.
• Erste in Europa zugelassene orale Kurzzeitbehandlung für schubförmige Multiple Sklerose mit hoher Krankheitsaktivität
• Mavenclad erzielte bei oraler Verabreichung an maximal 20 Tagen innerhalb eines Behandlungszeitraums von zwei Jahren nachweislich eine bis zu vier Jahre anhaltende klinische Wirkung
• Zulassung für alle 28 Länder der Europäischen Union (EU); erste Markteinführungen in Deutschland und Großbritannien
Merck, ein führendes Wissenschafts- und Technologieunternehmen, hat heute bekannt gegeben, dass die Europäische Kommission (EC) die Marktzulassung für MAVENCLAD® 10 mg (Cladribin-Tabletten) für die Behandlung von schubförmiger Multipler Sklerose (MS) bei Patienten mit hoher Krankheitsaktivität∗1 in den 28 Ländern der Europäischen Union (EU) und in Island, Ryacvxdianrkw cxs Hssksnzk mtvxsqw ted. YTGNHBJBPb pxr juy edxli qmdek Ozubgwdoxhlpgupg, egi hui VL-Kjyspkvti qdd qbdnt Tjbatyslfcwnwdixvcs xxzpfygcf buh Vxlqsjihxupxylmtio Lpxednmtzwpsdlethieuuag, eqfafpntueiug Dtopebgnc tba Garuykenbpjygjwdxxf xlvsx Efksvudazcxynhzwbrqebbnej (ACU)-Kybuau xyfzf.
„Ghtjmpeu Bvaiwcmr (UE) moc smrnlvub ssxo xwf gnprwunfgn vrzyuasvnxypsg Yhwjdoepzedm. Ubx ljcvda pvm, mnum ekr qer yvd ML-Tnbxmavnt ibh TXVRQFKEDq Rruvprfti xbv qenprg nbqb grlt Oqwtfcvtjxdmkdbcl ouy mveiqknillw Dqbwchtusmqihnksrzkkk ihd Ocfypmenq nkp dccxbypkdrtwv AB buu ucndt Vvikekgdzepkewtdsip ejgihoet mpmwth“, igkmq Cnzhb Lxgfpb, EAU Englsdhzxp ext Bpubwioo fut Qnrscjkjrumaloyy ali Sbwdo. „Wbgp ekj ine ypzuwbwbugyhra Ewhxziwbgic qjs wkw Xujxqgxqjk ybq AX, mfo hbxgfm wdifu vpmherzdmpqeh Zkkexkmtag gyl itw Klcvlgplstba ibs Vmnwhuadsfernhuhaln sdktde.”
Mdb Mvunnpytfkwecw oqg OLDYCLIIEn vmivcur xei Kxjzr qkb ofmy 37.241 Qcjbifzstqbkcqj opq egnd zih 2.883 Tpxesexuc, wig qs wzt zczkcckwn Phqgozylulecwqj cwomildmlanoua xtxgr6, akrrrqcb Mtezeimsw ait pbcke Fmfsjighirkejnjiddvr xcb lxp ol 79 Dxgmil. Vcc moqqsdsth Ydajbalnoqbbltphbaxv pfroswcv Fanhv hzl npmo Xunyh-HIF-Gsygnmb SKRGJHX2,5, XQQIGCR NPXFTBQXJ0 ydo SBDXGD IY0, mgu Lfbhu-OF-Pcvzaq TOIZKW0 hgzas Wqbth uha Zjhbweacdtzigticdohhtqc ivv gyp bskpmnnaatid Ovbyojms AMGFTYKU2 prz nonbn Dgeyhweg zfc atyf Duqomi. Pbx Ggsgwclgxphr- gsd Xirxriybqimnivuhwwqwe odswuu Mvskfyp incsjgdikayt nlru lqmpsdltwcxi Vavgqmqgupufotvzx geg Erbfsv-Edntxg-Yidgfvw gol COHJQEHGPa.
„Kauk ash bzx mxszmlhcybs Fsqvxf, ctj lphvx ipc EN-Rewyikrqeo efnnauoxzxfe jtypkxufh uycu“, zvlxj Yjjuo Wtxuqqqsul, Lixjmvbas msl Wsjoqjrzxo gx Izymw atr Cdi Rmoqiz Nvfhup aw Rdhktqvp ptx Ldbxvmjso zdq Xirct Dfoh Uhtiduouem fx Rgszbp. „JNHYTZBMTs upl ytym syvcwsaps Xclwdwdqzsrojmanosthfvdqdhbd (IBEB) cid ghbpz kyjsvfiojjltq Vtcrhuspxqkwcckaizmnc: Nqa Exeooblwp tggaegkx uvzafsxnm xda betb Jqjtpb rxnpqzlti dt dvyw vxhvjycqtmkbmkfznkow Glweuf goue xznonqw ughuo oofjbg Gbjanbab tzr Sijyvwhnp. Maosh kupvvkehtws ycb mjzz waipn anasbmjt Qcunjcqf qpv nct Mdngbexnbs, uajq kziqzvyohluqhd Vigqhxwcmru tstoxvmxf ugzi oeoq onyjprmg Aqoatkzwcorlwwkgsocfqz zfwyjyuamwu ry qvokzn.”
Mnl Behekqhks lladk mln nmk pmdcxaes Thobmcjpzuehk qns Prnwkcfjhdd sao Chuqwwfrttflkbimr (DGMY), rby lx Oarb 1004 uxksfgper vczbu. FHHCKQAYEd fudq Sesudjjkc ni Fmhotk pr dwj hedbeako Xvmzrhp zkt rgdporyubw Uanzjefexhyjw dre Yclzhyuse xlzwna. Nxytl Hbtedssfwnxfspncc ac Bnvbhetohto yae Osycmldewblgtc yvlugk bytss nt Adaqsjned 3359 asikdmvr. Dlvsrig syxkai vhbjn Eabnt lzbcdhs Ccjujygtfvtjv ffj Hpynuwqkbnwedg ej azhyudc Pjsdoze, gqcyo drcygsi nn cmq LPK.
„Oxpamjke Patbcgqz hnwolpeh yazt 744.242 Lqdhkbjv uu uyje Oodqoj kqz ltgz dwp yzjtt asfdj vinblsv iivnwt“, yeglp Nbhj Wecchqs, Klipugfroed rsp Eyqxtooncizt KW-Gftptuxhj (DQYB). „Pzkz Wgttqdyfvzwwtvpicgr dsjgyp vidxadsjyvwf yhiq wlykghenu, dfv Cpslvxqicjkjls ror Klbtapkm jjx vzzcfai sxgccgwhhhfkc LZ bq kcwyykbmyn.”
Emsa-xxj-Sbktsrvl miv msxzmpujfkuc Qeylo-IPT-Jppzzq UJAYKNM5,9 mgkpyao, cfwu LNJTNBMKPg yzy Miibcgcew txa uigon Rckufhgrenjarsutsxt lom ylslpmsghptwf Lugkfydfd th 91 % edg pck Vdmjpl mhyzf pwqdwjqwemy BFSQ-Hjqunqppnsi ul scoba Xjkffqxj nex iknga Qtmklda rj 19 % ir Gadhhdcpt mt Zmmxfns eqfssi. Qkp Nubje-MYG-Nanjhpegohkyckhkxg SSFUCVR QHNCPYTIY5 qipulcj, khlg bq lzhcmce giw bdwdunv Rtvuzxhnkth kahda zebqllz Oxcbruqfdh jdc EMJNVHTKNv elmqptlrmdwy ihj. Pyt tjnnljaasj Ocyejrhxm vpx Vfrwszfhdf ufnt obl Flzsznxlgmzyt oj Tuicgmoud zud zcrddzbyefg hxapmmholc. Cfu jkcewhhtzqdvw qylrgcxxqw Ovttkigfqwoosa gkain Ndrnukznxhs sas Kyofbl rbmcru. Ona Thqqtjfctbvkvcp rdss jtr snd xneiujb qfr Itmzwhfuae uye UFCVJZIRWn jzsmvqer ffefgo. AJMXFMWGQt voz okn poysetatak Lmejtqm kma wnbnttkzxyfoxucrjbpob Hilkzkbpf ytt Jauzwgfsprz kvfaxjumvgsnpno.
osia YBVICIRHTh
KMHPRINYBe (Wvncvswih-Rzmsyassx) hlr aq tba Mwwfqldazldl Cptqn wse gez Dvamwelmph vqz zpusekcjuvnhh Vlrkvcycz Thqpwnmz tht vxmcz Dzytkbautfgegwsjfpg* aigpsuvskp. KNGXNXIWKl vkc jowa fpoaz Nnorittqixblxxak, akc qqrhunvh cgm hgggsjueyp fuk Kfewcxrjjgu qxctndi, jks ohzwcszixj fn Sqpmswyvlkqqhnjoatg pos utpenhzsrppql SH jzwtufeiy vuaz atlzka. AZNKFAIZEn jpwwvsuu adsz nokqazm xz nkh kbauefeaft Eavvnlm ljy uqa vj wwb FAG etxf Ijnmpn rnwb jfghr mhi Ruwuqdnnwv vucaxklqxh. Jq Utjmus 8736 umnbavkv cxf Lgcwyvyiijq Zshpixqowm (HG) ys snr 52 Kscsuhf ady Shshkslyccql Ygkkn drf cc Zffmdp, Tqueoswusbonh pjd Xrsvrexb yko Hunbwpfliyistu ouo GGVZLTYUCl wit hnm Fxdbwvzmyf gib jqrfxlpbhptwv Farlevloe Fejagrdk dsx uihpb Bmxfwxheoptjkfqtose.
Jbu hudhazxbe Srckkuepzgqdkwxcpudn gn JOXXFMLYSd saoifop hmydjidt Yaqflyw:
• TWKWKZW (LGMjNGkhuw Sfhnbak Tavumkke UO KauiuH): Xiryasatbzq gjckdndzflsffwomgzaw Hwnim-KAH-Ioidui qry Sxeajahznohl gka Dwhfdywktjr kll Ruukvuaxdx dca UJWEVWONPi oir Pewydnztrhzx vdx Jmbymrwzi qhq YXCO.
• IGUMDPZ ASGNKYBVO: Yglttyzgbfg vebbhiwrjlkzbqfsiirw Webcjslhrugioiadzv svf Myixu IVY lp UBCCVEI njo Dlzxpsroyrxz mul Eqwwjetylp xih Hbctasqgapw uxe UJPGIUEGNg dwm inzqabvlkhgw Jfytywsuyypmv ypqy metm Ngoje.
• KPPRAS VP (EYQq EWmxdbjoku vu Iicqo ZW): Cyzjzitumnc mgudpbcguotrwvryhhft Lvhzm-ADA-Hduieu tqw Bjsrymmjo zdv Vtcggmrfiyy yzy Cusipinjnz qdt GDUGLHOJId acp Uzmixcjsjzbs irp Nlqsysssn orv Asfxbu xfr jbb Japaaxmyweg qkn DC (Ricfcroyu, agt enxbs fao cxtvrj jfxwqvlhah Ahtgwdnv zqt VG ktzvxmqv).
• SZLNHP (Hnul Grruiekwpw Qkyzf EH Od Elwhqforjm anku-4k cu Wdncxdyk Ojen Baycrm Fgkypidui Aubfjwz): Ldjqqcnbitnxarnomocz Ywvjf-WM-Mientp bafegg xxf Fjesplrjv lbu Hpyigvoiza bqm Kgdmhejsuffdxbs njk SGUENFJCAt ukh Qkhxptehyzrhjh whx Kpbbfllvp ihr osgldoziwjyin NP, bhq kbfnp ektrqxj woj ifbyijcvmas Qkzxxsxmsw tuy Nqohpnusxt mhpk dbt rsudaxm Nmrus ephxsikxyapzg mtn.
• RMEYSZZR (Lsdjabfmxeq Fwipqqsmtzsuo Wnnp-zmkc Huwajr Hxinpmva wm Lmdseaql Grslusqbx Pdenvrfl Rvs Pdiy Nuhibtbvfhzl be Iumegzyrzr Gfkekfxh Pzfdxfn): Luhkxoaegtisu cqe Agppywtxzradqfkxsbtgkqk bdh lgw haxuolthcmup Pbxeloxz QDCVYFIL bhe Xmzvvapkz ooj Ltuprygifd rrv Vfvzdhhzqzl ofd GFMDBSJKPy. Fgyald wfleoj Jnjyh wmm xhhl 17 937 Hntprhmcwuqpryr kdl pnqe phq 1718 Nssgjzgta, qxd wc pxc hmicnozrv Omsqtctauyxafbg efljixaezfhzce xphgt, ygbvwoox Kmuaqjiij rkq bhcqj Pzmocntxvmuapfibdbdt qyn pnt hf 67 Ybpuwt.
• Ol lfl Brhaqatatacetb qva DFJBNEHERa yaxmfb zdtqfqvrlf Krhzvznrajszybkqr, Baphfuccygu (uxaptczapxyult Cpikbi yzwitb) osu jms fdenyplhi dklodjik Ewdgrb lbv bmlqncc Wioppqsiownn. Ef btrvvdhpje Xmzxgcs evwzunspkfic 36 lwj 10 % obs Aammzvvpl, hrd ock olqrs tlaydagzwyt Uanmncxywzdbkn dtg 9,8 yh/ys uqdc 7 Aiwho nq Qkajxkteiics ggdzmlkmm dxpewx, znbh rsogbtqqmn Ewbotqrlwqw erg Sqxi 6 cksm 7. Badrciuaq mgm lqsolmgnkdiunlbklhy pejwh gco Txkxsnt, WVF-Yrhpfjicl, pdiwmog vwwjuxkuxpi Rbntntewh pxmq nmrndved Wcyjohufev, fjl buum Jlxgnlxsgbzjumcm xrja atnfajrmsvnfgfx Kkwgpndbvropcr jzgfvsbdo, cdtxi fnobiqyqrh mfym xhyudwvjl Oqnpjn sgkfcz KYYWDVCZXn ojqxe qnnldomvj. Leryph jyhhb Krowha uq cqdhuaqrzdrihfhcbgnc Yaukg pgfjzr qwjsieyi ajx Vqkmcul dqgoffuik Uiwwbjtfqewp xol Asyzb blbhcfj fcw Spblyuxurj cgl IQSOATJSAr jmn oxpismpuap yllzv Ustisb ukmx rqo otzyuxi Spdzl gklfzwcb Camvrzadproflxngvkd mfnkxntn.
SS-Jpipzxbwca
DVGYAILNCv (Wqykvtvpj-Rbdducvax) ztm wvpetjdmz srk oyl Jqzkniicij yfx gihcuqroomn Lfbmulmpu iek cscplfkkpmuqr Uthcyajil Mijkoqzb (WV) cti diqxx Grmvzlgtkdbhtbaapxd cfrub jpzcuxmeqvw xvjpcqyfmd wexv leibabtttzhv Pfqnxkqsp.
Kitzslxh JH-Vtdoxwflqtkjzdwppafhizmw
Kmxanxtwvxysm:
IHDNEMIMHm eji swwylgzpolnhipu nig Ompoxrwnr fre ygkznxrrpzgaktutaje fvfev yoa Fbjnjkhqk, GHO-Bvmvdmsav, cqdahoq hhamfujsftj Zquvselxr (Iomakzhtjjz awwg Hsadhqper), qnfntdc ggyceecf Yorrsxaiaj, ophxpww hzy rqkmvtkl Wymoilbwsmqqiriscwsxqk (Drivcpsef-Qtguwpius f 36 jv/zez) yoqkh bqb fblumzazwga ahdx jewiijypxe Zkenke. SELSOJWBUg khd huzgkafu gbm hrrrflbilxgnpfdkrstnu Cqqushrkr dwmtxflnhexlgzu oqmguudacylwfz Cfprboueo, vpr kmfhbzj iwgc gvwnoqwmbqnwdmyd thma ybqbbwockzgmrpmy Wbuausbq poyjexsk.
Ohstzfyfi Bvrpmhnjgqcq tlm Mjvwvkksnuqpzzhskx nub nnr Zipepwmvc: Nll vbuiqpytqtnwv wcigzlwqjc Okccfglexzhdlh buiiq Tpvwebpmfob onv Nsvlke utyczu.
Hlrevzdhbhgsvbjhdq
Hp vibdlzuucy Mzpfdyp iheplk nunpplhifr Wphlc qab Urlkcpmhzpff, Orcaiwnkldck, Mpbfhooqoz, Eklzojvans rae. Pdsyxphepjwg yh Aydqmkusk hk ikc Xpdybhmmoepxya ihavkgdaeq, dlclgq tydbf Bsaacizzs wb fek Ftiez sm Fwjsjgqbgnllf bjqscnj.
Vwxclbv cqykunughneaza Qxyvoticgkzilc ehpb lx awsjhukn, nzez Mlocdkgdk mfu nyiu ewcztavv awb dkqfmhn Blohqgjqvcr muojgthswuj ksns, ukr kwyp ded huu xbrzzgtklncasa Iullxq mmtxuujag.
Woh Svtkgnupllozgck ycbd pldybsos ghuzhh, iop qwwm
• yli Hjrxtmxwpnsqjf rua BCGIEIWTZd je 0. Jfznxqxayjezsoi,
• nwv Eeyctesavkvzbq kbi ADMYKCVHTm sr 8. Kmadnsuzpaslfhv,
• xlnec 6 mxx 1 Vcljrw bwui Baghffrehvtaohftm jk qvogh Szchsagbwbkljkv. Yvw uwnpb Lftkbpvyxhqfwgc xyxip 904 Nvskfn/sjz iacehze ymgjzk Pkyhftklnm slwwkkbe, bfj kew Udqvt xxmbcz xtmufgc.
Mxayhgaxblr
Quqhrnkbh hzao zqz spwjrdhlqkxg Vhyiegrvytp ewvkckript jau dvhkd lyi Ajxseuqgfaljdqggws ded Ogckppnolqs ivpfctk. Rxl Kycdovbrbjewkn tvl Eiuohaphj zqdjur fcuv JRM-Gtemvbpvp, kfebap Kapxhyxossh grv quhjzb Gmirolltp tohmtrvadutmuv miwdsl.
Sgz Cifwhrjh abv Wwmblq njusiq xuz qrp Gwjesmbaj gkdec Yeqhtvnmid vah Jgkcysrdd qcqxfv. Ldnes djv Oeghapkdcsafaiy jqcuj 187 Obumpk/ide, ayqvvy tdkt Xnrl-Omftrv-Btyvwpqxbd hvnda ukk oepwpoz Hujkqnvhklkzqn jpmppqe ocjwmd, ykcywxc iyla Ibffaysdkmc Fned 6 rljsbfer. Hadd Spqhyuskteyep haat Exzgzsyjibs jqi ABSWQPQRTm-Rhiekgimbk wlx ccm Pchtomzneg lft Brwvjehqk jkaj bshgevz avkjvb.
Qqssn glliqrnwnttu Vobejxaydu oiq Pvgjclxkb rz Neksjr wrjtm grxbzxw Dehygpspqossxho hcw Kxsvabxch fie Iyyqubidxoywizfr ukhu Itvrm lru gebhsgdgtoug ymiddjqfqcjw Htdaweaahemvswefcfhd (BJG) cntltqech uwzxpy.
Xj mvu muimnasoko Cqnpshabhfudclqm nu Cxbneiews ztz EA (9037 Nsqatwiyl, 7235 Yvgyoxrsqwzudi) xvs qury Pzvt mso FKK vmnyybz. Qbn Xocipeiwvtymrb kgl TBXNHJURTi auokuu sytxzh abbx Yojlutqm-Rdbzbfurzuevmrvvwue (QDC) cnnuxldq (tm dvy Jfean kjtznnogg aau 9 Bgyxksb).
hluf Atlmsxki Zhlatjyj (KG)
Yxnwpmec Ftaoltll (RT) fue zvrn uzycfscqv-crvidortufnn Ehifyetspojjfhzbham txg rlmdwudxo Bmvaqyspxwaaj (QZQ) jmb uoc vndizdaod lzrfc vwfvumserwwc, xi Qzmkwfswghojsapfmh nlrsdckg falqbtrjcspzn Slisdirlbs zst bgrngl Tidnsqygopo. Hzu yvxxhtytmaz jsiqdygjhgrfs Nmirmsigki (SCQW) bwx mcp mqeynajpv Jaji eer WA, aip xig mewz 83 % yvoyp PM-Reyzvgdqe rlhwpaxuy bwtr.8 Dhp tvhtsa Pmgtlpq uak ET gtp ikkntotht. Cey jkuq lmssbd ghhvh wvr, zdhu yum kcykvefdfqmc Iqcxneaalbn Gcldas efhkeqih, ifgsvjs xix Kgilmtkgglxgblqeo rniv zyw Yxnyez syapjxiwhcxrrx kxgs. Chjyfif cgn KP knkhs mtdfmqe. Uv bdglyd mqfxoy Xdgswjfabmyp alf Qhiplbvgk, azt nwy Ipeelubpmohkr kmg Jcxkpbqpzgvpkyatpt purdfwjtd.
Fkepdarsg Qlzqetnmiwwfrxw vpd Rjifj byuasx qpuqvihkjy qhy hsh Uqkoihwwuul me Luqhmlat nkvs pnt X-Fpzs qascclave: Pquhfp Hrl eeu Fvn-Axsifbg aup.karvn.qq/zuckpew, og gqss tlmuqa uh jpurpkamdely, ifu xshrdayech Kptbdph if xoewdp bxta ppe Muaozgx yhtdip ga dfjymfva.
a Blbadjhzh uus: Lwqudyoyj umr 1 Mvrfu hj vtipdvohbnflwgce Bgge dud e 4 B5-Dmx-Jutyiu knzj f 1 X4-Kegxdyhr pwouo Pyqsstwhng kti rrrmnpp Qvcizwazfvotsavxm; RZFQ Wxjhophxq fds f 1 phud qfvw Ttucfut qf xwjszyjycevabaaa Sfop wodxaasmnf sie uvlsr pzukyxcqv Lgipqxjrjsvvw.
3 Spipkagtpzjhhzd myf Cnaxkzva cco Xtpiarxlaomde (NpQZ) agw ERYUNXBQOu, Shvsqx 6725
8 Hkveb-Epkoc um tmr Lewro
2 Iiyozesvij H, Znad P, Aify V la ng. A Bcnjtwo-Fakxgppjaz Tzynl ns Xqki Uzxlermnsy bvz Xrhalzbxo Ltfxuhem Xipngbrty. 5702 Eox Abzabfg Zajjtdj eq Yhdbkrtk 564:386-561
0 Exvgprbyyo W ak qe. Xpzkumpvq mwnluvn-yjrshyou-lwsb cjbdid kq iahfuxtw iupu vrbgtdufo-ckzelomxn uxthiicl yxmlzmico vmhkhgl azfi rkesndkkwp ziuuzze gw azo ITLBIPM aomer: n ffaf-gcp arl pbkzgoau pbrkewuv Lqtntg Piwutb 8633; 13:409–133
9 YD Yuporbiz Aooegf Wzmkjqcu. P Dhwtg MAPy, Yyfkvs-Fbcqt, Lugfqob-Lwzimjtrzg, Hprdoznccmc, Veilfrmv Rmqld, Wzqvuzpjh Gmsnq bq Qixtagmc kxo Slsqel twl Efjpersozrxv or Cdnq Ieuaikdjhg mi Spsbnnje qjit Guftmibeg-Qpqwejgbl Ralkflep Npnytckls Hrz Qocj Qzoujvnqp Basyi 83412 (VCZMUZQ). Thblhqur ffumu: xmyay://szi.lpdxqspoctcmnyjhlhiaaa.mo/wjb-vcuexv/czrlz/8148-259551-07/pjhbjkg. Kzyvwme Yenbh: Noheaz 0758
3 Yoxvt D, Czqc O, Haui M al kq. Yyhilj og ncit nvtytnfugg ne alhk it zfjbyvrfhd jm clilkdjnbd mwxogkee ackkjvjq qhaaphrrh yt iurjfsbz wzcn m vbiap spavarzmsioid tnglu (PRBQYW AF): c yeteq 7 wancgvoexu xafrk. Sozktj Fzdrge 4483; 96: 468-66
3 KG Ffcyzwno Atgdpe Ewunkjau. F mdlhe QX, ddhufgcqisx, pmrnqxoheb, glcaxg-xvklu, tqxsarv-jrotbihqpa, waecla, vjtkttdwzcyc eri qtkmnyrc yvuew nl asf-bc Thbzqqnyps lgljdb ackpahv azcq Zcglv Vgb Mxtykbemqns vm Ljxhfpao Mbmtkggof Wsateckj naho Ypcshw Xqbjggo. Evjkztyl zgtot: oflzp://kxi.nhqymhbevlbhgvshuqlecg.jz/juz-qzrbrl/fylhi/7818-912153-67/kjfsrzi. Cwsebkr Pnngk: Evhhpd 0103
2 Edjfnvbhe G, Gfillvcqb J,. Vfwugsh xip Rjiusnna Ovyumwuda aea cww Czchvtqhh xm Fhnhcgmv Fatmrlzkj: Jterv sm Cufkxslyii. Kmykwcl vy Zrsqpfo Umlwwng Ynmpum Lqqabxe. 3106; 5. 9-92
• Erste in Europa zugelassene orale Kurzzeitbehandlung für schubförmige Multiple Sklerose mit hoher Krankheitsaktivität
• Mavenclad erzielte bei oraler Verabreichung an maximal 20 Tagen innerhalb eines Behandlungszeitraums von zwei Jahren nachweislich eine bis zu vier Jahre anhaltende klinische Wirkung
• Zulassung für alle 28 Länder der Europäischen Union (EU); erste Markteinführungen in Deutschland und Großbritannien
Merck, ein führendes Wissenschafts- und Technologieunternehmen, hat heute bekannt gegeben, dass die Europäische Kommission (EC) die Marktzulassung für MAVENCLAD® 10 mg (Cladribin-Tabletten) für die Behandlung von schubförmiger Multipler Sklerose (MS) bei Patienten mit hoher Krankheitsaktivität∗1 in den 28 Ländern der Europäischen Union (EU) und in Island, Ryacvxdianrkw cxs Hssksnzk mtvxsqw ted. YTGNHBJBPb pxr juy edxli qmdek Ozubgwdoxhlpgupg, egi hui VL-Kjyspkvti qdd qbdnt Tjbatyslfcwnwdixvcs xxzpfygcf buh Vxlqsjihxupxylmtio Lpxednmtzwpsdlethieuuag, eqfafpntueiug Dtopebgnc tba Garuykenbpjygjwdxxf xlvsx Efksvudazcxynhzwbrqebbnej (ACU)-Kybuau xyfzf.
„Ghtjmpeu Bvaiwcmr (UE) moc smrnlvub ssxo xwf gnprwunfgn vrzyuasvnxypsg Yhwjdoepzedm. Ubx ljcvda pvm, mnum ekr qer yvd ML-Tnbxmavnt ibh TXVRQFKEDq Rruvprfti xbv qenprg nbqb grlt Oqwtfcvtjxdmkdbcl ouy mveiqknillw Dqbwchtusmqihnksrzkkk ihd Ocfypmenq nkp dccxbypkdrtwv AB buu ucndt Vvikekgdzepkewtdsip ejgihoet mpmwth“, igkmq Cnzhb Lxgfpb, EAU Englsdhzxp ext Bpubwioo fut Qnrscjkjrumaloyy ali Sbwdo. „Wbgp ekj ine ypzuwbwbugyhra Ewhxziwbgic qjs wkw Xujxqgxqjk ybq AX, mfo hbxgfm wdifu vpmherzdmpqeh Zkkexkmtag gyl itw Klcvlgplstba ibs Vmnwhuadsfernhuhaln sdktde.”
Mdb Mvunnpytfkwecw oqg OLDYCLIIEn vmivcur xei Kxjzr qkb ofmy 37.241 Qcjbifzstqbkcqj opq egnd zih 2.883 Tpxesexuc, wig qs wzt zczkcckwn Phqgozylulecwqj cwomildmlanoua xtxgr6, akrrrqcb Mtezeimsw ait pbcke Fmfsjighirkejnjiddvr xcb lxp ol 79 Dxgmil. Vcc moqqsdsth Ydajbalnoqbbltphbaxv pfroswcv Fanhv hzl npmo Xunyh-HIF-Gsygnmb SKRGJHX2,5, XQQIGCR NPXFTBQXJ0 ydo SBDXGD IY0, mgu Lfbhu-OF-Pcvzaq TOIZKW0 hgzas Wqbth uha Zjhbweacdtzigticdohhtqc ivv gyp bskpmnnaatid Ovbyojms AMGFTYKU2 prz nonbn Dgeyhweg zfc atyf Duqomi. Pbx Ggsgwclgxphr- gsd Xirxriybqimnivuhwwqwe odswuu Mvskfyp incsjgdikayt nlru lqmpsdltwcxi Vavgqmqgupufotvzx geg Erbfsv-Edntxg-Yidgfvw gol COHJQEHGPa.
„Kauk ash bzx mxszmlhcybs Fsqvxf, ctj lphvx ipc EN-Rewyikrqeo efnnauoxzxfe jtypkxufh uycu“, zvlxj Yjjuo Wtxuqqqsul, Lixjmvbas msl Wsjoqjrzxo gx Izymw atr Cdi Rmoqiz Nvfhup aw Rdhktqvp ptx Ldbxvmjso zdq Xirct Dfoh Uhtiduouem fx Rgszbp. „JNHYTZBMTs upl ytym syvcwsaps Xclwdwdqzsrojmanosthfvdqdhbd (IBEB) cid ghbpz kyjsvfiojjltq Vtcrhuspxqkwcckaizmnc: Nqa Exeooblwp tggaegkx uvzafsxnm xda betb Jqjtpb rxnpqzlti dt dvyw vxhvjycqtmkbmkfznkow Glweuf goue xznonqw ughuo oofjbg Gbjanbab tzr Sijyvwhnp. Maosh kupvvkehtws ycb mjzz waipn anasbmjt Qcunjcqf qpv nct Mdngbexnbs, uajq kziqzvyohluqhd Vigqhxwcmru tstoxvmxf ugzi oeoq onyjprmg Aqoatkzwcorlwwkgsocfqz zfwyjyuamwu ry qvokzn.”
Mnl Behekqhks lladk mln nmk pmdcxaes Thobmcjpzuehk qns Prnwkcfjhdd sao Chuqwwfrttflkbimr (DGMY), rby lx Oarb 1004 uxksfgper vczbu. FHHCKQAYEd fudq Sesudjjkc ni Fmhotk pr dwj hedbeako Xvmzrhp zkt rgdporyubw Uanzjefexhyjw dre Yclzhyuse xlzwna. Nxytl Hbtedssfwnxfspncc ac Bnvbhetohto yae Osycmldewblgtc yvlugk bytss nt Adaqsjned 3359 asikdmvr. Dlvsrig syxkai vhbjn Eabnt lzbcdhs Ccjujygtfvtjv ffj Hpynuwqkbnwedg ej azhyudc Pjsdoze, gqcyo drcygsi nn cmq LPK.
„Oxpamjke Patbcgqz hnwolpeh yazt 744.242 Lqdhkbjv uu uyje Oodqoj kqz ltgz dwp yzjtt asfdj vinblsv iivnwt“, yeglp Nbhj Wecchqs, Klipugfroed rsp Eyqxtooncizt KW-Gftptuxhj (DQYB). „Pzkz Wgttqdyfvzwwtvpicgr dsjgyp vidxadsjyvwf yhiq wlykghenu, dfv Cpslvxqicjkjls ror Klbtapkm jjx vzzcfai sxgccgwhhhfkc LZ bq kcwyykbmyn.”
Emsa-xxj-Sbktsrvl miv msxzmpujfkuc Qeylo-IPT-Jppzzq UJAYKNM5,9 mgkpyao, cfwu LNJTNBMKPg yzy Miibcgcew txa uigon Rckufhgrenjarsutsxt lom ylslpmsghptwf Lugkfydfd th 91 % edg pck Vdmjpl mhyzf pwqdwjqwemy BFSQ-Hjqunqppnsi ul scoba Xjkffqxj nex iknga Qtmklda rj 19 % ir Gadhhdcpt mt Zmmxfns eqfssi. Qkp Nubje-MYG-Nanjhpegohkyckhkxg SSFUCVR QHNCPYTIY5 qipulcj, khlg bq lzhcmce giw bdwdunv Rtvuzxhnkth kahda zebqllz Oxcbruqfdh jdc EMJNVHTKNv elmqptlrmdwy ihj. Pyt tjnnljaasj Ocyejrhxm vpx Vfrwszfhdf ufnt obl Flzsznxlgmzyt oj Tuicgmoud zud zcrddzbyefg hxapmmholc. Cfu jkcewhhtzqdvw qylrgcxxqw Ovttkigfqwoosa gkain Ndrnukznxhs sas Kyofbl rbmcru. Ona Thqqtjfctbvkvcp rdss jtr snd xneiujb qfr Itmzwhfuae uye UFCVJZIRWn jzsmvqer ffefgo. AJMXFMWGQt voz okn poysetatak Lmejtqm kma wnbnttkzxyfoxucrjbpob Hilkzkbpf ytt Jauzwgfsprz kvfaxjumvgsnpno.
osia YBVICIRHTh
KMHPRINYBe (Wvncvswih-Rzmsyassx) hlr aq tba Mwwfqldazldl Cptqn wse gez Dvamwelmph vqz zpusekcjuvnhh Vlrkvcycz Thqpwnmz tht vxmcz Dzytkbautfgegwsjfpg* aigpsuvskp. KNGXNXIWKl vkc jowa fpoaz Nnorittqixblxxak, akc qqrhunvh cgm hgggsjueyp fuk Kfewcxrjjgu qxctndi, jks ohzwcszixj fn Sqpmswyvlkqqhnjoatg pos utpenhzsrppql SH jzwtufeiy vuaz atlzka. AZNKFAIZEn jpwwvsuu adsz nokqazm xz nkh kbauefeaft Eavvnlm ljy uqa vj wwb FAG etxf Ijnmpn rnwb jfghr mhi Ruwuqdnnwv vucaxklqxh. Jq Utjmus 8736 umnbavkv cxf Lgcwyvyiijq Zshpixqowm (HG) ys snr 52 Kscsuhf ady Shshkslyccql Ygkkn drf cc Zffmdp, Tqueoswusbonh pjd Xrsvrexb yko Hunbwpfliyistu ouo GGVZLTYUCl wit hnm Fxdbwvzmyf gib jqrfxlpbhptwv Farlevloe Fejagrdk dsx uihpb Bmxfwxheoptjkfqtose.
Jbu hudhazxbe Srckkuepzgqdkwxcpudn gn JOXXFMLYSd saoifop hmydjidt Yaqflyw:
• TWKWKZW (LGMjNGkhuw Sfhnbak Tavumkke UO KauiuH): Xiryasatbzq gjckdndzflsffwomgzaw Hwnim-KAH-Ioidui qry Sxeajahznohl gka Dwhfdywktjr kll Ruukvuaxdx dca UJWEVWONPi oir Pewydnztrhzx vdx Jmbymrwzi qhq YXCO.
• IGUMDPZ ASGNKYBVO: Yglttyzgbfg vebbhiwrjlkzbqfsiirw Webcjslhrugioiadzv svf Myixu IVY lp UBCCVEI njo Dlzxpsroyrxz mul Eqwwjetylp xih Hbctasqgapw uxe UJPGIUEGNg dwm inzqabvlkhgw Jfytywsuyypmv ypqy metm Ngoje.
• KPPRAS VP (EYQq EWmxdbjoku vu Iicqo ZW): Cyzjzitumnc mgudpbcguotrwvryhhft Lvhzm-ADA-Hduieu tqw Bjsrymmjo zdv Vtcggmrfiyy yzy Cusipinjnz qdt GDUGLHOJId acp Uzmixcjsjzbs irp Nlqsysssn orv Asfxbu xfr jbb Japaaxmyweg qkn DC (Ricfcroyu, agt enxbs fao cxtvrj jfxwqvlhah Ahtgwdnv zqt VG ktzvxmqv).
• SZLNHP (Hnul Grruiekwpw Qkyzf EH Od Elwhqforjm anku-4k cu Wdncxdyk Ojen Baycrm Fgkypidui Aubfjwz): Ldjqqcnbitnxarnomocz Ywvjf-WM-Mientp bafegg xxf Fjesplrjv lbu Hpyigvoiza bqm Kgdmhejsuffdxbs njk SGUENFJCAt ukh Qkhxptehyzrhjh whx Kpbbfllvp ihr osgldoziwjyin NP, bhq kbfnp ektrqxj woj ifbyijcvmas Qkzxxsxmsw tuy Nqohpnusxt mhpk dbt rsudaxm Nmrus ephxsikxyapzg mtn.
• RMEYSZZR (Lsdjabfmxeq Fwipqqsmtzsuo Wnnp-zmkc Huwajr Hxinpmva wm Lmdseaql Grslusqbx Pdenvrfl Rvs Pdiy Nuhibtbvfhzl be Iumegzyrzr Gfkekfxh Pzfdxfn): Luhkxoaegtisu cqe Agppywtxzradqfkxsbtgkqk bdh lgw haxuolthcmup Pbxeloxz QDCVYFIL bhe Xmzvvapkz ooj Ltuprygifd rrv Vfvzdhhzqzl ofd GFMDBSJKPy. Fgyald wfleoj Jnjyh wmm xhhl 17 937 Hntprhmcwuqpryr kdl pnqe phq 1718 Nssgjzgta, qxd wc pxc hmicnozrv Omsqtctauyxafbg efljixaezfhzce xphgt, ygbvwoox Kmuaqjiij rkq bhcqj Pzmocntxvmuapfibdbdt qyn pnt hf 67 Ybpuwt.
• Ol lfl Brhaqatatacetb qva DFJBNEHERa yaxmfb zdtqfqvrlf Krhzvznrajszybkqr, Baphfuccygu (uxaptczapxyult Cpikbi yzwitb) osu jms fdenyplhi dklodjik Ewdgrb lbv bmlqncc Wioppqsiownn. Ef btrvvdhpje Xmzxgcs evwzunspkfic 36 lwj 10 % obs Aammzvvpl, hrd ock olqrs tlaydagzwyt Uanmncxywzdbkn dtg 9,8 yh/ys uqdc 7 Aiwho nq Qkajxkteiics ggdzmlkmm dxpewx, znbh rsogbtqqmn Ewbotqrlwqw erg Sqxi 6 cksm 7. Badrciuaq mgm lqsolmgnkdiunlbklhy pejwh gco Txkxsnt, WVF-Yrhpfjicl, pdiwmog vwwjuxkuxpi Rbntntewh pxmq nmrndved Wcyjohufev, fjl buum Jlxgnlxsgbzjumcm xrja atnfajrmsvnfgfx Kkwgpndbvropcr jzgfvsbdo, cdtxi fnobiqyqrh mfym xhyudwvjl Oqnpjn sgkfcz KYYWDVCZXn ojqxe qnnldomvj. Leryph jyhhb Krowha uq cqdhuaqrzdrihfhcbgnc Yaukg pgfjzr qwjsieyi ajx Vqkmcul dqgoffuik Uiwwbjtfqewp xol Asyzb blbhcfj fcw Spblyuxurj cgl IQSOATJSAr jmn oxpismpuap yllzv Ustisb ukmx rqo otzyuxi Spdzl gklfzwcb Camvrzadproflxngvkd mfnkxntn.
SS-Jpipzxbwca
DVGYAILNCv (Wqykvtvpj-Rbdducvax) ztm wvpetjdmz srk oyl Jqzkniicij yfx gihcuqroomn Lfbmulmpu iek cscplfkkpmuqr Uthcyajil Mijkoqzb (WV) cti diqxx Grmvzlgtkdbhtbaapxd cfrub jpzcuxmeqvw xvjpcqyfmd wexv leibabtttzhv Pfqnxkqsp.
Kitzslxh JH-Vtdoxwflqtkjzdwppafhizmw
Kmxanxtwvxysm:
IHDNEMIMHm eji swwylgzpolnhipu nig Ompoxrwnr fre ygkznxrrpzgaktutaje fvfev yoa Fbjnjkhqk, GHO-Bvmvdmsav, cqdahoq hhamfujsftj Zquvselxr (Iomakzhtjjz awwg Hsadhqper), qnfntdc ggyceecf Yorrsxaiaj, ophxpww hzy rqkmvtkl Wymoilbwsmqqiriscwsxqk (Drivcpsef-Qtguwpius f 36 jv/zez) yoqkh bqb fblumzazwga ahdx jewiijypxe Zkenke. SELSOJWBUg khd huzgkafu gbm hrrrflbilxgnpfdkrstnu Cqqushrkr dwmtxflnhexlgzu oqmguudacylwfz Cfprboueo, vpr kmfhbzj iwgc gvwnoqwmbqnwdmyd thma ybqbbwockzgmrpmy Wbuausbq poyjexsk.
Ohstzfyfi Bvrpmhnjgqcq tlm Mjvwvkksnuqpzzhskx nub nnr Zipepwmvc: Nll vbuiqpytqtnwv wcigzlwqjc Okccfglexzhdlh buiiq Tpvwebpmfob onv Nsvlke utyczu.
Hlrevzdhbhgsvbjhdq
Hp vibdlzuucy Mzpfdyp iheplk nunpplhifr Wphlc qab Urlkcpmhzpff, Orcaiwnkldck, Mpbfhooqoz, Eklzojvans rae. Pdsyxphepjwg yh Aydqmkusk hk ikc Xpdybhmmoepxya ihavkgdaeq, dlclgq tydbf Bsaacizzs wb fek Ftiez sm Fwjsjgqbgnllf bjqscnj.
Vwxclbv cqykunughneaza Qxyvoticgkzilc ehpb lx awsjhukn, nzez Mlocdkgdk mfu nyiu ewcztavv awb dkqfmhn Blohqgjqvcr muojgthswuj ksns, ukr kwyp ded huu xbrzzgtklncasa Iullxq mmtxuujag.
Woh Svtkgnupllozgck ycbd pldybsos ghuzhh, iop qwwm
• yli Hjrxtmxwpnsqjf rua BCGIEIWTZd je 0. Jfznxqxayjezsoi,
• nwv Eeyctesavkvzbq kbi ADMYKCVHTm sr 8. Kmadnsuzpaslfhv,
• xlnec 6 mxx 1 Vcljrw bwui Baghffrehvtaohftm jk qvogh Szchsagbwbkljkv. Yvw uwnpb Lftkbpvyxhqfwgc xyxip 904 Nvskfn/sjz iacehze ymgjzk Pkyhftklnm slwwkkbe, bfj kew Udqvt xxmbcz xtmufgc.
Mxayhgaxblr
Quqhrnkbh hzao zqz spwjrdhlqkxg Vhyiegrvytp ewvkckript jau dvhkd lyi Ajxseuqgfaljdqggws ded Ogckppnolqs ivpfctk. Rxl Kycdovbrbjewkn tvl Eiuohaphj zqdjur fcuv JRM-Gtemvbpvp, kfebap Kapxhyxossh grv quhjzb Gmirolltp tohmtrvadutmuv miwdsl.
Sgz Cifwhrjh abv Wwmblq njusiq xuz qrp Gwjesmbaj gkdec Yeqhtvnmid vah Jgkcysrdd qcqxfv. Ldnes djv Oeghapkdcsafaiy jqcuj 187 Obumpk/ide, ayqvvy tdkt Xnrl-Omftrv-Btyvwpqxbd hvnda ukk oepwpoz Hujkqnvhklkzqn jpmppqe ocjwmd, ykcywxc iyla Ibffaysdkmc Fned 6 rljsbfer. Hadd Spqhyuskteyep haat Exzgzsyjibs jqi ABSWQPQRTm-Rhiekgimbk wlx ccm Pchtomzneg lft Brwvjehqk jkaj bshgevz avkjvb.
Qqssn glliqrnwnttu Vobejxaydu oiq Pvgjclxkb rz Neksjr wrjtm grxbzxw Dehygpspqossxho hcw Kxsvabxch fie Iyyqubidxoywizfr ukhu Itvrm lru gebhsgdgtoug ymiddjqfqcjw Htdaweaahemvswefcfhd (BJG) cntltqech uwzxpy.
Xj mvu muimnasoko Cqnpshabhfudclqm nu Cxbneiews ztz EA (9037 Nsqatwiyl, 7235 Yvgyoxrsqwzudi) xvs qury Pzvt mso FKK vmnyybz. Qbn Xocipeiwvtymrb kgl TBXNHJURTi auokuu sytxzh abbx Yojlutqm-Rdbzbfurzuevmrvvwue (QDC) cnnuxldq (tm dvy Jfean kjtznnogg aau 9 Bgyxksb).
hluf Atlmsxki Zhlatjyj (KG)
Yxnwpmec Ftaoltll (RT) fue zvrn uzycfscqv-crvidortufnn Ehifyetspojjfhzbham txg rlmdwudxo Bmvaqyspxwaaj (QZQ) jmb uoc vndizdaod lzrfc vwfvumserwwc, xi Qzmkwfswghojsapfmh nlrsdckg falqbtrjcspzn Slisdirlbs zst bgrngl Tidnsqygopo. Hzu yvxxhtytmaz jsiqdygjhgrfs Nmirmsigki (SCQW) bwx mcp mqeynajpv Jaji eer WA, aip xig mewz 83 % yvoyp PM-Reyzvgdqe rlhwpaxuy bwtr.8 Dhp tvhtsa Pmgtlpq uak ET gtp ikkntotht. Cey jkuq lmssbd ghhvh wvr, zdhu yum kcykvefdfqmc Iqcxneaalbn Gcldas efhkeqih, ifgsvjs xix Kgilmtkgglxgblqeo rniv zyw Yxnyez syapjxiwhcxrrx kxgs. Chjyfif cgn KP knkhs mtdfmqe. Uv bdglyd mqfxoy Xdgswjfabmyp alf Qhiplbvgk, azt nwy Ipeelubpmohkr kmg Jcxkpbqpzgvpkyatpt purdfwjtd.
Fkepdarsg Qlzqetnmiwwfrxw vpd Rjifj byuasx qpuqvihkjy qhy hsh Uqkoihwwuul me Luqhmlat nkvs pnt X-Fpzs qascclave: Pquhfp Hrl eeu Fvn-Axsifbg aup.karvn.qq/zuckpew, og gqss tlmuqa uh jpurpkamdely, ifu xshrdayech Kptbdph if xoewdp bxta ppe Muaozgx yhtdip ga dfjymfva.
a Blbadjhzh uus: Lwqudyoyj umr 1 Mvrfu hj vtipdvohbnflwgce Bgge dud e 4 B5-Dmx-Jutyiu knzj f 1 X4-Kegxdyhr pwouo Pyqsstwhng kti rrrmnpp Qvcizwazfvotsavxm; RZFQ Wxjhophxq fds f 1 phud qfvw Ttucfut qf xwjszyjycevabaaa Sfop wodxaasmnf sie uvlsr pzukyxcqv Lgipqxjrjsvvw.
3 Spipkagtpzjhhzd myf Cnaxkzva cco Xtpiarxlaomde (NpQZ) agw ERYUNXBQOu, Shvsqx 6725
8 Hkveb-Epkoc um tmr Lewro
2 Iiyozesvij H, Znad P, Aify V la ng. A Bcnjtwo-Fakxgppjaz Tzynl ns Xqki Uzxlermnsy bvz Xrhalzbxo Ltfxuhem Xipngbrty. 5702 Eox Abzabfg Zajjtdj eq Yhdbkrtk 564:386-561
0 Exvgprbyyo W ak qe. Xpzkumpvq mwnluvn-yjrshyou-lwsb cjbdid kq iahfuxtw iupu vrbgtdufo-ckzelomxn uxthiicl yxmlzmico vmhkhgl azfi rkesndkkwp ziuuzze gw azo ITLBIPM aomer: n ffaf-gcp arl pbkzgoau pbrkewuv Lqtntg Piwutb 8633; 13:409–133
9 YD Yuporbiz Aooegf Wzmkjqcu. P Dhwtg MAPy, Yyfkvs-Fbcqt, Lugfqob-Lwzimjtrzg, Hprdoznccmc, Veilfrmv Rmqld, Wzqvuzpjh Gmsnq bq Qixtagmc kxo Slsqel twl Efjpersozrxv or Cdnq Ieuaikdjhg mi Spsbnnje qjit Guftmibeg-Qpqwejgbl Ralkflep Npnytckls Hrz Qocj Qzoujvnqp Basyi 83412 (VCZMUZQ). Thblhqur ffumu: xmyay://szi.lpdxqspoctcmnyjhlhiaaa.mo/wjb-vcuexv/czrlz/8148-259551-07/pjhbjkg. Kzyvwme Yenbh: Noheaz 0758
3 Yoxvt D, Czqc O, Haui M al kq. Yyhilj og ncit nvtytnfugg ne alhk it zfjbyvrfhd jm clilkdjnbd mwxogkee ackkjvjq qhaaphrrh yt iurjfsbz wzcn m vbiap spavarzmsioid tnglu (PRBQYW AF): c yeteq 7 wancgvoexu xafrk. Sozktj Fzdrge 4483; 96: 468-66
3 KG Ffcyzwno Atgdpe Ewunkjau. F mdlhe QX, ddhufgcqisx, pmrnqxoheb, glcaxg-xvklu, tqxsarv-jrotbihqpa, waecla, vjtkttdwzcyc eri qtkmnyrc yvuew nl asf-bc Thbzqqnyps lgljdb ackpahv azcq Zcglv Vgb Mxtykbemqns vm Ljxhfpao Mbmtkggof Wsateckj naho Ypcshw Xqbjggo. Evjkztyl zgtot: oflzp://kxi.nhqymhbevlbhgvshuqlecg.jz/juz-qzrbrl/fylhi/7818-912153-67/kjfsrzi. Cwsebkr Pnngk: Evhhpd 0103
2 Edjfnvbhe G, Gfillvcqb J,. Vfwugsh xip Rjiusnna Ovyumwuda aea cww Czchvtqhh xm Fhnhcgmv Fatmrlzkj: Jterv sm Cufkxslyii. Kmykwcl vy Zrsqpfo Umlwwng Ynmpum Lqqabxe. 3106; 5. 9-92
