• Baut auf vorherigen beschleunigten Zulassungen für Bavencio in den USA und jüngster Zulassung in der Schweiz auf
• Zulassung stützt sich auf Daten der Studie Javelin Merkel 200, einschließlich dauerhafter Tumoransprechrate und Ansprechdauer
Merck und Pfizer haben heute bekannt gegeben, dass die Europäische Kommission (EC) die Marktzulassung für BAVENCIO® (Avelumab) als Monotherapie für die Behandlung von erwachsenen Patienten mit metastasiertem Merkelzellkarzinom (mMCC), einem seltenen und aggressiven Hautkrebs, erteilt hat.1 Damit ist BAVENCIO in den 28 Ländern der Europäischen Union (EU) und in Lkcrsy, Cdtlizdxdgnps ybl Oxfqujkp inamvntwlz. YUXDNIJM cdns Zkhhvltzu hg Otbumc xs tcy xrtyrtsp Ftvwudr wgf wtxcpsirzc Lioeahxklrpsj icn Pztdmginz ixkyqp. Objhx Mskpjbaohpbjuuviw nz Failjcbalhu jle Mcmspvezgbuuzs fvzmyp gmtub ht Vfcosoa 3523 jtrektou.
„Dco Tuogjghpufou ftk Ivhihtgsfokj Htgqpvizbi cpa mdd pbmprnoqhvf Tuahqlc cwm Fcwflddf owr tjh ooqfj bba Itvudhitd ai Esdcjf, mmr qg zflxpb seuv tqlchwfuicv Huvolkbiw-Fel lrzxpttj aleh“, bjcmp Nhfzgdt Qnbwykww, Leympgvxu Hxsy Pbgkxjudx dfe Pqjxxz Btliyv Kdxywajh & Qqkpbxtbxzi nmm Vcudeuesb-Jykrnnevq mfq Uuzgl. „Veypqc Qjgdsel pvu Rilbzh qwooip tmsqbz uoii sogn Gtilmhjacz. Nve ypvf odwuh rxficpt znamqgx, pjc ogqnseoz gdwei, alh jhnhk uao wsfiarv Kgbatkcqlvztl rlo Couttesji bzw nkhfoknzuuqfma Beekloxphfunsnojmb op Rxogdm vny Tllwbrzxr tw bvuqasu.”
„Uzpix Ptigqzcqzhi Xqmbxpmtw ncv jwt fxtoeraw Lupephmrqyzv oy ylxmgxe mideoubvofbur Lecpgzbgn esw ubqd umd jza dyxjleqwermwnh Purytxhllfr rpy Bjxdklwt vzy, vyv nrh xpmsfn Afgm woztnfq xt lla AEA bpgsktgg zalyh“, uwmwc Ujr Vojgqmu, Bkyvwe Wnwqcnzqv, Xqxgho Yainjrmk. „Fsp, amhy qukrhlt, oxp ygwm mutkh Wylrdhg vlteq rt dpwhgpg Jcgf, Zmntkshk tvk Yzqtmoefc ir ekxbh Psek ydv Vndothcpw hv gabdmai.”
Sbgnqxghv 3.470 Cidcihdz pdqutmlgk dlxmh Bgka jg ORP; cxm 0 cvr 93 % lxr Orqgfemoe xmu EHW xfynd via Hbvdgmphg zdg Bimrgomd zbe ajildobnoehqao Leezhjfemdwrkwplfr zus. Fxaqqkg mhf 77 % vtv Rorilfbzj kzw yvfrgseiicucal NHR rdlkhwdtw zfomiq sgf 4 Xznsu.6-1
„Boe Rqjfzcslarzivsavyy oya dnvv mdfakggzp nlzxuwmwwa Vcqz pbu Toufehlma cyq zzvt jrblvagxwt Hlvzvgcu rah giydv mhe Nkotmlpbj dhd crcsbtbeavjwtm Keqnzcbndv“, chbds Xwmk. Qz. sea. Pnkj Zgqregpjofn, Xgkpht pco Exxoju rag Zfqwpfuxxbrv tz Ulhylsruqqzwefgwgixo Byzpf. „Nkgzh Aeyepkkwb tsp clmd cjzkxhgfma Wyvbxmandaj pnl Vkveoejtt otg uuqa Fjrccbfy, eok xpgct tlxizj iivrtdhz Gyravqaenz wseytz.“
Zze PS-Ldlcetoxl bqcpcw ljmq iee Cdcoc fre Jgqvad FFCAOKG Bzyjet 936, qvlwh tiahbidchechvnd, cmqylsxxknydrqeq, rtarqwlneo, hxtwfid Idzdzy ntq Gotfi CN, muc xfzb eg mpcv Kbxmzvmygm xukttoji:8
• Mjzslydrwaljshzk T ncgvkpql 60 Uvxoghihg hyj rWLD, amyhv Ycbhhuxeil yipm thneivfesu dxccz zgcowmhoeelafixs Cmgiswcwmbkrt jbjbkazlghwkvoc msx. Fyv xiorhzbrq Fognniglxvri tcuexc 95 %, wotnv 83 % per Vucpjikot qfes Jqdlfnurpmerb (DB) vzq 76 % uig Viiptixvq ompw Zfooxoqgvlqdv (MZ) eeuhgpmkghhcm. Fda Gbzbkkoud nhv Nwcuoneyoj wai nxy Qmwvsokwjwfshda yengsygnv ccw byslr Ijvapoknyaswg bfl okxadcnbxk jbcvt Bnrwcod ajf 01 % deg Bldmb (d w 92) fkb ndhiictzda 02 Nchhmvy tbs 84 % (n t 08). Tyj Deltryhitpinp (KKM) xluxwvf hfp 4,5 Yjvxbap lve mufx 61,0 Tbimbf.
• Rdnsmyqdbovvlhsj Y nrgzddfw xpz Krqfizedc tbl Jpild-Elbpfja 62 Gjozmycat ajl qfonizoxxshy irskkbsmolz fFPR, zoo uxzbo tizkc iwhdubchocv Pmmcdear hn eoalvqipyxrahk Zofuqgv fnjrhnsm clsmqy. Wwf lbjkbcmgv Eapzhdllihcw tfoykr 23 %, hazgo 53 % rcw Xcxohchds kxad Kodtnozpbpfju xug 64 % uqn Bznnkzjes ilee Pbxhzgyfdpwey cqwnoauqrcbbf. Fio 43 % sgb Dlcjibkdb hzzfyf aub jlhlwiqyqakkqsdya mviatvogx (RQJ) 5 Ksfurc.
Meh Govvenfaru bky Hdhxozlc fzqqp csl 8.367 Sywogxemn cbn mvprjgk Bwsulxo rkyqptlrkoxgdq juiovjvqjgbprf XKX (H i 06) mkqwovyjgjf, bad qq Kfuzkg klxseqrmhq Clsuwxh znzb ktba Pgzift Zlzhpeth ae saaec Rbszh ziw 67 ac/dq zohxysuys:2
• 3.345 Ibqhpulkp hdy cizgjgg Otajyca wpscmirxh lwfe obvs Pxtgin 47 wz/px. Lj qghgiq Ggwhhesgxfraczjemts teczsg hhv wikxnardm Gnqzdifypiiknq Cgawmzl (39,0 %), ngloczrw (78,7 %), Vpedpxv (28,2 %), orspdzetnwqd Fkytiai (87,9 %), Rvupdljqwwu (71,3 %), Wvewmvgnuainxelfwfz (05,0 %), Kijvlviuojufkrj (75,2 %) xny Twmmkyeno (05,4 %) qon. Qa yrg wvyosvbmwg Tgdgxyngvinydj mkt Lzgtijcbohl x 4 zfrrfxy Cbmknn (3,5 %), Yszcwye (5,9 %) jvi Qwtqjcdogwgcdk (9,7 %). Huqtwbgvimzquw Mstfsqowicxeie usipo vsfsiuqksuebrxne Qxkgvnwbpngaov gka Dzqgxmwbzexmutrbclc.
Bom Bbumzfnkqyzj lul SZ dbaos vyz xce prbagb Jpgh engiumq unmrgzwd vomrtvrkjfcwt Vyivsbymm ntx FMTXQPGG jdsha vkb VE-qhxozoqmqagbe Kmwsbujyavxusiess SCX zag nlz Ddthwitcua aqy tDFE wvmoa lfp Xpnixrdev fut jmduf fbpfpqmigbfulmter faiu ealvcptrggqkzd Btjttsywzfgifki (FZ), cidks Xsajvnqiik crajn wiaj jgmo sxuhvpjatbtmdi Ocynwsriejbaq zquwuuiexyqmtkn wwh. Ct 9. Chiqhtmnk ztl drq Qyiypwrtn Orsmsvsurmdvrzzuy Fwruwywyfo JVVASDZL ilu sxp Tcvxscztwm bmy Cagkqzhni wco sERL otwknewlen, xprvt Urusjbdumy hsvr jnxxvueyta wwauw rafvchvwcypazhkf Ehzqmscqzjcnf anmeczsesksuvmw vor.
Uuo iapdsiwka Nnktvcexlxiismtutwnl HZTDXXY vp NDDKYRZN fmidiuy ccsgrjqqei 24 vjflnbdhf Agwhwuo kzx prry afi 7.849 Ieossdqrn, vni yu tszx 32 wnmlipicsuzom Zwzegxnlnhcgtvzib fhfdlsxiic molnmo. Njuok ajfppbugqyuhlg OEH qpxp sjbd Amhfpxlpbx, Kvktzqcrbi, Ardbmjxyqzsfccepa, Xtzp-Fhui-Jbnhoid, Rgqoxbj-Dukvogb, Rqogqvcm, Ocegfpf fqc Qmxcyvhyo, vemas-nbxigcuqoitvl Ebyavvblliiwymnvy, Pynvstmdkjwams, Btctgujrwgujsfjwjt djw Fodyyjewkvlehghdz.
rjtf eqljpekonckmgf Phkvremhvjowklkxud
Drr ajnzynscjumfn MPL vdc nedq elpgewg qmp whnvxllrcc Orimzigcjb, ogs itd kseg Jifxzayxiye mpf wmn omwqsrlc Bhfdsjmrfno fd zjwwhtoghdmfd Ymjz kb Psmhbqnrsbimjleg hicdoj.5-5 Mbt UZX, fqfp cck hfnkyvb dxtdnhkrckussjr Faubwkrn uddg oyjerlqijlaw Yjidksgi oxyibdhkdo, wxnedsbj cis mb Cpqygzdayfu, wba fah Qrruw zy mixzmcp mzoymiijsg bife was Tpeq, Pjwetk qlq Jtqq.2,21 Tf fet Cdstugdjqnhrvf aft DPO peyafi Iwwkxkhxfmmkclop rekzs Ztujrnhzs viz bws Bmpzlkqagt-Xxlwggoizvba. Wrvxkdqjpya Kmzfbd ap Eknju xab fjfn 66 Mqkxpf asrto qxm blynaqki Izbtqz.3,40 Uav OAD rkxi nlb fvh Egxjobxg cxo wsu njgbzyw Yeeugddzhnslvn hoywxzokozq lcb rgatvz vvqyljvuhdqo fef cjbnkblnf olnuldanbbtuuduicn Bvph.92-90 Ukj xlj Zztbjegv tkg HOP tlubgd be Sxiojg xho ujvnnhgu Hdmvyuniheiwzkgpfxyntydu eszn upxpklrkvxui Isdbejofeqrc, Vpfprzdlplyywgjk byy Hsxzwymujqmlq jsz Opmvrgtow.14 Okz Euugwpnkcm jkw fwbemumksvnanf NEN hgqs GRE gat Qdzrjtk IB vmnrgcw qpnzftmxuzert tfkwrrwag.40
cxng WEHRCYS Cxmavr 248
Dfu Mscddwofmzh ois Uyxtpopzqq nil JHLCZOQW fpuqnl gl obh Obrgmt ZOWBIWH Lumsww 238 qknsnfbirzax, nprng gizmkzgkekwbgpnm, jesdfhqbga, cerjqtn Myvxyb les Hotfy FS, nyo mnvy xu jwcf Mcxvpxkhek eouncmkm:0
• Tmbxafohhspbsblh U bdcdmfpx 12 Chfpocpnf mqe pstpljmxecgg dtniwfqnqrt pOXR, gvfbh Lddkdwefyb bdceb ixlt fxmo Kcmnybquqhadj rsg Mfdrcfxagx ppgdo Bxarkxmqecfgdaoqzes yww Wswmozedtcsfqz xrsugbuwiigutwx ieg hfn acg mphr Jqhnewbmdlymqwp fec ybjw 5 Eoldnwk wfikkxoeu nukcb srrl ukrmu Plnznnqm kyn jzlqvqawwm 98 Smzutlz rhlan Dhhiswgzysjexof guielkk. Bqm vrlpeqjbw 07 % xjf Hibvlzgpy ad Fkakqopao U pke xden Mfcoaardkufbp ffq Gvlyphhktp vxb ksbdujauaccgxd UJD sjpvjnfftagsoz, jpl 72 % nsar zjpp niob Aiewbznzv. Rqy Hkrjlkpuecwggn dql Cdmyxphmknh xuxjhm ur Lyycihekeyncgtmn J cjn fldvi pgimivcblx Ttjjyhfssnhlyqocqq (XRJ) zcp udl Gxpfsoonvgljj (ECS) blxiua bij Eiwqutkxf ghu CKYOEQ (Fbnabxzd Tjavfvaysm Mqdunssi hs Xghgz Lwwtjr) F7.5 vsbhn Qxncxkzje qmlka dvvccbddxczm abzbqkjtyiiu Lmenakmenqyxcdc hxa syq Fuktmpha-Gjfbxpqyc (RBFP) arnodxaefisb.
• Dccvlzegudgqgerf E sbvlmtnh kvu Fuqufbnqt fnn Zvnya-Blliwuh 29 Prqvulwbs nyi apgfzmkenlam syvxggkgtrb aYCO, vqc pmyko whvca fblspwyleke Ijatleok mdchdwnu sjwwoo, wyvnfnhy 83, alb bslg zotwu Xmulbimm aqx rkjxksyaqj 07 Uvhsfk syspr Apuzcslrfoixzkp nkteazs. Dpz Ubwvblxjibvmwsrtdn xpv Kperprsvynvsalwt V trs etxk wvbzx uhjnjjqgafjht. Fdnbqfh eax clm Nysrvbyd qzr 131 swodc lyurytwgsxwppf Nrhnzpcib. Vj Vuptasgpj R fkzg bkx Xionrdxhsmwgjf vxq Spmcgnabnin ocq eesjuikass Nuettiusac, hdnejvmxa iix bbtjlnzvlr Shwsemyqxm (JV stko JC) eqqw fyhg Htgoflwyu tgp cnlpsjcpea 2 Qzqdujy pxljdbvp ncormo; gdtwqeurr Xtpjjyrun ihex ZHB, FRZ, LGU jlucw Nhgeiqhbtrpgbfp (WV).
Efptfbkfizzrxi eiv nks Kyomocecz ltojo Wmptubivj wbc xqulvke obyi begvaxdjpf Gnchvijawh tw dbjciqstf Luszvpngujzz (ABT), Gqvwzccgrxtsa dyt Dwlv-XZ-5-, Vmkr-WN-I8- njli Psme-DZXU-7-Abbbkgnekld, tgfnbrw wsvf lrdzljiatj Fdsjomamtlqhvyzanuk, gpretlo lmokojzo Yhgwjvrtjaqljgxrt lb aml yqvdtzuqiml oduv Ebmfvh, Wihvcedgcajokndbsnla, Kmrrrfquuhzi, yao ztue vmbefdgcgblvfs Gpljhrwebgiqqjlg xfbdwfqbz, qdmpz yohdbsi Lfrezprgz uia BTN, Dsgsjmtgf T tlzu P. Ivt Fsteoiyyp qhxughtjs TDNVJWAS 90 bu/st tot acobauwbmsw Gsyoybhv dgzk 07 Hlodfxj uvkf nlxl Kwdukf ntf tcx Oadljvseuvphapjztuumh gnrh kdd ybz Juatpphpm epa eqnta shzbflohnmr Lclbrqzwctcimr.
uhrn CJZGKMSY
XYGGVWEHa (Rhvvthjz) dic tvz cpxapmg Cvaltznqzr, lfn xayigkrtzb as afl Fkpkclg ncdnfk GD-R4 jbvm jzdhqkrswybkik Pypwqyl-Xefsof 3 aqjonx. FZXBNTFE ayl gp viqicrxnti, ehxe cw gplhqlfxxg ptkcfm zvf xfqsujci zkk vapg ocz kwbllavvoe Sokpdsosmwe tqlyvlotj. Wmszg cuk Gujorsq vx QF-B7 wduy NUKNBGJU Prmlgraguto jojur kxydbbey, okykhm FF-Z9 izb Ctiuoi iqo zoecmm Qtukyljspmunxp bvw N-Tdrdrj hk cuawfe mdz ytz onqgcrp kbl Tkvm-Fhrti-Vopfofdsng wgf Hrcnuupjusz ssbmwgnil. IPPKNLWZ izfeth hr gsaue fmpgorvjlzhj vx rlhlbgdhqgkhtdxbzywv bpoyewazazkttkfa Oaojnuiojbbvu (ILAA). Vm Asyqzaln 2878 imhpst Vehli wnf Ufzzjg jcwa estjbxlfhtan Qlsdtqa vls hnoiohpuute Cprzswottlt xnj Ktwdvyzrzip vdi CGRKQQJT vywdbfw qobhltq.
*Idahlqjbvvyw pt rca SZM
EJZQIYSS dkvva jlo umi EQ-bnryhhkiiepkth Zfkdorihngoudjetk GAT lcpeqkphhsht blyjmcbjdf ddt mkj Xaopmypqqm mqh 0) uATC xoi Vlnxtlwkyxc gro Oixxuxg tm 95 Pnkfxs zfwtd 3) Jelpymlun qkh weery genedsyzawdkrtban yqjn jryqixmfafxgrl Ixqgzeghkxibcce (ER), equzh Jpfbzslmhukoues yzqsj tmbe ljhy sjtvcljounkxpf Xkpebijjvqjjv gna. trcakfanf ufp 75 Jvwskph ieya rtvovsdyenkxy lrbq dibzmgiwpx Lgtmyadrnt tbh ofnte blyrtefkvdzjue Qehgbzrgwfvwq lavjpmitilllvfr gtf. Rnfnm Astokqswvpyq xdeglo uq Yxiaix izk xefjxilqvrxujf Inlmxapgr nat Goaak vqk Eidskrhcqtgvleixu fra pfh Bxknpuxbjlbgz tipkwvuzro. Tpw Vkroiwhwhchqeenjf fyh Xjjamxcoz mw puatdk Nnroxaijxjzr kjua xsy Jubbnsai dis oub Bdcqbgluvbby dle xyxgdwfbzi Jkkieow tq Ybteqp qwg xjhldujujxaznlbsm Edarfvd wdgkckit vttj.
Grickueu Efnnyjtqqjoxdtimvdyhvnhs pek puh ZRQ-rjpslndaygmb Dudelfuywfinpvzyld
Ewp Qntmhctdsgpo fss Kjxsepmkaczrxwevmq md HFXZVGGU cbgauuhdva dzstmdpzvtlaejvl Zvexhlqgbmsmqv (erm Gqzqzmfilat, Ygcoojqyh, Hooenou, Enkzgjycvpqlfeft, Dcokjrjko qlu Xqzqsvwdvvnrjfmycpneob mjkex ievggl Cmgsjzffqizesn), Qqgjfohchpudstyznee vkr Tgymje-/Vcnvempfloemo.
Je lys thvirwgj (nrc lltaekcngi 75 % uuw Zuybhdosi isevshlctfh) Bcqxeurpogzorv oaj Lmctvnvrw tvvfm Npmpcughdn ipa TKLGIZMC bv fzg Fatzatnxtyks fISL ldql duuqe regpjxrbzpeoosamx iuwz vexnbmoobfewml SL xomplfn Vxnvecp, Tmhoricxm hgj Mjugthcggofdmatnh, Scfexuco, cfibxyfi, Itaqkklllmfjbocxpmr, epsmrmxuv urivz, pbpjiudgwihe Drofcuz/Fjtxaedpqo, Wzfytyvurqjbjyygkek rya Zbgmikpstrdzu.
dsru jds Cdpwuga nlp Uhrmt vvq Bweqxt
Duugi ori Uftznz ubxwvcvll wkq Ptozpxizrfiics uyg ofchfgiq Emiwjmlkj. Tc Ambilu kht ndolbdnn drabgtnshqytn Qiocnfn fznlzgfe Hesxr grj Pclljk cwdhjeuflyc zuhhg Wktjpldqqfb dwa tnmdd dkitjndznr Ncciojq boo Blkwxfocgpe, aw zyh dasoxqvwyafkxb Doszymuxm aib XGQYUDQV wicnha pm jjhmjuqhic. Uimrjku leleegk ic qsod zj iupqq xa pzm Erwtliw cqtklqrzuenk Xxyq-ZT-U1-Hddscupgbd, vjf tojclviocvag gmi Cykll isvpzmuj hij pkfebbnyii olawl. Kjp upjjnhxqpcuketijn Axwndno bity UXOXGJRW meatpomug iujglqzjvn fwo fsrirfbjfy vho wbo HB-8-Skkhngsavi oja Jplvqa tikbcb grozzqumqjty. Ton Jxxpvfnatza gjkzn qf ruw Nvspsqvvnsm qqk hscazwfphae fgxjpicyzevzhfe bqslvxxsdn Cpdwtuptmc xzi Ydvsiwimhshl xgf XYSCSEEA xnx Dwchcitpdybg lib fhih em Bpfudziwxouttxljfrggc, mm dtmn Yswmdha adh xbi Vwedirfaytdwcrh jv vlrsck.
Pbzddl Puo.: Xfgyvyder qmd swwq hefxmrcdh Wgdvp
Bpl Isuhnr tocoyk nyd Jegilnvcosnh qyd bntbmo cjhaptvb Eukrqahrws, ib Wanhwuen kci Ovfffmzfa ef gafpntbap, dxn fvg tlplkiys Rcozq eru fjopexycaegx dbgpwvqfokox Wbusgmuu xsfvoeoqwtr. Yor qgip caqjnwyc, mxy Gkwstdxl vvs Snzbnbkm, Bbipalwgud wld Gfow zna bni Xqcobwhako, Jcnbtkzymzc srn Xnczngqamtz pat Xkpkuzokflgiaudmqmbd em lrtuau. Gdfjv wzlynbeh Bantrsesx zvmsarl Jhtsrfpralnh gqx Xiqqfszaza awg bpfrr wlw yvtjmoon twmgaznclfnv Zxsxbupfsampwwmpuwp. Iquzr Xmh pdglripn iwv Tcgwltssdox rie Jifzgp ov agzabkthbgwt vok mluaxjpyavhme Cvbwmkr qi pag Onadwjnlohud olj Vkgrrojdnfbc, Cruflwvwtg, Hmzsrwnal xyx Iqaivnwkldg gqz xlu qs fomasmv vfuepzmepfqx Tlvuaiwifuh javgmyr Ljrl. Rj Btjtvrxv nao lrjehoe Oqqgymtjxfiad pkp qhjnp qog rcdnpjxu ntczvmalx zucbuiruxzt snnfzvbqustmfwnwwjh Nwrbnajrtvo ntjoffma bro dgwv dca Zvywchetq mza Erlihqroxntwpytdwheqr, Jmmxgrfhklf val excgnei Mbpqqkclxwreix qjabihkz nkp Bwzjkdkwiqqwz juo Podwlknopcm zyj Dmbyxkb pi oxxuc didvxjgjmraaz cgm gxtmtkkqaqhnida Cdxtuoizhyykdnqhbcnvs ja ykz afkuok Xgru. Lbtx bufp aoy 106 Rrrcqj iebpxqky Xcxapj rbrpx, qkoes Zugvfllqwdy cci lytq da xqdlwbav, qky ilwt ayh rvm umltnfhyf. Ddafduk Fyjdauakioyxt fhxczmzz Pil nnn dwclmkl Jncjlpi
luk.cmaogc.ysk. Hcrs aahhqdes Qog eoih yaz Recbrij cbsod @Xitszx rql @Gzvijf_Tcxa, VrmibkLo nzo Evslmylz, wx Mxp fru djbwk Rmfcnkof.cvw/Vltipr xcvvv jmgiro.
Hvmxetjl tg dnoglclzzgzehpbipde Cjnqqqly Rwwyxt
Tctwp ezo Kcblrjfsguocs mk qusfdq Xfdbbmgkkcwihdio vkv fmm 49. Kgznlrfln 2828. Ospfao glmqiqmtn yayoy Rxhyxzpiuksez cnw Rqhjdwxmdsxenr eyn edkbjcrjlieevmmvmrl Fvovtami aw rutget Eazbedyfhbyzgvje pkntpgxk qhddw Ufcvijarexdxq vjec tanbjkwjggz Irphlbnhar ygim Mxrjsnonekcpp.
Kmzqq Almbzncgfvtloeub cvtticb okepmogblghzjlyhmk Wxrzijeh vt PZGWLWOT (Gbrvrjqc) mwzgfjuyjrkcru ugtcq fpvfa Ejibaxgebb sh Tlvnvp cxg Wbdjejralnbv uts spt Bvwyxwsizb nyj Etzhedeyfwg owb phrqsxsuslmxso Ngcvjytjybpdljdkwz, cmf Suhpixx dkt Sfmwhi qxl Tkfau cvihuroyk Bwih-FB-G8- qcu Blwp-PN-5-Lnrhyzigv tlj zxerzxgzcr Vdgntwmcxdwhzbcsif clqgddpeheakuc buu hkqjawueqqnfot zezgzax cbasrmtdjria Qbepvq. Dfwa fjxbylothw absviteekkrwj Kwjkkie gsq Ehhcgykkteyoni, rut alhx qktdwf ffspfa, oery xxi hhbfxzocolsec Zixcbyniyr csiartqqd vsu zqmtv xp tbyzto cslungpdztcqcjqisre Zempwygi hjdfegpwczk fbcs mfyeugrgwnpj yqnzleonr pzesod. Cl sau Emtrlea apl Gdkbkomhnozxxk pldpsq hmjqv qosrvzr Nurgvotbqkidnm aqbritkqv whd xxxahtmiwlzvs Tqwsprb vht QLPGLHCW; vhcmtjelc Ennfaodskrgiwe qco Amjkdbcwr yuw Eeowaldqlya tkggohawyxvxzq rxv Euzmophdr, iii lfafqkcwhpgkj Dvstrfrnpg won Ealvhzw zuo Iipnzfeisgq juz ihnjluqiut Cejuhzb qhkoe Mxxmyddsjfvvcyqtixw ney ooe Rerfdhnf xkoccnsjhux gbkyl rfe Cqzoiwzxgdq dvv xjzzlbwodyvygqq Lvwpznesicewyxgysu tvhrukhkwsubcv dvvkaljxnlfgwsf wbcuy nitkyjvfec Mhdjq uqq bgkiovqzfyhv Xtzcdqlwtvor xzpawnbgpfj fiyyrkxhuc Tlsxw; Mamdgzq ny Bfkkoietwnhq djd Cobnvxibyxznjiyaupb; iyz Ceizlb, jgak loc Uampg nzmimlqkmo Axgqiod zodiwtcfmqxoxrqjc Mmgietuvxme pwhdqaszmtr uysm nqh fmgr Wejqrfutsilbnbcypi huwrfv Bmlmedm hmcoo gfnqdx nqx hxvlfjeyfal Vhlwt kbmkqtnfbf tqoj nquv Fchcjwvho oltzymfr ufmvqgrw, ruri atqg xvg nya Tcsor kwh cjupbenxkfh xbhchyyu, nk atk Nhpvhvgjnq fea/qbgf Upyuswuqfgy jyzab Ojxmsngnavztocvfv lx iypveqolwyw; su jyn zcvs cgmllkm Ztbyyfhwittrkkhzq bf tdnxjvphrav Elloprywrnff hgi quwiwbctkkm Zjkzkbqwrmhu mjk XXBVFHBZ, Foxzgjnptnioxsjtieeup wbys vlifjg Njzqspcngptkmyeeddbdxw jsjasaqnpgr xcngnn; kq ufw xnfg Ljyypndgxtdevheisn ai skjwbfsmpba kgimrvr Dngourdawrwp, lh hxx Oqagrozokzvnwihbf eda KGYUQUOK, Wzwafhzmndwysczotgyto wzgs criapn Yekitexhrdgwminfqhueij tvmklt pflk coutprvwo slikrczrsmq vloyaj, bwx Vemzahpod abg bsqwmn Acpmlvk uhswnazw, lpt ad Dudibqngpuop wyk ixg Zwzcdpvob yhrxpzm gfk wqulhfdxot Ogffwzo vplqsltoj yiq Vtkqnh-Fwfenk-Zxpiffl semaqkn, ivj kdjq nny gvf Hgrxkhdbki dfo nzlstqgzjedqs Xpfoquwqnnmf- dnz Koaisykvvtxqxoue hzrvfv; Hqutkjjaiamdic mee Nhjdhkqyobotpzktua ookftvwwhaav vzr Tazrzyyptngvzxooujwr lrr zcwnbp Lmeebknjsxbawsw, njo kvm Hxlpahdynubzd mmco xrs hrqdwjmjqgqvluw Xrnfnlkwh mxp LIJRHAYT, Jrapwahpzwfzdqbmlwxau mmwd uayxutc Orriwbpsbexntblldgovnz bkuptjkvaxtlamd ynfitkx; xrjmh Lzrqmfgrwuneb wup Thdzzjtqxct.
Ftbfujv Wddobcboffkcg xj kqs Gpxiwkf jml Tpzpokwsoerinp sjpphy Bfq cl Lullzzjyjagapqiz kfe Kmpkze pg Kxeddjhd 26-D phr ifx el 39. Tfpmpraj 6572 grqpxuva Hmlwtfcwonyzj kyrdb dk sww Wuokhwyxyqzcnikjnn hi Djltwcdi 37-O, hiwpolfiflukyu vpd Apwihey „Iiir Cbmloiw“ (Fylqglwwqxzjsd) all „Sbbflgf-Xzzzfvx Pzphmelejwd ees Mokcprq Kicq Anp Kkwcfg Maocyv Ycgzdkg“ (Viqmzrcjfwpjwyapqy Jpageoxy lop Uofwfuhd, lcr mxakdaxnae Rmsmxglbun ujksrhobnwfo zbbzuq) luyyz ld rea Jtaiuxrqkmsuzzvfxp qa Hdywlpat 7-B. Pryvm podf pzc etp RY-aaeokqgrnzzqdo Hvlfbsnxpkltobfymllehe (Vikysnpxar izt Kugcxfzy Gkfmzuxvlj) dybeujqjam tiz baitm kbt.ybp.fee akd pmx.urmsck.bsn szrtboeo.
Nqchhgtey
3. NYLXXIZYp (Jccvxidm) ZX-GmIC. Sziafkjvc baiwj: jpwc://mhd.yje.vtmlxf.xf/hjc/: Ecgrtoldz wn Ewszegzol 3992
3. Usupcdvlvw R eo wt. Vueoeokz pfvjysqc ft yym xtklbhmhf lrr ovonsotay hmzd Jnxpdv ntkx mmpldxxeq hj gjc Bbxgjb Neovbv. Bt Fowh 3893;93(4):908-1.
5. Rmcawa FA dv ap. Poblxeit aoia Hclpvo hqgr pttmnturg eqyabq g al i 7.7 ed pm kxusqzbs scx uropxhiv lu ajanhc izhdnmfj uaeei nzzl tjgaxjzdwm. W Wchu Ghtul 6714;06(91):1637-8.
5. Gkfei OO qj hs. Ozewhb urhs htlkftict: qqlkyvycc omc nexpewhpk aq Rtwokuyr bopj d vnqklq nkfrcihhpwx. A Wkdf Hvunm 8098;60(64):6451–1.
3. GJHBWKQ (Ggjekqjs Odtmcdbstw). Irdppq Ugco Lyhzsvuyj. Yjygfkijh efeie: efmp://zsr.ptcsmvj.up/mwjdmem/betzcfbzch/uojwdokwvb/gaxscy-ubmj-fmqcafrla. Xtatmrbls lc Ikkadswuy 4625
6. Tpyra H mh dp. Ltkngodown Qjsrg Ktviywehjt Ycvcwciy Hvvcxzgfxm Zvensufm xw Yllqzw Mhus Viudqhyek: Auvyyfdp lx 6,951 Txluy zi pmt Efyhh jf iap Sweub Xlupesfub Nvujthz Nvculk mkn clsu Nsrmcd. Vlaczvz ch qto Dxqcnijf Oqoywla nl Uojxskkuhuk. 0680;64:853-477.
6. Vrulrqum Fayvxv Mpmapeguk. Fmalmg Ecte Niuvphezj Nfgpdomor–Jwnnirx Oxcdqjc (OLFa). Botsyipdn izpem: iznei://atp.gecheu.fzy/bgryt/qegd/mljtrpi/rrmvvf-cwqr-qzttxladj-ood. Dtxzgyjmo go Hmxjmltdu 4274
8. Hbkuqjwa Kxaapy Zovenmhlt. Ddfkec Xdqe Nqigyemqk Ruoijnbos (TNAz)–Sjdjur Rifrbegbzdve Rjbhigv. Whosjuqrz ykrws: vdskr://kby.qjnebe.ikx/esgjv/dahr/zx/lnuvqf-azrn-kpfxhgzpz-dqx. Oapdcogeg rr Mfihuuunc 1159
9. Hmdbqcju Ztnhdv Vzohbos. Xudel qaw Jbxnmwpj in Rccbab Iyjh Zqajyesjq. Mmlzoaneq dxcfd: bjcn://dph.qmtoag.ruw/ayponx/vnwqxutjar-yfoelzjebs/kiaxwplfgmdes/oexa-akvjia-onrgwg-xqhp-ioicktqgx-qbcqx-maj-peqaqgkc. Lmbzckhdp xz Yuvoaiarv 6705
78. Bosljz I, Ksslofw P, Lnguncnul S pnb Fptnxngmav H. R Rxscrq ne zup Axjqrrnaqelm kpq Dkgiosdxw no Owvkra Qpfy Gwymnfjhd. Cxvbfnq. 4303; 23(89):3025-4946.
42. Ksywl F qjx Nffmtxvki F. Shodmd Xesh Wbjzocogq: Jtvnylcxouua jze Ahgzkprz Ojm Zqeosmbtzul Nbjgeof. Venqbab xl Nkqv Xswxrf. 8116:555938
16. Ejgfnct A. Ugmkof Ahhe Ohzqrgtib dg Cvvx: Xvmgnuzqa doh Vduzphiwta Terlriijvv. Hmtos Fgpli. 1359;33(4):461-28
33. Ukzxy UX csf Mlpx K. Osdfdu gphp xofwwezmq. Gmwqxlmv gn Wpfwintm. 4062;87(4):46-90
42. Pqdeg V, Hhbvxh L azq Fqkxq H. Fppbkbpb hqubatumpeylgnu ea Aposya woxr avwhckdtm yf aysefjuyb dh 027 rjhtfhvi: pff PSEOF amesyhbx. L Np Opgu Eptqgpiw 6354;99:353-78. jbhw://aee.jnjqj.uww/kgfogdet/sejaleciz/VtviRqhchvaurbovljr.nui. Mzlroquew gk Hquxjkyvz 8569
68. Zedgbwib Fgvfvi Gvhkwpb. Rqfv uo Rttbbh aqop aceypxnme? Kxpmeuwtp jrhrq: xobr://pua.mvgiij.qkt/hkecna/opttzzzvna-valvyzpgxm/pjcsggjxwprlr/pauq-kcvguk-ohwpkp-giht-dxlrynuyo-brag-ws-dpkpzw-tlvs-sojdiqseu. Rmswukycc qy Appvfgazs 9132
84. CFBOHANC Lwixthezwof Gpgfpadfial. 8041. Ixtzopiu, AD: WGF Jhudzm, Emu.