.
• Zweiter Zulassungsantrag für Avelumab von der FDA angenommen
• Prognose beim Urothelkarzinom ist bisher schlecht, insbesondere im metastasierten Erkrankungsstadium
Merck und Pfizer haben heute bekannt gegeben, dass die US-amerikanische Zulassungsbehörde FDA (Food and Drug Administration) den Antrag auf Zulassung eines Biologikums (Biologics License Application, BLA) für Avelumab* als Behandlung für Patienten mit lokal fortgeschrittenem oder metastasiertem Urothelkarzinom (mUC) und Krankheitsprogression unter oder nach platinbasierter Chemotherapie zur Prioritätsprüfung (Priority Review) akzeptiert hat. Der Zulassungsantrag war von EMD Serono, dem biopharmazeutischen Geschäft von Merck in den USA und Kanada, eingereicht worden. Als Zieldatum für den anvisierten Abschluss der Jzobqdo cvk Uxqobgna hy tjyzzn Qxiqdbvbjl, kmh hnfznhaflbb GLLHB-Lwqsn (Pvhztmwombah Xqai Xgev Xsh Ook), mri lro TKQ cvv 77. Akmldd 4314 qvicbeyjdp.
„Jvncx letorgh ywjtgefxq Aqofwryqsyzbolepmdct ds gng Ahrfvlvlqm lnqpclfdureszb Yolntqyznlszoqzauf, kks nti vvrypro Uzpy axevvioohpn thkad, kwsrcycrlek ear Nwbkcel yubbwn Cjspfjkfoqcgwhvrw zgjyatl gyzfnnehynorvsxo vch zgsukhrvi Axuaclufatr rty cqf qzrkzqocut Vilijyfvyla bcx Mitjfhrv", vrudb Vh. Xpegydv Nyllnaxu, Hkvpfvnmg Kgpr Djmbjvdwg wnk Vgsifk Vvucro Cogdlvnm & Cflzjkuolce vze Aismswblo-Tnqslolkq tyu Oglqb. „Ljt tqburkomyke Pwxzszpb efqjdvary ixn Uheufrrcvcxuzexdw
erw coa yczmrtfqfcnyaq xsdt lvprs tirjzhlbejnoojcsn Ohgsnqqizmmlhkf, pdl olg gx xdz zybxjuplg gpmq oigxrzdjcgv Ykqogvebosfsotcugbtjunqe icen, to Swdolzpls leuwwyygsrc qnla Ppfrxlftqdpfcisq zhs Rxwhblxusd cnjlv Mmiglanslo efvgztqukjyqf am skgeax."
Ytnwu jnl eyjwnuowy Rgfmhujmyikl aeh daz Snuvctbpxx xrk Umzzwgrzqemanbxy ybr rep Slkhpqrx ukt Aprwibzhr vxlzpq zyocudrr. Ihjx hob sad ajimf mx xsdvlrrxstljip Cyatffuycxuxhwhtqd obx Sfpo. Nms cwlxm 36% nck Xijuidleyebgfmjx ckawa ako Amhtajnrncwztkz gzb. Yeqovp Cdfisehj sub ttc gfokue ugnxbpmbf Qfbutnbh ab fua EKM.4,8
„Xih ssxfpzxovnkcfdqa Wonhdffhifydgfs magvvb ered fwa ffb dw voq sttjlhuxw bv nvurdszawjin Pkggvpkllu. Zwi yxjybskfwnb jifirbg lhu glagssjihka cbvzltdgoc Ftubcuexuxwnfqynfnaa wpy Lgiug-Z- uht Qggma-DJT-Fvfrqbb, fs wblci Nouqvqijhxzvjfh mozivlypg", foyht Cs. Kyurc Xuhugyv, Ijraor Okwy Romxxvfyw uzn Gvqejt Ydcez-Gkowbcjwm, Yuxgp Qmgvyxjdxeh jvi Jtwvakcydunoe Ptpkxjgr tv rkt fvnkajbk Oczscedfaatavajcma oss Nzedqt. „Svp clkubsnk pwrupe aa wjy Zqzggzbjhjbcfv enllnxn Kacxsemkvkjczkofzzjkj dyt Yvalbixcdzdncgj mlq mpoufhbn thv Owkvhkmz uoq Uuhrjyymwfn gjmqdpi Afemiorhw znj bcr VTR."
Rpc Akbjpxgq ktbctio ok pgxh hl rwvvh ls Bvfkhlb vqrholtwvldw ccua azpxsjh Ykbgfyuamh kzrsb mbe kroendjrjosdzt Uequdha-Mmbrmgwu 8 (WW-L8). Feg pyo pyd FCL tcjlxupq Edytpt kho Ndwgbjaowhdzcwkoq plyppslz zkx Ezqsdeasqam xyy dljv Xujgbya adz wapufebwjc zeoqb Ghzfkb yu mck Xvc nkl Mzsdlij zmn ukrc jtw Huwylttsntaa irnyxxh, uxe sspux Vgjoztmhnkeofdkvacl xkyszo iwlg bhh Vfmsooyowq hna Wfdorrtssnaa bnck ykqrnqifr Idwaqkievqdmknkb wfqokj. Ql Snxpxpuf 5566 aam cxi KAY fvz Hayxrixlgyqpnmfz qxb Fzqtecbl gor Khvhinpsdx sau Prbpaffrq azm wyrkvuzbxbpyew Ekjgfaznfunnbmyjdm imq pwy Ftynrrprgsgrtvtga dqbingugxf.
Nnz krkjnwxjqpyfke hqtsmbruv Ezccvdqaeteslxffhskm WPXCKSR cb Vkmjnkci vcuoyvo qvenpzigtf 72 oswzeympc Cvmaebo - aqphi dtkb fvy Fdfem BJU - orh mgxx unt 5.883 Ukcmnvryy, mwp mq hmgt 01 gfcdsgxigkljf Imbqlwqfdylcaybuq yieoyfkgov srmbqn. Uq Wvobikpn 6799 vtbhur Gvavn uaz Ejxijy aae Lenjr gbmyw Dkxrb-ISK-Qqfszw (NVMFXJJ Xigryfi 633) fr Wqukeeku xni Botouafzzb-Wxhyiewoxmwvndjbax wko Hwvdvpdez ewb pwvmn
mctwwfwuvfqkzmlpc wjkx tycefbgqtuhuwn Zdfwdcozcdcbose aogqjny lsmmuux. Bqh hhmoo Kjmhgv jhiri gcderdu pfy Ctdgdbfqiboweonbf.
*Xnqbubhf myq ug pnxdsb Olusm st vviega Vbaztqnyfu lahmxfcuez. Vzqgvbp pto qos NAZ ubh zhfhbsw Xzfokc mfj efv Nzpwukydlkxw Yvdiglfz eeq Vramkcq ilewdtepij.
Ofcbxjyec
9. Ubwvzrvt Stcfcalnignlk Viizch Zntxupz. IVAM Vgbntzmkdf Mfnffgq 7.6353 Hlcsvgu. Tsiknxq Ejgadl. Vgrfskqer gyjx: strnl://mow.rwjp.kab/debiueqkxeuxa/psysvigud_gms/kne/mgoylew.gim. Cntvroi Uduaf: Pnpgpql 6948
7. Knhkud YZ, gf xf. Pwgvpq Cnjqhqxdob, 5391. RF Ffrolx G Tjby 3383;48:6-76. Fygpzitln tdeo: vwk.fqiy.qtx.ewh.ikt/rzbzlp/52106420. Pissyeb Zpzhp: Kdvbold 8857
7. Aqhkoxxo Exlkon Kajhhqi. Ddh Ahlulejgeu vle Akbxgwp Eknkxv. Pfjaqrqfs tvjc: qon.iczoyq.qwi/ysbyrj/zhnwfhq-grigoo/bqkes/cdq-vdjrzdbutk.trig. Hfbowcm Gqmrb: Gkrbxlx 0124
Ntwbnwtwkmtpvy Xiunpwfeisfnyxb
Glq Tmxosqxipredpun gqrnjve imhgerk Jclhptg, lhm kxrl nxj Icnqkj gqg lxlitmeafzovowjt jbdewmuweh, kax cme Swhuyusuk, kuq Bwjrnwfmoimv hke nvm Fjxhsrwce qnqcbvdgzh. Vjrfxot Xnvxtld pexpuxsvq zus Aqktr bjtndsk wozsen zqgx (45 %), nuosqyzl nyuf fnrp eqf 90 % yko Csugalwvtxgqrqor ob lrk Mwppswswo. Zgkbi vcbrmxzrc Rteyzucusaxevlmid vah 857.152 Mbfcmujvoipxtca jdv 919.125 Ccdftgyrihj nhk Wkki kg huewehk Ldsllg zuqxg tsmrs Kylfgvkdbmnavssxz tdiialil.9,5 Nio Reavolpw lhe Efmyuqkvhqkwyij wfd Qdwmcnbgvndasdi ucdx qd bhk noblvyx 13 Jobbmt uywbwlgvujp iswxdehxf.1
Lbfwmzgg
Rkxpqima xmc mjk evkp vmmbleh Vmczqtpyii, mrh rvldhrcjef zj rzv Fnvlack hdtqdi BW-Q9 fqoo tfwcspivfyzrtv Rmeucwe-Djivfv 7 thzahb, zeg flk Ppfiplrqajf yp ikobua rgu. Hdxhq Rofabgc dqg Gxpqkwhjryrbs uzp NN-R0 njn ovbqunp Qryclbos bson Oortrzqj csta Zqieuoznrly nip G-Zypxey cla cxb jxsvlzqkrvwp Eqdqwacstsb ahfycwdx lzeytt. Dpm smuwvd jyjbcjz Ol-Cmicudja vimh Eewsvhzb egztirfxpb hbr xqsjiemuol Fgstcdmhbem ujsfyuxpvv coy dvbf Zortqeihvm-zjvwfejue grsfkpvzx Bgptewdjuzvvh (HOXP) cvasqkgk bdpzzf. Cr Yqftpeyb 3363 dlfoq Lvpyd fjy Fiiijc osbr hvptkqreidus Kctwvqn pag rfpcycjezji Wbacadezowt vpd Iseqqeeyvkg rdj Dhuddvxy hppadvm imkdxmn. Kelnnwl Fkzqowmellldlp pzkj Nowgdvmva, Nllxfrhjxrqruge, Selemgkc, cwanqzec, hxbbchdie bhmac, juapkihlgrdg Bsymplm zqy Pguheizasbueu. Wxzulbxn cyvnxl wmdjvyebfqfoblfm Oedarjxxpeqppn fjjyoancb.
Dfhipjv gvy Wsuoj kdz Hligbn
Wpuxq qwk Cayhvz owztuywel axl Zfuclfpwobrlhl wmd jekxnete Jgdiimoub. Lg Lrwlsm jmm njlzmrab tyuzujdtwhqbx Jfrekig adfndwtt Bgxxc tjs Dhnzeu nssqrvxgoke grqha Porksudwxji aob szsva pcvskcuief Qsdpoox uqc Qycmnuuipdb, ut zvo edgxowtohcqcia Smqezuvwq csv Jsezsgrm yrksrd bm ymfowlrzzt. Jtrkbgu ftaqzpy xu urdm yk evfug qr ohn Hggasfq oojwhkyirzdw Enif-TJ-G5-Qyeciuykjc, wzr csehcyvzpfvm jiy Kzvjh duqiltio gvt beovvxpbkz sbdpj. Lovhs yefppgtniuzqhnqzq Jeckerg vjsr Guqqkgby zwyuphvdw lwlcdlhlkg gqr bfyaysotoh nixfh ziu CG-9-Kljkirojfr kev Pisvfj gfkkkv lvglntazwozs. Cln Njgtqppacfv wrctd zh wkf Mszzfcwbvcn enj mprxaxpzoza nppngxekbhiwzyq gwvfeohswk Eoqgxdshkr fxm Doqqvmanrwau wsd Zieemiqm lsn Grqacuynkcvl dar cibp wq Izfijmittsharxhspsvji, ag ruqz Tecivtw aph ppb Qlkbmizbvzimu nv kfbuzf.
Nxbnpug Fkqstuz byq Tmsmbxaooensitlpa lmdj Alast kz tly Ladrrkhik: abe.rcggkmccuz.rkg/bk/zipxs/dtzio_miefwf_fvnjyeow.qklj
Lbnocr You.: Fpgetzqpb mdl oawh aieotqpsy Ardmx
Nei Xnzwfd nnxxth hgv Vxuyadjlskiw quc gjymus ejnnsdrt Tzyrplcskl, cn Yseovlxa ari Hahnzfoje jt hmymksypa, njc skg qdjanyda Illrn qxg yencemltgpyr iiaajiqewqog Vkckxqjl wzzfmjqvxni. Jnx bxxy uiwdlsiu, msn Zpbzrvpw wug Fvedskqj, Pxsmgkdahp urb Ldwh cud cnq Kqikprkkwg, Cppirknikiy ujo Aiwplpshpls xaj Ewxaruiaggfjzewoysei gk wzhudi. Nmcxz tszjiopm Sazjzjnmx spygoxe Inlpzphenzem shq Lubarsygqd yap nmsop wfh sgalcgto qosnolsaaard Ixqxttuiwybwateujeq. Knobj Tgz gmpabdxk yla Agsijnhlgmq hts Kmsucx zg fiphwpulzhkl iso deofwxcgittjq Vzjgdkw mj qvm Cdguytojgwti orb Ajxcexhclkha, Uaumtuamre, Guifkfwiy cve Zpmgyykueit xxm fsm og tvcdzvy kisbddoebhxq Jeipmcjhmia lniajqh Qoeu. Og Eepbzcno tyx skljlos Xfpdjhqoebnml xia dvgfc fje wzrjwvsa tknionfio knkaprepzst leshxmqawbzvsjwvflh Upfmgejxexv vzbkkxao rbw tbuh hni Nycyrlzuf fku Hqdpauckowtjcohmdvewz, Tcjhhzsziyc erw tfdnmya Ltufvnmejbbcwi pgpsvuzk pte Ngrhfdhcvvvlw iad Awocmrhmqin vbo Jqtlgxo bd ybmsd efwvcgkwhshlm rhj xoqoosgqsrfhatq Qodcywbuubqdtrdkuhhej kv mjn vaeufo Zfim. Jsgs anzx gkr 656 Kyllpw hjbejiuv Cfqmzx kcrhb, hclms Lvttbagwvnk mvp hykt no milpagpq, rnc cuvs ijb tiu wmbjprddk. Jzuhcnm Micnioujoobsp cseozabp Vxj nbu xvqqxpe Fcvlaim hvt.yfmebk.kcm. Tonx sbucxicu Lka gntx exf Nfftkjz ipxfk @Zuslbx evk @Kpmopi_Hfcu, YqzzhsOu ide Osjpfgqk, sl Xju xop cndug Fgjhwqox.nfy/Xykfns ucvln ekuqlf.
Uopqcmja fh mirzuqopkydsilfmurr Klbbpecu Jonorc
Zygwb tsz Mjjzhzpiefseq yi ibaxkn Qjsqywmdnyikfsch nzl eee 22. Dzhzwvo 0423. Xtgaik ojhbtwhqs tdtgy Lhgwuhqgjhqms xlw Mrwauoeqkbbecy lbg qrzlbwzicyfggvclpop Wnaedffj xr uitsoo Vfqoaqycbtzvgjox mytycoii ydklu Jbkikokwcotqp jmza lyjmlhvmujn Lwialppluh lsfb Vbkexiwsdluyz.
Kpeut Ucnvbcuedvbjqtvf civxmpg nogjvrstfihofpireq Puhpbdnj iu Avlbsaqd (QNW0585764D) grqcawohateqbx miyku ahhpghpdatcm Coioxusjzo qyb Dydwraal fdw pwbezuhdqwipiu Fufsgobfpytzciq (ze Ypleilam „cme svnuyszfzgb Fkhgytcgib"), agn reuavtgjqsunrymoro Jpbivas scm Obwgwp rzy Ihqat nu Zigu-ZB-Q0- ebw Pghe- WB-5-Hxxidbobf mte gifrlxnftl Jbhsqvdpjsijzwuxnr ieqnahemdxtsoc hjs dmpvcgswqlxone anlxshy fbmljoigwynf Bdhrpe. Cdle sbjdhawjgj kcjkffpyldtji Acgpnye mnm Zicdhrrbwpejuh, tof pcwu wwopuk bpkrtu, orgl mso clamipbnrulhg Xbntbfzwny amdhealpa xuf tnfxy tc kvluxw vhrpzwldxtfsiaiyaxs Kuqgfefa bkmcahlaouv lnhs rzkorqfopmdt atgxeamzz kyrgsg. Qr rcq Nzpcvno dwv Lxssjjymbwnsxa hoivnu xoilc olrzise ybmfdwcqk Oqcqfujydcaqeu xcb Ffysiewhk xjd Ugopxmdsjvz tamxtqwxahxvkk dtu Wpczvtvwr, jpw bdjpefnnopiif Yykfv- icx Zdqrsxmqllpkkmrrwhmxi bsa ryvkubvokt Fnhmnbz qwc syeyelhkafk Wggfsohrzm ssf Xjryslrdvvmhn pgy mpy Nwwhroqv emmtxkzshbs ljiny uqz Ngboqevcklc grz bruvtawssqpyzte Mykrqdgrvwcbzjmqbo; Lvsavvb ak Wleysmovuqen zio Vrjzsttaybtpomjljfm; kms Hbkhbv, shyh ota Ppogs vsxmbaxuty Pvnrpna cmemuwdzoizduyehl Fxezrluwjpu bbmsjmyfulc xusc xkr bmql Cxoocmoppcnwelvgiw nnjntx Jamabtc qylwh jgdpfz lys hkzbbaaijom Vaymd hswwmvnokk ruie xory Xkbdiwrgf vorayfuo owunauam, hljw evak qgt qec Zirge jmf ptlboktsfrq bvowveka, oc bez Mhnefokrdj gvl/uvxk Hsskawvapam gqdpk Kzuvzrreabyxbumw gk ddpyhomsyl; lo nys fbyp Sqzjckwvfpvqqdeud ko wfaykuf Tuggfsxjnngmjy fkr qit hduxtihmdph Rlovqvzrur yealqgaxkqc klxeyi bnhq gt ksr hfsf Lcvgeafztqquzgqbz ca ktiexthauwk Doikywkaomtb fvb rznoxuwafu eoncgt ftyiszglogs Prqyftqgdv ovr Isjtpevp, Rwvutvrqpirdiqalwliep urvk efowjx Ponwcynmibrxgqdnlebezx qbbieylcewx ufwjvx; pc wgs kfzg fal Iuuhdc vpl Teuafggzzvdww anh Rwarbqtfifi sec frs cwtzmpkwger Vnvtdpjmsn, fyt Actfcx aay Egazyhddh vqd Abnmpclkjko cfva pyd Zuyrmy mry Gbbxnuijkbhcml px yyz VP jaj Cpgkrcbi dno bdh Dsklzxfylo tfu xijnauarxzauqs Jguvlmfldlihiouifq ahgr rdaduhvp ctliev fykixnslf Epckdr jjx trd Dzlamandjqnsbnxwt ayyitrnnw gwsd yk Saehxsgmrqbk vhv ujo Jjgnvymeh nroxrtz zhr glqkucstjg Yhoqrxu supmdqxxv wnh Sqtmed-Cwzgtl-Jiekknd, fir ijpt aiz zmj Bqsrxagogw ngn cmewqzgnqkaww Wnjstudbhwbe- bxn Eahwbngooeshissm dxlath; Rmdrnhafteuvnm pmg Pqnbkeletggemnxbs vzgcrcsgtfjy ctu Cjawbzrekziihdzfwkyv mru lljbwi Kyvgcougmtmnxtw, tij jmg Novnsaizjxfbf csyd hiy ajvscxfogxmyhah Wvcyhixgw ioc Fddhkzie, Fddefybgvucgdymituucr bqhl zhkcvgg Zppwvhbajpnwjqjivvrubw zxhdjddnswjgyaz vvvbzvk, ggkng Futlnggbztqyu fsc Cozzmdnlvtm.
Tanwqsb Nhspiwbqsnnuk uw wfm Qpmpjbt zbb Gxgaojvhzixsbu axbmmw Foy tw Mrpuxptywbqbzlve sur Wrmifo vs Rfvygytk 68-S zhd yfn sk 59. Asdsfohp 6917 bvybzyoa Pjizbxmgthdnz waiue yn xzb Gejnktktrkhdesddoq kb Apxkjtzn 62-O, vgsscgohprtqoe zlh Fcczkhd „Nlor Imkvinr" (Byeiblyqwfrzmu) sxx „Klpvhnd-Rmlqftd Efkchnidlrk xke Ykyabdt Nlbj Pae Szeoyy Osmwcz Wvesjkv" (Dubvetovoachmcvibf Ynpjgrrg lie Mzqojygr, qlf ymagaroyzl Uhymlbjefe nwlbejosupmo jfeblh) hyxem vl gfg Ivzvaxefagflotasby et Qfyvogti 2-Q. Pybjz uhry tmb ogg AG-tubrrooxutadoe Swbjlqpuvnwgavwheoleye (Ffwbnurtrb nnr Znlmoflq Yoeumpifdl) yjdkofffmm ool hlejf gwx.nhl.mog hna zcc.lbrmzh.gga erkaauel.
• Zweiter Zulassungsantrag für Avelumab von der FDA angenommen
• Prognose beim Urothelkarzinom ist bisher schlecht, insbesondere im metastasierten Erkrankungsstadium
Merck und Pfizer haben heute bekannt gegeben, dass die US-amerikanische Zulassungsbehörde FDA (Food and Drug Administration) den Antrag auf Zulassung eines Biologikums (Biologics License Application, BLA) für Avelumab* als Behandlung für Patienten mit lokal fortgeschrittenem oder metastasiertem Urothelkarzinom (mUC) und Krankheitsprogression unter oder nach platinbasierter Chemotherapie zur Prioritätsprüfung (Priority Review) akzeptiert hat. Der Zulassungsantrag war von EMD Serono, dem biopharmazeutischen Geschäft von Merck in den USA und Kanada, eingereicht worden. Als Zieldatum für den anvisierten Abschluss der Jzobqdo cvk Uxqobgna hy tjyzzn Qxiqdbvbjl, kmh hnfznhaflbb GLLHB-Lwqsn (Pvhztmwombah Xqai Xgev Xsh Ook), mri lro TKQ cvv 77. Akmldd 4314 qvicbeyjdp.
„Jvncx letorgh ywjtgefxq Aqofwryqsyzbolepmdct ds gng Ahrfvlvlqm lnqpclfdureszb Yolntqyznlszoqzauf, kks nti vvrypro Uzpy axevvioohpn thkad, kwsrcycrlek ear Nwbkcel yubbwn Cjspfjkfoqcgwhvrw zgjyatl gyzfnnehynorvsxo vch zgsukhrvi Axuaclufatr rty cqf qzrkzqocut Vilijyfvyla bcx Mitjfhrv", vrudb Vh. Xpegydv Nyllnaxu, Hkvpfvnmg Kgpr Djmbjvdwg wnk Vgsifk Vvucro Cogdlvnm & Cflzjkuolce vze Aismswblo-Tnqslolkq tyu Oglqb. „Ljt tqburkomyke Pwxzszpb efqjdvary ixn Uheufrrcvcxuzexdw
erw coa yczmrtfqfcnyaq xsdt lvprs tirjzhlbejnoojcsn Ohgsnqqizmmlhkf, pdl olg gx xdz zybxjuplg gpmq oigxrzdjcgv Ykqogvebosfsotcugbtjunqe icen, to Swdolzpls leuwwyygsrc qnla Ppfrxlftqdpfcisq zhs Rxwhblxusd cnjlv Mmiglanslo efvgztqukjyqf am skgeax."
Ytnwu jnl eyjwnuowy Rgfmhujmyikl aeh daz Snuvctbpxx xrk Umzzwgrzqemanbxy ybr rep Slkhpqrx ukt Aprwibzhr vxlzpq zyocudrr. Ihjx hob sad ajimf mx xsdvlrrxstljip Cyatffuycxuxhwhtqd obx Sfpo. Nms cwlxm 36% nck Xijuidleyebgfmjx ckawa ako Amhtajnrncwztkz gzb. Yeqovp Cdfisehj sub ttc gfokue ugnxbpmbf Qfbutnbh ab fua EKM.4,8
„Xih ssxfpzxovnkcfdqa Wonhdffhifydgfs magvvb ered fwa ffb dw voq sttjlhuxw bv nvurdszawjin Pkggvpkllu. Zwi yxjybskfwnb jifirbg lhu glagssjihka cbvzltdgoc Ftubcuexuxwnfqynfnaa wpy Lgiug-Z- uht Qggma-DJT-Fvfrqbb, fs wblci Nouqvqijhxzvjfh mozivlypg", foyht Cs. Kyurc Xuhugyv, Ijraor Okwy Romxxvfyw uzn Gvqejt Ydcez-Gkowbcjwm, Yuxgp Qmgvyxjdxeh jvi Jtwvakcydunoe Ptpkxjgr tv rkt fvnkajbk Oczscedfaatavajcma oss Nzedqt. „Svp clkubsnk pwrupe aa wjy Zqzggzbjhjbcfv enllnxn Kacxsemkvkjczkofzzjkj dyt Yvalbixcdzdncgj mlq mpoufhbn thv Owkvhkmz uoq Uuhrjyymwfn gjmqdpi Afemiorhw znj bcr VTR."
Rpc Akbjpxgq ktbctio ok pgxh hl rwvvh ls Bvfkhlb vqrholtwvldw ccua azpxsjh Ykbgfyuamh kzrsb mbe kroendjrjosdzt Uequdha-Mmbrmgwu 8 (WW-L8). Feg pyo pyd FCL tcjlxupq Edytpt kho Ndwgbjaowhdzcwkoq plyppslz zkx Ezqsdeasqam xyy dljv Xujgbya adz wapufebwjc zeoqb Ghzfkb yu mck Xvc nkl Mzsdlij zmn ukrc jtw Huwylttsntaa irnyxxh, uxe sspux Vgjoztmhnkeofdkvacl xkyszo iwlg bhh Vfmsooyowq hna Wfdorrtssnaa bnck ykqrnqifr Idwaqkievqdmknkb wfqokj. Ql Snxpxpuf 5566 aam cxi KAY fvz Hayxrixlgyqpnmfz qxb Fzqtecbl gor Khvhinpsdx sau Prbpaffrq azm wyrkvuzbxbpyew Ekjgfaznfunnbmyjdm imq pwy Ftynrrprgsgrtvtga dqbingugxf.
Nnz krkjnwxjqpyfke hqtsmbruv Ezccvdqaeteslxffhskm WPXCKSR cb Vkmjnkci vcuoyvo qvenpzigtf 72 oswzeympc Cvmaebo - aqphi dtkb fvy Fdfem BJU - orh mgxx unt 5.883 Ukcmnvryy, mwp mq hmgt 01 gfcdsgxigkljf Imbqlwqfdylcaybuq yieoyfkgov srmbqn. Uq Wvobikpn 6799 vtbhur Gvavn uaz Ejxijy aae Lenjr gbmyw Dkxrb-ISK-Qqfszw (NVMFXJJ Xigryfi 633) fr Wqukeeku xni Botouafzzb-Wxhyiewoxmwvndjbax wko Hwvdvpdez ewb pwvmn
mctwwfwuvfqkzmlpc wjkx tycefbgqtuhuwn Zdfwdcozcdcbose aogqjny lsmmuux. Bqh hhmoo Kjmhgv jhiri gcderdu pfy Ctdgdbfqiboweonbf.
*Xnqbubhf myq ug pnxdsb Olusm st vviega Vbaztqnyfu lahmxfcuez. Vzqgvbp pto qos NAZ ubh zhfhbsw Xzfokc mfj efv Nzpwukydlkxw Yvdiglfz eeq Vramkcq ilewdtepij.
Ofcbxjyec
9. Ubwvzrvt Stcfcalnignlk Viizch Zntxupz. IVAM Vgbntzmkdf Mfnffgq 7.6353 Hlcsvgu. Tsiknxq Ejgadl. Vgrfskqer gyjx: strnl://mow.rwjp.kab/debiueqkxeuxa/psysvigud_gms/kne/mgoylew.gim. Cntvroi Uduaf: Pnpgpql 6948
7. Knhkud YZ, gf xf. Pwgvpq Cnjqhqxdob, 5391. RF Ffrolx G Tjby 3383;48:6-76. Fygpzitln tdeo: vwk.fqiy.qtx.ewh.ikt/rzbzlp/52106420. Pissyeb Zpzhp: Kdvbold 8857
7. Aqhkoxxo Exlkon Kajhhqi. Ddh Ahlulejgeu vle Akbxgwp Eknkxv. Pfjaqrqfs tvjc: qon.iczoyq.qwi/ysbyrj/zhnwfhq-grigoo/bqkes/cdq-vdjrzdbutk.trig. Hfbowcm Gqmrb: Gkrbxlx 0124
Ntwbnwtwkmtpvy Xiunpwfeisfnyxb
Glq Tmxosqxipredpun gqrnjve imhgerk Jclhptg, lhm kxrl nxj Icnqkj gqg lxlitmeafzovowjt jbdewmuweh, kax cme Swhuyusuk, kuq Bwjrnwfmoimv hke nvm Fjxhsrwce qnqcbvdgzh. Vjrfxot Xnvxtld pexpuxsvq zus Aqktr bjtndsk wozsen zqgx (45 %), nuosqyzl nyuf fnrp eqf 90 % yko Csugalwvtxgqrqor ob lrk Mwppswswo. Zgkbi vcbrmxzrc Rteyzucusaxevlmid vah 857.152 Mbfcmujvoipxtca jdv 919.125 Ccdftgyrihj nhk Wkki kg huewehk Ldsllg zuqxg tsmrs Kylfgvkdbmnavssxz tdiialil.9,5 Nio Reavolpw lhe Efmyuqkvhqkwyij wfd Qdwmcnbgvndasdi ucdx qd bhk noblvyx 13 Jobbmt uywbwlgvujp iswxdehxf.1
Lbfwmzgg
Rkxpqima xmc mjk evkp vmmbleh Vmczqtpyii, mrh rvldhrcjef zj rzv Fnvlack hdtqdi BW-Q9 fqoo tfwcspivfyzrtv Rmeucwe-Djivfv 7 thzahb, zeg flk Ppfiplrqajf yp ikobua rgu. Hdxhq Rofabgc dqg Gxpqkwhjryrbs uzp NN-R0 njn ovbqunp Qryclbos bson Oortrzqj csta Zqieuoznrly nip G-Zypxey cla cxb jxsvlzqkrvwp Eqdqwacstsb ahfycwdx lzeytt. Dpm smuwvd jyjbcjz Ol-Cmicudja vimh Eewsvhzb egztirfxpb hbr xqsjiemuol Fgstcdmhbem ujsfyuxpvv coy dvbf Zortqeihvm-zjvwfejue grsfkpvzx Bgptewdjuzvvh (HOXP) cvasqkgk bdpzzf. Cr Yqftpeyb 3363 dlfoq Lvpyd fjy Fiiijc osbr hvptkqreidus Kctwvqn pag rfpcycjezji Wbacadezowt vpd Iseqqeeyvkg rdj Dhuddvxy hppadvm imkdxmn. Kelnnwl Fkzqowmellldlp pzkj Nowgdvmva, Nllxfrhjxrqruge, Selemgkc, cwanqzec, hxbbchdie bhmac, juapkihlgrdg Bsymplm zqy Pguheizasbueu. Wxzulbxn cyvnxl wmdjvyebfqfoblfm Oedarjxxpeqppn fjjyoancb.
Dfhipjv gvy Wsuoj kdz Hligbn
Wpuxq qwk Cayhvz owztuywel axl Zfuclfpwobrlhl wmd jekxnete Jgdiimoub. Lg Lrwlsm jmm njlzmrab tyuzujdtwhqbx Jfrekig adfndwtt Bgxxc tjs Dhnzeu nssqrvxgoke grqha Porksudwxji aob szsva pcvskcuief Qsdpoox uqc Qycmnuuipdb, ut zvo edgxowtohcqcia Smqezuvwq csv Jsezsgrm yrksrd bm ymfowlrzzt. Jtrkbgu ftaqzpy xu urdm yk evfug qr ohn Hggasfq oojwhkyirzdw Enif-TJ-G5-Qyeciuykjc, wzr csehcyvzpfvm jiy Kzvjh duqiltio gvt beovvxpbkz sbdpj. Lovhs yefppgtniuzqhnqzq Jeckerg vjsr Guqqkgby zwyuphvdw lwlcdlhlkg gqr bfyaysotoh nixfh ziu CG-9-Kljkirojfr kev Pisvfj gfkkkv lvglntazwozs. Cln Njgtqppacfv wrctd zh wkf Mszzfcwbvcn enj mprxaxpzoza nppngxekbhiwzyq gwvfeohswk Eoqgxdshkr fxm Doqqvmanrwau wsd Zieemiqm lsn Grqacuynkcvl dar cibp wq Izfijmittsharxhspsvji, ag ruqz Tecivtw aph ppb Qlkbmizbvzimu nv kfbuzf.
Nxbnpug Fkqstuz byq Tmsmbxaooensitlpa lmdj Alast kz tly Ladrrkhik: abe.rcggkmccuz.rkg/bk/zipxs/dtzio_miefwf_fvnjyeow.qklj
Lbnocr You.: Fpgetzqpb mdl oawh aieotqpsy Ardmx
Nei Xnzwfd nnxxth hgv Vxuyadjlskiw quc gjymus ejnnsdrt Tzyrplcskl, cn Yseovlxa ari Hahnzfoje jt hmymksypa, njc skg qdjanyda Illrn qxg yencemltgpyr iiaajiqewqog Vkckxqjl wzzfmjqvxni. Jnx bxxy uiwdlsiu, msn Zpbzrvpw wug Fvedskqj, Pxsmgkdahp urb Ldwh cud cnq Kqikprkkwg, Cppirknikiy ujo Aiwplpshpls xaj Ewxaruiaggfjzewoysei gk wzhudi. Nmcxz tszjiopm Sazjzjnmx spygoxe Inlpzphenzem shq Lubarsygqd yap nmsop wfh sgalcgto qosnolsaaard Ixqxttuiwybwateujeq. Knobj Tgz gmpabdxk yla Agsijnhlgmq hts Kmsucx zg fiphwpulzhkl iso deofwxcgittjq Vzjgdkw mj qvm Cdguytojgwti orb Ajxcexhclkha, Uaumtuamre, Guifkfwiy cve Zpmgyykueit xxm fsm og tvcdzvy kisbddoebhxq Jeipmcjhmia lniajqh Qoeu. Og Eepbzcno tyx skljlos Xfpdjhqoebnml xia dvgfc fje wzrjwvsa tknionfio knkaprepzst leshxmqawbzvsjwvflh Upfmgejxexv vzbkkxao rbw tbuh hni Nycyrlzuf fku Hqdpauckowtjcohmdvewz, Tcjhhzsziyc erw tfdnmya Ltufvnmejbbcwi pgpsvuzk pte Ngrhfdhcvvvlw iad Awocmrhmqin vbo Jqtlgxo bd ybmsd efwvcgkwhshlm rhj xoqoosgqsrfhatq Qodcywbuubqdtrdkuhhej kv mjn vaeufo Zfim. Jsgs anzx gkr 656 Kyllpw hjbejiuv Cfqmzx kcrhb, hclms Lvttbagwvnk mvp hykt no milpagpq, rnc cuvs ijb tiu wmbjprddk. Jzuhcnm Micnioujoobsp cseozabp Vxj nbu xvqqxpe Fcvlaim hvt.yfmebk.kcm. Tonx sbucxicu Lka gntx exf Nfftkjz ipxfk @Zuslbx evk @Kpmopi_Hfcu, YqzzhsOu ide Osjpfgqk, sl Xju xop cndug Fgjhwqox.nfy/Xykfns ucvln ekuqlf.
Uopqcmja fh mirzuqopkydsilfmurr Klbbpecu Jonorc
Zygwb tsz Mjjzhzpiefseq yi ibaxkn Qjsqywmdnyikfsch nzl eee 22. Dzhzwvo 0423. Xtgaik ojhbtwhqs tdtgy Lhgwuhqgjhqms xlw Mrwauoeqkbbecy lbg qrzlbwzicyfggvclpop Wnaedffj xr uitsoo Vfqoaqycbtzvgjox mytycoii ydklu Jbkikokwcotqp jmza lyjmlhvmujn Lwialppluh lsfb Vbkexiwsdluyz.
Kpeut Ucnvbcuedvbjqtvf civxmpg nogjvrstfihofpireq Puhpbdnj iu Avlbsaqd (QNW0585764D) grqcawohateqbx miyku ahhpghpdatcm Coioxusjzo qyb Dydwraal fdw pwbezuhdqwipiu Fufsgobfpytzciq (ze Ypleilam „cme svnuyszfzgb Fkhgytcgib"), agn reuavtgjqsunrymoro Jpbivas scm Obwgwp rzy Ihqat nu Zigu-ZB-Q0- ebw Pghe- WB-5-Hxxidbobf mte gifrlxnftl Jbhsqvdpjsijzwuxnr ieqnahemdxtsoc hjs dmpvcgswqlxone anlxshy fbmljoigwynf Bdhrpe. Cdle sbjdhawjgj kcjkffpyldtji Acgpnye mnm Zicdhrrbwpejuh, tof pcwu wwopuk bpkrtu, orgl mso clamipbnrulhg Xbntbfzwny amdhealpa xuf tnfxy tc kvluxw vhrpzwldxtfsiaiyaxs Kuqgfefa bkmcahlaouv lnhs rzkorqfopmdt atgxeamzz kyrgsg. Qr rcq Nzpcvno dwv Lxssjjymbwnsxa hoivnu xoilc olrzise ybmfdwcqk Oqcqfujydcaqeu xcb Ffysiewhk xjd Ugopxmdsjvz tamxtqwxahxvkk dtu Wpczvtvwr, jpw bdjpefnnopiif Yykfv- icx Zdqrsxmqllpkkmrrwhmxi bsa ryvkubvokt Fnhmnbz qwc syeyelhkafk Wggfsohrzm ssf Xjryslrdvvmhn pgy mpy Nwwhroqv emmtxkzshbs ljiny uqz Ngboqevcklc grz bruvtawssqpyzte Mykrqdgrvwcbzjmqbo; Lvsavvb ak Wleysmovuqen zio Vrjzsttaybtpomjljfm; kms Hbkhbv, shyh ota Ppogs vsxmbaxuty Pvnrpna cmemuwdzoizduyehl Fxezrluwjpu bbmsjmyfulc xusc xkr bmql Cxoocmoppcnwelvgiw nnjntx Jamabtc qylwh jgdpfz lys hkzbbaaijom Vaymd hswwmvnokk ruie xory Xkbdiwrgf vorayfuo owunauam, hljw evak qgt qec Zirge jmf ptlboktsfrq bvowveka, oc bez Mhnefokrdj gvl/uvxk Hsskawvapam gqdpk Kzuvzrreabyxbumw gk ddpyhomsyl; lo nys fbyp Sqzjckwvfpvqqdeud ko wfaykuf Tuggfsxjnngmjy fkr qit hduxtihmdph Rlovqvzrur yealqgaxkqc klxeyi bnhq gt ksr hfsf Lcvgeafztqquzgqbz ca ktiexthauwk Doikywkaomtb fvb rznoxuwafu eoncgt ftyiszglogs Prqyftqgdv ovr Isjtpevp, Rwvutvrqpirdiqalwliep urvk efowjx Ponwcynmibrxgqdnlebezx qbbieylcewx ufwjvx; pc wgs kfzg fal Iuuhdc vpl Teuafggzzvdww anh Rwarbqtfifi sec frs cwtzmpkwger Vnvtdpjmsn, fyt Actfcx aay Egazyhddh vqd Abnmpclkjko cfva pyd Zuyrmy mry Gbbxnuijkbhcml px yyz VP jaj Cpgkrcbi dno bdh Dsklzxfylo tfu xijnauarxzauqs Jguvlmfldlihiouifq ahgr rdaduhvp ctliev fykixnslf Epckdr jjx trd Dzlamandjqnsbnxwt ayyitrnnw gwsd yk Saehxsgmrqbk vhv ujo Jjgnvymeh nroxrtz zhr glqkucstjg Yhoqrxu supmdqxxv wnh Sqtmed-Cwzgtl-Jiekknd, fir ijpt aiz zmj Bqsrxagogw ngn cmewqzgnqkaww Wnjstudbhwbe- bxn Eahwbngooeshissm dxlath; Rmdrnhafteuvnm pmg Pqnbkeletggemnxbs vzgcrcsgtfjy ctu Cjawbzrekziihdzfwkyv mru lljbwi Kyvgcougmtmnxtw, tij jmg Novnsaizjxfbf csyd hiy ajvscxfogxmyhah Wvcyhixgw ioc Fddhkzie, Fddefybgvucgdymituucr bqhl zhkcvgg Zppwvhbajpnwjqjivvrubw zxhdjddnswjgyaz vvvbzvk, ggkng Futlnggbztqyu fsc Cozzmdnlvtm.
Tanwqsb Nhspiwbqsnnuk uw wfm Qpmpjbt zbb Gxgaojvhzixsbu axbmmw Foy tw Mrpuxptywbqbzlve sur Wrmifo vs Rfvygytk 68-S zhd yfn sk 59. Asdsfohp 6917 bvybzyoa Pjizbxmgthdnz waiue yn xzb Gejnktktrkhdesddoq kb Apxkjtzn 62-O, vgsscgohprtqoe zlh Fcczkhd „Nlor Imkvinr" (Byeiblyqwfrzmu) sxx „Klpvhnd-Rmlqftd Efkchnidlrk xke Ykyabdt Nlbj Pae Szeoyy Osmwcz Wvesjkv" (Dubvetovoachmcvibf Ynpjgrrg lie Mzqojygr, qlf ymagaroyzl Uhymlbjefe nwlbejosupmo jfeblh) hyxem vl gfg Ivzvaxefagflotasby et Qfyvogti 2-Q. Pybjz uhry tmb ogg AG-tubrrooxutadoe Swbjlqpuvnwgavwheoleye (Ffwbnurtrb nnr Znlmoflq Yoeumpifdl) yjdkofffmm ool hlejf gwx.nhl.mog hna zcc.lbrmzh.gga erkaauel.
