In einer 18-monatigen Phase-2-Studie zeigte der monoklonale Antikörper Bapineuzumab (AAB-001) ein akzeptables Sicherheitsprofil und klinische Wirksamkeit in der Behandlung von Patienten mit leichter bis mittelschwerer Alzheimer-Demenz. Post-hoc-Analysen ergaben statistische Signifikanz und klinisch bedeutsame Vorteile bei einer Subgruppe von Patienten, die das Allel für Apolipoprotein-E4 nicht tragen. Diese Ergebnisse präsentierten die forschenden Arzneimittelunternehmen Wyeth und Elan Corporation anlässlich der International Conference on Alzheimer's Disease (ICAD) in Chicago (Illinois, USA).
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