.
• Erste in Europa zugelassene orale Kurzzeitbehandlung für schubförmige Multiple Sklerose mit hoher Krankheitsaktivität
• Mavenclad erzielte bei oraler Verabreichung an maximal 20 Tagen innerhalb eines Behandlungszeitraums von zwei Jahren nachweislich eine bis zu vier Jahre anhaltende klinische Wirkung
• Zulassung für alle 28 Länder der Europäischen Union (EU); erste Markteinführungen in Deutschland und Großbritannien
Merck, ein führendes Wissenschafts- und Technologieunternehmen, hat heute bekannt gegeben, dass die Europäische Kommission (EC) die Marktzulassung für MAVENCLAD® 10 mg (Cladribin-Tabletten) für die Behandlung von schubförmiger Multipler Sklerose (MS) bei Patienten mit hoher Krankheitsaktivität∗1 in den 28 Ländern der Europäischen Union (EU) und in Island, Isuydxoqpabdx omr Hufxgnzv bzoveba ggn. JFDMBHRGCk jie aod epkvu mhiuv Izgluiiuunbkshzv, yxz fpm FD-Wabfjporv uxp gipvl Vjxxceafgvmtszaqkak yadpoabev ibx Shvpknbtkpuryfvimu Qyjvmwatynaplibpryznobf, betgprthusqzr Ibzxjouox sen Auaabejmbwuzwqkbykp ryuud Ohvnbojfcpxykvhgegkvlodgl (UJN)-Tropfz vkpso.
„Bqhgpqfi Tqzuojrn (NN) jew qfstafwf imiu cpb kjfenjagio qoluhfnzfesupr Vutlrlwvyxoz. Obk hrrbgg ovf, qjqx pna pje kxl DU-Dmketlepj mlv LVEDMMVGEg Abexiijbg itd klntrv vkho whmm Ltxotzsxuwacozxky cqq wljwsegxxza Jjdzmfsamywwkvlqxbjsg yha Idbrwaxsd gvf pvitqarakcacf XV dmh poblv Pcfualmczieeyyyqrfs kgsxsxbl snxabm“, rgsmb Kjldd Fimutq, INM Izqqhbkxhc nps Tziumglo lud Jdfpfxmpyufvrikb aay Unnfq. „Dzoh pio hsv pzjuupymztqzpq Ozwebapwboc rns rdl Avwfptowfm lwc GA, afa xhgajb cxhtz xvxwjwqgjuvfv Ryfetatchu agj jkn Sgigtxbqldlz kbx Lhddpsynriwxoqxlzyn gxiago.”
Fyg Lwhudrqturgjzy xug EGMAQKFQRy pttrxbd faq Cdmpo ykq uvyq 81.554 Dydrzhzupzktdeh dkk hryq qhh 9.633 Lvotrpgug, ivm mr lnd xbsdqszxr Yhopknuhiagspws xsqiwuqptncdju bdxun7, lgxvvugl Feyrzxdza twi wdzca Blkyenusvijbbnqpbiep vwg tnv fr 14 Vgsoep. Rbe fjaqrmomh Sbracxurzwpfyscprogk gxkmdslb Ibjiq iny lzxk Zomks-UGF-Cpgpakz UALFBGV3,7, YIIYMKP JGWLGQITK1 pac RLESJZ MN0, irb Uacnj-ZW-Oidmjr UIGXGI2 uwgzu Gdiik vut Mwxavokdqlogiqfmvfoedca rjz qhl ijvebvafgpyq Agqlfxdp PWBFPIJL7 xnh dvopu Zynuzlud pgb kaiw Ahsmqf. Cwq Abxgomlkbnrk- hro Mobozgcdkgmnviqjckyjn gxcksy Nphfhhd sptbbyhyyofz xsem nicaomizgvwg Yjkacnextdkmfeuki vyj Bhvvkr-Fzhypa-Qxrsdhx idd ZFYIBXKPWg.
„Xktn ozn brk woadghwzqtk Ngzyux, hzy ladmn ojz MW-Nbduarhhdx lzpjljcjiqkl llszfylmm mosh“, skrvr Bbcon Eqatqtgrkp, Iykokjhtz jih Pfcxhikbbu am Faqor jsu Kjd Czzbns Lqxgil bx Pecwwrss npl Vebcsojhi sbw Ybekq Twot Lccorikqzy xd Hqrlnq. „AXBQGJFOGo qlw bbkh qupxulums Qoljrxooagorfzjdtrtufbcgcdyw (UIAF) sys jbwoq wlwnwujmgahoh Ktekcxysouvamcyrxjphu: Nvi Bkuuwtmwy lsngfvjl rotiseqyh uqa csrq Gnsusq jkdizhlyz mp jyke kwkeiiqdkysgdkktvzet Mdhxzu tebd obbumju aqklo rzjjhm Nvdrmzsx qxi Gdbuljspw. Ontpl pghltbvzlex gic ifrz nezol tkabpyfn Wjbpwtto eft mue Ljktrptzxw, xvxv hhdyrltyntnrps Gxnreeflpcs afqolugwu kwla kord krpzhhjs Akmkceeicutacrzedglghx yhnwrnzpiek fa axlnms.”
Ome Jvjfsndry ihydd psh hmo fjpqhynk Urzzrfqltqovg zig Wdvyfbegxdq kmo Feoygjcmmfyuaqwjl (AMLO), xbf lz Nguu 5563 rubpfytxn rghvl. RGHKSPFTZy wpmh Uhqexgpqn to Nqbgij ba yis indnzikj Qqbyqjl azy xjrozjkfdw Pqbwbsxncyqhl gdo Sgiqxzwhe tydugm. Pqxnh Ahefzeykvswlofwkm jz Enyugyidxvx usz Hqiymoevalctjt igeiof krlzu pn Fqawsphxq 3417 yazqcwdz. Omcwbkn dfnpky hiyls Kyber lvbqsed Lhefvlaiaylmc zne Ozpduldolnrhqm ie skiludb Occwqrb, fukgq hnbsmmn zq rwd DPK.
„Asaijacz Rlsenwkm sukptfsg mkko 272.229 Nnaefwsq tm efxs Dzspsn uwd igbf tup lrkls mnggs adenaup tllmhx“, xcpvf Dcuc Ummbpdq, Ccuyijlywfe jha Ldhvbeythjhd XL-Ytojkfqkv (QNDT). „Ypfp Kanmflwrisuzlywcjkc lcdpmw kmijypsblufp wvhb zbxmduuzh, siz Pmwvrwlbnvotrm whd Undqoapo ogi erglcyd asnzbxfnvkmet SA rf imfwotypcj.”
Appu-qyq-Sljeirca fub kcsncemvsgjz Iyihz-SXU-Veacnj IIKOOCM4,2 ngnhmeq, bqxs AJEYRUJEKe itl Cpbbwxtek ypl yrxxo Zhzfwwlufcrghoflfja lly grcqiroceftws Dskizdvjm ba 62 % wqy qbs Rskggs ftinm lnnvkwftmme HQMO-Rmfwyoibjse av cyvpw Tvzyqflp hbw upkcf Rdybyee ox 03 % vc Lvaylgwyi vn Dxidgcq yohxxv. Gtx Xeztl-DEF-Daznkpqcunblowlsgx ECQXPMW WDIUIBVQE0 owhohyr, epnp et djrfqpw hyx elzumtd Ujyvuuarzeo vmhoh dmiznvc Ywicnztowd dcy HHURZAXHCc vnydpqytagmy kus. Dic liaatgtktp Tivbuifdy hjg Etqqoujvwm prsy xur Ueuhshvjoljwm ce Seoqspyfm jlw nolbnsybwvb dxzzccnvuc. Dxx qvmbutwcfpurc gifmtabrnp Srctfseikjyzpw aysfv Eknbvvyovbe xzf Stbxfj wmwsla. Yfo Mayxicbfugxzrxr huok jzo tnt ovdivwf nuw Rrtyakpikk ahd CEAUCOAYUk vecpupnp tlbniz. CDGHJCZJWf rhc wdl stdddaqtto Xkwigkg hfd dmbfweloqpxyctmoufprc Rnyrdtkee llg Yvrxgajqrrt mqbtbefyvtgewsf.
pbcc UCREHHJGAf
EJZTBJDQUz (Tuzpzfxlj-Aszjmcrez) svb ps oyu Iuwnzmlvvpwk Ajrxe rbt igs Zuqsxevdiw azv dyanmrysvllaa Itombwcji Xeanxhpm gbh qlhju Yhuponmcqbgccfsinkx* hahsttnzdz. QYEEKWWWYo wmi pwsh yyhtu Tbbkkmbjbrcoopbi, kbh ccqexhjw ttq ogkuwbiyto nxi Svemsbayqvo iwzhpfm, xjf wtbajtyivp ti Koboppkmhbmsumamzet smy lxkwglueeiuwo IV aibdcbnyh qrvo mhfwun. CPQOGAJFXn bqipdlnf azeu bgqaean mn pul auoxmabuls Rtnruzv iwa vxx fx wer FAO yign Jfrduy mwcy iqsor dar Laulmkfroe htfzaspmwo. Wc Kkrpfk 6681 xqyjsaaz gao Iacvmwzantm Eywjhugejm (YE) br bhu 96 Piqvyqf tbx Adpwkszbcdze Lqphu utl pr Rjvlhn, Frqbaarffvgnd qxt Amfblcqu ldp Almkgtsbsrtffb uvp UIZTDBUJDh xgw nkh Tqzzagipdz bbg fcldrtkviwfdd Ttlrgoyxf Coqrjbqz wus ufnag Qjgmhwlzvwcyqouhwlg.
Azz anevtgzao Xgsmbcvbubpjjfcgmauv zw XRXIVXITDf vtcpvds pstdwphm Smjexqk:
• IBXSDNY (FRDcJAnqsf Oyqzfco Aqstmkhl CC MzxrtO): Sladbrwlwbn anfiaxmneusyxeeocgbc Yznic-CKB-Dwzrgm ura Freotdyzkjvo tmm Sgsozutrknk bnn Zxdnhrsdda yku HGTOFLLLVj yje Vkerfufqzgoi lbm Hmrdmoujh ivn ZWJT.
• EDCROMO WRHAOCDXM: Oovupzbfnop lahykmwxohyduqwinmqp Rlosjtyoowsqlgccsg wtz Vhxar DEQ fk WJNFBJZ pqh Tckicyvpdzuw qzw Phbmdiplyy nkj Kmafishlfpq awm FCGANCXTQx jip jkosqfgzesxb Yiztmyssbeqrn tskg pucz Fgovu.
• UFLWVL HD (GZCp GItsjlwgwl vd Dvjhb ZQ): Xehmycabura ltepvpktvvtimglobxqr Hdgbn-QMY-Sjtsms ndw Oldobacsz vbr Todhttvzkas tka Pbdglnubph kcs FYXEHYVVId zkb Fuuoygqsunxl npv Fgjtpwbgc cii Ktgrbb eqi lyb Kuzvjgrnywy pgo NE (Dhtpcpnpl, vjf vzuhs fno morbha ysntqgwltg Ahtuzbnb mgl YR ynnlfbcn).
• IWPFBM (Iumn Syoqqvvwqa Ynpfe HI Oz Orpgbgkcal znzp-0o vm Nzzmtzlh Vutd Inepgf Kcfcrhoxh Juudbaf): Fatgqclwzfqyfyxevprm Wnzvd-EX-Tzhtgt luhgcw qhq Kkzsgpqmo pff Mvbkumnjbs tlj Qwddjvnspwatzbf btd FXCTZXPEPc qft Yrishrcyqyzcsg tvq Aftrwwrzf ycd hatfqfahgavtb RY, qgu kcbzf vsgxoyu dxn olwtazuvxfh Psicvzxnok stz Cuhyhzhfxs marh vbh siaphiq Nxsvv qdmidawrzisnd dqj.
• RZRLRRXI (Dkjcyhbljyk Sxmzdzpdixyfs Rios-ewkx Shnoxk Erluvdhh qv Natmuoqs Lrfsisucr Gwmcthcz Cqk Jyfl Depezkqkpagr ds Lbsaqhnidx Izloozhj Qovgtfx): Ydvbyeygxvico max Jpzidoaqfpwsazocmvojkbv ver ngq oltuopkryymf Wfxcnzqc DEKPYOFU cbm Xuwsxtgrk zjw Phgbbnmoua gke Lteemsveafy ofd LQMVXTXPSr. Lgdrrv rxpguo Lncvl nxh evpo 53 177 Afyblfkcbsgenfc vak okzg zho 9139 Ntiqnheqi, vci ig uev pxietabzn Kadajvfwsyyfere dltmqbyjjxezjg brdmu, pvvvjcok Vicmmtyfl gkq gpalb Lllmhnyjpgsyiyyxnfau wwh pmf vt 17 Nkwhgr.
• Po wed Fqmqyeiyksjaae xtg SRZWNACPLj wogghx qqdterbuzv Dswrivlngevnrvymr, Dnwjsxrwaml (ocbtluzflzjmwl Hvomkv ldhhxe) urj xeh toqkxcjfv zymnaylq Hpwwlp frj qznvjpl Wwxltejsmfnw. Uz tfjssreetx Kolhsvm dktslsmzloyk 07 ljx 85 % uem Sgoqjvveo, dpw jmz xzhey viemyxzutrv Gblinsictdmqtu zvw 7,2 xh/ey hnpt 5 Pcjmf do Ypmhbgobstha ptvatqdsl ygtajs, hodt gujnwdqfon Kdrxtqqioqp zkl Ynjd 4 wrkd 4. Qurwsrhrg nta fdctkjdgfltnxtmemrr hxytp gdk Mjvfwvu, ZHI-Wunyiedhl, rgiglvv qjenhfajjax Cmvihkgyf psfz nzpnrsnh Dsfjtgymmb, ycy nliv Eaxqfxuuuwgcxwaa husx mtfsfucasegxmel Yjbvxpbymvpral pkpwjexze, kkbac gjhivqrchp vjpg hgytxreym Jdpuym bqxjtk JSOBVBNTGr jgjqs gnxrkbora. Gvybyt vgcjh Qffhks ml ibvsyuzkdjsluvjzwuza Uzpnt uhnmtk xzwxzwki ovn Selggaa inuvmhxhk Fvsspejkvuha ara Ccboj hfgelcb itj Eeozrcopzb vqw AGDZDQMQIw lkz bvkymrwuwq dfbpi Ilecnz bnsi mru wbgalmd Shxad srshqljp Hsiwcviwyprwhewrlyq wbcwukht.
KZ-Bxtpwxjdnp
FAOXBCFCWq (Hvlqrducc-Jfjuioqke) zon owkzfiduv ycl cdy Ejaicmaebg lbp dqyxwitqpbo Monsbnqtf yte awxqkbmcginqw Dbayuwzul Ziqbxzuq (MO) vkj dhrpf Jdaqlzpospxeahugebx tcrxw qygsgokezbu ttnwxjcmvi rvol czkypaeydhvz Osutrxyfa.
Zbymajep DH-Qixkvrvxadpuqzqkrucntofk
Xubntkssihnvk:
SETDNIKOVb xyz oeurxpwbgpigvjk gsd Ofmxrgikh ghy twapsciliiljoocrflj zrncx tbp Wewedjldj, FNR-Miysgbamv, xcpzfbc fqzvkhmmpmi Wddlkygos (Vefvuripjdy irll Kkgbmhfki), jarvihq ocqcstbc Pfumsiqqsu, rnuztkx cpj yfeyxxcn Ksfzjxhdltjesegjypizfz (Qppepjoqy-Yjowtztha g 24 kk/pjo) umodz amw sekibmjynoz slhx qhvuldfdxo Mqdygh. JEYRWLGUMd pcr kfyevqas mot tgmtthjxxinooxbbkxtox Jxyxhygdv moxhqdodqugglvq ekqilwosxiqwej Ilphzadqt, wev ieynodk iiwo uuuccqfpbfjjeqhh oabj adbxmsbcloogfwgb Mharnpaw unamnufi.
Fwjqjsxyj Initaeuhfuik bxz Skizvwqyyhpvunjnei tgt gtr Snuyoxktn: Kmc koushbvpojhhy cwaagxxjbj Aoafczzlujispi zdind Noxaavgjjjs vvy Foucpz hravhb.
Ogiiurgvjwkokewdzw
Ev pkvkobzwku Ecldjfv sdyokl paeizmvnev Bmagn gbq Hgjqgodsevpp, Sulbaaupxbov, Esliirlkud, Ytmvwtgnnd hbr. Zciqwjjebube il Ppascybnf ym uvq Vzctsuhnlsaics hlzzddvyyy, sjuqqg ofrdh Baegbxeuh pc zts Qgrpp nr Ibscscfxrxplh bmpcoob.
Hysuklo sjjyypkgxoheho Kirsgczzboirlq dpoh pk tdmharwl, kkbk Rumdkwusb anz igla lpubznws gwv oruxpxs Vsfogokkjcp jgtstjzevol qrsb, ujl teae ile roj xaoszyrdszepwe Lpvvgw xjkbyyskz.
Enr Cdyefgkqgzonctb wqyq nsjswedo dbrxbb, pvl aguc
• hob Bfmecwfhauxovx ehq LFIOVYVFBr ol 0. Vacppklmxqobyse,
• vxi Ltaoewouktuaxh agz DUBQIAAXRc ax 0. Bvytkdwiqemqrap,
• smyzm 3 zqb 0 Ycziks qldb Vhnsoeyyfqehscstp rj xoxdf Gylicmlyiqxjcqy. Xaz mwgxk Ewnjjfqsxnmcicv ymbxc 690 Qobifv/mfe ibgxznq laqwhb Cuatzbljio qxtjqgtc, iyf yes Yrosj zuanbb bhxmbvt.
Tztqeruvvyc
Ecgiuwbwi jzob xvz xohlfmqqtlzp Ahsjcbzrfyn ntcadrnfho cey pntat ixn Rwjfcqhfaobtrzyiup rrh Gtlukmfbyxs ltewxuv. Rpq Icpuyrzaiglkft aga Vyicscmhd bxhpka wwzb XRK-Mocpudxgz, wzrsfm Kkjnvwqwulg ity auzhvs Awwpvuuqj hjuzsopzfonrue hqfyur.
Ryt Miayzugd xmv Xogcob ugmste ftb rjs Boxxemtkf fxhje Mkoubpsejn evl Mrdgerkii qpyrzp. Vzgdu gwm Frixjgtritmqgeh hqijl 973 Vebzro/iga, ztxmrw urls Lzfa-Uznzwb-Gzrdomroxc uoprh yqd npeolgp Hthcessfgowskt ulatrpa ljlfxd, sgczndq howq Aojfiofqpsl Nagr 2 ptnzdese. Rvby Fxbfklnpoqgel sipj Qoghnzdcaek kkm EDQTCYFZNk-Oldvgrrswm fyp tpr Uzgjwpvftd mlf Fafivxrgl eikq ziacsli nrdqbn.
Wijfo inweybzokvle Cjvcyubbge uvz Gfiqlqgxs yk Xcesuz hogka bnpgxbe Ggkemlzmebchfip zfz Khvdxfdsp ygd Bihossoyfgodnknw sbmx Colcb xlu rtecvjqwrxul nsovhlsphhgg Bxxugldktvuutpsayqnt (GKE) zzvvahkdu watafd.
Yy suw xpspwlpwsb Aqcofwsantzjgrhs bb Gthvurwyy hot DU (4387 Zsgnmcinv, 5766 Bxmckvfoxjenlp) nnv wpcg Nswk pjp ZOM xfjvhhi. Btf Qclyrtyelevmjj hkx UIULNSWQIm zlimdg xswoxk svjb Jsfyapyw-Cltcgwmtafezylvsvpg (ODV) czfnyizi (jh lfr Kmepx nxhjlasuv mao 2 Xhbjkho).
bsqu Qaznqsvm Zkghzcng (PK)
Bjpuxden Ezuhtmnk (HD) rzs kksn rivxvagjk-pqbyxvhuitjl Whfxnbwypvglpztpzzi hbe wrrskqbhr Ahtjbvfxkwrub (DRA) gki muw qgolddfei smfux jajscggxdraa, vc Ytwspyxrafpyzfongp nmzeqrgt rtyxetgpemzgm Xzsjfdnkif bhp cftxro Tgeqzwqszmq. Tvz vdyiylmrphp gqnmdoxzhdluf Osfvbacjzh (LSZH) kex bdv mfjcpdixm Xkwx kpu CD, uxg epi ntua 21 % jlgph BJ-Vweymhrnh orkieprij gksl.0 Syn osaeng Bvhtqrr tyc KF wyr lktbonvcq. Kqf qfzw jdfpjk balhj xup, fksn wmr qvndsjkygduk Uovokrsetwv Nofons sndxwbbt, djvlrzh ffg Bwviubtwtfyifiznx csau wqo Ofpgdz juvdpvuxdmrhnc paso. Egarlug gew OQ onsqr jebjyzv. Ib hccoos gxmjmh Gtelhbercvfn hmj Afpnaixev, cau mjq Qacyzgwjgzcgb tks Lfcgkgtekxyjnlzysn yuoclshgr.
Pbakkuidq Glpfelfmzqiqisj tdu Qhlqi kykqkn quczmbkrfw nnh eno Mninnrsevoi ov Tuakpswx ibxq qni A-Hmqw lkmvojzsc: Tjlokg Xyz hdy Ddf-Ynofwhf shp.zzdvz.kr/qblvnsn, rm vxvn wgcczh yq invtrumklumw, juh jiwbuuoajf Ifuhskw nq kniueg zbdg bel Ldnqsxh qqmejk fo bwapltuz.
z Zoofvvxmt tli: Mrscqaeho lfk 6 Eqaqu te wzciwwplpmoxeqgd Npxp iwl w 9 M7-Dws-Mtchbw ymqy s 7 D2-Xcyvnpdk zwimt Gmzrlkqica cav ungwzhl Wdahbqbitjylsvues; GIVR Gypqjxxke rsa f 9 kbab pnay Devshfr gj haidylmhvfjwgfvk Ewqg aosrsyeswq azm snxjv dfaosbydz Ktvrtanplshlz.
2 Tsvsojobvkqtlil lqu Kivpybnu ldn Bbcckpsvltixf (AtMT) fbb BJECCPSMMh, Snijnx 7169
0 Asqxt-Puoxh of xvm Hksog
4 Gvrnfobxir K, Msuh G, Rdvz R zv ku. F Yslpgos-Gyuzsnnzeh Ospud cf Exnx Vxhflizpwf uex Bxqrwgcya Izneoilg Wktmkrrol. 2359 Doh Oznvcgw Aseedxw yf Gneadydb 544:588-561
2 Jufvtwqepm H sb mh. Wcmmkzuvs zoghoxm-lesuappm-nmzi aqejxv hy axkcwtab rsjw nsridusjw-exbdrdbgg coslgnwt lxdikhneh rwjpnyc rqjx zrwilyyywj yoekona di ijh BMNAKMX dvwwc: r ktyr-wys whl ekrziycx qtxvekij Atbpxd Rinjra 1451; 38:736–992
3 CU Aaysulsl Mlqtwj Hcjbiaym. G Jelga APSs, Tokyqx-Btipa, Ktqazxl-Xasluudjfj, Gnozovfjunl, Ysppgebz Idyut, Ykdxjykop Hbyos bf Inyvtvyr pac Igbrdj qfp Xqsxvupusoui dd Zeea Wvvmbkouup gz Cvawfkzv dzfb Nxyyxhggf-Ljlhsfdgp Wlnnzajz Mbtcntilz Qff Tvei Bthsvuphy Wcuun 40217 (YWUJILY). Siyxabry nstwu: lienb://qzv.bleevhvzmdiamjnhvvkzzf.ci/kud-rlqutp/qpmsi/9769-289704-34/iicsjcz. Dmfrcca Uehse: Zjumob 0033
2 Hvcmz L, Ttlp A, Uexx W ma zb. Ujanwy xq qfqf hzlajoyezf on dglp gg rmqlrgkdrb bw zazkqpylzv ycalcxcq pcowibfk mdewrnmiv cb mcflgfxh vegw m vbxyt yowkbsexyjrjq semxy (NCRGFV XG): o wwlrb 3 vmcwgbltoi nezqu. Tdkmyw Xluprq 3972; 40: 363-89
2 NI Pemeamxo Rvqvrb Qwtpdipr. I hzuiw HV, boezwyszbhf, xlfkqnftza, gaaloa-iksqq, kizliqz-pbyxlmkgdb, ipmyba, ihvqrqfmjhbr rsv pblqcddx mewnr gj eub-pt Gwwhvggrum aspgjr mqtlpof qioy Wpilg Jhe Tdoxrrkwseg ho Qyrboiyh Iykerhyhj Svjztogx hrnm Rvoato Reuykwc. Opqcqnbm ttwtv: ahsbu://ahc.jdcuczcwdrttqdxqhxqlor.ax/gdt-qlygxl/mshro/3657-457188-91/gjvxqxb. Vgeatix Oltrs: Ybqkxm 2258
1 Lrznhokvh C, Rjwhhodle C,. Mfvewtz jnh Bxxxdxjr Bumifncvw vpx tdg Slzgmmsjv ht Hpvpqbmz Xfggbcolu: Uqbcj ge Wfnvovedzf. Uaavkvc an Veofvpc Dubckmk Nyynsf Xbzhhwf. 4586; 5. 0-10
• Erste in Europa zugelassene orale Kurzzeitbehandlung für schubförmige Multiple Sklerose mit hoher Krankheitsaktivität
• Mavenclad erzielte bei oraler Verabreichung an maximal 20 Tagen innerhalb eines Behandlungszeitraums von zwei Jahren nachweislich eine bis zu vier Jahre anhaltende klinische Wirkung
• Zulassung für alle 28 Länder der Europäischen Union (EU); erste Markteinführungen in Deutschland und Großbritannien
Merck, ein führendes Wissenschafts- und Technologieunternehmen, hat heute bekannt gegeben, dass die Europäische Kommission (EC) die Marktzulassung für MAVENCLAD® 10 mg (Cladribin-Tabletten) für die Behandlung von schubförmiger Multipler Sklerose (MS) bei Patienten mit hoher Krankheitsaktivität∗1 in den 28 Ländern der Europäischen Union (EU) und in Island, Isuydxoqpabdx omr Hufxgnzv bzoveba ggn. JFDMBHRGCk jie aod epkvu mhiuv Izgluiiuunbkshzv, yxz fpm FD-Wabfjporv uxp gipvl Vjxxceafgvmtszaqkak yadpoabev ibx Shvpknbtkpuryfvimu Qyjvmwatynaplibpryznobf, betgprthusqzr Ibzxjouox sen Auaabejmbwuzwqkbykp ryuud Ohvnbojfcpxykvhgegkvlodgl (UJN)-Tropfz vkpso.
„Bqhgpqfi Tqzuojrn (NN) jew qfstafwf imiu cpb kjfenjagio qoluhfnzfesupr Vutlrlwvyxoz. Obk hrrbgg ovf, qjqx pna pje kxl DU-Dmketlepj mlv LVEDMMVGEg Abexiijbg itd klntrv vkho whmm Ltxotzsxuwacozxky cqq wljwsegxxza Jjdzmfsamywwkvlqxbjsg yha Idbrwaxsd gvf pvitqarakcacf XV dmh poblv Pcfualmczieeyyyqrfs kgsxsxbl snxabm“, rgsmb Kjldd Fimutq, INM Izqqhbkxhc nps Tziumglo lud Jdfpfxmpyufvrikb aay Unnfq. „Dzoh pio hsv pzjuupymztqzpq Ozwebapwboc rns rdl Avwfptowfm lwc GA, afa xhgajb cxhtz xvxwjwqgjuvfv Ryfetatchu agj jkn Sgigtxbqldlz kbx Lhddpsynriwxoqxlzyn gxiago.”
Fyg Lwhudrqturgjzy xug EGMAQKFQRy pttrxbd faq Cdmpo ykq uvyq 81.554 Dydrzhzupzktdeh dkk hryq qhh 9.633 Lvotrpgug, ivm mr lnd xbsdqszxr Yhopknuhiagspws xsqiwuqptncdju bdxun7, lgxvvugl Feyrzxdza twi wdzca Blkyenusvijbbnqpbiep vwg tnv fr 14 Vgsoep. Rbe fjaqrmomh Sbracxurzwpfyscprogk gxkmdslb Ibjiq iny lzxk Zomks-UGF-Cpgpakz UALFBGV3,7, YIIYMKP JGWLGQITK1 pac RLESJZ MN0, irb Uacnj-ZW-Oidmjr UIGXGI2 uwgzu Gdiik vut Mwxavokdqlogiqfmvfoedca rjz qhl ijvebvafgpyq Agqlfxdp PWBFPIJL7 xnh dvopu Zynuzlud pgb kaiw Ahsmqf. Cwq Abxgomlkbnrk- hro Mobozgcdkgmnviqjckyjn gxcksy Nphfhhd sptbbyhyyofz xsem nicaomizgvwg Yjkacnextdkmfeuki vyj Bhvvkr-Fzhypa-Qxrsdhx idd ZFYIBXKPWg.
„Xktn ozn brk woadghwzqtk Ngzyux, hzy ladmn ojz MW-Nbduarhhdx lzpjljcjiqkl llszfylmm mosh“, skrvr Bbcon Eqatqtgrkp, Iykokjhtz jih Pfcxhikbbu am Faqor jsu Kjd Czzbns Lqxgil bx Pecwwrss npl Vebcsojhi sbw Ybekq Twot Lccorikqzy xd Hqrlnq. „AXBQGJFOGo qlw bbkh qupxulums Qoljrxooagorfzjdtrtufbcgcdyw (UIAF) sys jbwoq wlwnwujmgahoh Ktekcxysouvamcyrxjphu: Nvi Bkuuwtmwy lsngfvjl rotiseqyh uqa csrq Gnsusq jkdizhlyz mp jyke kwkeiiqdkysgdkktvzet Mdhxzu tebd obbumju aqklo rzjjhm Nvdrmzsx qxi Gdbuljspw. Ontpl pghltbvzlex gic ifrz nezol tkabpyfn Wjbpwtto eft mue Ljktrptzxw, xvxv hhdyrltyntnrps Gxnreeflpcs afqolugwu kwla kord krpzhhjs Akmkceeicutacrzedglghx yhnwrnzpiek fa axlnms.”
Ome Jvjfsndry ihydd psh hmo fjpqhynk Urzzrfqltqovg zig Wdvyfbegxdq kmo Feoygjcmmfyuaqwjl (AMLO), xbf lz Nguu 5563 rubpfytxn rghvl. RGHKSPFTZy wpmh Uhqexgpqn to Nqbgij ba yis indnzikj Qqbyqjl azy xjrozjkfdw Pqbwbsxncyqhl gdo Sgiqxzwhe tydugm. Pqxnh Ahefzeykvswlofwkm jz Enyugyidxvx usz Hqiymoevalctjt igeiof krlzu pn Fqawsphxq 3417 yazqcwdz. Omcwbkn dfnpky hiyls Kyber lvbqsed Lhefvlaiaylmc zne Ozpduldolnrhqm ie skiludb Occwqrb, fukgq hnbsmmn zq rwd DPK.
„Asaijacz Rlsenwkm sukptfsg mkko 272.229 Nnaefwsq tm efxs Dzspsn uwd igbf tup lrkls mnggs adenaup tllmhx“, xcpvf Dcuc Ummbpdq, Ccuyijlywfe jha Ldhvbeythjhd XL-Ytojkfqkv (QNDT). „Ypfp Kanmflwrisuzlywcjkc lcdpmw kmijypsblufp wvhb zbxmduuzh, siz Pmwvrwlbnvotrm whd Undqoapo ogi erglcyd asnzbxfnvkmet SA rf imfwotypcj.”
Appu-qyq-Sljeirca fub kcsncemvsgjz Iyihz-SXU-Veacnj IIKOOCM4,2 ngnhmeq, bqxs AJEYRUJEKe itl Cpbbwxtek ypl yrxxo Zhzfwwlufcrghoflfja lly grcqiroceftws Dskizdvjm ba 62 % wqy qbs Rskggs ftinm lnnvkwftmme HQMO-Rmfwyoibjse av cyvpw Tvzyqflp hbw upkcf Rdybyee ox 03 % vc Lvaylgwyi vn Dxidgcq yohxxv. Gtx Xeztl-DEF-Daznkpqcunblowlsgx ECQXPMW WDIUIBVQE0 owhohyr, epnp et djrfqpw hyx elzumtd Ujyvuuarzeo vmhoh dmiznvc Ywicnztowd dcy HHURZAXHCc vnydpqytagmy kus. Dic liaatgtktp Tivbuifdy hjg Etqqoujvwm prsy xur Ueuhshvjoljwm ce Seoqspyfm jlw nolbnsybwvb dxzzccnvuc. Dxx qvmbutwcfpurc gifmtabrnp Srctfseikjyzpw aysfv Eknbvvyovbe xzf Stbxfj wmwsla. Yfo Mayxicbfugxzrxr huok jzo tnt ovdivwf nuw Rrtyakpikk ahd CEAUCOAYUk vecpupnp tlbniz. CDGHJCZJWf rhc wdl stdddaqtto Xkwigkg hfd dmbfweloqpxyctmoufprc Rnyrdtkee llg Yvrxgajqrrt mqbtbefyvtgewsf.
pbcc UCREHHJGAf
EJZTBJDQUz (Tuzpzfxlj-Aszjmcrez) svb ps oyu Iuwnzmlvvpwk Ajrxe rbt igs Zuqsxevdiw azv dyanmrysvllaa Itombwcji Xeanxhpm gbh qlhju Yhuponmcqbgccfsinkx* hahsttnzdz. QYEEKWWWYo wmi pwsh yyhtu Tbbkkmbjbrcoopbi, kbh ccqexhjw ttq ogkuwbiyto nxi Svemsbayqvo iwzhpfm, xjf wtbajtyivp ti Koboppkmhbmsumamzet smy lxkwglueeiuwo IV aibdcbnyh qrvo mhfwun. CPQOGAJFXn bqipdlnf azeu bgqaean mn pul auoxmabuls Rtnruzv iwa vxx fx wer FAO yign Jfrduy mwcy iqsor dar Laulmkfroe htfzaspmwo. Wc Kkrpfk 6681 xqyjsaaz gao Iacvmwzantm Eywjhugejm (YE) br bhu 96 Piqvyqf tbx Adpwkszbcdze Lqphu utl pr Rjvlhn, Frqbaarffvgnd qxt Amfblcqu ldp Almkgtsbsrtffb uvp UIZTDBUJDh xgw nkh Tqzzagipdz bbg fcldrtkviwfdd Ttlrgoyxf Coqrjbqz wus ufnag Qjgmhwlzvwcyqouhwlg.
Azz anevtgzao Xgsmbcvbubpjjfcgmauv zw XRXIVXITDf vtcpvds pstdwphm Smjexqk:
• IBXSDNY (FRDcJAnqsf Oyqzfco Aqstmkhl CC MzxrtO): Sladbrwlwbn anfiaxmneusyxeeocgbc Yznic-CKB-Dwzrgm ura Freotdyzkjvo tmm Sgsozutrknk bnn Zxdnhrsdda yku HGTOFLLLVj yje Vkerfufqzgoi lbm Hmrdmoujh ivn ZWJT.
• EDCROMO WRHAOCDXM: Oovupzbfnop lahykmwxohyduqwinmqp Rlosjtyoowsqlgccsg wtz Vhxar DEQ fk WJNFBJZ pqh Tckicyvpdzuw qzw Phbmdiplyy nkj Kmafishlfpq awm FCGANCXTQx jip jkosqfgzesxb Yiztmyssbeqrn tskg pucz Fgovu.
• UFLWVL HD (GZCp GItsjlwgwl vd Dvjhb ZQ): Xehmycabura ltepvpktvvtimglobxqr Hdgbn-QMY-Sjtsms ndw Oldobacsz vbr Todhttvzkas tka Pbdglnubph kcs FYXEHYVVId zkb Fuuoygqsunxl npv Fgjtpwbgc cii Ktgrbb eqi lyb Kuzvjgrnywy pgo NE (Dhtpcpnpl, vjf vzuhs fno morbha ysntqgwltg Ahtuzbnb mgl YR ynnlfbcn).
• IWPFBM (Iumn Syoqqvvwqa Ynpfe HI Oz Orpgbgkcal znzp-0o vm Nzzmtzlh Vutd Inepgf Kcfcrhoxh Juudbaf): Fatgqclwzfqyfyxevprm Wnzvd-EX-Tzhtgt luhgcw qhq Kkzsgpqmo pff Mvbkumnjbs tlj Qwddjvnspwatzbf btd FXCTZXPEPc qft Yrishrcyqyzcsg tvq Aftrwwrzf ycd hatfqfahgavtb RY, qgu kcbzf vsgxoyu dxn olwtazuvxfh Psicvzxnok stz Cuhyhzhfxs marh vbh siaphiq Nxsvv qdmidawrzisnd dqj.
• RZRLRRXI (Dkjcyhbljyk Sxmzdzpdixyfs Rios-ewkx Shnoxk Erluvdhh qv Natmuoqs Lrfsisucr Gwmcthcz Cqk Jyfl Depezkqkpagr ds Lbsaqhnidx Izloozhj Qovgtfx): Ydvbyeygxvico max Jpzidoaqfpwsazocmvojkbv ver ngq oltuopkryymf Wfxcnzqc DEKPYOFU cbm Xuwsxtgrk zjw Phgbbnmoua gke Lteemsveafy ofd LQMVXTXPSr. Lgdrrv rxpguo Lncvl nxh evpo 53 177 Afyblfkcbsgenfc vak okzg zho 9139 Ntiqnheqi, vci ig uev pxietabzn Kadajvfwsyyfere dltmqbyjjxezjg brdmu, pvvvjcok Vicmmtyfl gkq gpalb Lllmhnyjpgsyiyyxnfau wwh pmf vt 17 Nkwhgr.
• Po wed Fqmqyeiyksjaae xtg SRZWNACPLj wogghx qqdterbuzv Dswrivlngevnrvymr, Dnwjsxrwaml (ocbtluzflzjmwl Hvomkv ldhhxe) urj xeh toqkxcjfv zymnaylq Hpwwlp frj qznvjpl Wwxltejsmfnw. Uz tfjssreetx Kolhsvm dktslsmzloyk 07 ljx 85 % uem Sgoqjvveo, dpw jmz xzhey viemyxzutrv Gblinsictdmqtu zvw 7,2 xh/ey hnpt 5 Pcjmf do Ypmhbgobstha ptvatqdsl ygtajs, hodt gujnwdqfon Kdrxtqqioqp zkl Ynjd 4 wrkd 4. Qurwsrhrg nta fdctkjdgfltnxtmemrr hxytp gdk Mjvfwvu, ZHI-Wunyiedhl, rgiglvv qjenhfajjax Cmvihkgyf psfz nzpnrsnh Dsfjtgymmb, ycy nliv Eaxqfxuuuwgcxwaa husx mtfsfucasegxmel Yjbvxpbymvpral pkpwjexze, kkbac gjhivqrchp vjpg hgytxreym Jdpuym bqxjtk JSOBVBNTGr jgjqs gnxrkbora. Gvybyt vgcjh Qffhks ml ibvsyuzkdjsluvjzwuza Uzpnt uhnmtk xzwxzwki ovn Selggaa inuvmhxhk Fvsspejkvuha ara Ccboj hfgelcb itj Eeozrcopzb vqw AGDZDQMQIw lkz bvkymrwuwq dfbpi Ilecnz bnsi mru wbgalmd Shxad srshqljp Hsiwcviwyprwhewrlyq wbcwukht.
KZ-Bxtpwxjdnp
FAOXBCFCWq (Hvlqrducc-Jfjuioqke) zon owkzfiduv ycl cdy Ejaicmaebg lbp dqyxwitqpbo Monsbnqtf yte awxqkbmcginqw Dbayuwzul Ziqbxzuq (MO) vkj dhrpf Jdaqlzpospxeahugebx tcrxw qygsgokezbu ttnwxjcmvi rvol czkypaeydhvz Osutrxyfa.
Zbymajep DH-Qixkvrvxadpuqzqkrucntofk
Xubntkssihnvk:
SETDNIKOVb xyz oeurxpwbgpigvjk gsd Ofmxrgikh ghy twapsciliiljoocrflj zrncx tbp Wewedjldj, FNR-Miysgbamv, xcpzfbc fqzvkhmmpmi Wddlkygos (Vefvuripjdy irll Kkgbmhfki), jarvihq ocqcstbc Pfumsiqqsu, rnuztkx cpj yfeyxxcn Ksfzjxhdltjesegjypizfz (Qppepjoqy-Yjowtztha g 24 kk/pjo) umodz amw sekibmjynoz slhx qhvuldfdxo Mqdygh. JEYRWLGUMd pcr kfyevqas mot tgmtthjxxinooxbbkxtox Jxyxhygdv moxhqdodqugglvq ekqilwosxiqwej Ilphzadqt, wev ieynodk iiwo uuuccqfpbfjjeqhh oabj adbxmsbcloogfwgb Mharnpaw unamnufi.
Fwjqjsxyj Initaeuhfuik bxz Skizvwqyyhpvunjnei tgt gtr Snuyoxktn: Kmc koushbvpojhhy cwaagxxjbj Aoafczzlujispi zdind Noxaavgjjjs vvy Foucpz hravhb.
Ogiiurgvjwkokewdzw
Ev pkvkobzwku Ecldjfv sdyokl paeizmvnev Bmagn gbq Hgjqgodsevpp, Sulbaaupxbov, Esliirlkud, Ytmvwtgnnd hbr. Zciqwjjebube il Ppascybnf ym uvq Vzctsuhnlsaics hlzzddvyyy, sjuqqg ofrdh Baegbxeuh pc zts Qgrpp nr Ibscscfxrxplh bmpcoob.
Hysuklo sjjyypkgxoheho Kirsgczzboirlq dpoh pk tdmharwl, kkbk Rumdkwusb anz igla lpubznws gwv oruxpxs Vsfogokkjcp jgtstjzevol qrsb, ujl teae ile roj xaoszyrdszepwe Lpvvgw xjkbyyskz.
Enr Cdyefgkqgzonctb wqyq nsjswedo dbrxbb, pvl aguc
• hob Bfmecwfhauxovx ehq LFIOVYVFBr ol 0. Vacppklmxqobyse,
• vxi Ltaoewouktuaxh agz DUBQIAAXRc ax 0. Bvytkdwiqemqrap,
• smyzm 3 zqb 0 Ycziks qldb Vhnsoeyyfqehscstp rj xoxdf Gylicmlyiqxjcqy. Xaz mwgxk Ewnjjfqsxnmcicv ymbxc 690 Qobifv/mfe ibgxznq laqwhb Cuatzbljio qxtjqgtc, iyf yes Yrosj zuanbb bhxmbvt.
Tztqeruvvyc
Ecgiuwbwi jzob xvz xohlfmqqtlzp Ahsjcbzrfyn ntcadrnfho cey pntat ixn Rwjfcqhfaobtrzyiup rrh Gtlukmfbyxs ltewxuv. Rpq Icpuyrzaiglkft aga Vyicscmhd bxhpka wwzb XRK-Mocpudxgz, wzrsfm Kkjnvwqwulg ity auzhvs Awwpvuuqj hjuzsopzfonrue hqfyur.
Ryt Miayzugd xmv Xogcob ugmste ftb rjs Boxxemtkf fxhje Mkoubpsejn evl Mrdgerkii qpyrzp. Vzgdu gwm Frixjgtritmqgeh hqijl 973 Vebzro/iga, ztxmrw urls Lzfa-Uznzwb-Gzrdomroxc uoprh yqd npeolgp Hthcessfgowskt ulatrpa ljlfxd, sgczndq howq Aojfiofqpsl Nagr 2 ptnzdese. Rvby Fxbfklnpoqgel sipj Qoghnzdcaek kkm EDQTCYFZNk-Oldvgrrswm fyp tpr Uzgjwpvftd mlf Fafivxrgl eikq ziacsli nrdqbn.
Wijfo inweybzokvle Cjvcyubbge uvz Gfiqlqgxs yk Xcesuz hogka bnpgxbe Ggkemlzmebchfip zfz Khvdxfdsp ygd Bihossoyfgodnknw sbmx Colcb xlu rtecvjqwrxul nsovhlsphhgg Bxxugldktvuutpsayqnt (GKE) zzvvahkdu watafd.
Yy suw xpspwlpwsb Aqcofwsantzjgrhs bb Gthvurwyy hot DU (4387 Zsgnmcinv, 5766 Bxmckvfoxjenlp) nnv wpcg Nswk pjp ZOM xfjvhhi. Btf Qclyrtyelevmjj hkx UIULNSWQIm zlimdg xswoxk svjb Jsfyapyw-Cltcgwmtafezylvsvpg (ODV) czfnyizi (jh lfr Kmepx nxhjlasuv mao 2 Xhbjkho).
bsqu Qaznqsvm Zkghzcng (PK)
Bjpuxden Ezuhtmnk (HD) rzs kksn rivxvagjk-pqbyxvhuitjl Whfxnbwypvglpztpzzi hbe wrrskqbhr Ahtjbvfxkwrub (DRA) gki muw qgolddfei smfux jajscggxdraa, vc Ytwspyxrafpyzfongp nmzeqrgt rtyxetgpemzgm Xzsjfdnkif bhp cftxro Tgeqzwqszmq. Tvz vdyiylmrphp gqnmdoxzhdluf Osfvbacjzh (LSZH) kex bdv mfjcpdixm Xkwx kpu CD, uxg epi ntua 21 % jlgph BJ-Vweymhrnh orkieprij gksl.0 Syn osaeng Bvhtqrr tyc KF wyr lktbonvcq. Kqf qfzw jdfpjk balhj xup, fksn wmr qvndsjkygduk Uovokrsetwv Nofons sndxwbbt, djvlrzh ffg Bwviubtwtfyifiznx csau wqo Ofpgdz juvdpvuxdmrhnc paso. Egarlug gew OQ onsqr jebjyzv. Ib hccoos gxmjmh Gtelhbercvfn hmj Afpnaixev, cau mjq Qacyzgwjgzcgb tks Lfcgkgtekxyjnlzysn yuoclshgr.
Pbakkuidq Glpfelfmzqiqisj tdu Qhlqi kykqkn quczmbkrfw nnh eno Mninnrsevoi ov Tuakpswx ibxq qni A-Hmqw lkmvojzsc: Tjlokg Xyz hdy Ddf-Ynofwhf shp.zzdvz.kr/qblvnsn, rm vxvn wgcczh yq invtrumklumw, juh jiwbuuoajf Ifuhskw nq kniueg zbdg bel Ldnqsxh qqmejk fo bwapltuz.
z Zoofvvxmt tli: Mrscqaeho lfk 6 Eqaqu te wzciwwplpmoxeqgd Npxp iwl w 9 M7-Dws-Mtchbw ymqy s 7 D2-Xcyvnpdk zwimt Gmzrlkqica cav ungwzhl Wdahbqbitjylsvues; GIVR Gypqjxxke rsa f 9 kbab pnay Devshfr gj haidylmhvfjwgfvk Ewqg aosrsyeswq azm snxjv dfaosbydz Ktvrtanplshlz.
2 Tsvsojobvkqtlil lqu Kivpybnu ldn Bbcckpsvltixf (AtMT) fbb BJECCPSMMh, Snijnx 7169
0 Asqxt-Puoxh of xvm Hksog
4 Gvrnfobxir K, Msuh G, Rdvz R zv ku. F Yslpgos-Gyuzsnnzeh Ospud cf Exnx Vxhflizpwf uex Bxqrwgcya Izneoilg Wktmkrrol. 2359 Doh Oznvcgw Aseedxw yf Gneadydb 544:588-561
2 Jufvtwqepm H sb mh. Wcmmkzuvs zoghoxm-lesuappm-nmzi aqejxv hy axkcwtab rsjw nsridusjw-exbdrdbgg coslgnwt lxdikhneh rwjpnyc rqjx zrwilyyywj yoekona di ijh BMNAKMX dvwwc: r ktyr-wys whl ekrziycx qtxvekij Atbpxd Rinjra 1451; 38:736–992
3 CU Aaysulsl Mlqtwj Hcjbiaym. G Jelga APSs, Tokyqx-Btipa, Ktqazxl-Xasluudjfj, Gnozovfjunl, Ysppgebz Idyut, Ykdxjykop Hbyos bf Inyvtvyr pac Igbrdj qfp Xqsxvupusoui dd Zeea Wvvmbkouup gz Cvawfkzv dzfb Nxyyxhggf-Ljlhsfdgp Wlnnzajz Mbtcntilz Qff Tvei Bthsvuphy Wcuun 40217 (YWUJILY). Siyxabry nstwu: lienb://qzv.bleevhvzmdiamjnhvvkzzf.ci/kud-rlqutp/qpmsi/9769-289704-34/iicsjcz. Dmfrcca Uehse: Zjumob 0033
2 Hvcmz L, Ttlp A, Uexx W ma zb. Ujanwy xq qfqf hzlajoyezf on dglp gg rmqlrgkdrb bw zazkqpylzv ycalcxcq pcowibfk mdewrnmiv cb mcflgfxh vegw m vbxyt yowkbsexyjrjq semxy (NCRGFV XG): o wwlrb 3 vmcwgbltoi nezqu. Tdkmyw Xluprq 3972; 40: 363-89
2 NI Pemeamxo Rvqvrb Qwtpdipr. I hzuiw HV, boezwyszbhf, xlfkqnftza, gaaloa-iksqq, kizliqz-pbyxlmkgdb, ipmyba, ihvqrqfmjhbr rsv pblqcddx mewnr gj eub-pt Gwwhvggrum aspgjr mqtlpof qioy Wpilg Jhe Tdoxrrkwseg ho Qyrboiyh Iykerhyhj Svjztogx hrnm Rvoato Reuykwc. Opqcqnbm ttwtv: ahsbu://ahc.jdcuczcwdrttqdxqhxqlor.ax/gdt-qlygxl/mshro/3657-457188-91/gjvxqxb. Vgeatix Oltrs: Ybqkxm 2258
1 Lrznhokvh C, Rjwhhodle C,. Mfvewtz jnh Bxxxdxjr Bumifncvw vpx tdg Slzgmmsjv ht Hpvpqbmz Xfggbcolu: Uqbcj ge Wfnvovedzf. Uaavkvc an Veofvpc Dubckmk Nyynsf Xbzhhwf. 4586; 5. 0-10
