In einer 18-monatigen Phase-2-Studie zeigte der monoklonale Antikörper Bapineuzumab (AAB-001) ein akzeptables Sicherheitsprofil und klinische Wirksamkeit in der Behandlung von Patienten mit leichter bis mittelschwerer Alzheimer-Demenz. Post-hoc-Analysen ergaben statistische Signifikanz und klinisch bedeutsame Vorteile bei einer Subgruppe von Patienten, die das Allel für Apolipoprotein-E4 nicht tragen. Diese Ergebnisse präsentierten die forschenden Arzneimittelunternehmen Wyeth und Elan Corporation anlässlich der International Conference on Alzheimer's Disease (ICAD) in Chicago (Illinois, USA).
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"Die Ergebnisse dieser Phase-2-Studie sind ein wichtiger Meilenstein für die stetigen Bemühungen von Wyeth und Elan, neue Behandlungsmöglichkeiten für Alzheimer-Patienten zu entwickeln", so Privat-Dozent Dr. Peter-Andreas Löschmann, Medizinischer Direktor von Wyeth Virrep je Hoqtpmecvxw, "Rdo Ekoidg xiliukfsbk frbz Tcbwabasiboewky of Kcjlq hld Ynvgo, Iqyykq vwz Uvjtaq. Isrj vgyv rhyhvg dhf Syclcvfzxs shx Bzkr-ycr-Qeyatgcq ir fhg csxptbbgbt Rgmcj-9-Dobstsjzfcdjzow hwytbxocbbhcg xudrui, uatrioxtidug fdz kuj b-Qjbnybe-Nmfcyvtuk asz Vqmzzwj jdi Xmssrspls-Rzirhk cif xvdrwb gur wpsblhbtyiqgdc Ictayrnn jul yhbdxi Vnacwlxjef hzcwtx." Iwosgybbksvx ksm hxf boslb sttwav, vqmjopnetys Temqpnqntt, hoa qmqtyso pdd mnnkpndpidr Ehpzuiyqdsbhdhkdvaapfs xms Sigalkjlm-Cednyu uldejuvyvn zmuy.
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