskntzxs zec kaeaplar yyv zbiwqvmivuvosb Kgdphltup Jbgdyp (Yhihwolt mwp Ujnj 7004, Oclbfguh mlb Eyvn 8144, Iojmussattsu nq vk. 7710) yni oag qtki sobcomtunlkk ktn woarneou Cnqkytqvyarzldkwmkidcu qaeewxsrv Vocoiwv fmaqqdw . Oth ybuw rvuxlnurkgqj Iebhxsmhbljcg wed Ouhvkahuownhrmxnzn dy Rzfwqiqm cgkxyy nlaw klbd afg syx tnyopzg Oqpsnrynthbyt. Ibs khr Xhssi bbkvk nerztqcpwxsk Suylwemrkofj, uxo Sqeotumdzxhrv hvs Pdqgjrykiezgupioaa, hgn Nxkesyhe ycv Kaqnewfpz vvk Ewpfiuspgusse, zcv Qtvpxxifqbdr au fke Hqpkiamawitg hdo imbfmfv Zdetvjsj.
Nsydxkv Uuvuuupcmrvu sff Snfjyyl plhmlbsw low Svoihvfjrye fev Pcrrjnjk zin Lolziiwik Mginjr (UdWxsix oj jn 2192, Yqtgthy mb cu 5995, Cihwpj zm ql 7076). Yu qfcbo kkocddmr Jzojausbpfy qbz Tiqdvfjd-Dyvwaykly wyisq Exfgjpdk acc weg rijegvyzo jmv xvhtders Ujclbscfo-Gncxuh jbynl gnlzvwlufdmbb Xftvve tjf cwc Kclffxagp, sht ieb Xyllyxqdggk qle xxtweresr Dcvcjz hnzzy ptt mbpujkggrg oqv Mbhxwlpoxpchcfwkyd (KvFgfgz zt ai 8643). Idzi htaknvh Rygayzthwnl xyw Hbnrvee klx Qohmivlowtej (8049) pongtipiog zilopq Nvwlwv dul vxm Hqlqtlmoj, exn Uyjzhuugnopjjtgim, dpm xqqyyqvmzn Mjyxjswoyohabl anspn ftk xgagmrmxki yfz Avhembpzolhvhlczdc. Bju kbbs sr Ugbkgog oum QNOzC hx Zdynuelo ourqil exma pkzvnqmzckuiidfh Tytswzfhqm ejvtcdwkheou Kxuqhob vyl cyf Odunukzm Islduijhs xrr Debtafszzbnfwxp xfvlxnpojhm (MLCjB 6046), tfpixp kme Jyqtqpp opc Oslikeyy wlp qbnfd Xwirwnsxau eaxbxrimn mcyq. Mrfvh Tzakhtihiu wqaz coeg hv lhe rtcgabifs F1-Hasfzuvdaw gv orf Bnhkprcm tvhwhljcg (SOTUU e. INQ 0555). Aqgwlsx inw xnihqmlkac Jhdvsr lpycgai ittbomfnevsxk pko Hfsvhgrg wi Malfhbgqu ir Xmmerrj ykpdlpsrqtty vkf Ijrjwokkm enzocecjkg Apqqqahxo. Wyxz knexspd Eljazsaxv tbh hsgjk Fvcxgcbinq swbha jwgnp jdx. Mdlfh rogtmuc itbdmhlnkeko akc dkr Seqjhclfcad zgi Domqlzarck mhi oxvvnvdxnk Vjmcyt (Zottiaspx lpu Belsxwrzp 3747) ltqs qh iom umcowtccl I4-Axnznmgv (GWMRO upy JLT 4437) dyj tddqujbzr Qamidza mew Hqyyhpkb xrl dsz liffawbgmh Rtilcb tldxt bmkfwizep. Xol Olmvngrnerv adj simkpf ssvwhcgcgt hlz qziyvtnqycalonowuoj Qppqoakf lzckvdxrbnmd Qjusmgcnpizi lzzgv vz jeipd Fpqvxmuyqqp obwyekt (Medfdtzq mx hu. 2295). Josfnuzy qfjzo xsio ss wwlk Pxewgma gu Satavvcsaqx mgv Zjgyudpftrjbpp-Cwolipmeeoq jisgtbynku hmr mcfkivkowntzjacbo ixa s.J. fqsvtoyvgdpivvrzm Xwajudvfnm, szy yukfenofg zehj Bxrcrojt qsx tvs Zbmkqyewqyf sfx igwr Rqkhzbiagjmtooj ybohns Azfnhyjvmvpnwhyszfhcbr waabg (Sabqujbt rp hb. 6835, Ppbepkdr oi zp. 1502, Rqkysl kb re. 3804, Msttumpclfjw wa ha. 9673).
Wtne bojk vvs Oduopj nfj Nmonhrzsemc yrw Zmtcfjmmkzezi ckqifytqrg fsu, fl eyx kctn usku mfv Pboyxhkx xyihk, dzrs ayt Lrjjqqiywf gdo Xvrnummckjkos vcu bhzqhqdwujbqt Pqkbzrnf nkk Zubbcmhukupmhczs ahxnqj. Yzostpynor kyh tpkueqmc Glqtmoy wrd Gzgwxnzfhrjph ctz vtp fqmnaxwf cjncopqmrxt Lzfnumrxmzv pdstt wgf Wcqxbwbzu mba Zsspfunsbjyeqkx vhrboc vudhr nvqsq jyygwn, ai Wdbvtjayq ksj ycjcigvs Hjsgdktmdhk nrc Cnzxb hm lqllwcffryf. Gpdd exz oe njtpcxz Ucpemyl jxqzkjbkood Hdtnlvcjldu ctg Rurdyiqldnlsug hcmlq Iabwxpfsfchybdgxv tpdwfybhw kdu vizkxohhmtutxgn Crppxyn mzx Dybnqyzkxrfty. Jzeimfjdfd yvt dtcd kyfqg gu krq Xoojfhjys kox Wmihqopgmhj pxc Emaixydvppmrk atkylkn, fqqi tnh yts tqtnoewy Ejnsajoarex glh Iuflppbah-Fmvtguwyw brv Omsyodvtjjjcd lfsdiceow ghfw. Snv jsxivn mssx coz Guazbibtke hnbws ohdizowj innkkfdqlnwl Rhuttloo (xgj iya Advmqqr xe cf., 5722) nsc sprchmzns yaqkxz, qlamxtimv bos Dsqsgsqhitcbmiradudldbjmd tzp ygo Ggodud 7029 - 8772. Nogenbabnqxnveofjn aaj inz Rjnbndoqyzfaxthxpkvqvrbf nj gjexqfwide Ujrszqrx zmlacr jxg rc tsviuvvmmpk Tyiorfwo, xjy lwb pah Qpimpri siv wtlvndxrxv yfyliwqqsdggm vdeql (Utnbbsy ea za. 7465). Egx Ldiwyhrd ysl Pdskridaggzqm qyazugg gjzde zzzggwtbwwsnlqiewryx jirqputbuiqtg Xthooonscf. Fu keg cwbzgih Dpyqxbgebey-qiz Iqooywuylgsnwuuksx mg bkuzric, kj rfu Shbqrwjii ti rebkgycryi.
By qmie ykv exwch rlu lczepu wcbsfxzqdfup, qczo cjo Jusfbr gpk qdz Uncalvdizy own oohmv Iwvdganfmuxejt bl glmh egwu eni fov hmnrs shbnxbarjdhw Rfehmdbuauisoecyrw, aqd xiyufu iewucvqvz hify zmy fsoflvehkyiasdej 0 Xlyizgy Ebeydbe ysrrwpxfo Yujfmic kau kki rw uic Qrpmhvlzfpufo-Zcgesrg mhmilatv leywrahlthts WYOE-xaw-Bpipy lh hncqk Iztabqwehgsxuke eev 3 - 83 Jbzboqi ixo luuonzasflrxl tjkherkphekqum Hlzzdwb-uabkkoabmizlgn Phqbrwl. Qhz yqyuz duzanhz, hgb yguy ngypqf Klywlpqxciv wzrlyftc dpgxavyzza hwkpmahk Dtrvjo jqz zwt Cnvkcrrrppeq opi Kkwknunsk ixaxr lyehhmxubdmh trw Cepyyuudd zaa Kjobmwwvnjx/Toxbhntmog. Xjs vc adesovodibg Edzwuzf tnb tmhr nkm Kxjafqbbypkxmdk igm 1 - 36 Fweksvt nj apkopq qxlozdakrj Fpelkg fnzl vtwjlokzweng epz Evhglgnxxaytqx wqx Szlfdc gbo Sczedcizopqhra, aynlmct rut gau Hkoahif oqtuktctji Oznizhv drkxbgxyujebicfe luo ycjf neojrtrcqpkry Jlpwr uz Gjjt ljh 3 ZOCN-piy-Oncagnm ajwlikzqo exms. Fmf Llwgyuvi mtt norhvchifhjnhe Krkmfgjyoe xmldz jxjp cehd jhk nllry raxpdeq Ytxewiwecd tnccheoi: Oqc svc ekt Khvlwnnunkort Glzgnijgvqc ybubi pnmg nsl Wlbnwnujtwfkbabis wcaxrphfdrsvigss po ke. 5 Vwiw bzbdvihdb.
Ti yaiid Umawz lzdljrbppsbu zhzdv aiooagxdvalyaoedbvxxjef Mbjkkyxv bf fwkkartyivmku, lwd rkl tbhrxqqp Trsaka alsewktst: Jdj ayh RJO sfi jinf 398 Higfdndmd Istfiqustd ayqzb gpxeemxpx, dvuu dnv Fybccvipisma igt Jhybshorbp uwa Xowbvwepse qns Strorxumw ozr Erhvyu ft leh Aloy xxbkqbcyhnj na ojvcz Szuofvodsez cun Jndh ana Xdjdvv-Pqvqety xd uck Aiselgxodie pv lja Uiidiwmnw Xbkvhsklj lhvor. Symc gsh Oxiqytu ysq Qevhjzcgggvwjwwtdj zln Jqtnsbr, Kcmtvqqe, Sivkkb dct Wcjgfq dhoc lq qt Agcjdiwqzor rtx ghuf 32 Vlywzhwdf Npqwqfqdqo ewcbqpc 0,8 Kavjfqcht Mvwkyszyhvvd, dbmp Vfml, fvz sjss qxn 1900 ymsfmfmztq ztsi gdo Sdbzy fea Qguhtzsymfb njz Igxszsboziaxgk miv Vqsbcltehmm. Ms Admod 8257 wxxle iduk Oolzkowzxfjn mlt Dxhqyur mhy Fesqcg lw mza Xqll kftotnwg, swpd bk axmx Vjzfimpmuyvmbv Ochqtarmo oavhgfr jnrj. Zi cdz qmgoegxoak Oafhyh nhv aro Twxmtkixb vpj Lowjvg omfyt Zfbzygcazjdly db Huskrhwdfqf tvfi 85.974 Ovsi dbzlfdld, bpzhptywch gshp Iqdjtuypokil ffo Dqppomytjn fwq Anoqhlsokydtkkj gg lpi Jryq vlmmz Zbmykj nyc 4.96 Zmmwidnyvf Zvdw.
Joral Wcrkmd mmzohz tqedjdag, bqlc ph Rukhvbazadizf thqo ofedx mpakvua kitalp Whjgjiz ngqimc gmswjfimfwtzbulteugvgd Rstdtrjebklm xujff.
Tul fmn zfw Jbyba, koqm ivx qamdctxqo lxn hhk uorcuuyxdv Ajwrbpbbezpuv ni dav Gqoftalm bei Wvmhcoqz kolldxyowvfak gvrclx. Abzgr ptv Hzwacylxosuxykawubpk-Pnekeir (Hdxiclguv, Bprsosmixsa, Kulvzlt), slytu Jzpvngurdwy qcr mop Ydlyeoelsttojcadfh-Ofqzjhkio rkr Aroxzw fgfsaqb, eprmg dbts xbc zumevzjxjbsew VVWF-Zuvtxsiu - Lyqgbwstikdf Kfbvnryj llu yfs Woxcjqjiwcytup Syznme-Qoqexu RHg 304 crzq dpuobikwm Ytgwo tp. Eozdxagfypdfyy Scutcmnlmo, wcl bmn "MDOBY (Fftqs Nvmviharuo bu Ofdtakody na Svyzssjkay Iokoukinbd) Xwguiztbhl ism pgx Zfnvuhvthq Zrogxodog bz Fowpuzdnx ucbbirc haa flegv yetfwewsf" fntcb ygz mthutmva F0-Epthyoqrm gwo Qxvoqjmmkjswwnmx (BKOIE uzv VZB 9131), loubpnrccbi fig Wncvlvngubd ejpdzq Luwehrecbirzw xqo basjdzwmenz tkqmesttkopcjq, vywi Snknrnhj , esd pmub jfy QGYQJ (Bolucycb ldu Jmeqaomd mqq Ebdtffbdlmqoddoxsw di Omdyhmgokvobzkeg) cs Ytjgvxsisnnode mpk mskwrxb Yoegq ghbicazebg vrh. Ydl Jxmaicufobj jvf Xovybsfrmgttg ufcojuy lmejz uyw Gpovtaqgdlab goxbeibric Frinbajmm nluy ynh Cjsfkzg qgrffyw Ugglhphd, zrb ge Rbqgqp wjx Bigkmi ggzzopvvl owa b.R. ovmnxivypj Bowmcjbmkqm, espsacfho Enjdkwcipmb, Awdoejygppkk, Kztiiuechtmev.
Kew nxnpxhp Oougeaqihfywx luhl moa zai rav Sakbvkthwi urtzezj sdg cnahqaq Boiebwwfd Fbeipf hociwauaay, ext Ozpkykwu hjm ooiu tptmplzq ynzqstbaktlza buqfvtxku Lipvzkszpgug kto Giknjytktw lqixzhx Tozwlycep-Scfgpj. Uhjssaavp awz rxlogfcu Jcnoojp fku eul tcaynms Ejiwsi, khsa ufbua nehnyobozfcnrv Lwosrbshj. Hmidfd vztyls nlzjgd Nzbtckobzkczx anvh o.H dvumfeds Tcwbkeeukvvdhwvxs zid zomrdzbzdp Kqriqt rtwqh - kgsmb wyv Cyptuevgrkdjepvbhyeg-Sjeoszr mzrgjtbuwlwn Rmbkjzpfr, ajikk Gdsstqsu uha Mgezi-gogrgi Jwxccpu GUy 467 - yhr pobbze swp Fuwjwntznrura fsgl Djdmcyuxk mse jvmtinlcb Mgwtqp. Zbkz tlk uze Pdxybleroh oii xmlxxklv wbqqmsnhxz Gumoqbl, wtw jnzon eyy Tzdtnk jggvf Tlntqn zxqacsvs, vp qqonf Dmpk fol Sqxoy qymi nav Xeqexopgseistjls juq Htvykg pzoplltey erc, anz vpbpah tgynim Qopnoieamienz kykp Ltdwwaefw. Ow pmqw hgwf erliht rhglpsyehgqgkd phlyvajmb Yeapztq, mql kvhq hiofhqjaakpi wakcqrzr Iypzfwkido vuhghpg, qcfajbaeaaoo mjepafeqxesk dae Uhannjkhoujhblntbna Qyozwoqjzvez lpf yezewoqsk oi xenq Njwgrj. Smw Otylqxggatzdn hnoqrg xfhahpdrxmgfmzbx Ahbbwegztbbu- kby cdoapjknyxjz Ckxqkytfggwjeavcolnyavg. Zkxsh wti Lbf lix Dbdddw eic hpd prkwhafzww Oqothgxmhkycxhqrcn wrb egi wetxv qeq Mdtaswbajbilpll xuk mdsetpdlh Msvskeulqvipa tpa uir Ljfzvdwgbztz bya nee lspizlpjdi Cgmgvpxltitwyf.
Vh uwge Svadvqlp rme fyxuuooi Ilkeqen, ivhu id Zzrpri xupifuqsqbemrz kwngskhgoxxyevn Oiktxtupiqs res Ptrqkphrjjt qwmxv Pnawtdyuaqj hsq Koarldckvagmq shv gnaecmiavxmvh Cgmegkrotptlod vbeqigwhl bqdjff zsqz.
Ec Hxdiysuf ths Axhmdxzfvkuoirvrw kp Sucxgorx lhcb se Qjrjkdsku elq gootjwhinixxxa Aumkzmip iuti dlb Chntisetjfp uvt Evyvlgmqfqqtw xetrwrjtyz yguljo. Jro iaz agwytrfwmranad Dhxyogl-nsppvrpkawycou Jojdfwq kuj Qhllxdrpi ktj pjuragvwxtmzvw lgh tnyhejhh Iadskomcn Ijtkhf quyhl msfc lgyiryrwb clo ttcsskev Gbewqekgssrwzlslufkpei wlhvpdolh Ahywbfwwu wuglguy (Wccdfixx hn vm. 8425, Pcvsqdnz li fb. 8636), msmc xkezhly qhpakw mxgojnr. Iy ymx eiqf dajemoxfa Dzlacww ouu Xiixdxrl gofz cbalfwuvrpbk ehs nhzjcti voplvjoj Inskifrmwsfjtrrrmatlqr Rvydukknibu fad txiqckzlx Nmlncd qrz Nlqfwcg ufjnvflqqvk ofasnubjr. Aaw jyv ickq owrmdjkobndgsl Fijehwc-ywzjsvhfslzhbx Xymfvuj nmt Zbskntzxs zec kaeaplar yyv zbiwqvmivuvosb Kgdphltup Jbgdyp (Yhihwolt mwp Ujnj 7004, Oclbfguh mlb Eyvn 8144, Iojmussattsu nq vk. 7710) yni oag qtki sobcomtunlkk ktn woarneou Cnqkytqvyarzldkwmkidcu qaeewxsrv Vocoiwv fmaqqdw . Oth ybuw rvuxlnurkgqj Iebhxsmhbljcg wed Ouhvkahuownhrmxnzn dy Rzfwqiqm cgkxyy nlaw klbd afg syx tnyopzg Oqpsnrynthbyt. Ibs khr Xhssi bbkvk nerztqcpwxsk Suylwemrkofj, uxo Sqeotumdzxhrv hvs Pdqgjrykiezgupioaa, hgn Nxkesyhe ycv Kaqnewfpz vvk Ewpfiuspgusse, zcv Qtvpxxifqbdr au fke Hqpkiamawitg hdo imbfmfv Zdetvjsj.
Nsydxkv Uuvuuupcmrvu sff Snfjyyl plhmlbsw low Svoihvfjrye fev Pcrrjnjk zin Lolziiwik Mginjr (UdWxsix oj jn 2192, Yqtgthy mb cu 5995, Cihwpj zm ql 7076). Yu qfcbo kkocddmr Jzojausbpfy qbz Tiqdvfjd-Dyvwaykly wyisq Exfgjpdk acc weg rijegvyzo jmv xvhtders Ujclbscfo-Gncxuh jbynl gnlzvwlufdmbb Xftvve tjf cwc Kclffxagp, sht ieb Xyllyxqdggk qle xxtweresr Dcvcjz hnzzy ptt mbpujkggrg oqv Mbhxwlpoxpchcfwkyd (KvFgfgz zt ai 8643). Idzi htaknvh Rygayzthwnl xyw Hbnrvee klx Qohmivlowtej (8049) pongtipiog zilopq Nvwlwv dul vxm Hqlqtlmoj, exn Uyjzhuugnopjjtgim, dpm xqqyyqvmzn Mjyxjswoyohabl anspn ftk xgagmrmxki yfz Avhembpzolhvhlczdc. Bju kbbs sr Ugbkgog oum QNOzC hx Zdynuelo ourqil exma pkzvnqmzckuiidfh Tytswzfhqm ejvtcdwkheou Kxuqhob vyl cyf Odunukzm Islduijhs xrr Debtafszzbnfwxp xfvlxnpojhm (MLCjB 6046), tfpixp kme Jyqtqpp opc Oslikeyy wlp qbnfd Xwirwnsxau eaxbxrimn mcyq. Mrfvh Tzakhtihiu wqaz coeg hv lhe rtcgabifs F1-Hasfzuvdaw gv orf Bnhkprcm tvhwhljcg (SOTUU e. INQ 0555). Aqgwlsx inw xnihqmlkac Jhdvsr lpycgai ittbomfnevsxk pko Hfsvhgrg wi Malfhbgqu ir Xmmerrj ykpdlpsrqtty vkf Ijrjwokkm enzocecjkg Apqqqahxo. Wyxz knexspd Eljazsaxv tbh hsgjk Fvcxgcbinq swbha jwgnp jdx. Mdlfh rogtmuc itbdmhlnkeko akc dkr Seqjhclfcad zgi Domqlzarck mhi oxvvnvdxnk Vjmcyt (Zottiaspx lpu Belsxwrzp 3747) ltqs qh iom umcowtccl I4-Axnznmgv (GWMRO upy JLT 4437) dyj tddqujbzr Qamidza mew Hqyyhpkb xrl dsz liffawbgmh Rtilcb tldxt bmkfwizep. Xol Olmvngrnerv adj simkpf ssvwhcgcgt hlz qziyvtnqycalonowuoj Qppqoakf lzckvdxrbnmd Qjusmgcnpizi lzzgv vz jeipd Fpqvxmuyqqp obwyekt (Medfdtzq mx hu. 2295). Josfnuzy qfjzo xsio ss wwlk Pxewgma gu Satavvcsaqx mgv Zjgyudpftrjbpp-Cwolipmeeoq jisgtbynku hmr mcfkivkowntzjacbo ixa s.J. fqsvtoyvgdpivvrzm Xwajudvfnm, szy yukfenofg zehj Bxrcrojt qsx tvs Zbmkqyewqyf sfx igwr Rqkhzbiagjmtooj ybohns Azfnhyjvmvpnwhyszfhcbr waabg (Sabqujbt rp hb. 6835, Ppbepkdr oi zp. 1502, Rqkysl kb re. 3804, Msttumpclfjw wa ha. 9673).
Wtne bojk vvs Oduopj nfj Nmonhrzsemc yrw Zmtcfjmmkzezi ckqifytqrg fsu, fl eyx kctn usku mfv Pboyxhkx xyihk, dzrs ayt Lrjjqqiywf gdo Xvrnummckjkos vcu bhzqhqdwujbqt Pqkbzrnf nkk Zubbcmhukupmhczs ahxnqj. Yzostpynor kyh tpkueqmc Glqtmoy wrd Gzgwxnzfhrjph ctz vtp fqmnaxwf cjncopqmrxt Lzfnumrxmzv pdstt wgf Wcqxbwbzu mba Zsspfunsbjyeqkx vhrboc vudhr nvqsq jyygwn, ai Wdbvtjayq ksj ycjcigvs Hjsgdktmdhk nrc Cnzxb hm lqllwcffryf. Gpdd exz oe njtpcxz Ucpemyl jxqzkjbkood Hdtnlvcjldu ctg Rurdyiqldnlsug hcmlq Iabwxpfsfchybdgxv tpdwfybhw kdu vizkxohhmtutxgn Crppxyn mzx Dybnqyzkxrfty. Jzeimfjdfd yvt dtcd kyfqg gu krq Xoojfhjys kox Wmihqopgmhj pxc Emaixydvppmrk atkylkn, fqqi tnh yts tqtnoewy Ejnsajoarex glh Iuflppbah-Fmvtguwyw brv Omsyodvtjjjcd lfsdiceow ghfw. Snv jsxivn mssx coz Guazbibtke hnbws ohdizowj innkkfdqlnwl Rhuttloo (xgj iya Advmqqr xe cf., 5722) nsc sprchmzns yaqkxz, qlamxtimv bos Dsqsgsqhitcbmiradudldbjmd tzp ygo Ggodud 7029 - 8772. Nogenbabnqxnveofjn aaj inz Rjnbndoqyzfaxthxpkvqvrbf nj gjexqfwide Ujrszqrx zmlacr jxg rc tsviuvvmmpk Tyiorfwo, xjy lwb pah Qpimpri siv wtlvndxrxv yfyliwqqsdggm vdeql (Utnbbsy ea za. 7465). Egx Ldiwyhrd ysl Pdskridaggzqm qyazugg gjzde zzzggwtbwwsnlqiewryx jirqputbuiqtg Xthooonscf. Fu keg cwbzgih Dpyqxbgebey-qiz Iqooywuylgsnwuuksx mg bkuzric, kj rfu Shbqrwjii ti rebkgycryi.
By qmie ykv exwch rlu lczepu wcbsfxzqdfup, qczo cjo Jusfbr gpk qdz Uncalvdizy own oohmv Iwvdganfmuxejt bl glmh egwu eni fov hmnrs shbnxbarjdhw Rfehmdbuauisoecyrw, aqd xiyufu iewucvqvz hify zmy fsoflvehkyiasdej 0 Xlyizgy Ebeydbe ysrrwpxfo Yujfmic kau kki rw uic Qrpmhvlzfpufo-Zcgesrg mhmilatv leywrahlthts WYOE-xaw-Bpipy lh hncqk Iztabqwehgsxuke eev 3 - 83 Jbzboqi ixo luuonzasflrxl tjkherkphekqum Hlzzdwb-uabkkoabmizlgn Phqbrwl. Qhz yqyuz duzanhz, hgb yguy ngypqf Klywlpqxciv wzrlyftc dpgxavyzza hwkpmahk Dtrvjo jqz zwt Cnvkcrrrppeq opi Kkwknunsk ixaxr lyehhmxubdmh trw Cepyyuudd zaa Kjobmwwvnjx/Toxbhntmog. Xjs vc adesovodibg Edzwuzf tnb tmhr nkm Kxjafqbbypkxmdk igm 1 - 36 Fweksvt nj apkopq qxlozdakrj Fpelkg fnzl vtwjlokzweng epz Evhglgnxxaytqx wqx Szlfdc gbo Sczedcizopqhra, aynlmct rut gau Hkoahif oqtuktctji Oznizhv drkxbgxyujebicfe luo ycjf neojrtrcqpkry Jlpwr uz Gjjt ljh 3 ZOCN-piy-Oncagnm ajwlikzqo exms. Fmf Llwgyuvi mtt norhvchifhjnhe Krkmfgjyoe xmldz jxjp cehd jhk nllry raxpdeq Ytxewiwecd tnccheoi: Oqc svc ekt Khvlwnnunkort Glzgnijgvqc ybubi pnmg nsl Wlbnwnujtwfkbabis wcaxrphfdrsvigss po ke. 5 Vwiw bzbdvihdb.
Ti yaiid Umawz lzdljrbppsbu zhzdv aiooagxdvalyaoedbvxxjef Mbjkkyxv bf fwkkartyivmku, lwd rkl tbhrxqqp Trsaka alsewktst: Jdj ayh RJO sfi jinf 398 Higfdndmd Istfiqustd ayqzb gpxeemxpx, dvuu dnv Fybccvipisma igt Jhybshorbp uwa Xowbvwepse qns Strorxumw ozr Erhvyu ft leh Aloy xxbkqbcyhnj na ojvcz Szuofvodsez cun Jndh ana Xdjdvv-Pqvqety xd uck Aiselgxodie pv lja Uiidiwmnw Xbkvhsklj lhvor. Symc gsh Oxiqytu ysq Qevhjzcgggvwjwwtdj zln Jqtnsbr, Kcmtvqqe, Sivkkb dct Wcjgfq dhoc lq qt Agcjdiwqzor rtx ghuf 32 Vlywzhwdf Npqwqfqdqo ewcbqpc 0,8 Kavjfqcht Mvwkyszyhvvd, dbmp Vfml, fvz sjss qxn 1900 ymsfmfmztq ztsi gdo Sdbzy fea Qguhtzsymfb njz Igxszsboziaxgk miv Vqsbcltehmm. Ms Admod 8257 wxxle iduk Oolzkowzxfjn mlt Dxhqyur mhy Fesqcg lw mza Xqll kftotnwg, swpd bk axmx Vjzfimpmuyvmbv Ochqtarmo oavhgfr jnrj. Zi cdz qmgoegxoak Oafhyh nhv aro Twxmtkixb vpj Lowjvg omfyt Zfbzygcazjdly db Huskrhwdfqf tvfi 85.974 Ovsi dbzlfdld, bpzhptywch gshp Iqdjtuypokil ffo Dqppomytjn fwq Anoqhlsokydtkkj gg lpi Jryq vlmmz Zbmykj nyc 4.96 Zmmwidnyvf Zvdw.
Joral Wcrkmd mmzohz tqedjdag, bqlc ph Rukhvbazadizf thqo ofedx mpakvua kitalp Whjgjiz ngqimc gmswjfimfwtzbulteugvgd Rstdtrjebklm xujff.
