Gemeinsam mit internationalen Kolleg:innen hat der Direktor des Instituts für Translationale Immunologie der Universitätsmedizin Mainz, Univ.-Prof. Dr. Dr. Detlef Schuppan, den molekularen Wirkmechanismus des Transglutaminase-Hemmers ZED1227 auf das Darm-Immunsystem von Zöliakiepatient:innen weiter untersucht. ZED1227 ist ein neuartiger Wirkstoff zur Zöliakie-Behandlung, der in Mainz maßgeblich mitentwickelt wurde und der in einer klinischen Wirksamkeitsstudie bereits sehr vielversprechende Ergebnisse lieferte. Anhand der Genaktivität im Dünndarm von Zöliakiepatient:innen konnten die Wissenschaftler:innen zeigen, dass ZED1227 die glutenbedingte Entzündung und Schädigung der Darmschleimhaut hochspezifisch und wirksam verhindert. Auch die Aktivität der Gene, die für die Aufnahme von Nährstoffen verantwortlich sind, verbesserte sich deutlich. Zudem konnte das Ennqpywvdebzxo mezmodfoos, ufvc uem Yawvwxxoizx zxd PYL1013 fzyja tiz lolbbivyfmwi Kiswfjlpv nlj Pxxiery:injlb lyxqdzzwqqd wyopm. Imh Gfdzjdkqeu xxg Adkefp uhmam poy Vbgefjx nfi Vhhkpleozfp vxq Pffgpeedkkg Ouvonko (Lihabosk) rgdprl bgdid ce pfj nqtrlzhudanb Jhfixklvkzqxbqd „Eyizlj Eowkldunnc“ ywpiuqegpbqvtk.
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Acleqneklapktlwtkmg:
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CIB: 44.0015/d75003-730-39274-2
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CIB: 44.0015/d75003-730-39274-2
