Fettreiches Essen macht dick. Hinter diesem einfachen Zusammenhang verbergen sich komplexe Signalwege, über die Botenstoffe im Gehirn den Energiehaushalt steuern. Wissenschaftler des Max-Planck-Instituts für neurologische Forschung in Köln und des Exzellenzclusters CECAD der Universität zu Köln haben nun einen wichtigen Schritt in diesem komplexen Regelkreis aufgeklärt. Sie konnten zeigen, wie das Hormon Insulin im so genannten ventromedialen Hypothalamus des Gehirns wirkt. Insulin wird infolge von fettreicher Ernährung vermehrt ausgeschüttet. In speziellen Nervenzellen - den SF-1-Neuronen - setzt es eine Signalkaskade in Gang, in deren Zentrum das Enzym PI3-Kinase steht. Über mehrere Zwischenschritte hemmt Insulin so die Weiterleitung von Nervenimpulsen, dass epo Wexbvcastjcmwqzo qiugjvuzjjq xnf ckz Dujvgaanqyqlubsf rmibuim hyvb. Dog jsmocua lmhhxspqziz zbl Ffxxymccldjgbg.
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